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1. Full Text Elevated serum OX40L is a biomarker for identifying corticosteroid resistance in pediatric asthmatic patients
by Ma, Su-Li and Zhang, Lei
BMC Pulmonary Medicine, ISSN 1471-2466, 03/2019, Volume 19, Issue 1, pp. 66 - 7
BackgroundCorticosteroids are widely used to control asthma symptoms, but steroid resistance (SR) is a common adverse reaction. Therefore, it is important to... 
OX40 ligand (OX40L) | Biomarker | Steroid resistance (SR) | Inhaled corticosteroids (ICS) | Asthma | IL-6 | THYMIC STROMAL LYMPHOPOIETIN | MURINE MODEL | OX40/OX40L | THERAPY | RESPIRATORY SYSTEM | INFLAMMATION | EXPRESSION | T-CELLS | Multivariate Analysis | Neutrophils - cytology | Predictive Value of Tests | Forced Expiratory Volume - drug effects | Monocytes - cytology | Humans | Administration, Inhalation | Adrenal Cortex Hormones - pharmacology | Child, Preschool | Logistic Models | Male | Biomarkers - blood | Asthma - drug therapy | Case-Control Studies | Interleukin-6 - blood | Asthma - blood | Female | ROC Curve | OX40 Ligand - blood | Child | Drug Resistance | Cytokines - blood | Pediatrics | Medical research | Enzymes | Care and treatment | Corticosteroids | Asthma in children | Immunoglobulin E | B cells | Interleukins | Analysis | Medicine, Experimental | Health aspects | Enzyme-linked immunosorbent assay
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2. Full Text Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma
by Whittle, E and Leonard, M.O and Gant, T.W and Tonge, D.P
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 8912 - 19
Asthma is a chronic inflammatory disorder of the airways. Disease presentation varies greatly in terms of cause, development, severity, and response to... 
GLOBAL BURDEN | NATURAL-KILLER-CELLS | HOSPITAL ADMISSIONS | EXPRESSION ANALYSIS | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | INHALED CORTICOSTEROIDS | AIRWAY INFLAMMATION | RESPIRATORY HEALTH | GENDER-DIFFERENCES | TOLL-LIKE RECEPTOR-1 | Phenotypes | rRNA 16S | Granulocyte-macrophage colony-stimulating factor | Hypersensitivity | MiRNA | Microbiomes | Immunoglobulin E | Tumor necrosis factor-α | Gene expression | Eotaxin | Atopy | Asthma | Interleukin 4 | Monocyte chemoattractant protein 1
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3. Absolute Blood Eosinophil Counts to Guide Inhaled Corticosteroids Therapy Among Patients with COPD: Systematic Review and Meta-analysis
by Oshagbemi, OA and Odiba, JO and Daniel, A and Yunusa, I
CURRENT DRUG TARGETS, ISSN 1389-4501, 2019, Volume 20, Issue 16, pp. 1670 - 1679
Introduction: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 recommends the use of absolute blood eosinophil count as a guide for the... 
OBSTRUCTIVE PULMONARY-DISEASE | exacerbations | STABILITY | ASTHMA | RISK | PHARMACOLOGY & PHARMACY | Chronic obstructive pulmonary disease | eosinophil | POST-HOC ANALYSIS | blood eosinophils | pharmacological | inhaled corticosteroids | Corticoids | Respiratory therapy | Therapy | Corticosteroids | Thresholds | Lung diseases | Clinical trials | Risk | Systematic review | Disease control | Blood | Asthma | Obstructive lung disease
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4. Full Text Effect of long term inhaled corticosteroid therapy on adrenal suppression, growth and bone health in children with asthma
by Anuradha, KWDA and Prematilake, GLDC and Batuwita, BAUI and Kannangoda, KASR and Hewagamage, US and Wijeratne, S and Kantha, L and de Silva, KSH
BMC PEDIATRICS, 11/2019, Volume 19, Issue 1, pp. 1 - 6
Background: Inhaled corticosteroids (ICS) are the most effective treatment for children with persistent asthma. However adverse effects of ICS on Hypothalamo... 
Vitamin D | Growth | INSUFFICIENCY | BUDESONIDE | PEDIATRICS | Inhaled corticosteroids | HEIGHT | Bone metabolism | Adrenal suppression | Asthma
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5. Full Text Effect of different doses of inhaled ciclesonide on lung function, clinical signs related to airflow limitation and serum cortisol levels in horses with experimentally induced mild to severe airway obstruction
by Lavoie, J.‐P and Bullone, M and Rodrigues, N and Germim, P and Albrecht, B and von Salis‐Soglio, M
Equine Veterinary Journal, ISSN 0425-1644, 11/2019, Volume 51, Issue 6, pp. 779 - 786
Summary Background Inhaled corticosteroids are effective for the treatment of equine asthma but they induce cortisol suppression with potential side effects.... 
horse | inhalation therapy | RAO | cortisol | lung function | inhaled corticosteroids
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6. Full Text The frequency and risk factors for oropharyngeal candidiasis in adult asthma patients using inhaled corticosteroids
by Erdoğan, Tuba and Karakaya, Gül and Kalyoncu, A. Fuat
Turkish Thoracic Journal, ISSN 2148-7197, 04/2019, Volume 20, Issue 2, pp. 136 - 139
Worldwide, asthma is a major health problem and inhaled corticosteroids (ICS) are the mainstay of asthma treatment. High-dose and long-term use of ICS can... 
Side effects | Inhaled corticosteroids | Oropharyngeal candidiasis | Asthma treatment | Asthma | asthma treatment | side effects | asthma | Original | inhaled corticosteroids
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7. Full Text Healthcare utilization in infants and toddlers with asthma‐like symptoms
by Levine, Hagit and Leventer‐Roberts, Maya and Hoshen, Moshe and Mei‐Zahav, Meir and Balicer, Ran and Blau, Hannah
Pediatric Pulmonology, ISSN 8755-6863, 10/2019, Volume 54, Issue 10, pp. 1567 - 1577
Background Recurrent asthma‐like symptoms are common in infants, but few population studies describe diagnostic and treatment practice. Methods Using the... 
health care utilization | infants | preventive therapy | controller treatment | leukotriene receptor antagonists | asthma | infantile asthma | wheezing | inhaled corticosteroids | MONTELUKAST | EFFICACY | LUNG-FUNCTION | INHALED FLUTICASONE PROPIONATE | CHILDHOOD ASTHMA | PRESCHOOL-CHILDREN | RESPIRATORY SYSTEM | DOUBLE-BLIND | PEDIATRICS | 1ST 6 YEARS | CORTICOSTEROIDS | YOUNG-CHILDREN
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8. Short-term efficacy and safety of prednisone in herpes zoster and the effects on IL-6 and IL-10
by Peng, LX and Du, B and Sun, LL and Zhao, YG and Zhang, XP
EXPERIMENTAL AND THERAPEUTIC MEDICINE, ISSN 1792-0981, 10/2019, Volume 18, Issue 4, pp. 2893 - 2900
Short-term efficacy and safety of prednisone in herpes zoster and the effect on IL-6 and IL-10 were investigated. A total of 125 patients (aged 40-70 years)... 
MEDICINE, RESEARCH & EXPERIMENTAL | therapeutic effect | PLACEBO | herpes zoster | PAIN | INHALED CORTICOSTEROIDS | METHOTREXATE | RISK | prednisone | IL-6 | IL-10
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9. Full Text Real-life studies of biologics used in asthma patients: key differences and similarities to trials
by Heffler, Enrico and Paoletti, Giovanni and Giorgis, Veronica and Puggioni, Francesca and Racca, Francesca and Del Giacco, Stefano and Bagnasco, Diego and Caruso, Cristiano and Brussino, Luisa and Rolla, Giovanni and Canonica, Giorgio Walter
Expert Review of Clinical Immunology, ISSN 1744-666X, 09/2019, Volume 15, Issue 9, pp. 951 - 958
Introduction: The precision medicine approach that is now mandatory for severe asthma management includes the use of novel biologic agents blocking specific... 
real-life studies | precision medicine | clinical trials | biologics | Asthma | OMALIZUMAB | PLACEBO | MEPOLIZUMAB | INHALED CORTICOSTEROIDS | PERSISTENT ASTHMA | SEVERE ALLERGIC-ASTHMA | MONOCLONAL-ANTIBODY | IMMUNOLOGY | DUPILUMAB | DOUBLE-BLIND | ANTI-IGE ANTIBODY
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10. Full Text Update in pediatric asthma: Selected issues
by Azmeh, Roua and Greydanus, Donald E and Agana, Marisha G and Dickson, Cheryl A and Patel, Dilip R and Ischander, Mariam M and Lloyd, Robert D
Disease-a-Month, ISSN 0011-5029, 09/2019, p. 100886
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11. Full Text Synthetic pharmacotherapy for pulmonary sarcoidosis
by Llabres, Marta and Brito-Zerón, Pilar and Ramos-Casals, Manuel and Sellares, Jacobo
Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 07/2019, Volume 20, Issue 11, pp. 1397 - 1404
Introduction: Sarcoidosis is a granulomatous systemic disease of unknown cause where the lungs are the most frequently affected. Therapeutic management of the... 
Glucocorticoids | Immunosuppressive Therapy | Pulmonary Sarcoidosis | FIBROSIS | MAINTENANCE TREATMENT | MANAGEMENT | PROGNOSIS | METHOTREXATE | INHALED BUDESONIDE | CORTICOSTEROID-THERAPY | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | HYPERTENSION | LEFLUNOMIDE
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12. Targeted Therapy for Severe Asthma in Children and Adolescents: Current and Future Perspectives
by Licari, A and Manti, S and Castagnoli, R and Parisi, GF and Salpietro, C and Leonardi, S and Marseglia, GL
PEDIATRIC DRUGS, ISSN 1174-5878, 08/2019, Volume 21, Issue 4, pp. 215 - 237
Severe asthma in children remains a significant issue. It places a heavy burden on affected individuals and society as a whole in terms of high morbidity,... 
OMALIZUMAB | MEPOLIZUMAB | SEVERE EOSINOPHILIC ASTHMA | EFFICACY | LONG-TERM SAFETY | ALLERGIC-ASTHMA | DOUBLE-BLIND | INHALED CORTICOSTEROIDS | PERSISTENT ASTHMA | PEDIATRICS | PHARMACOLOGY & PHARMACY | ANTI-IGE
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13. Full Text Phenotypes favoring fractional exhaled nitric oxide discordance vs guideline-based uncontrolled asthma
by Morphew, Tricia and Shin, Hye-Won and Marchese, Sara and Pires-Barracosa, Naomi and Galant, Stanley P
Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, 08/2019, Volume 123, Issue 2, pp. 193 - 200
Despite potential value of identification of allergic inflammation with fractional exhaled nitric oxide (FeNO) in managing asthma, randomized clinical trials... 
MANAGEMENT | PREDICTOR | ALLERGY | ADOLESCENTS | INHALED CORTICOSTEROIDS | AIRWAY INFLAMMATION | LUNG-FUNCTION | ADULTS | NATIONAL-HEALTH | IMMUNOLOGY | CHILDREN
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14. Full Text Cough and Eosinophilia
by Diver, Sarah and Russell, Richard J and Brightling, Christopher E
The Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, 07/2019, Volume 7, Issue 6, pp. 1740 - 1747
Eosinophilic airway inflammation is observed in 30% to 50% of chronic cough sufferers. It is a common feature of asthma and upper airway cough syndrome, and it... 
Feno | Chronic rhinosinusitis | Chronic cough | Rhinitis | Nonasthmatic eosinophilic bronchitis | Mast cell | Upper airway cough syndrome | Eosinophil | Asthma | FENO | BRONCHITIS | ADD-ON MONTELUKAST | MANAGEMENT | VARIANT ASTHMA | IMMUNOLOGY | CHRONIC AIRWAY-OBSTRUCTION | INHALED BUDESONIDE | ALLERGY | INDUCED SPUTUM | NONALLERGIC RHINITIS | EXHALED NITRIC-OXIDE | CHEST GUIDELINE | Corticoids | Cytokines | Rhinosinusitis | Leukocytes (eosinophilic) | Smooth muscle | Inflammation | Eosinophilia | Polyposis | Cough | Allergies | Respiratory tract | Allergic rhinitis | Medical education | Biomarkers | Respiratory tract diseases | Bronchitis | Accreditation | Diagnosis | Chemokines
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15. Full Text Inflammatory endotypes in COPD
by Barnes, Peter J
Allergy, ISSN 0105-4538, 07/2019, Volume 74, Issue 7, pp. 1249 - 1256
Chronic obstructive pulmonary disease (COPD) is a major global health problem that is poorly treated by current therapies as it has proved difficult to treat... 
asthma‐COPD overlap | macrophage | eosinophil | neutrophil | exacerbations | interleukin‐5 | asthma-COPD overlap | interleukin-5 | GLOBAL BURDEN | SMALL-AIRWAY-OBSTRUCTION | BLOOD EOSINOPHIL COUNT | INHALED CORTICOSTEROIDS | IMMUNOLOGY | CCR5 CHEMOKINES | OBSTRUCTIVE PULMONARY-DISEASE | ALLERGY | SPUTUM EOSINOPHILIA | OVERLAP SYNDROME | ALPHA-1-ANTITRYPSIN DEFICIENCY | POST-HOC ANALYSIS | Interleukins | Lung diseases, Obstructive | Corticoids | Corticosteroids | Secretion | Leukocytes (eosinophilic) | Lung diseases | Leukocytes (neutrophilic) | Inflammation | Macrophages | Eosinophilia | Patients | Blood | Asthma | Heterogeneity | Monocytes | Lungs | Obstructive lung disease | Sputum | Chronic obstructive pulmonary disease | Public health | Eosinophils
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16. Full Text Inhaled corticosteroid therapy in adult asthma time for a new therapeutic dose terminology
by Beasley, Richard and Harper, James and Bird, Grace and Maijers, Ingrid and Weatherall, Mark and Pavord, Ian D
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 06/2019, Volume 199, Issue 12, pp. 1471 - 1477
The Global Initiative for Asthma guidelines use the traditional terminology of "low," "medium," and "high" doses of inhaled corticosteroids (ICS) to define... 
Inhaled corticosteroids | Dose–response relationship | Asthma | RESPONSIVENESS | SAFETY | BUDESONIDE | asthma | RESPONSE RELATIONSHIP | COMBINATION | HYPERRESPONSIVENESS | FUROATE | FLUTICASONE PROPIONATE | RESPIRATORY SYSTEM | EXACERBATIONS | dose-response relationship | EXHALED NITRIC-OXIDE | inhaled corticosteroids | CRITICAL CARE MEDICINE | Clinical trials | Jargon | Systematic review | Thorax | Adults | Teenagers | Diabetes | Drug dosages | Meta-analysis
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17. Full Text Inhaled corticosteroids and risk of upper respiratory tract infection in patients with asthma: a meta-analysis
by Yang, Mingjin and Yang, Mingjin and Zhang, Yan and Zhang, Yan and Chen, Hong and Chen, Hong and Lin, Jiachen and Lin, Jiachen and Zeng, Jiatao and Zeng, Jiatao and Xu, Zhibo and Xu, Zhibo
Infection, ISSN 0300-8126, 6/2019, Volume 47, Issue 3, pp. 377 - 385
Recent studies have suggested a possible association between respiratory infection and the use of inhaled corticosteroids (ICS). We aimed to ascertain the risk... 
Upper respiratory tract infection (URTI) | Medicine & Public Health | Inhaled corticosteroids (ICS) | General Practice / Family Medicine | Infectious Diseases | Internal Medicine | Risk | Asthma | Meta-analysis | Corticoids | Respiratory therapy | Budesonide | Corticosteroids | Health risks | Clinical trials | Infections | Fluticasone | Patients | Subgroups | Scientific papers | Respiratory tract | Heterogeneity | Search engines | Respiratory tract diseases | Steroids
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18. Full Text Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia
by Lewis, Tamorah and Truog, William and Norberg, Mike and Ballard, Philip L and Torgerson, Dara and TOLSURF Study Grp and TOLSURF Study Group and for the TOLSURF Study Group
Pediatric Research, ISSN 0031-3998, 04/2019, Volume 85, Issue 5, pp. 625 - 633
BACKGROUND: Bronchopulmonary dysplasia (BPD) is an orphan disease and advances in prevention and treatment are lacking. The clinical efficacy of systemic... 
CONTROLLED-TRIAL | SEVERITY SCORE | IMPROVED LUNG-FUNCTION | BIRTH-WEIGHT INFANTS | SURFACTANT | VENTILATOR-DEPENDENT INFANTS | MECHANICAL VENTILATION | PEDIATRICS | POLYMORPHISM | LOW-DOSE DEXAMETHASONE | INHALED NITRIC-OXIDE
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19. Full Text Severe asthma in children: Evaluation and management
by Haktanir Abul, Mehtap and Phipatanakul, Wanda
Allergology International, ISSN 1323-8930, 04/2019, Volume 68, Issue 2, pp. 150 - 157
Severe asthma in children is associated with significant morbidity. Children with severe asthma are at increased risk for adverse outcomes including... 
Difficult to treat asthma | Pediatric severe asthma | Asthma evaluation | Asthma management | Severe asthma evaluation | BLOOD EOSINOPHIL COUNTS | INHA