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Free Radical Biology and Medicine, ISSN 0891-5849, 09/2017, Volume 110, pp. 102 - 116
Oxidative stress has a critical role in the pathogenesis of acetaminophen (APAP) induced hepatocellular necrosis, and the identification of novel approaches to... 
Oxidative stress | Hepatic hypoxia-inducible factors | Acetaminophen | Chronic intermittent hypoxia | Transcriptional repression | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | RECEPTOR-ALPHA | PROTECTS | LIVER-INJURY | CYP-MEDIATED BIOACTIVATION | FATTY-ACID | ENDOCRINOLOGY & METABOLISM | MICE | TRANSCRIPTION FACTOR | Acetaminophen - adverse effects | Liver - pathology | Luciferases - metabolism | Oxidative Stress | Hepatocytes - pathology | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Hepatocytes - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Luciferases - genetics | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Analgesics, Non-Narcotic - adverse effects | Cytochrome P-450 CYP1A2 - genetics | NF-E2-Related Factor 2 - genetics | Membrane Proteins - metabolism | Chemical and Drug Induced Liver Injury - pathology | Basic Helix-Loop-Helix Transcription Factors - deficiency | Genes, Reporter | Hepatocytes - drug effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | Liver - metabolism | Gene Expression Regulation | PPAR alpha - genetics | Chemical and Drug Induced Liver Injury - genetics | Cytochrome P-450 CYP1A2 - metabolism | Mice, Knockout | Animals | Chemical and Drug Induced Liver Injury - metabolism | Cytochrome P-450 CYP3A - metabolism | NF-E2-Related Factor 2 - metabolism | Mice | PPAR alpha - metabolism | Primary Cell Culture | Index Medicus
Journal Article
Natural Product Reports, ISSN 0265-0568, 2017, Volume 34, Issue 9, pp. 1141 - 1172
Covering: up to January 2017Cytochrome P450 enzymes (P450s) are some of the most exquisite and versatile biocatalysts found in nature. In addition to their... 
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 06/2012, Volume 90, Issue 10, pp. 1354 - 1363
The aryl hydrocarbon receptor (AHR) has physiological roles in the absence of exposure to exogenous ligands, and mediates adaptive and toxic responses to the... 
Signal transducer and activator of transcription 5b | Aryl hydrocarbon receptor | Cytokine-inducible Src homology 2 domain-containing protein | Growth hormone receptor | Cytochrome P450 | Janus kinase 2 | Inflammatory markers | NADPH-cytochrome P450 oxidoreductase | 2,3,7,8-tetrachlorodibenzo-p-dioxin | Major urinary protein 2 | inflammatory markers | PHYSIOLOGY | growth hormone receptor | POLYCYCLIC AROMATIC-HYDROCARBONS | AH RECEPTOR | cytochrome P450 | DEFICIENT MICE | MICROARRAY ANALYSIS | aryl hydrocarbon receptor | TRANSCRIPTIONAL SUPPRESSION | MESSENGER-RNAS | cytokine-inducible Src homology 2 domain-containing protein | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD | PHARMACOLOGY & PHARMACY | major urinary protein 2 | 5'-FLANKING REGION | LIVER GENE-EXPRESSION | signal transducer and activator of transcription 5b | SEXUAL-DIMORPHISM | Cytochrome P-450 CYP1A1 - genetics | NADPH-Ferrihemoprotein Reductase - genetics | Receptors, Somatotropin - metabolism | Cytochrome P-450 Enzyme Inhibitors | Cytochrome P-450 Enzyme System - metabolism | Male | RNA, Messenger - metabolism | Cytochrome P450 Family 2 | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Liver - immunology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cytochrome P-450 CYP3A - genetics | Liver - drug effects | Janus Kinase 2 - metabolism | STAT5 Transcription Factor - antagonists & inhibitors | Environmental Pollutants - administration & dosage | Enzyme Induction - drug effects | Receptors, Aryl Hydrocarbon - metabolism | Membrane Proteins - metabolism | Environmental Pollutants - toxicity | Janus Kinase 2 - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - agonists | Basic Helix-Loop-Helix Transcription Factors - genetics | Membrane Proteins - genetics | Liver - metabolism | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Receptors, Aryl Hydrocarbon - genetics | NADPH-Ferrihemoprotein Reductase - biosynthesis | Down-Regulation - drug effects | Receptors, Somatotropin - antagonists & inhibitors | Polychlorinated Dibenzodioxins - administration & dosage | Receptors, Somatotropin - genetics | Mice, Knockout | Receptors, Aryl Hydrocarbon - agonists | Proteins - genetics | Animals | Cytochrome P-450 CYP3A Inhibitors | Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Cytochrome P-450 CYP3A - metabolism | Cytochrome P-450 Enzyme System - genetics | Polychlorinated Dibenzodioxins - toxicity | Mice | Cytochrome P-450 CYP1A1 - biosynthesis | Proteins - antagonists & inhibitors | Physiological aspects | Hydrocarbons | Somatotropin | Health aspects | Dioxin | Cytochrome P-450
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 2006, Volume 44, Issue 9, pp. 1474 - 1484
In humans, apiaceous vegetables (carrots, parsnips, celery, parsley, etc.) inhibit cytochrome P-450 1A2, a biotransformation enzyme known to activate several... 
Carrot | Furanocoumarin | Apiaceae | Flavonoid | Aflatoxin | CYP1A2 | furanocoumarin | DIETARY FLAVONOIDS | PHENOLIC-COMPOUNDS | FOOD SCIENCE & TECHNOLOGY | aflatoxin | HUMAN LIVER-MICROSOMES | SACCHAROMYCES-CEREVISIAE | MECHANISM-BASED INACTIVATION | IN-VITRO | HUMAN HEPATOCYTES | GRAPEFRUIT JUICE | COUMARIN 7-HYDROXYLASE ACTIVITY | TOXICOLOGY | flavonoid | carrot | INDUCIBLE EXPRESSION
Journal Article
Cardiovascular Research, ISSN 0008-6363, 3/2009, Volume 81, Issue 4, pp. 669 - 677
Journal Article
Nutrition, ISSN 0899-9007, 2016, Volume 32, Issue 2, pp. 174 - 178
Abstract Flavonoid resveratrol modulates the transcription factor NF-κB; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity... 
Gastroenterology and Hepatology | Obesity | Flavonoids | Microbiota | Type 2 diabetes mellitus | Alzheimer's disease | Resveratrol | CELLS | OXIDATIVE STRESS | RISK-FACTORS | MITOCHONDRIAL-FUNCTION | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | AUTOPHAGY | SIRT1 | NUTRITION & DIETETICS | INSULIN-RESISTANCE | MOUSE MODEL | Autistic Disorder - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Brain-Derived Neurotrophic Factor - genetics | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Lipoxins - pharmacology | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Stilbenes - pharmacology | Metabolic Syndrome - chemically induced | Vascular Endothelial Growth Factor A - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Diabetes Mellitus, Type 2 - prevention & control | Gastrointestinal Tract - microbiology | Interleukin-17 - genetics | Gastrointestinal Tract - drug effects | Antioxidants - pharmacology | Autistic Disorder - prevention & control | Transcription Factors - genetics | Cytochrome P-450 CYP1A1 - metabolism | Transcription Factors - metabolism | Interleukin-17 - metabolism | Gastrointestinal Microbiome - drug effects | Interleukin-17 - antagonists & inhibitors | NF-kappa B - genetics | Cell Differentiation - drug effects | Metabolic Syndrome - prevention & control | Cell Proliferation - drug effects | Diabetes Mellitus, Type 2 - chemically induced | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Type 2 diabetes | COX-2 inhibitors | Bisphenol-A | Endothelial growth factors | Microbiota (Symbiotic organisms) | Cytochrome P-450 | Schizophrenia | Bipolar disorder | T cells | Cell differentiation | Fatty acids | Autism | Stem cells | Tumor proteins | Pathogenesis | p53 Protein | Lipids | Proteins | Antioxidants | Signal transduction | Lymphocytes | Rodents | Oxidation | Growth factors | Cytochromes P450 | Diabetes mellitus | Rapamycin | Metabolism | Bisphenol A | Alloxan | Brain-derived neurotrophic factor | Insulin resistance | Hypoxia | Diabetes | Alzheimers disease | Autoimmune diseases | Metabolic disorders | Dementia | Apoptosis | Tumors
Journal Article