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Oncogene, ISSN 0950-9232, 07/2008, Volume 27, Issue 29, pp. 4065 - 4074
Genotoxic stress activates the phosphatidylinositol 3-kinase-like kinases ( PIKKs) that phosphorylate proteins involved in cell cycle arrest, DNA repair and... 
DEPENDENT PHOSPHORYLATION | cell cycle | DNA damage | DAMAGE-INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | KINASE | RNA SURVEILLANCE PROTEIN | DOUBLE-STRAND BREAKS | p53 | CELL BIOLOGY | UBIQUITINATION | HUMAN SMG-1 | ONCOLOGY | reactive oxygen species | GENETICS & HEREDITY | IONIZING-RADIATION
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 06/2000, Volume 20, Issue 12, pp. 4210 - 4223
Journal Article
Journal Article
CELL CYCLE, ISSN 1538-4101, 04/2010, Volume 9, Issue 8, pp. 1617 - 1628
The decatenation G(2) checkpoint is proposed to delay cellular progression from G(2) into mitosis when intertwined daughter chromatids are insufficiently... 
DNA STRAND BREAKS | TOPOISOMERASE-II-ALPHA | ONCOGENE-INDUCED SENESCENCE | MAMMALIAN-CELLS | DAMAGE | p53 | CELL BIOLOGY | decatenation G checkpoint | CHK2 | INHIBITION | CHK1 | CELL-CYCLE CHECKPOINT | HUMAN-DIPLOID FIBROBLASTS | CHEK2 | CHEK1 | ICRF-193 | ATM | IONIZING-RADIATION | TYPE-16 E6 | ATR
Journal Article
STEM CELLS, ISSN 1066-5099, 08/2009, Volume 27, Issue 8, pp. 1822 - 1835
Journal Article
Frontiers in Genetics, ISSN 1664-8021, 2015, Volume 5, p. 70
Journal Article
Journal Article
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 12/2004, Volume 24, Issue 24, pp. 10650 - 10660
The basic leucine zipper transcription factor, CCAAT/enhancer binding protein alpha (C/EBPalpha), is abundantly expressed in keratinocytes of the skin;... 
BINDING-PROTEIN-ALPHA | TRANSCRIPTION FACTORS | DIFFERENTIATION PROGRAM | INDUCED PHOSPHORYLATION | GROWTH ARREST | PROLIFERATION ARREST | ANTIPROLIFERATIVE ROLE | BIOCHEMISTRY & MOLECULAR BIOLOGY | POSTTRANSLATIONAL MODIFICATIONS | CELL-PROLIFERATION | SKIN-CANCER | CELL BIOLOGY
Journal Article
Journal Article
Journal of Hematology and Oncology, ISSN 1756-8722, 11/2015, Volume 8, Issue 1, p. 125
Background: Although progress in children, in adults, ALL still carries a dismal outcome. Here, we explored the in vitro and in vivo activity of PF-00477736... 
Checkpoint kinase | Acute lymphoblastic leukemia | Drug-sensitivity | DNA damage | New targets | PHOSPHORYLATION | PF-00477736 | G CHECKPOINT | CHEMOTHERAPY-INDUCED APOPTOSIS | CANCER | CDC25A | DNA-DAMAGE CHECKPOINT | CHK1 | ONCOLOGY | IONIZING-RADIATION | HEMATOLOGY | PHASE-I | Protein Kinases - metabolism | Cell Cycle - genetics | Protein Kinases - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Cell Survival - genetics | Apoptosis - genetics | Dose-Response Relationship, Drug | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Leukemia, Experimental - genetics | Pyrazoles - pharmacology | Cell Survival - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Leukemia, Experimental - drug therapy | Benzodiazepinones - pharmacology | Mice, Inbred C57BL | Gene Expression Regulation, Leukemic - drug effects | Gene Expression Profiling - methods | Blotting, Western | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Survival Analysis | Cell Line, Tumor | Checkpoint Kinase 1 | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Leukemia, Experimental - metabolism | Microscopy, Fluorescence | Complications and side effects | Care and treatment | Analysis | Acute lymphocytic leukemia | Research | Apoptosis
Journal Article
Journal Article