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science & technology (264) 264
life sciences & biomedicine (258) 258
insulin-degrading enzyme (214) 214
animals (157) 157
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alzheimer's disease (138) 138
insulysin - metabolism (127) 127
insulin degrading enzyme (113) 113
neurosciences & neurology (100) 100
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insulin - metabolism (56) 56
biological and medical sciences (53) 53
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neprilysin (49) 49
alzheimer disease - metabolism (45) 45
cell biology (44) 44
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alzheimer disease - pathology (25) 25
amyloid (25) 25
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insulin‐degrading enzyme (25) 25
molecular sequence data (25) 25
amino acid sequence (23) 23
clinical neurology (23) 23
fundamental and applied biological sciences. psychology (23) 23
proteins (23) 23
aged, 80 and over (22) 22
degenerative and inherited degenerative diseases of the nervous system. leukodystrophies. prion diseases (22) 22
peptide fragments - metabolism (22) 22
peptides (22) 22
physiological aspects (22) 22
diabetes (21) 21
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mice, inbred c57bl (21) 21
middle aged (21) 21
proteolysis (21) 21
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β-amyloid (19) 19
adult (18) 18
alzheimer disease (18) 18
amyloid beta-protein precursor - metabolism (18) 18
cells, cultured (18) 18
degradation (18) 18
substrate specificity (18) 18
type 2 diabetes (18) 18
amyloid beta-protein precursor - genetics (17) 17
blotting, western (17) 17
cell line, tumor (17) 17
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alzheimer disease - drug therapy (15) 15
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neurodegenerative diseases (15) 15
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brain - drug effects (13) 13
protein binding (13) 13
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type 2 diabetes mellitus (13) 13
biochemistry, general (12) 12
genetic aspects (12) 12
glucose (12) 12
insulin - blood (12) 12
kinetics (12) 12
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presenilin-1 - genetics (12) 12
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1. Full Text Expression and functional profiling of neprilysin, insulin‐degrading enzyme, and endothelin‐converting enzyme in prospectively studied elderly and Alzheimer’s brain
by Wang, Suqing and Wang, Rui and Chen, Lang and Bennett, David A and Dickson, Dennis W and Wang, Deng‐Shun
Journal of neurochemistry, ISSN 0022-3042, 10/2010, Volume 115, Issue 1, pp. 47 - 57
insulin‐degrading enzyme | Alzheimer’s disease | neprilysin | β‐amyloid | Alzheimer’s disease brain | amyloid‐degrading enzymes | degradation | endothelin‐converting enzyme | insulin-degrading enzyme | Alzheimer's disease brain | endothelin-converting enzyme | Alzheimer's disease | amyloid-degrading enzymes | β-amyloid | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Metalloendopeptidases - genetics | Tissue Banks | Prospective Studies | Aspartic Acid Endopeptidases - biosynthesis | Humans | Brain - enzymology | Insulysin - biosynthesis | Male | Aspartic Acid Endopeptidases - genetics | Gene Expression Regulation, Enzymologic - physiology | Neprilysin - biosynthesis | Endothelin-Converting Enzymes | RNA - genetics | Synaptophysin - genetics | Amyloid beta-Peptides - genetics | Aged, 80 and over | Female | Neprilysin - genetics | Alzheimer Disease - psychology | Brain Chemistry - genetics | Cognition Disorders - enzymology | Amyloid beta-Peptides - biosynthesis | Electrophoresis, Polyacrylamide Gel | Cognition Disorders - genetics | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Metalloendopeptidases - biosynthesis | RNA - biosynthesis | Gene Expression Regulation, Enzymologic - genetics | Synaptophysin - biosynthesis | Alzheimer Disease - metabolism | Indicators and Reagents | Insulysin - genetics | Aged | Alzheimer Disease - genetics | Medical colleges | Brain | Messenger RNA | Proteases | Pharmacy | Fluorescence | Public health | Target marketing | Neurochemistry | Proteins | Enzymes | Alzheimers disease | Ribonucleic acid--RNA | Index Medicus | AD brain | Alzheimer’s disease (AD) | endothelin converting enzyme (ECE) | insulin degrading enzyme (IDE) | Amyloid degrading enzymes | neprilysin (NEP) | β-amyloid (Aβ)
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2. Full Text Substrate-Selective Enzyme Inhibitors
by Chu, Qian and Chang, Tina and Saghatelian, Alan
Trends in pharmacological sciences (Regular ed.), ISSN 0165-6147, 10/2019, Volume 40, Issue 10, pp. 716 - 718
insulin-degrading enzyme | substrate-selective inhibition | chemical biology | enzyme reprogramming | exo site | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Insulin | Enzyme Inhibitors | Insulysin | Enzyme inhibitors | Index Medicus
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3. Full Text Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis
by Qiu, Wei Qiao and Folstein, Marshal F
Neurobiology of aging, ISSN 0197-4580, 2006, Volume 27, Issue 2, pp. 190 - 198
Insulin | Type 2 diabetes and Alzheimer's disease | Insulin-degrading enzyme | Amyloid β-peptide | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Neurology | Diabetes. Impaired glucose tolerance | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Hyperinsulinism - metabolism | Apolipoprotein E4 | Insulysin - metabolism | Alzheimer Disease - complications | Humans | Risk | Diabetes Mellitus, Type 2 - metabolism | Apolipoproteins E - metabolism | Insulin - metabolism | Animals | Models, Biological | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Insulysin - genetics | Diabetes Mellitus, Type 2 - complications | Index Medicus
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4. Full Text Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease
by Kurochkin, Igor V and Guarnera, Enrico and Berezovsky, Igor N
Trends in pharmacological sciences (Regular ed.), ISSN 0165-6147, 01/2018, Volume 39, Issue 1, pp. 49 - 58
insulin-degrading enzyme | amyloids | aggregation | Alzheimer’s disease | allostery and allosteric mutations | neurotoxic oligomers | Alzheimer's disease | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Enzymes | Insulin | Index Medicus
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5. Full Text Statins promote the degradation of extracellular amyloid β-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion
by Tamboli, Irfan Y and Barth, Esther and Christian, Leonie and Siepmann, Martin and Kumar, Sathish and Singh, Sandesh and Tolksdorf, Karen and Heneka, Michael T and Lütjohann, Dieter and Wunderlich, Patrick and Walter, Jochen
The Journal of biological chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 48, pp. 37405 - 37414
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Insulin-degrading Enzyme | Amyloid Degradation | Drug Action | Amyloid | Statin | Alzheimer Disease | Exocytosis | Cholesterol | Cell Biology | MVB Exosome Pathways | Microglia
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6. Full Text Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
by Malito, E and Hulse, R E and Tang, W.-J
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 8/2008, Volume 65, Issue 16, pp. 2574 - 2585
Biochemistry, general | insulin-degrading enzyme | Alzheimer’s disease | amyloid-β peptide | Biomedicine general | Cell Biology | Life Sciences | X-ray crystallography | Life Sciences, general | neprilysin | anti-amyloidogenic therapy | metalloprotease | presequence peptidase | Presequence peptidase | Anti-amyloidogenic therapy | Metalloprotease | Neprilysin | Amyloid-β peptide | Alzheimer's disease | Insulin-degrading enzyme | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Amino Acid Sequence | Insulysin - metabolism | Animals | Humans | Alzheimer Disease - therapy | Amyloid beta-Peptides - metabolism | Molecular Sequence Data | Substrate Specificity | Neprilysin - chemistry | Protein Processing, Post-Translational | Neprilysin - metabolism | Insulysin - chemistry | Index Medicus
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7. Full Text Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer’s disease?
by Nalivaeva, Natalia N and Beckett, Caroline and Belyaev, Nikolai D and Turner, Anthony J
Journal of neurochemistry, ISSN 0022-3042, 01/2012, Volume 120, Issue 1, pp. 167 - 185
angiotensin‐converting enzyme | insulin‐degrading enzyme | valproate | amyloid β‐peptide | neprilysin | endothelin‐converting enzyme | insulin-degrading enzyme | amyloid β-peptide | endothelin-converting enzyme | angiotensin-converting enzyme | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Amyloid - antagonists & inhibitors | Plaque, Amyloid - pathology | Humans | Alzheimer Disease - enzymology | Proteolysis - drug effects | Animals | Alzheimer Disease - prevention & control | Alzheimer Disease - metabolism | Amyloid beta-Protein Precursor - metabolism | Plaque, Amyloid - metabolism | Amyloid beta-Protein Precursor - antagonists & inhibitors | Amyloid beta-Protein Precursor - physiology | Drug Delivery Systems - methods | Cysteine | Peptides | Neurons | Proteases | Analysis | Amyloid beta-protein | Physiological aspects | Universities and colleges | Health aspects | Alzheimer's disease | Biodegradation | Enzymes | Drug therapy | Alzheimers disease | Index Medicus
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