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Molecular Carcinogenesis, ISSN 0899-1987, 02/2017, Volume 56, Issue 2, pp. 436 - 446
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2012, Volume 447, Issue 1, pp. 125 - 136
Phosphorylation of STAT3 (signal transducer and activator of transcription 3) is critical for its nuclear import and transcriptional activity. Although a... 
Signal transducer and activator of transcription 3 (STAT3) | Transcriptome analysis | Interleukin-6 (IL-6) | Nucleocytoplasmic trafficking | Transcription factor | Cytokine | cytokine | transcription factor | nucleocytoplasmic trafficking | COLONY-STIMULATING FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-CELLS | interleukin-6 (IL-6) | UNPHOSPHORYLATED STAT3 | STAT3 ISOFORMS | ACTIVATED STAT3 | PATHWAY | signal transducer and activator of transcription 3 (STAT3) | EPIDERMAL-GROWTH-FACTOR | transcriptome analysis | PROTEIN-TYROSINE-PHOSPHATASE | SIGNAL TRANSDUCER | Mutagenesis, Site-Directed | Alternative Splicing | Gene Expression - drug effects | Humans | Cells, Cultured | DNA Primers - genetics | STAT3 Transcription Factor - chemistry | Gene Knockout Techniques | src Homology Domains | Animals | Cell Nucleus - metabolism | Base Sequence | HEK293 Cells | STAT3 Transcription Factor - deficiency | Mice | Kinetics | Phosphorylation - drug effects | Cell Nucleus - drug effects | Cytokines - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tyrosine - chemistry | Amino Acid Substitution | Index Medicus | ERt, substrate-binding portion of the oestrogen receptor | WT, wild-type | HEK, human embryonic kidney | VP16, viral protein 16 | Fc, cytoplasmic fluorescence | gp130, glycoprotein 130 | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | MEF, murine embryonic fibroblast | iSTAT3, inducible specific STAT3 spliceform | Fn, nuclear fluorescence | GO, gene ontology | FBS, fetal bovine serum | STAT3, signal transducer and activator of transcription 3 | OSM, oncostatin M | CLSM, confocal laser-scanning microscopy | DAPI, 4′,6-diamidino-2-phenylindole | SHP, SH2 domain-containing protein tyrosine phosphatase | JAK, Janus kinase | IL, interleukin | Fc, ratio of nuclear to cytoplasmic fluorescence | SH2, Src homology 2 | Hsp90, heat-shock protein of 90 kDa | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2006, Volume 281, Issue 22, pp. 15215 - 15226
Studies of gene regulation by oxygen have revealed novel signal pathways that regulate the hypoxia-inducible factor (HIF) transcriptional system through... 
ACTIVATION | INDUCIBLE FACTOR-1 HIF-1 | PROLYL HYDROXYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RENAL-CELL-CARCINOMA | GROWTH-FACTOR | FACTOR (HIF)-1-ALPHA | UP-REGULATION | TUMOR-GROWTH | NEGATIVE REGULATOR
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 09/2017, Volume 19, Issue 9, pp. 1289 - 1294
AimTo quantify the expression of sodium-glucose co-transporter (SGLT)2 and SGLT1, their cognate basolateral transporters, GLUT2 and GLUT1, and the... 
type 2 diabetes | clinical physiology | inhibitor | SGLT2 | SGLT2 inhibitor | RAT | TRANSPORTERS | ALBUMINURIA | PROXIMAL TUBULAR CELLS | GLOMERULAR HYPERFILTRATION | NEPHROPATHY | HYPERGLYCEMIA | PROTEIN EXPRESSION | ENDOCRINOLOGY & METABOLISM | BRUSH-BORDER MEMBRANE | KIDNEY | Kidney Tubules - physiopathology | Kidney - pathology | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Sodium-Glucose Transporter 1 - genetics | Kidney Neoplasms - surgery | Kidney - metabolism | Carcinoma - complications | Kidney Neoplasms - physiopathology | Nephrectomy | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Retrospective Studies | Sodium-Glucose Transporter 1 - metabolism | Kidney Tubules - pathology | Carcinoma - pathology | Kidney Neoplasms - complications | Kidney Tubules - metabolism | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology | Sodium-Glucose Transporter 2 - genetics | Hypoglycemic Agents - therapeutic use | Reproducibility of Results | Glomerular Filtration Rate | Kidney - drug effects | Kidney Tubules - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Sodium-Glucose Transporter 2 - metabolism | Carcinoma - surgery | Carcinoma - physiopathology | Gene Expression Regulation - drug effects | Kidney Neoplasms - pathology | Aged | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | Neoplasm Staging | Type 2 diabetes | Immunohistochemistry | Viral antibodies | Care and treatment | Antibodies | Glucose | Muscle proteins | Dextrose | Diabetes | Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 12/2008, Volume 217, Issue 3, pp. 674 - 685
Sleep‐disordered breathing with recurrent apnea (periodic cessation of breathing) results in chronic intermittent hypoxia (IH), which leads to cardiovascular... 
MICE PARTIALLY DEFICIENT | RESPONSES | OXIDATIVE STRESS | PHYSIOLOGY | INDUCIBLE FACTOR 1-ALPHA | PROLINE HYDROXYLATION | LONG-TERM FACILITATION | SLEEP-APNEA | CAROTID-BODY | PC12 CELLS | HIF-ALPHA | CELL BIOLOGY | Intermittent hypoxia | Calcium signaling | mTOR | HIF-1α | Prolyl hydroxylases | NADPH oxidase
Journal Article