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Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 01/2019, Volume 29, Issue 1, pp. 11 - 23
Introduction: Tryptophan-2, 3-dioxygenase (TDO2) is a tryptophan-degrading enzyme constitutively expressed in the liver and to a lesser extend in the brain.... 
tryptophan 2 | anticancer | 3-dioxygenase | immunotherapy | Kynurenine pathway | CELLS | CHEMISTRY, MEDICINAL | MECHANISM | INDOLEAMINE 2,3-DIOXYGENASE | ENZYME | INTERFERON-GAMMA | METABOLISM | DEGRADATION | PHARMACOLOGY & PHARMACY | TUMORAL IMMUNE RESISTANCE
Journal Article
Journal Article
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 04/2018, Volume 77, pp. 600 - 607
Indoleamine 2,3-dioxygenase is a heme-containing enzyme implicated in the down regulation of the anti-tumor immune response, and considered a promising... 
Anti-tumor | Tryptophan | Kynurenine | Indoleamine 2,3-dioxygenase | Inhibitor | In vivo target inhibition | 4-Bromophenylhydrazinyl benzenesulfonylphenylurea | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | benzenesulfonylphenylurea | PROLIFERATION | 4-Bromophenylhydrazinyl | T-CELL | SUPPRESSION | DRAINING LYMPH-NODES | TRYPTOPHAN CATABOLISM | PLASMACYTOID DENDRITIC CELLS | LUNG-CANCER | IDO | EXPRESSION | DERIVATIVES | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Sulfones - pharmacology | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | CD3 Complex - isolation & purification | Sulfones - chemistry | Enzyme Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Sulfones - chemical synthesis | Biomarkers, Tumor - analysis | Enzyme Inhibitors - pharmacology | Rats | Antineoplastic Agents - chemistry | Biomarkers, Tumor - isolation & purification | Rats, Sprague-Dawley | CD3 Complex - analysis | Animals | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - metabolism | Neoplasms, Experimental - drug therapy | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Drug Screening Assays, Antitumor | T cells | Pharmaceutical industry | Tumors
Journal Article
International Journal of Immunopathology and Pharmacology, ISSN 0394-6320, 09/2017, Volume 30, Issue 3, pp. 215 - 226
Indoleamine 2,3-dioxygenase (IDO) is involved in tumor immune escape and resistance to chemotherapy, and is clinically correlated with tumor progression. IDO... 
paclitaxel | indoleamine 2,3-dioxygenase | 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (NLG919) | chemotherapy | immunotherapy | TARGET | CELLS | IMMUNOLOGY | PATHOLOGY | SUPPRESSION | CANCER | THERAPY | PHARMACOLOGY & PHARMACY | EXPRESSION | Original s
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2017, Volume 323, pp. 74 - 80
Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in the immune system by regulating tryptophan levels and T cell differentiation. Several tumor types... 
IDO inhibitors | Clinical trials | Aryl Hydrocarbon Receptor | AHR agonists | IDO1 | Cancer | DENDRITIC CELLS | KYNURENINE PATHWAY | AH RECEPTOR | TRYPTOPHAN CATABOLISM | INTERFERON-GAMMA | COLORECTAL-CANCER | THERAPEUTIC TARGET | DISEASE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | T-CELLS | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Cytochrome P-450 CYP1A1 - genetics | Basic Helix-Loop-Helix Transcription Factors - agonists | Basic Helix-Loop-Helix Transcription Factors - genetics | Risk Assessment | Humans | Enzyme Inhibitors - pharmacology | Receptors, Aryl Hydrocarbon - genetics | Enzyme Induction | Hep G2 Cells | Receptors, Aryl Hydrocarbon - agonists | Animals | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | Enzyme Inhibitors - toxicity | Receptors, Aryl Hydrocarbon - metabolism | Ligands | Transcription, Genetic | Mice | Cytochrome P-450 CYP1A1 - biosynthesis | Genes, Reporter | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Physiological aspects | Tryptophan | T cells | Xenobiotics | Cells | Herbicides | Medical colleges | Dioxin | Cytochrome P-450 | Index Medicus | DIOXIN | KYNURENINE | TRYPTOPHAN | NEOPLASMS | CLINICAL TRIALS | DMSO | SUBSTRATES | QUINOLINES | 60 APPLIED LIFE SCIENCES | LUCIFERASE | MEDICAL SURVEILLANCE | ENZYME ACTIVITY | XENOBIOTICS | HYDROXY COMPOUNDS | LIGANDS | METABOLISM | DRUGS | GENES | PHOSPHATES | CELL DIFFERENTIATION | MICE | RECEPTORS | BEARS
Journal Article