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03/2012
Cellular adaptation to conditions of stress is critical to the survival of all organisms. In mammalian cells, reduced oxygen availability, or hypoxia, triggers... 
0992 | Hypoxia-inducible Factor | Kidney Cancer
Dissertation
Kidney International, ISSN 0085-2538, 12/2019, Volume 96, Issue 6, pp. 1250 - 1253
Journal Article
Life Sciences, ISSN 0024-3205, 11/2019, Volume 237, p. 116952
Cancer stem cells (CSC) constitute a small area of the tumor mass and are characterized by self-renewal, differentiation and the ability to promote the... 
Cancer stem cell | Hypoxia | Hypoxia inducible factor | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2006, Volume 103, Issue 49, pp. 18727 - 18732
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 12/2008, Volume 8, Issue 12, pp. 967 - 975
During the past century it has been established that regions within solid tumours experience mild to severe O-2 deprivation owing to aberrant vascular... 
CELL LUNG-CANCER | GLUCOSE-REGULATED PROTEINS | TRANSCRIPTIONAL ACTIVITY | HUMAN ERYTHROPOIETIN GENE | TUMOR-SUPPRESSOR FUNCTION | SOLID TUMORS | ONCOLOGY | INDUCIBLE FACTOR 1-ALPHA | FACTOR-I | NECK-CANCER | UBIQUITIN-PROTEASOME PATHWAY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2018, Volume 115, Issue 32, p. E7458
Paredes et al recently described Poldip2 as a novel regulator of mitochondrial lipoylation through stabilisation of ACSM1 (1). We have several concerns with... 
Animals | Hypoxia-Inducible Factor 1 | Attitude | Thioctic Acid
Journal Article
Nature Immunology, ISSN 1529-2908, 2009, Volume 10, Issue 1, pp. 83 - 91
The mucosal immune system of the intestine is separated from a vast array of microbes by a single layer of epithelial cells. Cues from the commensal microflora... 
NATURAL-KILLER-CELLS | INDUCIBLE FACTOR | HOMEOSTASIS | GUT CRYPTOPATCHES | LYMPHOID-TISSUES | RECOGNITION | INFLAMMATION | HUMAN INTESTINAL-MUCOSA | NK-CELLS | IMMUNOLOGY | INNATE IMMUNITY
Journal Article
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 12/2012, Volume 367, Issue 24, pp. 2322 - 2333
  Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly... 
ISCHEMIA-REPERFUSION INJURY | ECTO-5'-NUCLEOTIDASE CD73 | MEDICINE, GENERAL & INTERNAL | ISCHEMIA/REPERFUSION INJURY | INDUCED VASCULAR LEAK | A2B ADENOSINE RECEPTOR | INDUCIBLE FACTOR-I | EXPERIMENTAL COLITIS | ACUTE LUNG INJURY | ATP RELEASE | T-CELLS | Proteins | Disease | Ischemia | Rodents | Ligands | Asthma | Apoptosis
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 11/2008, Volume 8, Issue 11, pp. 865 - 873
The von Hippel-Lindau disease is caused by inactivating germline mutations of the VHL tumour suppressor gene and is associated with an increased risk of a... 
RNA-POLYMERASE-II | HYDROXYLASE DOMAIN PROTEIN-2 | ONCOLOGY | HYPOXIA-INDUCIBLE-FACTOR | PROLINE HYDROXYLATION | RENAL-CELL-CARCINOMA | VASCULAR TUMORS | HIF-ALPHA | GENE-PRODUCT | PROLYL HYDROXYLASE | FACTOR-ALPHA
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 11/2008, Volume 8, Issue 11, pp. 865 - 873
The von Hippel-Lindau disease is caused by inactivating germline mutations of the VHL tumour suppressor gene and is associated with an increased risk of a... 
Neoplasms - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Genes, Tumor Suppressor | Hypoxia-Inducible Factor 1 - metabolism | Humans | Oxygen - metabolism
Journal Article
11/2012
Clear cell renal cell carcinoma (ccRCC) is an aggressive malignancy characterized by inactivation of the von Hippel-Lindau tumour suppressor gene, the protein... 
renal cell carcinoma | GAL3ST1 | 0379 | von Hippel-Lindau | 0992 | sulfatide | hypoxia-inducible factor | 0307 | tumour hypoxia
Dissertation
Oncogene, ISSN 0950-9232, 07/2017, Volume 36, Issue 30, p. 4380
This corrects the article DOI: 10.1038/onc.2017.8 
GATA-3 protein | Hypoxia-inducible factor 1a | Cellular biology | Invasiveness | Cancer
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 2013, Volume 20, Issue 3, pp. 408 - 418
  Hypoxia-inducible factor 1 (HIF-1) is a crucial transcription factor for the cellular adaptive response to hypoxia, which contributes to multiple events in... 
acute myeloid leukemia (AML) | hypoxia-inducible factor 1a (HIF-1a) | microRNA
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2007, Volume 178, Issue 12, pp. 7516 - 7519
Sepsis, the leading cause of death in intensive care units, reflects a detrimental host response to infection in which bacteria or LPS act as potent activators... 
HYPOXIA-INDUCIBLE FACTOR | ACTIVATION | GENE | MACROPHAGES | FACTOR-I | HIF-1-ALPHA | IMMUNOLOGY | NF-KAPPA-B | CELL | EPIDEMIOLOGY | ENDOTHELIAL GROWTH-FACTOR
Journal Article
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