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Trends in pharmacological sciences, ISSN 0165-6147, 08/2019
Enzymes with multiple substrates pose a unique challenge for drug development because of an increased potential for on-target side effects. Maianti and... 
Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 2010, Volume 115, Issue 1, pp. 47 - 57
P>The brain steady state level of beta-amyloid (A beta) is determined by the balance between its production and removal, the latter through egress across blood... 
insulin-degrading enzyme | Alzheimer's disease brain | neprilysin | endothelin-converting enzyme | degradation | Alzheimer's disease | amyloid-degrading enzymes | β-amyloid | MOUSE-BRAIN | PROTEIN A-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE PATHOGENESIS | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | SENILE PLAQUES | beta-amyloid | AMYLOID-BETA PEPTIDE | FLUOROMETRIC ASSAY | HUMAN CEREBRAL-CORTEX | PLAQUE-FORMATION | TRANSGENIC MICE | Metalloendopeptidases - genetics | Tissue Banks | Prospective Studies | Aspartic Acid Endopeptidases - biosynthesis | Humans | Brain - enzymology | Insulysin - biosynthesis | Male | Aspartic Acid Endopeptidases - genetics | Gene Expression Regulation, Enzymologic - physiology | Neprilysin - biosynthesis | Endothelin-Converting Enzymes | RNA - genetics | Synaptophysin - genetics | Amyloid beta-Peptides - genetics | Aged, 80 and over | Female | Neprilysin - genetics | Alzheimer Disease - psychology | Brain Chemistry - genetics | Cognition Disorders - enzymology | Amyloid beta-Peptides - biosynthesis | Electrophoresis, Polyacrylamide Gel | Cognition Disorders - genetics | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Metalloendopeptidases - biosynthesis | RNA - biosynthesis | Gene Expression Regulation, Enzymologic - genetics | Synaptophysin - biosynthesis | Alzheimer Disease - metabolism | Indicators and Reagents | Insulysin - genetics | Aged | Alzheimer Disease - genetics | Medical colleges | Brain | Messenger RNA | Proteases | Pharmacy | Fluorescence | Public health | Target marketing | Neurochemistry | Proteins | Enzymes | Alzheimers disease | Ribonucleic acid--RNA | Index Medicus
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 12/2010, Volume 29, Issue 23, pp. 3952 - 3966
Macrophage inflammatory protein‐1 (MIP‐1), MIP‐1α (CCL3) and MIP‐1β (CCL4) are chemokines crucial for immune responses towards infection and inflammation. Both... 
insulin‐degrading enzyme | MIP‐1 polymerization | chemokine | X‐ray crystallography | chemotactic gradient | insulin-degrading enzyme | X-ray crystallography | MIP-1 polymerization | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOSAMINOGLYCAN BINDING | PHASE-II | IDENTIFICATION | MIP-1-ALPHA | CELL BIOLOGY | BREAST-CANCER | IN-VIVO | OLIGOMERIZATION | AGGREGATION | MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA | Chemokine CCL3 - immunology | Humans | Protein Multimerization | Chemokine CCL4 - genetics | Molecular Sequence Data | Crystallography, X-Ray | Male | Chemokine CCL3 - chemistry | Chemokine CCL4 - chemistry | Chemokine CCL3 - genetics | Chemokine CCL3 - metabolism | Chemokine CCL4 - metabolism | Insulysin - chemistry | Amino Acid Sequence | Cell Line | Insulysin - metabolism | Macrophage Inflammatory Proteins - metabolism | Mice, Inbred C57BL | Models, Molecular | Polymerization | Macrophage Inflammatory Proteins - chemistry | Macrophage Inflammatory Proteins - genetics | Animals | Macrophage Inflammatory Proteins - immunology | Protein Binding | Protein Conformation | Mice | Chemokine CCL4 - immunology | Mutation | Enzymes | Immunology | Cytokines | Molecular biology | Index Medicus | CLEARANCE | POLYMERS | MONOMERS | DISTRIBUTION | MACROPHAGES | DEPOLYMERIZATION | MONOCYTES | CRYSTAL STRUCTURE | POLYMERIZATION | MATERIALS SCIENCE | INACTIVATION | ENDOTHELIUM | ENZYMES | INFLAMMATION | MUTATIONS
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 01/2018, Volume 39, Issue 1, pp. 49 - 58
After decades of research and clinical trials there is still no cure for Alzheimer’s disease (AD). While impaired clearance of amyloid beta (Aβ) peptides is... 
insulin-degrading enzyme | amyloids | aggregation | Alzheimer’s disease | allostery and allosteric mutations | neurotoxic oligomers
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2010, Volume 395, Issue 2, pp. 430 - 443
Insulin-degrading enzyme (IDE) is involved in the clearance of many bioactive peptide substrates, including insulin and amyloid-β, peptides vital to the... 
X-ray crystallography | insulin-degrading enzyme | mass spectrometry | metalloprotease | substrate specificity | AMYLOID BETA-PROTEIN | MACROMOLECULAR STRUCTURES | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR-MAGNETIC-RESONANCE | PROTEOLYSIS | GRAPHICS | INHIBITION | SUBSTRATE | EPIDERMAL-GROWTH-FACTOR | DEGRADATION | PEPTIDASE | Humans | Multiprotein Complexes | Molecular Sequence Data | Substrate Specificity | Crystallography, X-Ray | Amyloid - chemistry | Tandem Mass Spectrometry | Insulin-Like Growth Factor II - genetics | Amyloid - metabolism | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Insulin - genetics | Insulysin - chemistry | Transforming Growth Factor alpha - metabolism | Peptide Fragments - genetics | Amino Acid Sequence | Amyloid - genetics | Insulysin - metabolism | Peptide Fragments - metabolism | Transforming Growth Factor alpha - chemistry | Models, Molecular | Binding Sites - genetics | Static Electricity | Insulin-Like Growth Factor II - chemistry | Insulin-Like Growth Factor II - metabolism | Sequence Homology, Amino Acid | Insulin - metabolism | Peptide Fragments - chemistry | Islet Amyloid Polypeptide | Insulin - chemistry | Insulysin - genetics | Amyloid beta-Peptides - chemistry | In Vitro Techniques | Index Medicus
Journal Article
Journal Article