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1. Full Text Autophagy inhibitors
by Pasquier, Benoit and Pasquier, Benoit
Cellular and Molecular Life Sciences, ISSN 1420-682X, 3/2016, Volume 73, Issue 5, pp. 985 - 1001
Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular and molecular mechanisms underlying this process are highly complex and... 
Life Sciences | Biochemistry, general | Autophagosomes | Hydroxychloroquine | Life Sciences, general | PI3K | Lysosomotropic agent | ULK | Autophagy | PIK3C3/Vps34 | Biomedicine general | Cell Biology | MAMMALIAN TARGET | SIGNALING PATHWAYS | INDUCED APOPTOSIS | PHOSPHATIDYLINOSITOL 3-KINASE | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-DEATH | CELL BIOLOGY | SELECTIVE INHIBITOR | REV-ERB-BETA | HIGHLY POTENT | NUTRIENT STRESS | Lysosomes - drug effects | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Drug Discovery - methods | Pyrimidines - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Pyrimidines - chemistry | Pyrimidinones - chemistry | Autophagy-Related Protein-1 Homolog | Chloroquine - analogs & derivatives | Chloroquine - pharmacology | Protein Kinase Inhibitors - chemistry | Animals | Lysosomes - metabolism | Signal Transduction - drug effects | Chloroquine - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Pyrimidinones - pharmacology | Protein Kinase Inhibitors - pharmacology | Proteins | Nervous system diseases | Drug discovery | Phosphotransferases | Signal transduction | Pharmacology | Kinases
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2. Full Text Targeting autophagy in cancer
by Levy, Jean M. Mulcahy and Towers, Christina G and Thorburn, Andrew
Nature Reviews Cancer, ISSN 1474-175X, 09/2017, Volume 17, Issue 9, pp. 528 - 542
Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing... 
BREAST-CANCER | ADVANCED SOLID TUMORS | ONCOLOGY | CHAPERONE-MEDIATED AUTOPHAGY | PHASE-I TRIAL | ER STRESS | SURVIVAL MECHANISM | CISPLATIN RESISTANCE | INHIBITS AUTOPHAGY | HMGB1 EXPRESSION | HYPOXIA-INDUCED AUTOPHAGY | Hydroxychloroquine - therapeutic use | Tumor Escape | Microtubule-Associated Proteins - metabolism | Humans | Chloroquine - therapeutic use | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Autophagy - drug effects | Neoplasms - drug therapy | Animals | Biomarkers, Tumor - metabolism | Autophagy - genetics | Sequestosome-1 Protein - metabolism | Autophagy (Cytology) | Molecular targeted therapy | Care and treatment | Health aspects | Innovations | Cancer | Lysosomes | Autophagy | Macromolecules | Phagocytosis
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3. Full Text Metabolic Control of Autophagy
by Galluzzi, Lorenzo and Pietrocola, Federico and Levine, Beth and Kroemer, Guido
Cell, ISSN 0092-8674, 12/2014, Volume 159, Issue 6, pp. 1263 - 1276
Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation to adverse microenvironmental conditions, including... 
NICOTINAMIDE RIBOSIDE | GLUCOSE-HOMEOSTASIS | ACTIVATED PROTEIN-KINASE | AMINO-ACIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXTENDS LIFE-SPAN | BECLIN 1 PHOSPHORYLATION | MITOCHONDRIAL DISEASE | DIET-INDUCED OBESITY | NEONATAL AUTOPHAGY | STRESS-INDUCED AUTOPHAGY | CELL BIOLOGY | Animals | Metabolic Networks and Pathways | Signal Transduction | Humans | Cells - metabolism | Homeostasis | Autophagy - drug effects | Cellular signal transduction | Magneto-electric machines | Machinery | Cells
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4. Full Text Autophagy in cancer metastasis
by Mowers, E.E and Sharifi, M.N and Macleod, K.F
Oncogene, ISSN 0950-9232, 03/2017, Volume 36, Issue 12, pp. 1619 - 1630
Autophagy is a highly conserved self-degradative process that has a key role in cellular stress responses and survival. Recent work has begun to explore the... 
STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | TUMOR-CELLS | OVARIAN-CANCER | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | ONCOLOGY | GENETICS & HEREDITY | EXTRACELLULAR-MATRIX | FOCAL ADHESION KINASE | HYPOXIA-INDUCED AUTOPHAGY | SUPPRESSOR GENE ARHI | Immunologic Surveillance | Neoplasms - metabolism | Cell Cycle - genetics | Neoplasms - etiology | Signal Transduction | Tumor Escape - genetics | Anoikis - genetics | Humans | Gene Expression Regulation | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Tumor Microenvironment - immunology | Neoplasm Metastasis | Neoplasms - therapy | Animals | Tumor Microenvironment - genetics | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Autophagy - genetics | Neoplasms - pathology | Tumor Escape - immunology | Autophagy (Cytology) | Metastasis | Research | Cell differentiation | Analysis | Cellular biology | Autophagy | Cancer | Review
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5. Full Text Yet another function of p53 - The switch that determines whether radiation-induced autophagy will be cytoprotective or nonprotective: Implications for autophagy inhibition as a therapeutic strategy
by Chakradeo, Shweta and Sharma, Khushboo and Alhaddad, Aisha and Bakhshwin, Duaa and Le, Ngoc and Harada, Hisashi and Nakajima, Wataru and Yeudall, W. Andrew and Torti, Suzy V and Torti, Frank M and Gewirtz, David A
Molecular Pharmacology, ISSN 0026-895X, 05/2015, Volume 87, Issue 5, pp. 803 - 814
The influence of autophagy inhibition on radiation sensitivity was studied in human breast, head and neck, and non-small cell lung cancer cell lines, in cell... 
BREAST-CANCER CELLS | HEPATOCELLULAR-CARCINOMA | TUMOR XENOGRAFTS | IN-VITRO | RADIOSENSITIZATION | INDUCED APOPTOSIS | PHARMACOLOGY & PHARMACY | INDUCED CYTOTOXICITY | MACROAUTOPHAGY | CHLOROQUINE | CONTRIBUTES | Cell Line, Tumor | Cell Survival - genetics | Radiation Tolerance - genetics | Autophagy - genetics | Humans | Tumor Suppressor Protein p53 - genetics | Index Medicus
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6. Full Text Autophagy
: Regulation and role in development
by Hale, Amber N and Ledbetter, Dan J and Gawriluk, Thomas R and Rucker, III, Edmund B
Autophagy, ISSN 1554-8627, 07/2013, Volume 9, Issue 7, pp. 951 - 972
Autophagy is an evolutionarily conserved cellular process through which long-lived proteins and damaged organelles are recycled to maintain energy homeostasis.... 
development | autophagy | regulation | knockout models | Development | Knockout models | Regulation | Autophagy | UBIQUITIN-PROTEASOME SYSTEM | BECLIN 1-DEPENDENT AUTOPHAGY | TUMOR-SUPPRESSOR ACTIVITY | ENDOPLASMIC-RETICULUM STRESS | ISOLATED RAT HEPATOCYTES | SACCHAROMYCES-CEREVISIAE | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | CELL BIOLOGY | MOUSE MODEL | HYPOXIA-INDUCED AUTOPHAGY | AMINO-ACID DEPRIVATION | Animals | Models, Biological | Stress, Physiological - genetics | Humans | Phagosomes - metabolism | Apoptosis - genetics | Autophagy - genetics | Growth and Development | Review
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7. Full Text Autophagy and cancer therapy
by Thorburn, Andrew and Thamm, Douglas H and Gustafson, Daniel L
Molecular Pharmacology, ISSN 0026-895X, 2014, Volume 85, Issue 6, pp. 830 - 838
Autophagy is the process by which cellular material is delivered to lysosomes for degradation and recycling. There are three different types of autophagy, but... 
INDUCED CELL-DEATH | COLON-CANCER | TARGETING AUTOPHAGY | MYELOMA CELLS | HMGB1 RELEASE | PHARMACOLOGY & PHARMACY | TUMOR-CELLS | ENDOPLASMIC-RETICULUM STRESS | INDUCED CYTOTOXICITY | HISTONE DEACETYLASE INHIBITORS | CHEMOTHERAPY-INDUCED APOPTOSIS | Neoplasms - pathology | Neoplasms - immunology | Autophagy | Humans | Disease Progression | Neoplasms - drug therapy | Minireview
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8. Full Text Master Autophagy Regulator Transcription Factor EB Regulates Cigarette Smoke-Induced Autophagy Impairment and Chronic Obstructive Pulmonary Disease–Emphysema Pathogenesis
by Bodas, Manish and Patel, Neel and Silverberg, David and Walworth, Kyla and Vij, Neeraj
Antioxidants & Redox Signaling, ISSN 1523-0864, 07/2017, Volume 27, Issue 3, pp. 15 - 167
Aims: Recent studies have shown that cigarette smoke (CS)-induced oxidative stress impairs autophagy, resulting in aggresome-formation that correlates with... 
Original Research Communications | ROS | autophagy | AGGRESOME FORMATION | INDUCED APOPTOSIS | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TFEB | BRAIN-CELLS | ACTIVATED RECEPTOR-ALPHA | cigarette smoke | emphysema | LYSOSOMAL BIOGENESIS | UNFOLDED PROTEIN RESPONSE | LIPID-RAFTS | THERAPEUTIC TARGET | ENDOCRINOLOGY & METABOLISM | tobacco | oxidative stress | COPD | Cell Line | Smoke - adverse effects | Humans | Male | Pulmonary Emphysema - metabolism | Gemfibrozil - pharmacology | Autophagy | Pulmonary Emphysema - chemically induced | Gene Knockdown Techniques | Gene Expression Regulation - drug effects | Animals | Cell Nucleus - metabolism | Cell Nucleus - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Pulmonary Emphysema - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Female | Mice | Tobacco - adverse effects | Disease Models, Animal | Autophagy (Cytology) | Transcription factors | Lung diseases, Obstructive | Emphysema, Pulmonary | Research | Health aspects | Risk factors | Cigarette smoke | Oxidative stress | Reactive oxygen species | Senescence | Pathogenesis | Interleukin | Impairment | Innovations | Staining | Immunoblotting | Smoke | Tissues | Caspase-3 | Accumulation | Interleukin 6 | Proteins | Lysates | Bronchoalveolar lavage | Rodents | Chronic obstructive pulmonary disease | Localization | Alveoli | Lung diseases | Bronchus | Caspase | Exposure | Nitric-oxide synthase | Tobacco | Gemfibrozil | Obstructive lung disease | In vivo methods and tests | Emphysema | In vitro methods and tests | Phagocytosis | Apoptosis | Smoking | Valosin-containing protein
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9. Full Text Autophagy in liver diseases
by Rautou, Pierre-Emmanuel and Mansouri, Abdellah and Lebrec, Didier and Durand, François and Valla, Dominique and Moreau, Richard
Journal of Hepatology, ISSN 0168-8278, 2010, Volume 53, Issue 6, pp. 1123 - 1134
Autophagy, or cellular self-digestion, is a cellular pathway crucial for development, differentiation, survival, and homeostasis. Its implication in human... 
Gastroenterology and Hepatology | Hepatitis | Starvation | Autophagic vacuole | Hepatocellular carcinoma | Autophagosome | LC3 | Survival | RAT HEPATOCYTES | ALPHA-ANTITRYPSIN DEFICIENCY | ENDOPLASMIC-RETICULUM STRESS | STARVATION-INDUCED AUTOPHAGY | HEPATOCELLULAR-CARCINOMA | HEPATITIS-C VIRUS | INSULIN-RESISTANCE | GASTROENTEROLOGY & HEPATOLOGY | MALLORY-DENK BODIES | INTRACELLULAR INCLUSIONS | MUTANT ALPHA-ANTITRYPSIN-Z | Liver - pathology | Fatty Liver - pathology | Humans | Liver Diseases - pathology | Male | Autophagy - physiology | Liver - physiopathology | Liver Diseases, Alcoholic - physiopathology | Liver Neoplasms - physiopathology | Female | Liver Neoplasms - pathology | alpha 1-Antitrypsin Deficiency - pathology | Liver Diseases, Alcoholic - pathology | Acute Lung Injury - physiopathology | Carcinoma, Hepatocellular - physiopathology | Reperfusion Injury - pathology | Fatty Liver - physiopathology | Acute Lung Injury - pathology | Hepatitis, Viral, Human - pathology | Hepatitis, Viral, Human - physiopathology | Animals | Models, Biological | Carcinoma, Hepatocellular - pathology | Reperfusion Injury - physiopathology | alpha 1-Antitrypsin Deficiency - physiopathology | Mice | Liver Diseases - physiopathology | Proteins | Liver cancer | Leukemia | Lymphomas | Hepatitis C | Hepatitis C virus | Health aspects | Protein kinases
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