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Journal Article
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 06/2019, Volume 50, pp. 55 - 65
Protein–protein interactions (PPIs) occur in complex networks. These networks are highly dependent on cellular context and can be extensively altered in... 
HEAT-SHOCK PROTEINS | USP7 | BIOPHYSICS | ACTIVE-SITE | SMALL-MOLECULE INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELECTIVE INHIBITORS | AAA-ATPASE | MUTATIONS | UBIQUITIN LIGASES | CANCER | ATPASE P97 | Virus diseases | Proteins | Homeostasis | Heat shock proteins | Biomedical engineering
Journal Article
Analytical Chemistry, ISSN 0003-2700, 04/2003, Volume 75, Issue 7, pp. 1584 - 1589
In this study we developed an inducible synthetic renilla luciferase protein-fragment-assisted complementation-based bioluminescence assay to quantitatively... 
RENIFORMIS LUCIFERASE | LIVING SUBJECTS | CHEMISTRY, ANALYTICAL | BETA-GALACTOSIDASE COMPLEMENTATION | GREEN FLUORESCENT PROTEIN | MAMMALIAN-CELLS | EXPRESSION | RECONSTITUTION | RECRUITMENT SYSTEM | INTEIN | STRATEGIES | Proteins | Bioluminescence | Chemistry, Analytic | Tumor necrosis factor | Analysis | Causes of | Research | Cells | Organic compounds
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2007, Volume 104, Issue 49, pp. 19256 - 19261
Protein-protein recognition is the cornerstone of multiple cellular and pathological functions. Therefore, protein-protein interaction inhibition (2P2I) is... 
Molecules | Databases | Drug interactions | Molecular interactions | Libraries | Drug design | Goods and services tax | Viability | Chemicals | HIV 1 | Docking | NMR | Scoring function | Src homology 3 | COMPLEX | drug design | IMMUNODEFICIENCY-VIRUS | scoring function | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | KINASE | PATHOGENESIS | docking | TYPE-1 NEF | HCK | BIOLOGY | SH3 DOMAIN | Anti-HIV Agents - pharmacology | Drug Evaluation, Preclinical - methods | Cercopithecus aethiops | nef Gene Products, Human Immunodeficiency Virus - chemistry | src Homology Domains - drug effects | Two-Hybrid System Techniques | Anti-HIV Agents - chemistry | Animals | Computer Simulation | nef Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors | Drug Design | nef Gene Products, Human Immunodeficiency Virus - metabolism | Protein Conformation | Anti-HIV Agents - isolation & purification | COS Cells | Drugs | Control | Viral proteins | Physiological aspects | Influence | Genetic aspects | Product/Service Evaluations | HIV (Viruses) | Properties | Medical screening | Protein-protein interactions | Methods | Biochemistry, Molecular Biology | Anti-HIV Agents | src Homology Domains | Life Sciences | Drug Evaluation, Preclinical | nef Gene Products, Human Immunodeficiency Virus | Biological Sciences
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article