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The Plant Journal, ISSN 0960-7412, 06/2017, Volume 90, Issue 5, pp. 929 - 940
Journal Article
The FEBS Journal, ISSN 1742-464X, 03/2017, Volume 284, Issue 6, pp. 868 - 874
Journal Article
ELIFE, ISSN 2050-084X, 04/2015, Volume 4, p. e07314
The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the integrated stress response... 
GUANINE-NUCLEOTIDE-EXCHANGE | UNFOLDED PROTEIN RESPONSE | 40S RIBOSOMAL-SUBUNIT | OPEN READING FRAMES | MESSENGER-RNA | BIOLOGY | TRANSLATION INITIATION | INITIATION-FACTOR EIF2B | VANISHING WHITE-MATTER | MAMMALIAN-CELLS | GENETIC INTERACTION MAPS | RNA, Small Interfering - genetics | Phosphorylation | Humans | Thapsigargin - antagonists & inhibitors | Acetamides - pharmacology | Structure-Activity Relationship | Protein Subunits - metabolism | Acetamides - chemical synthesis | Neuroprotective Agents - pharmacology | Cyclohexylamines - pharmacology | Eukaryotic Initiation Factor-2B - genetics | HEK293 Cells | Binding Sites | Genes, Reporter | Protein Subunits - genetics | Gene Expression | Neuroprotective Agents - chemistry | Cyclohexylamines - chemical synthesis | Endoplasmic Reticulum Stress - drug effects | Bacterial Proteins - genetics | Cyclohexylamines - chemistry | Nootropic Agents - chemical synthesis | Nootropic Agents - chemistry | Neuroprotective Agents - chemical synthesis | Acetamides - chemistry | High-Throughput Screening Assays | K562 Cells | Protein Binding | Thapsigargin - pharmacology | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Eukaryotic Initiation Factor-2B - metabolism | Protein Subunits - antagonists & inhibitors | HeLa Cells | Eukaryotic Initiation Factor-2B - antagonists & inhibitors | Nootropic Agents - pharmacology | Protein Multimerization - drug effects | Luminescent Proteins - metabolism | RNA, Small Interfering - metabolism | Cell culture | Transcription factors | Neurodegenerative diseases | Serine | Translation initiation | Cognitive ability | Kinases | Proteins | Protein synthesis | Stress response | Dimerization | Long-term depression | Binding sites
Journal Article
NeuroMolecular Medicine, ISSN 1535-1084, 9/2019, Volume 21, Issue 3, pp. 303 - 313
Journal Article
Science, ISSN 0036-8075, 03/2018, Volume 359, Issue 6383, pp. 1483 - 1483
Regulation by the integrated stress response (ISR) converges on the phosphorylation of translation initiation factor eIF2 in response to a variety of stresses.... 
COMPLEX | INHIBITION | ALPHA-SUBUNIT | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | REGULATORY SUBCOMPLEX | ARCHITECTURE | INITIATION-FACTOR EIF2B | EIF2-ALPHA | TRANSLATIONAL CONTROL | INSIGHTS | Memory - drug effects | Phosphorylation | Recombinant Proteins - ultrastructure | Escherichia coli | Humans | Cyclohexylamines - chemistry | Recombinant Proteins - chemistry | Acetamides - pharmacology | Recombinant Proteins - genetics | Nootropic Agents - chemistry | Protein Folding | Cryoelectron Microscopy | Eukaryotic Initiation Factor-2B - chemistry | Acetamides - chemistry | Cyclohexylamines - pharmacology | Protein Stability - drug effects | Eukaryotic Initiation Factor-2B - genetics | Protein Conformation | Eukaryotic Initiation Factor-2B - ultrastructure | Mutation | Nootropic Agents - pharmacology | Protein Multimerization - drug effects | Neuroimaging | Exchanging | Brain | Regulations | Atomic force microscopy | Traumatic brain injury | Target recognition | Disorders | Cognitive ability | Nervous system | Cognition | Ultracentrifugation | Guanine | Convergence | Analogs | Proteins | Head injuries | Synthesis | Rodents | Atomic structure | Guanine nucleotide exchange factor | Stress response | Dimerization | Assembly | Symmetry | Stresses | Enzymes | Translation | Translation initiation | Pharmacology | Electron microscopy | Sedimentation | Chemical compounds | Substrates | Mutants | Neurological diseases | Transmission electron microscopy | Composite materials | Inhibitors | Cognition & reasoning | Microscopy | Ionic strength | Dismantling | Binding sites
Journal Article
Scientific reports, ISSN 2045-2322, 2018, Volume 8, Issue 1, pp. 3773 - 10
Vanishing white matter (VWM) is a genetic childhood white matter disorder, characterized by chronic as well as episodic, stress provoked, neurological... 
LEUKOENCEPHALOPATHY | UNFOLDED PROTEIN RESPONSE | MULTIDISCIPLINARY SCIENCES | DISEASE | ENDOPLASMIC-RETICULUM | INITIATION-FACTOR EIF2B | MUTATIONS | VANISHING WHITE-MATTER | MAMMALIAN-CELLS | OLIGODENDROCYTES | CELL-DEATH | Transcription | Protein synthesis | Astrocytes | Protein biosynthesis | Children | Mutation | Stress response | Substantia alba
Journal Article
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 2006, Volume 34, Issue 1, pp. 22 - 29
eIF2B (eukaryotic initiation factor 2B) is a GEF (guanine nucleotide-exchange factor) that plays, with its substrate eIF2, a key regulatory role in the... 
Guanine nucleotide-exchange factor (GEF) | Childhood ataxia with central nervous system hypomyelination/ leukoencephalopathy with vanishing white matter syndrome (CACH/VWM syndrome) | Translation | Leukodystrophy | Eukaryotic initiation factor 28 (eIF2B) | NUCLEOTIDE-EXCHANGE FACTOR | MESSENGER-RNA TRANSLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT-ONSET LEUKOENCEPHALOPATHY | leukodystrophy | translation regulation | INITIATION-FACTOR 2B | VANISHING WHITE-MATTER | PROTEIN-SYNTHESIS | NERVOUS-SYSTEM HYPOMYELINATION | COMPLEX-FORMATION | FACTOR EIF2B | translation | CHILDHOOD ATAXIA | guanine nucleotide-exchange factor (GEF) | childhood ataxia with central nervous system hypomyelination/leukoencephalopathy with vanishing white matter syndrome (CACH/VWM syndrome) | eukaryotic initiation factor 2B (eIF2B) | Ataxia - physiopathology | Humans | Genotype | Hereditary Central Nervous System Demyelinating Diseases - physiopathology | Protein Subunits - metabolism | Syndrome | Hereditary Central Nervous System Demyelinating Diseases - pathology | Phenotype | Guanine Nucleotide Exchange Factors - metabolism | Eukaryotic Initiation Factor-2 - genetics | Eukaryotic Initiation Factor-2B - genetics | Eukaryotic Initiation Factor-2 - metabolism | Eukaryotic Initiation Factor-2B - metabolism | Mutation | Ataxia - genetics | Hereditary Central Nervous System Demyelinating Diseases - genetics | Protein Subunits - genetics
Journal Article
SCIENCE, ISSN 0036-8075, 05/2019, Volume 364, Issue 6439, pp. 491 - 491
The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor... 
INHIBITION | ALPHA-SUBUNIT | RNA | PHOSPHORYLATION | CRYSTAL-STRUCTURE | FACTOR EIF2B | MULTIDISCIPLINARY SCIENCES | INITIATION-FACTOR 2B | EIF2-ALPHA | TRANSLATION | BINDING
Journal Article
Journal Article