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Cancer research (Chicago, Ill.), ISSN 1538-7445, 02/2011, Volume 71, Issue 4, pp. 1263 - 1271
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Th1 Cells - pathology | Th1 Cells - physiology | Prognosis | Th2 Cells - physiology | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma - mortality | Gene Expression Profiling | Th2 Cells - immunology | Th1 Cells - immunology | Colorectal Neoplasms - diagnosis | Lymphocytes, Tumor-Infiltrating - physiology | T-Lymphocytes, Cytotoxic - pathology | Th1 Cells - metabolism | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Microarray Analysis | T-Lymphocytes, Helper-Inducer - immunology | Lymphocytes, Tumor-Infiltrating - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-4 - genetics | Th2 Cells - pathology | Th17 Cells - pathology | Colorectal Neoplasms - mortality | T-Lymphocytes, Cytotoxic - immunology | Th17 Cells - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Carcinoma - immunology | Interleukin-4 - metabolism | Carcinoma - diagnosis | Forkhead Transcription Factors - genetics | Th2 Cells - metabolism | T-Lymphocytes, Cytotoxic - physiology | T-Lymphocytes, Helper-Inducer - physiology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | T-Lymphocytes, Cytotoxic - metabolism | Survival Analysis | Th17 Cells - immunology | Carcinoma - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 05/2011, Volume 29, Issue 15, pp. 1949 - 1955
Breast carcinomas are often infiltrated by inflammatory cells, particularly macrophages and T lymphocytes, but the significance of these cells remains unclear... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Prognosis | Breast Neoplasms - immunology | Cell Count | Humans | Middle Aged | Treatment Outcome | Breast Neoplasms - pathology | Adult | Breast Neoplasms - mortality | Female | Retrospective Studies | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Age | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 06/2011, Volume 108, Issue 26, pp. 10656 - 10661
Journal Article
British journal of cancer, ISSN 1532-1827, 03/2015, Volume 112, Issue 9, pp. 1501 - 1509
Journal Article
Nature (London), ISSN 1476-4687, 06/2018, Volume 558, Issue 7710, pp. 454 - 459
The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CD8-Positive T-Lymphocytes - cytology | Male | CD4-Positive T-Lymphocytes - immunology | Immune Tolerance - immunology | Melanoma - genetics | CD8-Positive T-Lymphocytes - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Transcription, Genetic | Lymphocytes, Tumor-Infiltrating - cytology | Reproducibility of Results | Gene Regulatory Networks - genetics | Interleukin-27 - immunology | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Receptors, Cell Surface - metabolism | Positive Regulatory Domain I-Binding Factor 1 - metabolism | Mice, Knockout | Animals | Melanoma - immunology | Immune Tolerance - genetics | Proto-Oncogene Proteins c-maf - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Receptors, Cell Surface - genetics | Genetic aspects | Genetic transcription | Observations | T cells | Transcription factors | PD-1 protein | CD8 antigen | Gene regulation | Homeostasis | Effector cells | Lymphocytes T | Genomes | CD223 antigen | Immunity | Interleukin 27 | Proteins | Receptors | CTLA-4 protein | Lymphocytes | Bioinformatics | Cytokines | Immunoregulation | Melanoma | Protein C | c-Maf protein | Activated protein C | Gene expression | Ribonucleic acid--RNA | Molecular chains | CD4 antigen | Exhaustion | Computer applications | Receptor mechanisms | Bayesian analysis | Tumors | Index Medicus
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 06/2011, Volume 121, Issue 6, pp. 2350 - 2360
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 16, pp. 6187 - 6192
.... In a preclinical study, we evaluated IL-15 combined with antibodies to block negative immune regulator cytotoxic T lymphocyte antigen 4 (CTLA-4... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Humans | Male | Interferon-gamma - metabolism | Prostatic Neoplasms - immunology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flow Cytometry | T-Lymphocyte Subsets - drug effects | Antibodies - immunology | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Cytotoxicity, Immunologic - drug effects | Prostatic Neoplasms - drug therapy | Disease Models, Animal | Amino Acid Sequence | Prostatic Neoplasms - pathology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Kaplan-Meier Estimate | CTLA-4 Antigen - metabolism | Treatment Outcome | Interleukin-5 - administration & dosage | Lymphocytes, Tumor-Infiltrating - drug effects | CTLA-4 Antigen - immunology | B7-H1 Antigen - immunology | Antibodies - administration & dosage | B7-H1 Antigen - metabolism | T-Lymphocytes, Regulatory - drug effects | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Cell Line, Tumor | Mice | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | CD4-Positive T-Lymphocytes - drug effects | Lymphocytes, Tumor-Infiltrating - immunology | Tumor Burden - immunology | Interleukins | Immunotherapy | Physiological aspects | Development and progression | T cells | Health aspects | Prostate cancer | Index Medicus | Adenocarcinoma | Animal models | Cell survival | CD8 antigen | Immunoregulation | Antibodies | Clinical trials | Cytotoxicity | Lymphocytes T | Interleukin 15 | CD4 antigen | CTLA-4 protein | PD-L1 protein | gamma -Interferon | Antitumor activity | CD25 antigen | Natural killer cells | Prostate | Tumors | Biological Sciences
Journal Article
Nature (London), ISSN 0028-0836, 06/2019, Volume 571, Issue 7764, pp. 270 - 274
Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the functional effector or memory T cell states(1-6). Here we identify... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CD8-Positive T-Lymphocytes - cytology | CD8-Positive T-Lymphocytes - pathology | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Receptors, Antigen, T-Cell - immunology | Transcription, Genetic | Lymphocytes, Tumor-Infiltrating - cytology | High Mobility Group Proteins - metabolism | High Mobility Group Proteins - deficiency | Homeodomain Proteins - genetics | Cell Differentiation - immunology | Phenotype | Animals | Lymphocytes, Tumor-Infiltrating - pathology | Neoplasms - immunology | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | High Mobility Group Proteins - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Physiological aspects | Genetic aspects | T cells | Cell differentiation | Tumors | Chromatin | Transcription factors | CD8 antigen | Differentiation (biology) | Chronic infection | Effector cells | Stimulation | Infections | Lymphocytes T | Genomes | NF-AT protein | Ovarian cancer | T-cell receptor | Liver cancer | Receptors | Cell activation | Clonal deletion | Listeria | Lymphocytes | Bioinformatics | Hepatocyte nuclear factor 1 | Deoxyribonucleic acid--DNA | Antigens | Data analysis | Immunological memory | Memory cells | Cloning | Melanoma | T cell receptors | Cell death | Exhaustion | Stem cells | Receptor mechanisms | Viral infections | Index Medicus
Journal Article