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Annual Review of Biochemistry, ISSN 0066-4154, 2005, Volume 74, Issue 1, pp. 115 - 128
Hypoxia-inducible factor (HIF) is a master transcriptional regulator of hypoxia-inducible genes and consists of a labile a subunit (such as HIF1 alpha) and a... 
Von Hippel-Lindau | EGLN | FIH | Hydroxylation | Hypoxia-inducible factor (HIF) | HYPOXIA-INDUCIBLE FACTOR | hydroxylation | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPEL-LINDAU PROTEIN | FACTOR 1-ALPHA | hypoxia-inducible factor (HIF) | MITOCHONDRIAL RESPIRATORY-CHAIN | von Hippel-Lindau | NITRIC-OXIDE | PROLYL-HYDROXYLASES | TUMOR-SUPPRESSOR PROTEIN | ENDOTHELIAL GROWTH-FACTOR | UBIQUITIN-PROTEASOME PATHWAY | PAS DOMAIN PROTEIN | Transcription Factors - chemistry | Humans | Multiprotein Complexes | Hypoxia-Inducible Factor 1, alpha Subunit | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Immediate-Early Proteins - metabolism | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Immediate-Early Proteins - chemistry | Nuclear Proteins - genetics | Tumor Suppressor Proteins - metabolism | Hypoxia-Inducible Factor 1 | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Dioxygenases | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Proline - chemistry | Transcription Factors - metabolism | Animals | Immediate-Early Proteins - genetics | Procollagen-Proline Dioxygenase - genetics | Models, Biological | Von Hippel-Lindau Tumor Suppressor Protein | Procollagen-Proline Dioxygenase - chemistry | Ubiquitin-Protein Ligases - genetics | Proline | Research | Gene expression | Proteins | Oxygen | Biochemistry | Tumors
Journal Article
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 06/2012, Volume 19, Issue 6, pp. 968 - 979
Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase/Akt pathway, and are key regulators of the... 
C-Myc | FOXO | Reactive oxygen species | HIF-1a | Mitochondrial biogenesis | TRANSFORMATION | FORKHEAD TRANSCRIPTION FACTOR | C-MYC DEGRADATION | ACTIVATION | HIF-1 alpha | PROTEIN-KINASE-B | c-Myc | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPOXIA | mitochondrial biogenesis | CELL BIOLOGY | COMPLEX-III | BIOGENESIS | reactive oxygen species | ROS | Reactive Oxygen Species - metabolism | DNA, Mitochondrial - metabolism | Oxidative Stress | Signal Transduction | Humans | Gene Expression Regulation | Mitochondria - metabolism | Forkhead Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Cell Hypoxia | Mitochondria - genetics | RNA Interference | Forkhead Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Cell Line, Tumor | Forkhead Box Protein O1 | Proto-Oncogene Proteins c-myc - genetics | Forkhead Transcription Factors - antagonists & inhibitors | Forkhead Box Protein O3 | Superoxide Dismutase - metabolism | Apoptosis | RNA, Small Interfering - metabolism | Oxidative stress | Transcription factors | Hypoxia-inducible factor 1 alpha | Detoxification | c-Myc protein | AKT protein | Data processing | Superoxide dismutase | Mitochondrial DNA | Gene expression | Metabolism | Gene silencing | Mitochondria | Cell cycle | Forkhead protein | copy number | FOXO3 protein | Original Paper | HIF-1α
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 05/2005, Volume 288, Issue 5, pp. 1079 - 1090
Journal Article
Genes and Development, ISSN 0890-9369, 2000, Volume 14, Issue 4, pp. 391 - 396
In glioblastoma-derived cell lines, PTEN does not significantly alter apoptotic sensitivity or cause complete inhibition of DNA synthesis. However, in these... 
PTEN | Angiogenesis | Gene expression | Glioblastoma | SURVIVAL PATHWAY | angiogenesis | KINASE | AKT | DEVELOPMENTAL BIOLOGY | INDUCTION | CELL-SURVIVAL | HYPOXIA | BRAIN-TUMORS | glioblastoma | GENETICS & HEREDITY | GERMLINE MUTATIONS | TUMOR-SUPPRESSOR | gene expression | ENDOTHELIAL GROWTH-FACTOR | Prostaglandin-Endoperoxide Synthases - biosynthesis | Vascular Endothelial Growth Factor A | Insulin-Like Growth Factor I - pharmacology | Vascular Endothelial Growth Factors | Humans | Neoplasm Proteins - physiology | Protein-Serine-Threonine Kinases | Brain Neoplasms - pathology | Cyclooxygenase 1 | Phosphofructokinase-1 - genetics | Phosphoric Monoester Hydrolases - deficiency | Recombinant Fusion Proteins - physiology | Phosphofructokinase-1 - biosynthesis | Genetic Complementation Test | Hypoxia-Inducible Factor 1, alpha Subunit | Lymphokines - genetics | Transfection | Glioblastoma - genetics | PTEN Phosphohydrolase | Gene Deletion | Lymphokines - biosynthesis | Tumor Cells, Cultured | Culture Media, Serum-Free - pharmacology | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Prostaglandin-Endoperoxide Synthases - genetics | DNA-Binding Proteins - physiology | Phosphoric Monoester Hydrolases - genetics | Hypoxia-Inducible Factor 1 | Isoenzymes - genetics | Neoplasm Proteins - biosynthesis | Brain Neoplasms - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Endothelial Growth Factors - biosynthesis | Phosphoric Monoester Hydrolases - physiology | Disease Progression | Membrane Proteins | Proto-Oncogene Proteins c-akt | Endothelial Growth Factors - genetics | Glioblastoma - pathology | Proto-Oncogene Proteins - physiology | Nuclear Proteins - physiology | Transcription Factors | Cell Hypoxia - genetics | Isoenzymes - biosynthesis | Tumor Suppressor Proteins | Apoptosis | Phosphotransferases (Alcohol Group Acceptor) - biosynthesis | Tumor suppressor genes | Genetic aspects | Research | Neovascularization | Cytochemistry | Glioblastoma multiforme | Carcinogenesis | Research Communication
Journal Article
Journal Article
Efficient identification of tetR-expressing cell lines for tetracycline-regulated gene expression, 08/2004
The technology of tetracycline-inducible gene expression has been successfully used in experimental biology to identify the function and downstream signaling... 
Biotechnology | 10T1/2 cells, Ras, Tetracycline-inducible expression system, tetR, T-REx. ej04021
Journal