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Biochemical Journal, ISSN 0264-6021, 01/2004, Volume 377, Issue 1, pp. 205 - 213
TCDD (2,3,7,8-tetrachlorodibenzo-p-dixoin) induces phase II drug-metabolizing enzyme NQO1 [NAD(P)H:quinone oxidoreductase; EC 1.6.99.2; DT-diaphorase] in a... 
AhR (aryl hydrocarbon receptor) | DRE (dioxin response element) | TCDD (2,3,7,8-tetrachlorodibenzo-p- dioxin) | ARE (antioxidant response element) | NQO1 [NAD(P)H:quinone oxidoreductase 1] | Nrf2 (nuclear factor erythroid 2-related factor 2) | NQO1 [NAD(P)H : quinone oxidoreductase 1] | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | POLYMORPHISM | IDENTIFICATION | ANTIOXIDANT RESPONSE ELEMENT | CARCINOGENESIS | DT-DIAPHORASE | NQO1 GENE | GENE-EXPRESSION | TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) | UBIQUITIN-PROTEASOME PATHWAY | INDUCIBLE EXPRESSION | Leucine Zippers | Multienzyme Complexes - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Proteasome Endopeptidase Complex | Trans-Activators - chemistry | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Cysteine Endopeptidases - metabolism | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - metabolism | Transcription, Genetic | Protein Synthesis Inhibitors - pharmacology | Ubiquitins - metabolism | DNA-Binding Proteins - physiology | Signal Transduction | Cells, Cultured | Enzyme Induction | Antioxidants - pharmacology | DNA-Binding Proteins - chemistry | Cycloheximide - pharmacology | NAD(P)H Dehydrogenase (Quinone) - biosynthesis | Animals | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Ligands | NF-E2-Related Factor 2 | Trans-Activators - metabolism | Mice
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2003, Volume 278, Issue 45, pp. 44966 - 44974
Journal Article
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 01/2013, Volume 17, Issue 1, pp. 30 - 54
Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors, HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐... 
Hypoxia‐inducible factors | Targeted therapies | Cancer‐initiating cells | Hypoxia | Cancer progression | Metabolic pathways | Cancer stem/progenitor cells | Metastasis‐initiating cells | Metastases | Hypoxia-inducible factors | Cancer-initiating cells | Metastasis-initiating cells | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICALLY RELEVANT SUBTYPES | PANCREATIC-CANCER | Cancer stem | progenitor cells | CHRONIC MYELOID-LEUKEMIA | INHIBITS TUMOR-GROWTH | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | PROSTATE-CANCER | GENE-EXPRESSION | FATTY-ACID SYNTHASE | ENDOTHELIAL GROWTH-FACTOR | Neoplasms - metabolism | Hypoxia - drug therapy | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Molecular Targeted Therapy | Hypoxia - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasm Metastasis | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Intercellular Signaling Peptides and Proteins - genetics | Transcription Factors - genetics | Neoplasms - drug therapy | Transcription Factors - metabolism | Hypoxia - genetics | Hypoxia - pathology | Cell Transformation, Neoplastic - drug effects | Neoplasms - pathology | Apoptosis | Prevention | Glucose metabolism | Physiological aspects | Development and progression | Genetic transcription | Metastasis | Transforming growth factors | Vascular endothelial growth factor | Cancer | Energy metabolism | Regulators | Transcription factors | Mesenchyme | AKT protein | Insulin-like growth factors | Kinases | Autophagy | Cancer therapies | Neoplasms | Proteins | Homing | Angiogenesis | Signal transduction | Receptors | Epidermal growth factor | Bone marrow | Tumor necrosis factor-TNF | Growth factors | Deprivation | Cell survival | Cytokines | Epidermal growth factor receptors | MiRNA | Breast cancer | Rapamycin | Metabolism | Gene expression | Cell differentiation | Insulin | CXCR4 protein | 1-Phosphatidylinositol 3-kinase | Signaling | Pancreatic cancer | Stem cells | Glycolysis | Regulation | Prostate | Cell migration | Tumors | Reviews
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 29, pp. 21197 - 21207
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2013, Volume 451, Issue 3, pp. 427 - 437
The compound BAY 11-7082 inhibits I kappa B alpha [inhibitor of NF-kappa B (nuclear factor kappa B)alpha] phosphorylation in cells and has been used to... 
Linear ubiquitin assembly complex (LUBAC) | Myeloid differentiation factor 88 (MyD88) | Nuclear factor κB (NF-κB) | Lymphoma | Ubiquitin conjugating 13 (Ubc13) | Proteasome | nuclear factor kappa B (NF-kappa B) | proteasome | ACTIVATION | CELL LYMPHOMA-CELLS | LINEAR POLYUBIQUITIN CHAINS | linear ubiquitin assembly complex (LUBAC) | BIOCHEMISTRY & MOLECULAR BIOLOGY | lymphoma | KINASE | IKK | myeloid differentiation factor 88 (MyD88) | CROSS-TALK | IN-VIVO | CONJUGATING ENZYMES | NF-KAPPA-B | NEMO | ubiquitin conjugating 13 (Ubc13) | Nitriles - pharmacology | Humans | Receptors, Interleukin-1 - genetics | Ubiquitin - metabolism | Molecular Sequence Data | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | I-kappa B Proteins - metabolism | Sulfones - pharmacology | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Amino Acid Sequence | NF-KappaB Inhibitor alpha | Ubiquitin - antagonists & inhibitors | NF-kappa B p50 Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Conjugating Enzymes - genetics | Macrophages - cytology | Interleukin-1 - pharmacology | Receptors, Interleukin-1 - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Myeloid Differentiation Factor 88 - metabolism | TRAF, tumour-necrosis-factor-receptor-associated factor | HRMS, high-resolution mass spectra | K48-pUb, Lys48-linked polyubiquitin | UBE, ubiquitin-activating enzyme | IKK, IκB kinase | NEMO, NF-κB essential modifier | HEK, human embryonic kidney | TBK1, tumour-necrosis-factor-receptor-associated factor-associated NF-κB activator-binding kinase 1 | JNK, c-Jun N-terminal kinase | HOIP, haem-oxidized IRP2 ligase-1-interacting protein | LUBAC, linear ubiquitin assembly complex | ERK, extracellular-signal-regulated kinase | HTLV-1, human T-cell lymphotropic virus 1 | K63-pUb, Lys63-linked polyubiquitin | IRAK, IL-receptor-associated kinase | pUb, polyubiquitin | IκB, inhibitor of NF-κB | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | MyD88, myeloid differentiation factor 88 | DLBCL, diffuse large B-cell lymphoma | GFP, green fluorescent protein | NF-κB, nuclear factor κB | MS, tandem MS | Ubc, ubiquitin conjugating | TAK1, transforming growth factor β-activated kinase 1 | DAPI, 4′,6-diamidino-2-phenylindole | IL-1R, IL-1 receptor | DMEM, Dulbecco’s modified Eagle’s medium | HIF1α, hypoxia-inducible factor 1α | IL, interleukin | NEDD8, neural-precursor-cell-expressed developmentally down-regulated 8 | RBR, RING-between-RING, TAB, TAK1-binding protein | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase | PAMP, pathogen-associated molecular pattern
Journal Article