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humans (145) 145
index medicus (132) 132
animals (107) 107
ink4a/arf (95) 95
cell biology (89) 89
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ink4a-arf locus (68) 68
cyclin-dependent kinase inhibitor p16 - genetics (62) 62
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expression (52) 52
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gene expression regulation, neoplastic (26) 26
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physiological aspects (25) 25
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proliferation (23) 23
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aging (22) 22
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demethylase jmjd3 contributes (22) 22
mice, inbred c57bl (22) 22
tumor suppression (22) 22
adult (21) 21
ink4a/arf expression (21) 21
multidisciplinary sciences (20) 20
nuclear proteins - genetics (20) 20
repressor proteins - genetics (20) 20
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epigenesis, genetic (19) 19
histones - metabolism (19) 19
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macromolecular substances (18) 18
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polycomb repressive complex 1 (18) 18
self-renewal (18) 18
signal transduction (18) 18
tumor suppressor protein p14arf - metabolism (18) 18
activation (17) 17
gene silencing (17) 17
genes (17) 17
immunohistochemistry (17) 17
mice, transgenic (17) 17
promoter regions, genetic (17) 17
proto-oncogene proteins - genetics (17) 17
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analysis (16) 16
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genetics (16) 16
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ink4 protein (15) 15
jumonji domain-containing histone demethylases - metabolism (15) 15
kinases (15) 15
medicine, research & experimental (15) 15
neoplasms (15) 15
nuclear proteins - metabolism (15) 15
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1. Full Text Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk
by Burd, Christin E and Jeck, William R and Liu, Yan and Sanoff, Hanna K and Wang, Zefeng and Sharpless, Norman E
PLoS genetics, ISSN 1553-7390, 12/2010, Volume 6, Issue 12, pp. e1001233 - 15
Human genome-wide association studies have linked single nucleotide polymorphisms (SNPs) on chromosome 9p21.3 near the INK4/ARF (CDKN2a/b) locus with... 
SEQUENCE VARIANT | MYOCARDIAL-INFARCTION | GENETIC ASSOCIATION | ABDOMINAL AORTIC-ANEURYSM | GENETICS & HEREDITY | INK4A/ARF EXPRESSION | SUSCEPTIBILITY LOCI | CHROMOSOME 9P21 | CELL-PROLIFERATION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Gene Expression | Genome-Wide Association Study | RNA, Untranslated - metabolism | Exons | Atherosclerosis - genetics | DNA, Circular - chemistry | Humans | Risk Factors | Cyclin-Dependent Kinase Inhibitor p16 - genetics | DNA, Circular - genetics | Atherosclerosis - epidemiology | DNA, Circular - metabolism | RNA, Untranslated - genetics | Atherosclerosis - metabolism | RNA Splicing | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | RNA, Untranslated - chemistry | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Nucleic Acid Conformation | RNA | Atherosclerosis | Physiological aspects | Tumor suppressor genes | Genetic aspects | Research | Single nucleotide polymorphisms | Risk factors | Mortality | Cell division | Genetics | Cardiovascular disease | Influence | Genomes
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2. Full Text JMJD3 expression is an independent prognosticator in patients with esophageal squamous cell carcinoma
by Li, Shau-Hsuan and Lu, Hung-I and Chen, Chang-Han and Chen, Yen-Hao and Lo, Chien-Ming and Huang, Wan-Ting and Tien, Wan-Yu and Lan, Ya-Chun and Tsai, Hsin-Ting
Surgery, ISSN 0039-6060, 05/2019, Volume 165, Issue 5, pp. 946 - 952
The Jumonji-domain containing 3 has diverse roles in multiple cancers. Here, we investigated its prognostic significance in esophageal squamous cell carcinoma.... 
INK4A/ARF | SURGERY | ACTIVATION | HISTONE DEMETHYLASE JMJD3 | UTX | SENESCENCE | CANCER | CONTRIBUTES | Immunohistochemistry | Medical colleges | Care and treatment | Squamous cell carcinoma | Analysis | Esophageal cancer
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3. Full Text Epigenetic regulation of p14(ARF) and p16(INK4A) expression in cutaneous and uveal melanoma
by Venza, M and Visalli, M and Biondo, C and Lentini, M and Catalano, T and Teti, D and Venza, I
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, ISSN 1874-9399, 03/2015, Volume 1849, Issue 3, pp. 247 - 256
Inactivation of p14(ARF) and p16(INK4A) by epigenetic changes in cutaneous and uveal melanoma has been here investigated. Compared with melanocytes, p14(ARF)... 
Human melanoma | METHYLATION ANALYSIS | PROMOTER HYPERMETHYLATION | LOW-FREQUENCY | BIOCHEMISTRY & MOLECULAR BIOLOGY | Promoter methylation | p14(ARF) | MALIGNANT-MELANOMA | Epi-drug | P53 | INACTIVATION | CIGARETTE-SMOKING | BIOPHYSICS | P16 | GROWTH ARREST | INK4A/ARF LOCUS | p16(INK4A) | Histone deacetylation
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4. Full Text DPY30 regulates pathways in cellular senescence through ID protein expression
by Simboeck, Elisabeth and Gutierrez, Arantxa and Cozzuto, Luca and Beringer, Malte and Caizzi, Livia and M Keyes, William and Di Croce, Luciano
The EMBO Journal, ISSN 0261-4189, 08/2013, Volume 32, Issue 16, pp. 2217 - 2230
Cellular senescence is an intrinsic defense mechanism to various cellular stresses: while still metabolically active, senescent cells stop dividing and enter a... 
senescence | DPY30 | ID proteins | chromatin | MLL | Chromatin | Senescence | INK4A-ARF LOCUS | P16(INK4A) EXPRESSION | SECRETORY PHENOTYPE | HISTONE-3 LYSINE-4 | DOSAGE COMPENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | LOOP-HELIX PROTEINS | TARGET GENES | SET1 COMPLEX | TUMOR-SUPPRESSOR | TRANSCRIPTION FACTOR | Humans | beta-Galactosidase | Cellular Senescence - physiology | Gene Expression Regulation - physiology | Nuclear Proteins - metabolism | Inhibitor of Differentiation Protein 1 - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Gene Knockdown Techniques | Flow Cytometry | Chromatin Immunoprecipitation | RNA Interference | Microarray Analysis | Fluorescent Antibody Technique | Signal Transduction - physiology | Colony-Forming Units Assay | Nuclear Proteins - genetics | Protein expression | Cellular biology
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5. Full Text Expression and significance of histone H3K27 demethylases in renal cell carcinoma
by Shen, Yongqing and Shen, Yongqing and Guo, Xiaoqiang and Wang, Yuejia and Qiu, Wei and Qiu, Wei and Chang, Yanzhong and Zhang, Aili and Zhang, Aili and Duan, Xianglin
BMC cancer, ISSN 1471-2407, 2012, Volume 12, Issue 1, pp. 470 - 470
Background: The histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering the physical state of... 
JMJD3 | INK4A/ARF | SUPPRESSOR | INK4A-ARF LOCUS | JMJD3 CONTRIBUTES | INDUCED SENESCENCE | CANCER | GENE | ONCOLOGY | Renal cell carcinoma | UTX | Epigenetics | Histone H3K27 demethylase | PROTEINS | Up-Regulation | Kidney Neoplasms - genetics | Polycomb Repressive Complex 2 - genetics | Histone Demethylases - biosynthesis | Cyclin-Dependent Kinase 4 - genetics | Humans | Middle Aged | Transcriptional Activation | Carcinoma, Renal Cell - genetics | Male | RNA, Messenger - metabolism | Histone Demethylases - genetics | Adult | Carcinoma, Renal Cell - enzymology | Female | Nuclear Proteins - genetics | RNA, Messenger - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Nuclear Proteins - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Jumonji Domain-Containing Histone Demethylases - genetics | Enhancer of Zeste Homolog 2 Protein | Histone Demethylases - metabolism | Kidney Neoplasms - enzymology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Aged | Methylation | Polycomb Repressive Complex 2 - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Physiological aspects | Development and progression | Monoamine oxidase | Carcinoma, Renal cell | Research | Analysis | Epigenetic inheritance | Chromatin | RNA | Genes | Genetic research | Genetic aspects | Gene expression | Cancer | Index Medicus
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6. Full Text Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3
by Jung, Ji-Won and Lee, Seunghee and Seo, Min-Soo and Park, Sang-Bum and Kurtz, Andreas and Kang, Soo-Kyung and Kang, Kyung-Sun
Cellular and Molecular Life Sciences, ISSN 1420-682X, 4/2010, Volume 67, Issue 7, pp. 1165 - 1176
Aging is linked to loss of the self-renewal capacity of adult stem cells. Here, we observed that human multipotent stem cells (MSCs) underwent cellular... 
Life Sciences | Biochemistry, general | JMJD3 | Polycomb gene | Senescence | Life Sciences, general | Epigenetic | Biomedicine general | Cell Biology | Multipotent stem cell | TARGET | INK4A-ARF LOCUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | P16(INK4A) | CELL BIOLOGY | HUMAN FIBROBLASTS | HETEROCHROMATIN FORMATION | DIFFERENTIATION | INHIBITOR | PROTEINS | Promoter Regions, Genetic | Up-Regulation | Adult Stem Cells - cytology | Histone Deacetylases - genetics | Down-Regulation | Epigenesis, Genetic | Humans | Multipotent Stem Cells - metabolism | Cells, Cultured | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Polycomb-Group Proteins | Jumonji Domain-Containing Histone Demethylases - genetics | Valproic Acid - pharmacology | Adult Stem Cells - metabolism | RNA Interference | Cellular Senescence | Multipotent Stem Cells - cytology | Histone Deacetylase Inhibitors - pharmacology | Jumonji Domain-Containing Histone Demethylases - metabolism | Repressor Proteins - metabolism | RNA, Small Interfering - metabolism | Stem cell research | Anopheles | Stem cells | Histones | Genetic research | Adults | Universities and colleges | Public health | Aging | Enzymes | Gene expression
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7. Full Text p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age
by Wong, Esther Sook Miin and Le Guezennec, Xavier and Demidov, Oleg N and Marshall, Nicolette Theresa and Wang, Siew Tein and Krishnamurthy, Janakiraman and Sharpless, Norman E and Dunn, N. Ray and Bulavin, Dmitry V
Developmental Cell, ISSN 1534-5807, 07/2009, Volume 17, Issue 1, pp. 142 - 149
Aging is a complex organismal process that is controlled by genetic, environmental, and behavioral factors. Accumulating evidence supports a role for different... 
CELLCYCLE | SIGNALING | INK4A/ARF | APOPTOSIS | ACTIVATION | PATHWAY | MAP KINASE | TUMOR-SUPPRESSOR | WIP1 PHOSPHATASE | SENESCENCE | DEVELOPMENTAL BIOLOGY | P38-ALPHA | TUMORIGENESIS | CELL BIOLOGY | Islets of Langerhans - physiology | Humans | Liver - metabolism | Mice, Inbred C57BL | Phosphoprotein Phosphatases - metabolism | Protein Phosphatase 2C | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Repressor Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Kidney - metabolism | Animals | Phosphoprotein Phosphatases - genetics | Aging - physiology | Spleen - metabolism | Islets of Langerhans - cytology | Cell Cycle - physiology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Lung - metabolism | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | Repressor Proteins - metabolism | Phosphatases | Cell cycle
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8. Full Text Bmi1 promotes prostate tumorigenesis via inhibiting p16(INK4A) and p14(ARF) expression
by Fan, C and He, LZ and Kapoor, A and Gillis, A and Rybak, AP and Cutz, JC and Tang, DM
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, ISSN 0925-4439, 11/2008, Volume 1782, Issue 11, pp. 642 - 648
We report here that the polycomb group protein Bmi1 promotes prostate tumorigenesis. Bmi1 is detected at higher levels in androgen-independent PC3 and DU145... 
CANCER PATIENTS | METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | p14(ARF) | MOLECULAR MARKER | PROLIFERATION | Bmi1 | OVEREXPRESSION | BIOPHYSICS | EPITHELIAL-CELLS | GENE | CELL SELF-RENEWAL | MYC TRANSGENIC MICE | INK4A/ARF LOCUS | p16(INK4A) | Prostate cancer
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9. Full Text MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence
by Culerrier, Raphaël and Carraz, Maëlle and Mann, Carl and Djabali, Malek
Molecular Biology of the Cell, ISSN 1059-1524, 09/2016, Volume 27, Issue 17, pp. 2726 - 2734
The tumor suppressor proteins p15(INK4B), p16(INK4A), and p14(ARF), encoded by the INK4AB/ARF locus, are crucial regulators of cellular senescence. The locus... 
INK4A-ARF LOCUS | TARGET GENES | ACTIVATION | METHYLATION | ACETYLATION | CELL-CYCLE ARREST | STRESS | DEMETHYLASE JMJD3 CONTRIBUTES | HISTONE H3 PHOSPHORYLATION | IMMEDIATE-EARLY GENES | CELL BIOLOGY | Phosphorylation | Cell Proliferation | Humans | Transcriptional Activation | Polycomb-Group Proteins | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Aging - genetics | Cell Cycle | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Histones - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - physiology | Tumor Suppressor Protein p14ARF - metabolism | Aging - metabolism | Life Sciences
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10. Full Text Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging
by Liu, Y and Sanoff, HK and Cho, H and Burd, CE and Torrice, C and Ibrahim, JG and Thomas, NE and Sharpless, NE
AGING CELL, ISSN 1474-9726, 08/2009, Volume 8, Issue 4, pp. 439 - 448
P>Expression of the p16(INK4a) tumor suppressor sharply increases with age in most mammalian tissues, and contributes to an age-induced functional decline of... 
CDKN2a | LYMPHOCYTE SUBSETS | INK4A/ARF EXPRESSION | exercise | CHROMOSOME 9P21 | INK4 | CELLULAR SENESCENCE | IL-6 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | frailty | ARF | smoking | IN-VIVO | GENE-EXPRESSION | TUMOR-SUPPRESSOR | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | TELOMERE LENGTH | Humans | Middle Aged | Gene Expression Regulation | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Male | Biomarkers - blood | Exercise | Aging - physiology | T-Lymphocytes - metabolism | Adolescent | Aged, 80 and over | Adult | Female | Transcription, Genetic | Aged | ADP-Ribosylation Factors - genetics | Cyclin-Dependent Kinase Inhibitor p16 - blood | Smoking
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11. Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma
by Wang, Jiajun and Liu, Li and Long, Qilai and Bai, Qi and Xia, Yu and Xi, Wei and Xu, Jiejie and Guo, Jianming
Oncology Letters, ISSN 1792-1074, 2017, Volume 14, Issue 2, pp. 1550 - 1560
Previous studies have demonstrated abnormal H3K27 methylation status during clear cell renal cell carcinoma (ccRCC) carcinogenesis, and have suggested that the... 
Jumonji domain-containing protein 3 | Clear cell renal cell carcinoma | Overall survival | Disease free survival | Prognostic biomarker | INK4A/ARF | clear cell renal cell carcinoma | ENHANCER | jumonji domain-containing protein 3 | CANCER | RADICAL NEPHRECTOMY | ONCOLOGY | overall survival | prognostic biomarker | disease free survival | CONTRIBUTES | EZH2 | TOOL
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12. Full Text INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice
by Le, Oanh and Palacio, Lina and Bernier, Gilbert and Batinic-Haberle, Ines and Hickson, Gilles and Beauséjour, Christian
Stem Cell Reports, ISSN 2213-6711, 06/2018, Volume 10, Issue 6, pp. 1721 - 1733
Brain neurogenesis is severely impaired following exposure to ionizing radiation (IR). We and others have shown that the expression of the tumor suppressor... 
senescence | neurogenesis | INK4a/ARF | DNA damage | irradiation | p53 | OXIDATIVE STRESS | CHILDHOOD-CANCER | ADULT NEUROGENESIS | HEMATOPOIETIC STEM-CELLS | ACUTE LYMPHOBLASTIC-LEUKEMIA | DNA-DAMAGE | CRANIAL IRRADIATION | IONIZING-RADIATION | HIPPOCAMPAL NEUROGENESIS | COGNITIVE DEFICITS | CELL & TISSUE ENGINEERING | CELL BIOLOGY
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13. Full Text Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes
by Taneera, Jalal and Fadista, Joao and Ahlqvist, Emma and Zhang, Mengze and Wierup, Nils and Renström, Erik and Groop, Leif and Lund University and Neuroendocrine Cell Biology and Genomics, Diabetes and Endocrinology and Genomik, diabetes och endokrinologi and Institutionen för kliniska vetenskaper, Malmö and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden and Neuroendokrin cellbiologi and Department of Clinical Sciences, Malmö
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2013, Volume 375, Issue 1-2, pp. 35 - 42
Microarray gene expression data were used to analyze the expression pattern of cyclin, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitor... 
Type 2 diabetes | Human islet | Cyclin | Beta-cell | Microarray | Cell cycle | INK4A/ARF EXPRESSION | PROLIFERATION | CANCER | CELL BIOLOGY | REPLICATION | HYPERGLYCEMIA | RETINOBLASTOMA PROTEIN | PRIMARY MECHANISM | INSULIN-RESISTANCE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | Cyclin-Dependent Kinases - metabolism | Oligonucleotide Array Sequence Analysis | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Cyclins - genetics | Transcriptome | Male | Gene Expression Profiling | Cyclin-Dependent Kinase Inhibitor Proteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Case-Control Studies | Cyclin-Dependent Kinase Inhibitor Proteins - genetics | Cyclins - metabolism | Islets of Langerhans - metabolism | Aging | Female | Cyclin-Dependent Kinases - genetics | Insulin Secretion | Genetic Predisposition to Disease | Genetic Association Studies | Cells, Cultured | Insulin - metabolism | Aged | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - pathology | Genes, cdc | Human | Databases | Inhibitors | Genes | Diabetes | Kinases | Gene expression | Low level | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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14. Full Text Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals
by Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin
细胞研究：英文版, ISSN 1001-0602, 2015, Volume 25, Issue 11, pp. 1205 - 1218
ASXL1 mutations are frequently found in hematological tumors, and loss of Asxll promotes myeloid transforma- tion in mice. Here we present data supporting a... 
转录激活 | 基因活性 | 增殖 | 肿瘤抑制 | 诱导表达 | 致癌 | 信号 | 活化作用 | Polycomb | tumor suppressor | INK4A | INK4B | H2A ubiquitylation | TRANSFORMATION | INK4A-ARF LOCUS | METHYLATION | FREQUENT MUTATION | P15(INK4B) | CANCER | CELL BIOLOGY | GENE | MYELODYSPLASTIC SYNDROMES | BAP1 | Cell Line | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Cell Proliferation | Humans | Polycomb-Group Proteins - metabolism | Animals | Ubiquitin Thiolesterase - metabolism | Mice | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Histones - metabolism | Mutation | Ubiquitin-Specific Proteases - metabolism | Repressor Proteins - metabolism | Original
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15. Full Text A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level
by Balasubramanian, Sivaprakasam and Kanade, Santosh and Han, Bingshe and Eckert, Richard L
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 43, pp. 36179 - 36189
The polycomb group (PcG) proteins, Bmi-1 and Ezh2, are important epigenetic regulators that enhance skin cancer cell survival. We recently showed that Bmi-1... 
MULTIPLE-MYELOMA | BREAST-CANCER | EZH2 HISTONE METHYLTRANSFERASE | SKIN-CANCER CELLS | BMI-1 ONCOPROTEIN | INK4A-ARF LOCUS | MECHANISM | SULFORAPHANE | COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | Gene Expression Regulation, Enzymologic - drug effects | G2 Phase - genetics | Polycomb Repressive Complex 2 - genetics | Proteasome Inhibitors - pharmacology | Apoptosis - drug effects | Humans | Apoptosis - genetics | Nuclear Respiratory Factor 1 - genetics | Proteasome Endopeptidase Complex - biosynthesis | Enhancer of Zeste Homolog 2 Protein | G2 Phase - drug effects | Proteasome Endopeptidase Complex - genetics | Leupeptins - pharmacology | Ubiquitination - drug effects | Gene Expression Regulation, Enzymologic - genetics | Cysteine Proteinase Inhibitors - pharmacology | Nuclear Respiratory Factor 1 - metabolism | Cell Line, Tumor | Polycomb Repressive Complex 2 - metabolism | Ubiquitination - genetics | Nrf2 | Protein Synthesis and Degradation | Bmi-1 | Keratinocytes | Epidermis | Polycomb | Keratinocyte | Squamous Cell Carcinoma | Ezh2 | Proteasome
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