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1. Full Text Mechanics of microtubules
by Hawkins, Taviare and Mirigian, Matthew and Selcuk Yasar, M and Ross, Jennifer L
Journal of Biomechanics, ISSN 0021-9290, 2009, Volume 43, Issue 1, pp. 23 - 30
Abstract Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and cellular processes. For instance, microtubules for the... 
Physical Medicine and Rehabilitation | Cytoskeletal network | Flexural rigidity | Flexibility | Microtubule bundle | PERSISTENCE LENGTH | GROWING MICROTUBULES | COMPLEX | ENGINEERING, BIOMEDICAL | THERMAL FLUCTUATIONS | ACTIN-FILAMENTS | DYNAMIC INSTABILITY | INDIVIDUAL MICROTUBULES | SINGLE-MICROTUBULE | BIOPHYSICS | PROTEINS | Biomechanical Phenomena | Animals | Humans | Microtubules - physiology | Cytoskeleton - physiology | Cell Movement | Microtubule-Associated Proteins - physiology | Mechanical properties | Muscle proteins | Actin | Proteins | Cellular biology | Microscopy | Mechanics | Cytoskeleton | Experiments | Biomechanics | Cellular | Cellular communication | Filaments | Morphology | Division | Chromosomes
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2. Full Text Fast kinetics of Taxol binding to microtubules: Effects of solution variables and microtubule-associated proteins
by Díaz, José Fernando and Barasoain, Isabel and Andreu, José Manuel
Journal of Biological Chemistry, ISSN 0021-9258, 03/2003, Volume 278, Issue 10, pp. 8407 - 8419
The kinetics of Taxol association to and dissociation from stabilized microtubules has been measured by competition with the reference fluorescent derivative... 
CANCER-CELLS | ANGSTROM RESOLUTION | IN-VITRO | ALPHA-BETA-TUBULIN | STABILIZING AGENTS | PROTOFILAMENT NUMBER | COMMON PHARMACOPHORE | PACLITAXEL RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPUTER-SIMULATION | INDIVIDUAL MICROTUBULES | Paclitaxel - metabolism | Microtubules - metabolism | Animals | Solutions | Cattle | Microtubule-Associated Proteins - metabolism | Kinetics
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3. Full Text Force production by disassembling microtubules
by Ataullakhanov, Fazly I and McIntosh, J. Richard and Grishchuk, Ekaterina L and Molodtsov, Maxim I
Nature, ISSN 0028-0836, 11/2005, Volume 438, Issue 7066, pp. 384 - 388
Microtubules (MTs) are important components of the eukaryotic cytoskeleton: they contribute to cell shape and movement, as well as to the motions of organelles... 
SLOWLY HYDROLYZABLE ANALOG | IN-VITRO | COMPLEX | INFORMATION | MULTIDISCIPLINARY SCIENCES | DEPOLYMERIZATION | GENERATION | DYNAMIC INSTABILITY | CHROMOSOMES | INDIVIDUAL MICROTUBULES | GTP HYDROLYSIS | Tetrahymena - chemistry | Biopolymers - chemistry | Glass | Biopolymers - metabolism | Microspheres | Biomechanical Phenomena | Microtubules - metabolism | Tubulin - metabolism | Animals | Tetrahymena - metabolism | Cattle | Models, Biological | Microtubules - chemistry | Tubulin - chemistry | Cellular biology | Polymers | Chromosomes
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4. Full Text EB1 regulates microtubule dynamics and tubulin sheet closure in vitro
by Vitre, Benjamin and Coquelle, Frédéric M and Heichette, Claire and Garnier, Cyrille and Chrétien, Denis and Arnal, Isabelle
Nature Cell Biology, ISSN 1465-7392, 2008, Volume 10, Issue 4, pp. 415 - 421
End binding 1 ( EB1) is a plus-end-tracking protein (+TIP) that localizes to microtubule plus ends where it modulates their dynamics and interactions with... 
INSTABILITY | MECHANISM | APC | PROTOFILAMENT NUMBERS | STRUCTURAL BASIS | P150(GLUED) | POLYMERIZATION | PLUS-END-TRACKING | INDIVIDUAL MICROTUBULES | PROTEINS | CELL BIOLOGY | Microtubules - metabolism | Tubulin - metabolism | Animals | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Models, Biological | Swine | Microtubules - ultrastructure | Protein Conformation | Mice | Microscopy, Video | Usage | Microtubules | Video microscopy | Genetic aspects | Research | Tubulins | Health aspects | Biochemistry, Molecular Biology | Microtubule-Associated Proteins | Cellular Biology | Life Sciences | Tubulin | Biomolecules | Subcellular Processes
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5. Full Text Microtubule dynamics
by Valiron, O and Caudron, N and Job, D
Cellular and Molecular Life Sciences, ISSN 1420-682X, 12/2001, Volume 58, Issue 14, pp. 2069 - 2084
Microtubules are fibrous elements in the cytoplasm of eukaryotic cells, where they perform a wide variety of functions. Microtubules are major organizers of... 
microtubule associated proteins | dynamics | regulation | Microtubules | organization | Regulation | Organization | Microtubule associated proteins | Dynamics | XENOPUS EGG EXTRACTS | GUANOSINE DIPHOSPHATE | microtubules | INDIVIDUAL MICROTUBULES | SELF-ORGANIZATION | BINDING PROTEIN | IN-VITRO | TUBULIN RING COMPLEX | MITOTIC SPINDLE | KINETIC-ANALYSIS | GAMMA-TUBULIN | Microtubules - metabolism | Tubulin - metabolism | Animals | Biological Clocks - physiology | Humans | Eukaryotic Cells - ultrastructure | Microtubules - ultrastructure | Microtubule Proteins - metabolism | Cytoplasm - metabolism | Eukaryotic Cells - metabolism | Tubulin - chemistry | Proteins | Cell division | Eukaryotes | Cellular biology | Polymers
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6. Full Text MICROTUBULE POLYMERIZATION DYNAMICS
by Desai, Arshad and Mitchison, Timothy J
Annual Review of Cell and Developmental Biology, ISSN 1081-0706, 11/1997, Volume 13, Issue 1, pp. 83 - 117
The polymerization dynamics of microtubules are central to their biological functions. Polymerization dynamics allow microtubules to adopt spatial arrangements... 
regulation | mechanism | cytoskeleton | dynamic instability | Cytoskeleton | Regulation | Dynamic instability | Mechanism | SLOWLY HYDROLYZABLE ANALOG | BETA-TUBULIN | XENOPUS EGG EXTRACTS | REAL-TIME OBSERVATIONS | DEVELOPMENTAL BIOLOGY | INDIVIDUAL MICROTUBULES | GREEN FLUORESCENT PROTEIN | MITOTIC SPINDLE | SURFACE LATTICE | KINESIN-RELATED PROTEIN | GTP HYDROLYSIS | Microtubule-Associated Proteins - chemistry | Thermodynamics | Tubulin - metabolism | Animals | Microtubule-Associated Proteins - metabolism | Microtubules - physiology | Microtubules - ultrastructure | Microtubules - chemistry | Polymers - chemistry | Guanosine Triphosphate - metabolism | Tubulin - chemistry | Dimerization
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7. Full Text Ectopic A-lattice seams destabilize microtubules
by Katsuki, Miho and Drummond, Douglas R and Cross, Robert A
Nature Communications, ISSN 2041-1723, 01/2014, Volume 5, Issue 1, p. 3094
Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams... 
STABILIZE MICROTUBULES | FLAGELLAR MICROTUBULES | IN-VITRO | POLYMERIZATION DYNAMICS | PROTOFILAMENT NUMBER | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | DYNAMIC INSTABILITY | INDIVIDUAL MICROTUBULES | GTP CAP | SCHIZOSACCHAROMYCES-POMBE | Microtubule-Associated Proteins - metabolism | Molecular Conformation | Protein Multimerization | Guanosine Triphosphate - analogs & derivatives | Rats | Guanosine Triphosphate - metabolism | Kinesin - metabolism | Protein Transport | Microtubules - metabolism | Tubulin - metabolism | Animals | Models, Biological | Surface Properties | Schizosaccharomyces pombe Proteins - metabolism | Microtubules - chemistry | Guanosine Diphosphate - metabolism | Sus scrofa
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8. Full Text 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
by Kathy Kamath and Tatiana Okouneva and Gary Larson and Dulal Panda and Leslie Wilson and Mary Ann Jordan
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2006, Volume 5, Issue 9, pp. 2225 - 2233
2-Methoxyestradiol (2ME2), a metabolite of estradiol-17β, is a novel antimitotic and antiangiogenic drug candidate in phase I and II clinical trials for the... 
Methoxyestradiol | Mitotic Arrest | Chemotherapy | Microtubule | GFP-tubulin | CELLS | INSTABILITY | ONCOLOGY | TUBULIN POLYMERS | TAXOL | GROWTH | VINBLASTINE | INDIVIDUAL MICROTUBULES | ENDOGENOUS MAMMALIAN METABOLITE | BINDING | KINETIC STABILIZATION | Estradiol - analogs & derivatives | Interphase - physiology | Tubulin Modulators - pharmacology | Humans | Breast Neoplasms - metabolism | Strongylocentrotus purpuratus | Microtubules - metabolism | Tubulin - metabolism | Cattle | Microtubules - drug effects | Spindle Apparatus - physiology | Estradiol - pharmacology | Tubulin Modulators - pharmacokinetics | Microtubules - physiology | Angiogenesis Inhibitors - pharmacology | Breast Neoplasms - drug therapy | Estradiol - pharmacokinetics | Animals | Mitosis - drug effects | Mitosis - physiology | Breast Neoplasms - pathology | Cell Line, Tumor | Antimitotic Agents - pharmacology | Mice | Spindle Apparatus - drug effects | Interphase - drug effects
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9. Full Text Evolving Tip Structures Can Explain Age-Dependent Microtubule Catastrophe
by Coombes, Courtney E and Yamamoto, Ami and Kenzie, Madeline R and Odde, David J and Gardner, Melissa K
Current Biology, ISSN 0960-9822, 07/2013, Volume 23, Issue 14, pp. 1342 - 1348
Microtubules are key structural and transport elements in cells. The dynamics at microtubule ends are characterized by periods of slow growth, followed by... 
STABILIZE MICROTUBULES | SELF-ASSEMBLY KINETICS | IN-VITRO | MCAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDS | DYNAMIC INSTABILITY | INDIVIDUAL MICROTUBULES | TUBULIN | GTP CAP | LATTICE | CELL BIOLOGY | Microtubule-Associated Proteins - chemistry | Microscopy, Electron, Transmission | Microtubule-Associated Proteins - metabolism | Models, Molecular | Microtubules - metabolism | Tubulin - metabolism | Computer Simulation | Microtubules - ultrastructure | Microtubules - chemistry | Tubulin - chemistry | Saccharomycetales - cytology | Saccharomycetales - metabolism | Microscopy, Fluorescence | Fluorescence | Electron microscopy | Tubulins | Gross domestic product | Cells | Biomedical engineering
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10. Full Text Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF‐7 cells
by Banerjee, Mithu and Singh, Parminder and Panda, Dulal
The FEBS Journal, ISSN 1742-464X, 08/2010, Volume 277, Issue 16, pp. 3437 - 3448
In this study, curcumin, a potential anticancer agent, was found to dampen the dynamic instability of individual microtubules in living MCF‐7 cells. It... 
apoptosis | delayed mitosis | combination study | BubR1 | dynamic instability | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLE ARREST | SPINDLE ASSEMBLY CHECKPOINT | POLYMERIZATION | INDUCTION | INDIVIDUAL MICROTUBULES | P53 | BREAST-CANCER CELLS | INHIBITION | TUBULIN BINDING | KINETIC STABILIZATION | Apoptosis - drug effects | Humans | Curcumin - pharmacology | Protein Transport - drug effects | Breast Neoplasms - drug therapy | Kinesin - metabolism | Tubulin - drug effects | Mitosis - drug effects | Time Factors | Microtubules - drug effects | Protein Stability - drug effects | Cell Line, Tumor | Female | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Spindle Apparatus - drug effects | Cell Cycle - drug effects | Tumor proteins | Kinesin | Apoptosis | Cell division | Ratios | Biochemistry | Cellular biology
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