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Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1159 - 1167
The cytotoxic farnesyl transferase inhibitor BMS-214662 has been shown to potently induce mitochondrial apoptosis in primitive CD34+ chronic myeloid leukaemia... 
BMS-214662 | HSC | MEK inhibitor | CML | TKI | PD184352 | CHRONIC MYELOGENOUS LEUKEMIA | KINASE INHIBITORS | INDUCE APOPTOSIS | CHRONIC MYELOID-LEUKEMIA | IN-VITRO | ONCOLOGY | PHILADELPHIA-CHROMOSOME | IMATINIB | QUIESCENT | CML CELLS | DIFFERENTIATION | HEMATOLOGY | Antigens, CD34 - analysis | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myeloid, Chronic-Phase - pathology | Neoplasm Proteins - antagonists & inhibitors | K562 Cells - drug effects | Blast Crisis - enzymology | MAP Kinase Kinase 1 - genetics | Tumor Cells, Cultured - enzymology | Genes, Dominant | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Benzamides - pharmacology | Farnesyltranstransferase - antagonists & inhibitors | MAP Kinase Kinase Kinases - antagonists & inhibitors | Hematopoietic Stem Cells - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Benzodiazepines - pharmacology | Blast Crisis - pathology | Tumor Cells, Cultured - drug effects | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Leukemia, Myeloid, Chronic-Phase - enzymology | K562 Cells - enzymology | Drug Synergism | Recombinant Fusion Proteins - genetics | Genes, ras | Hematopoietic Stem Cells - enzymology | Neoplastic Stem Cells - enzymology | Drug Screening Assays, Antitumor | Oncogene Protein p21(ras) - genetics | Antimitotic agents | Physiological aspects | Chronic myeloid leukemia | Research | Drug therapy | Antineoplastic agents | Protein kinases | Health aspects | Apoptosis | Index Medicus | FTI | CD34
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2009, Volume 11, Issue 6, pp. 739 - 746
Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis. Besides its classic morphogenic... 
PROTEIN | INHIBITION | GENE | MECHANISM | SONIC HEDGEHOG | NEURONAL DEATH | PRODUCT INDUCES APOPTOSIS | KAPPA-B | CASPASE ACTIVATION | CELL-DEATH | CELL BIOLOGY | RNA, Small Interfering - genetics | Caspase 9 - metabolism | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Hedgehog Proteins - genetics | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Patched Receptors | Neoplasm Proteins - genetics | Cell Line | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Chick Embryo | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Adaptor Proteins, Signal Transducing - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Causes of | Physiological aspects | Cell receptors | Research | Proteases | Apoptosis | Index Medicus | Caspase 9 | Signal Transduction | Multiprotein Complexes | Receptors, Cell Surface | Cellular Biology | Hedgehog Proteins | Life Sciences | Muscle Proteins | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Homeodomain Proteins | Neoplasm Proteins | CARD Signaling Adaptor Proteins | RNA, Small Interfering | Transcription Factors | Development Biology | physiology | genetics | metabolism
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4870 - 4879
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 2011, Volume 39, Issue 14, pp. 6069 - 6085
The p53-family member p73 plays a role in various cellular signaling pathways during development and growth control and it can have tumor suppressor... 
WILD-TYPE P53 | TRANSCRIPTIONAL ACTIVITY | NEUROTROPHIN RECEPTOR | TUMOR-SUPPRESSOR FUNCTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | BINDING SITES | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | INDUCE APOPTOSIS | CELL-CYCLE PROGRESSION | NF-KAPPA-B | Molecular Biology
Journal Article
Carcinogenesis, ISSN 0143-3334, 06/2013, Volume 34, Issue 6, pp. 1323 - 1330
Journal Article
Genes and Development, ISSN 0890-9369, 05/1998, Volume 12, Issue 9, pp. 1304 - 1314
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e59330 - e59330
Endoplasmic reticulum (ER) stress-mediated cell apoptosis has been implicated in various cell types, including fibroblasts. Previous studies have shown that... 
5-FLUOROURACIL | TRANSLOCATION | OXIDATIVE STRESS | UNFOLDED PROTEIN RESPONSE | LAMINECTOMY | C INDUCES APOPTOSIS | ER STRESS | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIA | CHOP | CELL-DEATH | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | Apoptosis - drug effects | eIF-2 Kinase - metabolism | Humans | Cell Survival - genetics | Apoptosis - genetics | Endoplasmic Reticulum Stress - genetics | Activating Transcription Factor 6 - genetics | Heat-Shock Proteins - genetics | Bcl-2-Like Protein 11 | Lipid Peroxidation - drug effects | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | eIF-2 Kinase - genetics | In Situ Nick-End Labeling | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Mitomycin - pharmacology | Activating Transcription Factor 6 - metabolism | Signal Transduction - drug effects | Fibroblasts - drug effects | Fibroblasts - cytology | Transcription Factor CHOP - metabolism | Analysis | Mitomycin | Apoptosis | Cell proliferation | Oxidative stress | Cell culture | Reactive oxygen species | Bax protein | Bcl-2 protein | Staining | Homology | Propidium iodide | CCAAT/enhancer-binding protein | Kinases | ADP | Caspase-3 | Stomach cancer | Western blotting | Proteins | Signal transduction | Ribose | Protein folding | Rodents | Surgery | Cell cycle | Fibroblasts | Mitomycin C | Stresses | Inositol | Iodides | Activating transcription factor 6 | Poly(ADP-ribose) polymerase | Caspase | Stress | Esophagus | Polymerase | DNA nucleotidylexotransferase | Signaling | Scars | Orthopedics | Annexin V | Endoplasmic reticulum | Viability | BIM protein | Index Medicus
Journal Article