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Nature Medicine, ISSN 1078-8956, 01/2009, Volume 15, Issue 1, pp. 50 - 58
Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia (T-ALL).... 
MEDICINE, RESEARCH & EXPERIMENTAL | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR EXPRESSION | CYCLE ARREST | SRG3 | CELL BIOLOGY | NOTCH1 CONFERS | GOBLET CELLS | GENE | LINE | DIFFERENTIATION | PROMOTER | Glucocorticoids - administration & dosage | Glucocorticoids - therapeutic use | Cyclins - genetics | Receptors, Glucocorticoid - metabolism | Cyclin D2 | Enzyme Inhibitors - administration & dosage | Bcl-2-Like Protein 11 | Membrane Proteins - physiology | Apoptosis Regulatory Proteins - genetics | Female | Homeostasis - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Dexamethasone - administration & dosage | Membrane Proteins - genetics | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins - genetics | Mice, SCID | Mice, Knockout | Dexamethasone - therapeutic use | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Homeostasis - physiology | Proto-Oncogene Proteins - physiology | Receptors, Glucocorticoid - genetics | Apoptosis Regulatory Proteins - physiology | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Receptors, Glucocorticoid - physiology | Receptor, Notch1 - physiology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 4, pp. 331 - 342
Journal Article
Blood, ISSN 0006-4971, 08/2013, Volume 122, Issue 6, pp. 969 - 980
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 09/2017, Volume 172, pp. 62 - 68
Acute lymphoblastic leukemia (ALL) is characterized by the accumulation of abnormal lymphoblasts in the bone marrow and blood. Though great progress has been... 
Glucocorticoid (GC) | MiR-124 | Proliferation | NR3C1 | Acute lymphoblastic leukemia (ALL) | Apoptosis | ACTIVATION | DEXAMETHASONE-INDUCED APOPTOSIS | PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | RISK | BETA ISOFORM | CEM-C1 CELLS | MICRORNA-124 | B-CELL | ENDOCRINOLOGY & METABOLISM | EXPRESSION | Receptors, Glucocorticoid - deficiency | MicroRNAs - antagonists & inhibitors | Apoptosis - drug effects | Humans | Child, Preschool | Apoptosis - genetics | Drug Resistance, Neoplasm | Male | MicroRNAs - metabolism | Receptors, Glucocorticoid - metabolism | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Dexamethasone - pharmacology | Bone Marrow Cells - drug effects | Female | Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology | Child | Signal Transduction | Bone Marrow Cells - pathology | Metabolism, Inborn Errors - metabolism | Gene Expression Regulation, Leukemic | Metabolism, Inborn Errors - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | RNA, Antisense - metabolism | Receptors, Glucocorticoid - genetics | Cell Line, Tumor | Glucocorticoids - pharmacology | Protein Binding | Cell Proliferation - drug effects | MicroRNAs - genetics | Metabolism, Inborn Errors - pathology | Bone Marrow Cells - metabolism | RNA, Antisense - genetics | Medical colleges | Corticosteroids | Biological control | Genetically modified organisms | Genetic engineering | Pests | Acute lymphocytic leukemia | Drug resistance | Steroids
Journal Article
Biochemistry (Moscow), ISSN 0006-2979, 3/2017, Volume 82, Issue 3, pp. 351 - 365
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 03/2015, Volume 16, Issue 3, pp. 466 - 476
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2016, Volume 197, Issue 10, pp. 3782 - 3791
Journal Article
RSC Advances, ISSN 2046-2069, 01/2018, Volume 8, Issue 1, pp. 23 - 242
Glucocorticoid resistance (GCR) remains a significant problem and is the most important reason for treatment failure of glucocorticoids (GCs). How to increase... 
CELLS | ACTIVATION | ISOFORMS | ASTHMATIC-CHILDREN | INDUCED APOPTOSIS | PHOSPHORYLATION | EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | MOLECULAR-MECHANISMS | Binding | Proteins | Ovalbumin | Sensitivity | Dexamethasone | Glucocorticoids | Impairment | Apoptosis | Asthma
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 1, pp. 230 - 242
Glucocorticoid resistance (GCR) remains a significant problem and is the most important reason for treatment failure of glucocorticoids (GCs). How to increase... 
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2016, Volume 22, Issue 3, pp. 621 - 632
Purpose: The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination... 
PROTEIN BIM | RAPAMYCIN | THERAPY | ONCOLOGY | INDUCED APOPTOSIS | IN-VIVO | CYCLE ARREST | PTEN | AKT | MECHANISMS | CHILDHOOD | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Quinolines - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Dexamethasone - pharmacology | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Imidazoles - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Cell Line, Tumor | Glucocorticoids - pharmacology | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | BEZ235 | Dexamethasone | acute lymphoblastic leukemia | MCL-1 | BIM
Journal Article