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PLoS ONE, ISSN 1932-6203, 05/2009, Volume 4, Issue 5, pp. e5622 - e5622
Background: The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b), Arf and p16(Ink4a)) and is frequently inactivated in a large number of human... 
BIOLOGY | NIH 3T3 Cells | Myeloid-Lymphoid Leukemia Protein - metabolism | Cellular Senescence | Repressor Proteins - metabolism | Fibroblasts - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Cycle Proteins - metabolism | Gene Silencing | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Nuclear Proteins - metabolism | Polycomb-Group Proteins | Enhancer of Zeste Homolog 2 Protein | Polycomb Repressive Complex 2 | Animals | Cyclin-Dependent Kinase Inhibitor p16 - chemistry | Polycomb Repressive Complex 1 | Histone-Lysine N-Methyltransferase - metabolism | Embryo, Mammalian - cytology | Models, Biological | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Protein Binding | DNA Replication Timing | Fibroblasts - cytology | Mice | Histones - metabolism | Methylation | Proteins | Epigenetic inheritance | DNA replication | Senescence | Chromatin | Genes | INK4a protein | Genomes | Recruitment | Cell growth | Transcription activation | Cell cycle | Fibroblasts | Cyclin-dependent kinase inhibitors | Deoxyribonucleic acid--DNA | p16 Protein | INK4 protein | Embryo fibroblasts | Gene expression | Embryos | Loci | DNA biosynthesis | Polycomb group proteins | Replication origins | Pilot projects | Insects | Stem cells | Epigenetics | Tumor suppressor genes | Replication | Embryo, Mammalian | Histone-Lysine N-Methyltransferase | Repressor Proteins | Cell Aging | Nuclear Proteins | Cyclin-Dependent Kinase Inhibitor p16 | Life Sciences | Immunology | Histones | Myeloid-Lymphoid Leukemia Protein | Proto-Oncogene Proteins | Cell Cycle Proteins | Deoxyribonucleic acid | DNA
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2015, Volume 465, Issue 1, pp. 71 - 76
Shikonin, a natural naphthoquinone isolated from the Chinese traditional medicine Zi Cao ( ), is known to suppress the growth of several cancer cell types. In... 
Shikonin | p73 | p16INK4A | ICBP90 | Tumor suppressor gene | Apoptosis | p16 | UHRF1 | CCAAT-BINDING-PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | INDUCTION | II-ALPHA EXPRESSION | IN-VITRO | BIOPHYSICS | GENE | PATHWAY | COLORECTAL-CANCER | SRA DOMAIN | p16(INK4A) | Luciferases - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Luciferases - genetics | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Proteolysis - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | DNA-Binding Proteins - agonists | MCF-7 Cells | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - genetics | Caspase 3 - genetics | Female | CCAAT-Enhancer-Binding Proteins - genetics | Nuclear Proteins - genetics | Genes, Reporter | CCAAT-Enhancer-Binding Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - agonists | Signal Transduction | DNA (Cytosine-5-)-Methyltransferase 1 | Cyclin-Dependent Kinase Inhibitor p16 - agonists | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Naphthoquinones - pharmacology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Poly(ADP-ribose) Polymerases - metabolism | Tumor Protein p73 | Poly(ADP-ribose) Polymerases - genetics | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | HeLa Cells | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Tumor Suppressor Proteins - agonists | Sugars | Cancer | Monosaccharides | Protein binding
Journal Article
Nature genetics, ISSN 1061-4036, 2000, Volume 26, Issue 3, pp. 291 - 299
To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest... 
LYMPHOMAGENESIS | APOPTOSIS | STABILIZES P53 | AMPLIFICATION | INK4A LOCUS | GENETICS & HEREDITY | C-MYC | MDM2 | GENE FAMILY | CELL-CYCLE ARREST | ARF TUMOR-SUPPRESSOR | T-Box Domain Proteins - physiology | Protein Biosynthesis | Humans | E2F Transcription Factors | Cyclin-Dependent Kinase Inhibitor p16 | T-Box Domain Proteins - isolation & purification | Adenocarcinoma - metabolism | Cell Transformation, Neoplastic - genetics | Gene Deletion | Repressor Proteins - isolation & purification | Neoplastic Syndromes, Hereditary - genetics | Genes, BRCA1 | Neoplasm Proteins - genetics | Tumor Suppressor Protein p14ARF | Oncogenes | DNA-Binding Proteins | Fibroblasts - metabolism | Cell Cycle Proteins - isolation & purification | Repressor Proteins - genetics | Transcription Factor DP1 | Breast Neoplasms - genetics | Polycomb Repressive Complex 1 | Neoplasm Proteins - isolation & purification | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Fibroblasts - cytology | Mice | COS Cells | Cell Cycle Proteins - physiology | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Chromosomes, Human, Pair 17 - genetics | Breast Neoplasms - metabolism | Repressor Proteins - physiology | Transfection | Cell Cycle Proteins - genetics | Female | Adenocarcinoma - genetics | Tumor Cells, Cultured | Nuclear Proteins - genetics | Cellular Senescence - genetics | Promoter Regions, Genetic | E2F1 Transcription Factor | Neoplasm Proteins - biosynthesis | Cells, Cultured | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | T-Box Domain Proteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Animals | Gene Amplification | Retinoblastoma-Binding Protein 1 | Fibroblasts | Physiological aspects | Development and progression | Breast cancer | Genetic aspects | Research | Risk factors
Journal Article
Cell Biochemistry and Biophysics, ISSN 1085-9195, 1/2012, Volume 62, Issue 1, pp. 229 - 235
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 08/2013, Volume 33, Issue 16, pp. 3113 - 3124
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
DAMAGE RESPONSE | LACKING RB1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RETINOBLASTOMA TUMOR-SUPPRESSOR | MOUSE | HUMAN FIBROBLASTS | MICE | HUMAN CANCER-CELLS | CPG METHYLATION | DIFFERENTIATION | P16(INK4A) | CELL BIOLOGY | Humans | Gene Expression Regulation, Neoplastic | DNA (Cytosine-5-)-Methyltransferases - chemistry | Embryo, Mammalian - metabolism | Cell Cycle Proteins - chemistry | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | DNA Methylation | Ubiquitination | Gene Deletion | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Signal Transduction | DNA (Cytosine-5-)-Methyltransferase 1 | Mice, Inbred C57BL | Retinoblastoma Protein - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Enzyme Stability | Protein-Serine-Threonine Kinases - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | DNA (Cytosine-5-)-Methyltransferases - genetics | Thyroid Neoplasms - genetics | Animals | Embryo, Mammalian - cytology | Retinoblastoma Protein - genetics | Thyroid Gland - pathology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Mice | Protein-Serine-Threonine Kinases - chemistry | Thyroid Gland - metabolism | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19503
Epigenetic regulation of gene expression is well known mechanism that regulates cellular senescence of cancer cells. Here we show that inhibition of DNA... 
BREAST-CANCER | LUNG-CANCER | IN-VITRO | METHYLATION | GENE | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | HUMAN FIBROBLASTS | HUMAN CANCER-CELLS | DIFFERENTIATION | HISTONE DEACETYLASE | Immunohistochemistry | Cell Cycle - genetics | Humans | Multipotent Stem Cells - metabolism | Cellular Senescence - drug effects | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | Flow Cytometry | Chromatin Immunoprecipitation | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cellular Senescence - genetics | DNA (Cytosine-5-)-Methyltransferase 1 | Cells, Cultured | Enzyme Inhibitors - pharmacology | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Enhancer of Zeste Homolog 2 Protein | Transcription Factors - metabolism | Azacitidine - pharmacology | Polycomb Repressive Complex 2 | Polycomb Repressive Complex 1 | Multipotent Stem Cells - cytology | CpG Islands - genetics | Cell Proliferation - drug effects | MicroRNAs - genetics | Cell Cycle - drug effects | Proteins | Epigenetic inheritance | MicroRNA | Methyltransferases | Genes | DNA | Stem cells | Methylation | Gene expression | Azacytidine | Veterinary colleges | Senescence | INK4a protein | Kinases | Cord blood | DNA methylation | Aging | Inhibition | Active control | Deoxyribonucleic acid--DNA | CpG islands | p16 Protein | DNMT1 protein | MiRNA | Aging (artificial) | siRNA | Ribonucleic acid--RNA | Polycomb group proteins | Cyclin-dependent kinase inhibitor p21 | Lysine | Epigenetics | DNA methyltransferase | Umbilical cord | Histone H3 | Cancer | Deoxyribonucleic acid | Ribonucleic acids
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21397
Journal Article
Nature, ISSN 0028-0836, 05/2009, Volume 459, Issue 7245, pp. 387 - 392
Journal Article