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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2016, Volume 36, Issue 1, pp. 134 - 144
OBJECTIVE—Pulmonary hypertension (PH) is characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and ultimately... 
hypoxia-inducible factor 1 | pulmonary | macrophages | resistin-like molecule | hypertension | interleukins | ACTIVATION | MUSCLE-CELL PROLIFERATION | VEGF RECEPTOR-2 | INTERLEUKIN-6 | INDUCED LUNG FIBROSIS | INFLAMMATION | ARTERIAL-HYPERTENSION | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Vascular Remodeling | Epithelial Cells - metabolism | Humans | Hypertension, Pulmonary - physiopathology | Male | Vascular Endothelial Growth Factor A - metabolism | Hypertension, Pulmonary - chemically induced | Hypertension, Pulmonary - prevention & control | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Intercellular Signaling Peptides and Proteins - metabolism | Pulmonary Artery - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Female | Interleukin-6 - metabolism | Organ Culture Techniques | Disease Models, Animal | Fibroblasts - metabolism | Macrophages - pathology | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Epithelial Cells - pathology | Genotype | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Mice, Knockout | Macrophages - metabolism | Phenotype | Animals | Hemodynamics | In Vitro Techniques | Pulmonary Artery - pathology | Apoptosis | Cell Movement | Index Medicus | hypoxia-inducible factor 1α | hypoxia-induced mitogenic factor | FIZZ1 | RELMα | macrophage | Pulmonary hypertension | interleukin-6
Journal Article
Journal Article
Respiratory Research, ISSN 1465-9921, 01/2013, Volume 14, Issue 1, pp. 1 - 1
Background: Both chronic hypoxia and allergic inflammation induce vascular remodeling in the lung, but only chronic hypoxia appears to cause PH. We investigate... 
Vascular remodeling | Hypoxia-induced mitogenic factor (HIMF) | Chronic hypoxia | Pulmonary hypertension | Th2-mediated inflammation | GENE SET ENRICHMENT | PI-3K/AKT-NF-KAPPA-B SIGNALING PATHWAY | MURINE SCHISTOSOMIASIS | INDUCED LUNG FIBROSIS | MATRIX METALLOPROTEINASES | RESPIRATORY SYSTEM | CATHEPSIN-K | ARTERIAL-HYPERTENSION | ENDOTHELIAL-CELLS | UP-REGULATION | TENASCIN-C | Up-Regulation | Ovalbumin - immunology | Pneumonia - pathology | Hypertension, Pulmonary - physiopathology | Male | Gene Expression Profiling | Hypertrophy, Right Ventricular - etiology | Th2 Cells - immunology | Intercellular Signaling Peptides and Proteins - metabolism | Pulmonary Artery - metabolism | Arterial Pressure | Pneumonia - immunology | Hypertrophy, Right Ventricular - metabolism | Disease Models, Animal | Antigens | Aspergillus - immunology | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - immunology | Hypertension, Pulmonary - metabolism | Hypoxia - complications | Pulmonary Artery - physiopathology | Animals | Hypertrophy, Right Ventricular - immunology | Pneumonia - complications | Mice | Chronic Disease | Hypertension, Pulmonary - etiology | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Pulmonary Artery - immunology | Cardiovascular system | Heart enlargement | Analysis | Hypoxia | Inflammation | Lymphokines | Proteins | Hypertension | Pulmonary arteries | Rodents | Chronic obstructive pulmonary disease | Muscular system | Veins & arteries | Index Medicus | Research
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 12/2006, Volume 291, Issue 6, pp. 1159 - 1168
From a mouse model of hypoxia-induced pulmonary hypertension, we previously found a highly upregulated protein in the lung that we named hypoxia-induced... 
Pulmonary inflammation | Resistin-like molecule α | Vascular endothelial growth factor receptor-2 | Found in inflammatory zone 1 | Hypoxia-induced mitogenic factor | Vascular endothelial growth factor | Monocyte chemotactic protein-1 | CELLS | PHYSIOLOGY | pulmonary inflammation | found in inflammatory zone 1 | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | vascular endothelial growth factor receptor-2 | FAMILY | hypoxia-induced mitogenic factor | monocyte chemotactic protein-1 | IN-VITRO | RESPIRATORY SYSTEM | vascular endothelial growth factor | INFLAMMATION | NITRIC-OXIDE | resistin-like molecule alpha | UP-REGULATION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | INDUCED PULMONARY-HYPERTENSION | Cell Line | Injections, Intravenous | Intercellular Signaling Peptides and Proteins | Nerve Growth Factor - pharmacology | Rats | Endothelium, Vascular - drug effects | Inflammation | Pulmonary Artery | Lung - physiology | Endothelium, Vascular - physiology | Nerve Growth Factor - administration & dosage | Animals | Cell Division | Lung - drug effects | Proteins - administration & dosage | Mice | Proteins - pharmacology | Vascular Endothelial Growth Factor Receptor-2 - physiology | Vascular Endothelial Growth Factor A - physiology | Angiogenic Proteins - pharmacology | Hypertension | Proteins | Hypoxia | Cellular biology | Clinical outcomes | Inflammatory diseases | Index Medicus
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 10/2010, Volume 299, Issue 4, pp. C805 - C817
Stanzel RD, Lourenssen S, Nair DG, Blennerhassett MG. Mitogenic factors promoting intestinal smooth muscle cell proliferation. Am J Physiol Cell Physiol 299:... 
Smooth muscle cell | Platelet-derived growth factor | Rat | Intestine | Mitosis | Insulin-like growth factor-1 | Tissue culture | PATHWAYS | IGF-I | PHYSIOLOGY | smooth muscle cell | intestine | rat | CROHNS-DISEASE | tissue culture | platelet-derived growth factor | insulin-like growth factor-1 | RECEPTOR | mitosis | CELL BIOLOGY | INSULIN | INFLAMMATORY-BOWEL-DISEASE | STRICTURES | RAT COLITIS | EXPRESSION | GROWTH-FACTOR-I | Insulin-Like Growth Factor I - pharmacology | Humans | Colitis - pathology | Male | Insulin-Like Growth Factor I - genetics | Receptor, Platelet-Derived Growth Factor beta - genetics | Platelet-Derived Growth Factor - genetics | Intestines - anatomy & histology | Colitis - chemically induced | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Intestines - pathology | Epidermal Growth Factor - genetics | Proto-Oncogene Proteins c-sis | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Myocytes, Smooth Muscle - physiology | Rats | Platelet-Derived Growth Factor - pharmacology | Rats, Sprague-Dawley | Animals | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Cell Proliferation - drug effects | Trinitrobenzenesulfonic Acid - toxicity | Epidermal Growth Factor - pharmacology | Cell proliferation | Physiological aspects | Smooth muscle | Intestines | Research | Inflammatory bowel disease | Cell division | Phosphorylation | Models | Rodents | Cells | Index Medicus
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 05/2003, Volume 92, Issue 10, pp. 1065 - 1067
In a mouse chronic hypoxia model of pulmonary hypertension, we discovered a novel hypoxia-inducible gene in lung, FIZZ1/RELMα, first through a cDNA array... 
Hypoxia-induced mitogenic factor | Angiogenesis | Akt | Proliferation | Vasoconstriction | CARDIAC & CARDIOVASCULAR SYSTEMS | proliferation | angiogenesis | TISSUE | FAMILY | hypoxia-induced mitogenic factor | FIZZ1 | RESISTIN | MOLECULE-ALPHA | PERIPHERAL VASCULAR DISEASE | vasoconstriction | HEMATOLOGY | EXPRESSION
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 10/2006, Volume 35, Issue 4, pp. 444 - 456
Journal Article
Experimental Cell Research, ISSN 0014-4827, 2006, Volume 312, Issue 18, pp. 3559 - 3569
Our previous studies have indicated that hypoxia-induced mitogenic factor (HIMF) has angiogenic properties in an matrigel plug model and HIMF upregulates... 
Hypoxia-induced mitogenic factor | Angiogenesis | Signal transduction | Endothelial cells | RAT AORTA | LUNG | endothelial cells | signal transduction | angiogenesis | VEGF | IDENTIFICATION | TUBE FORMATION | CELL BIOLOGY | hypoxia-induced mitogenic factor | SIGNAL-TRANSDUCTION | IN-VITRO | ONCOLOGY | GROWTH-FACTOR | UP-REGULATION | EXPRESSION | Cell Proliferation | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Aorta - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Cell Movement - physiology | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Cinnamates - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Endothelial Cells - physiology | Recombinant Proteins - metabolism | Nerve Growth Factor - metabolism | Intercellular Signaling Peptides and Proteins | Mice, Inbred C57BL | Cells, Cultured | Nerve Growth Factor - genetics | Recombinant Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | Proteins - genetics | Neovascularization, Physiologic - physiology | Animals | Proteins - metabolism | Endothelial Cells - cytology | Signal Transduction - physiology | Mice | Aorta - cytology | Enzyme Activation | Tyrosine | Phosphatidylinositol | Analysis | Von Willebrand factor | Phosphotransferases | Vascular endothelial growth factor | Endothelium | Heart | Inhibitor drugs | Kinases | Rodents | Cell adhesion & migration | Index Medicus | PHOSPHORYLATION | LUNGS | CELL PROLIFERATION | IN VIVO | 60 APPLIED LIFE SCIENCES | GROWTH FACTORS | ANOXIA | TYROSINE | IN VITRO | PHOSPHOTRANSFERASES | SPROUTING | MICE | RECEPTORS
Journal Article
FEBS Letters, ISSN 0014-5793, 02/2006, Volume 580, Issue 3, pp. 900 - 903
Journal Article
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, ISSN 1044-1549, 03/2005, Volume 32, Issue 3, pp. 185 - 191
After pneumonectomy, the remaining lung increases in size. This process is referred to as compensatory lung growth. Various pathways likely play important... 
hypoxia-induced mitogenic factor | mouse | CELLS | RAT | RESPIRATORY SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | pneumonectomy | MECHANISMS | MICE | compensatory lung growth | FAMILY | CELL BIOLOGY
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 03/2005, Volume 32, Issue 3, pp. 185 - 191
Journal Article
FEBS Letters, ISSN 0014-5793, 2006, Volume 580, Issue 9, pp. 2207 - 2215
Journal Article