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1. Full Text Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE -/- mice
by Douglas, Gillian and Bendall, Jennifer K and Crabtree, Mark J and Tatham, Amy L and Carter, Emma E and Hale, Ashley B and Channon, Keith M
Cardiovascular Research, ISSN 0008-6363, 04/2012, Volume 94, Issue 1, pp. 20 - 29
Vascular disease states are associated with endothelial dysfunction and increased production of reactive oxygen species derived from NADPH oxidases. However,... 
VCAM-1 | Macrophages | NADPH oxidase | Nox2 | Atherosclerosis | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | NITRIC-OXIDE SYNTHASE | ANGIOTENSIN-II | APOLIPOPROTEIN-E | CELL-ADHESION MOLECULE-1 | NAD(P)H OXIDASE | APOE(-/-) MICE | HUMAN ATHEROSCLEROSIS | TRANSGENIC MICE | Blood Pressure | Up-Regulation | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Atherosclerosis - genetics | Humans | NADPH Oxidases - metabolism | Aortic Diseases - chemically induced | Atherosclerosis - enzymology | Time Factors | Superoxides - metabolism | NADPH Oxidases - genetics | Aortic Diseases - enzymology | Angiotensin II | Aortic Diseases - pathology | Disease Models, Animal | Atherosclerosis - pathology | Signal Transduction | Atherosclerosis - physiopathology | Atherosclerosis - chemically induced | Mice, Transgenic | Chemotaxis | NADPH Oxidase 2 | Disease Progression | Membrane Glycoproteins - genetics | Mice, Knockout | Aortic Diseases - genetics | Aortic Diseases - physiopathology | Macrophages - metabolism | Animals | Apolipoproteins E - genetics | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Endothelial Cells - enzymology | Reactive oxygen species | Chemiluminescence | Superoxide | Endothelial cells | NAD(P)H oxidase | Endothelium | Cell activation | Vascular diseases | Arteriosclerosis | Angiotensin | CYBB protein | Cell adhesion | Aorta | Blood pressure | Original
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2. Full Text Activation of the AMPK/Sirt1 pathway by a leucine–metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans
by Banerjee, Jheelam and Bruckbauer, Antje and Zemel, Michael B
Metabolism, ISSN 0026-0495, 11/2016, Volume 65, Issue 11, pp. 1679 - 1691
We have previously shown leucine (Leu) to activate Sirt1 by lowering its for NAD , thereby amplifying the effects of other sirtuin activators and improving... 
AMPK | Sirt1 | Leucine | Metformin | Insulin sensitivity | HEPATIC GLUCONEOGENESIS | CELLS | PHOSPHORYLATION | PROTEIN-KINASE ACTIVATION | INDUCED OBESE MICE | RECEPTOR SUBSTRATE-1 | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RESISTANCE | Sirtuin 1 - metabolism | Cell Line | AMP-Activated Protein Kinases - metabolism | Leucine - pharmacology | Humans | Metformin - pharmacology | Insulin Resistance | Muscle, Skeletal - metabolism | Transcription Factors - genetics | Hypoglycemic Agents - pharmacology | Drug Synergism | Transcription Factors - metabolism | Caenorhabditis elegans | Animals | Signal Transduction - drug effects | Muscle, Skeletal - drug effects | Lipid Metabolism - drug effects | Glucose - metabolism | Mice | Fatty Acids - metabolism | Acetyl-CoA Carboxylase - metabolism | Glucose metabolism | Muscles | Physiological aspects | Glucose | Insulin | Dextrose | Glycogen | Liver | Amino acids | Fatty acids | Synthesis | Protein kinases | Protein binding
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3. Full Text Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe−/− mice
by Zhu, Lin and Zhu, Jimin and Zhu, Hong and Zhang, Danying and Weng, Shuqiang and Dong, Ling and Liu, Taotao and Hu, Yu and Shen, Xizhong
Atherosclerosis, ISSN 0021-9150, 01/2018, Volume 268, pp. 117 - 126
Gut microbiota plays a major role in metabolic disorders. Berberine is used to treat obesity, diabetes and atherosclerosis. The mechanism underlying the role... 
Gut microbiota | Berberine | Akkermansia | Inflammation | Atherosclerosis | ENDOTOXEMIA-INDUCED INFLAMMATION | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | MACROPHAGES | MICROBIOTA | CORONARY-ARTERY | CROSS-TALK | MUCINIPHILA | DISEASE | PERIPHERAL VASCULAR DISEASE | PHOSPHATIDYLCHOLINE | INDUCED OBESITY
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4. Full Text Acute increases in synaptic GABA detectable in the living human brain: A [11C]Ro15-4513 PET study
by Stokes, Paul R.A and Myers, Jim F and Kalk, Nicola J and Watson, Ben J and Erritzoe, David and Wilson, Sue J and Cunningham, Vincent J and Barros, Daniela Riano and Hammers, Alexander and Turkheimer, Federico E and Nutt, David J and Lingford-Hughes, Anne R
NeuroImage, ISSN 1053-8119, 10/2014, Volume 99, pp. 158 - 165
The inhibitory γ-aminobutyric acid (GABA) neurotransmitter system is associated with the regulation of normal cognitive functions and dysregulation has been... 
Tiagabine | GABA | Synaptic | [11C]Ro15-4513 | PET | TIAGABINE-INDUCED STUPOR | RECEPTOR SUBUNITS | SUBTYPES | NEUROSCIENCES | NEUROIMAGING | IN-VIVO | BENZODIAZEPINE | SPECTRAL-ANALYSIS | [C-11]Ro15-4513 | BINDING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | MODULATION | Brain Chemistry - drug effects | Memory - drug effects | Brain - diagnostic imaging | Double-Blind Method | gamma-Aminobutyric Acid - metabolism | Humans | Middle Aged | Male | Positron-Emission Tomography | Psychomotor Performance - drug effects | Benzodiazepines | Dose-Response Relationship, Drug | Azides | Synapses - metabolism | GABA Agonists - pharmacology | Adult | Receptors, GABA-A - metabolism | Nipecotic Acids - pharmacology | Radiopharmaceuticals | Brain | Studies | Medical research | Anxieties | Rodents
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5. Full Text Peripheral opioid receptor blockade increases postoperative morphine demands—A randomized, double-blind, placebo-controlled trial
by Jagla, Christina and Martus, Peter and Stein, Christoph
Pain, ISSN 0304-3959, 10/2014, Volume 155, Issue 10, pp. 2056 - 2062
A significant proportion of morphine analgesia is mediated outside the central nervous system, as demonstrated by 40% increased demands during peripheral... 
Methylnaltrexone | Analgesia | Morphine | Peripheral | Opioid receptor | Opioids | INDUCED CONSTIPATION | KNEE ARTHROSCOPY | ANTINOCICEPTION | INTRAARTICULAR MORPHINE | NEUROSCIENCES | RAT MODEL | CLINICAL NEUROLOGY | QUATERNARY NARCOTIC-ANTAGONISTS | MCGILL PAIN QUESTIONNAIRE | CLINICAL-TRIALS | ANESTHESIOLOGY | INFLAMMATORY PAIN | Naltrexone - analogs & derivatives | Pain, Postoperative - etiology | Analgesia, Patient-Controlled | Arthroplasty, Replacement, Knee - adverse effects | Double-Blind Method | Pain, Postoperative - drug therapy | Humans | Middle Aged | Analgesics, Opioid - therapeutic use | Male | Young Adult | Naltrexone - pharmacology | Narcotic Antagonists - pharmacology | Adolescent | Aged, 80 and over | Adult | Female | Aged | Pain Measurement | Morphine - therapeutic use | Quaternary Ammonium Compounds - pharmacology | Clinical trials
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6. Full Text Microbes & neurodevelopment – Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala
by Stilling, Roman M and Ryan, Feargal J and Hoban, Alan E and Shanahan, Fergus and Clarke, Gerard and Claesson, Marcus J and Dinan, Timothy G and Cryan, John F
Brain, Behavior, and Immunity, ISSN 0889-1591, 2015, Volume 50, pp. 209 - 220
Highlights • The amygdala is an important brain region for emotional behaviour, such as social life and anxiety, and is activated by social interaction. •... 
Psychiatry | Allergy and Immunology | MAP-kinase pathway | Activity-induced | RNA editing | RNA-seq | Differential gene expression | Gene regulation | Gut–brain axis | Hyper-excitability | Microbiome | Immediate early gene | Gut-brain axis | NERVOUS-SYSTEM | INTESTINAL MICROBIOTA | PSYCHIATRY | BASOLATERAL AMYGDALA | STRESS-RESPONSE | IMMUNOLOGY | BRAIN-GUT AXIS | ANXIETY-LIKE BEHAVIOR | NEUROSCIENCES | POSTMYOCARDIAL INFARCTION DEPRESSION | SOCIAL-BEHAVIOR | GENE-EXPRESSION | EPIGENETIC REGULATION | Amygdala - microbiology | Microbiota - physiology | Animals | Signal Transduction | Amygdala - metabolism | Male | Amygdala - growth & development | Gene Expression Profiling | Mice | Neurons - metabolism | Genes, Immediate-Early | Interpersonal Relations | Genetic aspects | Genetic transcription | Microbiota (Symbiotic organisms) | Social aspects | RNA | Neurons | Genes | Genomics | Autism | Anopheles | Analysis | Physiological aspects | Genetic research
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7. Full Text Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
by Turner, Nigel and Bruce, Clinton R and Beale, Susan M and Hoehn, Kyle L and So, Trina and Rolph, Michael S and Cooney, Gregory J
Diabetes, ISSN 0012-1797, 08/2007, Volume 56, Issue 8, pp. 2085 - 2092
A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been proposed as a major factor leading to the accumulation of intramuscular... 
RECEPTOR-GAMMA COACTIVATOR-1 | METABOLISM | DIET | OBESE ZUCKER RATS | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | DOWN-REGULATION | TRIACYLGLYCEROL ACCUMULATION | UNCOUPLING PROTEIN-3 | LIPOPROTEIN-LIPASE | HUMAN SKELETAL-MUSCLE | Glucose Tolerance Test | Obesity - chemically induced | Oxidation-Reduction | Fats - pharmacology | Insulin Resistance | Rats | Male | Glucose - pharmacology | Mitochondria - metabolism | Oxygen - metabolism | Obesity - metabolism | Obesity - pathology | Animals | Mitochondrial Proteins - metabolism | Muscles - drug effects | Lipid Metabolism - drug effects | Biomarkers | Glucose - metabolism | Mice | Muscles - metabolism | Fatty Acids - metabolism | Physiological aspects | Insulin resistance | Lipids | Biological oxidation (Metabolism) | Research | Health aspects | Risk factors
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8. Full Text Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice
by Oh, Gi-Su and Kim, Hyung-Jin and Choi, Jae-Hyuck and Shen, AiHua and Choe, Seong-Kyu and Karna, Anzani and Lee, Seung Hoon and Lee, Chul-Ho and Jo, Hyang-Jeong and Yang, Sei-Hoon and Kwak, Tae Hwan and Park, Raekil and So, Hong-Seob
Kidney International, ISSN 0085-2538, 03/2014, Volume 85, Issue 3, pp. 547 - 560
Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors. In addition to its antitumor activity, cisplatin affects normal cells... 
NAD | NQO1 | nephrotoxicity | cisplatin | sirtuins | TRANSCRIPTION FACTORS | NAD(P)H-QUINONE OXIDOREDUCTASE-1 NQO1 | PYRIDINE-NUCLEOTIDES | POSTTRANSLATIONAL MODIFICATIONS | CELL-SURVIVAL | SIRT1 DEACETYLASE | PLATINUM COMPLEXES | CEREVISIAE LIFE-SPAN | NAD(+) | UROLOGY & NEPHROLOGY | INDUCED RENAL INJURY | NF-KAPPA-B | Sirtuin 1 - metabolism | Animals | Cisplatin - toxicity | Transcription Factor RelA - metabolism | Mice, Inbred C57BL | Naphthoquinones - pharmacology | Acute Kidney Injury - chemically induced | NAD(P)H Dehydrogenase (Quinone) - physiology | NAD - analysis | Acute Kidney Injury - prevention & control | Antineoplastic Agents - toxicity | Basic Research
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9. Full Text Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug–Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial
by Washio, Ema and Esaki, Motohiro and Maehata, Yuji and Miyazaki, Masashi and Kobayashi, Hiroyuki and Ishikawa, Hideki and Kitazono, Takanari and Matsumoto, Takayuki
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2016, Volume 14, Issue 6, pp. 809 - 815.e1
Background & Aims Some studies have reported a high incidence of small bowel injuries in 60%–80% of subjects who take nonselective nonsteroidal... 
Gastroenterology and Hepatology | COX-2 | Damage | Intestine | Cyclooxygenase-2 Inhibitor | Cyclooxygenase-2 inhibitor | RISK-FACTORS | HEALTHY-SUBJECTS | INTESTINAL MUCOSAL INJURY | VIDEO CAPSULE ENDOSCOPY | CROSS-OVER | PREVENTION | PLUS OMEPRAZOLE | CELECOXIB | IN-VITRO | DOUBLE-BLIND | GASTROENTEROLOGY & HEPATOLOGY | Celecoxib - adverse effects | Rabeprazole - adverse effects | Celecoxib - administration & dosage | Japan - epidemiology | Proton Pump Inhibitors - adverse effects | Prospective Studies | Tertiary Care Centers | Double-Blind Method | Intestinal Diseases - chemically induced | Humans | Capsule Endoscopy | Male | Healthy Volunteers | Incidence | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Proton Pump Inhibitors - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Adult | Female | Intestinal Diseases - epidemiology | Placebos - administration & dosage | Intestinal Diseases - pathology | Intestinal Mucosa - pathology | Rabeprazole - administration & dosage | Prevention | Medical colleges | College graduates | Clinical trials | Proton pump inhibitors | Nonsteroidal anti-inflammatory drugs | Cancer | COX-2 inhibitors
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