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1. Full Text Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer’s Disease: in Search of a Relevant Mechanism
by Grieb, Paweł
Molecular Neurobiology, ISSN 0893-7648, 4/2016, Volume 53, Issue 3, pp. 1741 - 1752
Streptozotocin (STZ), a glucosamine-nitrosourea compound derived from soil bacteria and originally developed as an anticancer agent, in 1963 has been found to... 
Neurology | Brain | Neurosciences | Biomedicine | Insulin receptors | Insulin producing cells | Neurobiology | Intracerebroventricular streptozotocin injection | Non-transgenic Alzheimer’s disease model | Cell Biology
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2. Full Text Graphene quantum dots as universal fluorophores and their use in revealing regulated trafficking of insulin receptors in adipocytes
by Zheng, Xin Ting and Than, Aung and Ananthanaraya, Arundithi and Kim, Dong-Hwan and Chen, Peng
ACS Nano, ISSN 1936-0851, 07/2013, Volume 7, Issue 7, pp. 6278 - 6286
Graphene quantum dots (GQDs) hold great promise as a new class of fluorophores for bioimaging, owing to their remarkable physicochemical properties including... 
insulin receptors | fluorophore | TNFα | apelin | graphene quantum dot | TNF alpha | UP-CONVERSION | OXIDE | PHOTOLUMINESCENCE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | NANO-GRAPHENE | SENSORS | CHEMISTRY, MULTIDISCIPLINARY | REDUCTION | PATHWAY | GLUCOSE | TRACKING | FLUORESCENT-PROBES | Contrast Media - chemical synthesis | Animals | Microscopy, Fluorescence - methods | Nanoparticles - chemistry | Quantum Dots | Receptor, Insulin - metabolism | Mice | Graphite - chemistry | 3T3-L1 Cells | Fluorescent Dyes | Protein Transport | Receptors | Medical imaging | Tracking | Graphene | Quantum dots | Dynamics | Fluorescence | Chemical compounds | Insulin
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3. Full Text Diabetes mellitus and risk of breast cancer: A meta‐analysis
by Larsson, Susanna C and Mantzoros, Christos S and Wolk, Alicja
International Journal of Cancer, ISSN 0020-7136, 08/2007, Volume 121, Issue 4, pp. 856 - 862
Diabetes mellitus has been associated with an increased risk of several types of cancers, but its relationship with breast cancer remains unclear. We conducted... 
epidemiology | breast cancer | meta‐analysis | systematic review | diabetes | Systematic review | Breast cancer | Diabetes | Epidemiology | Meta-analysis | MORTALITY | meta-analysis | FOLLOW-UP | MEDICAL CONDITIONS | PREMENOPAUSAL WOMEN | INSULIN-RECEPTORS | SERUM-INSULIN | ONCOLOGY | POPULATION-BASED COHORT | NUTRITION | POSTMENOPAUSAL WOMEN | GROWTH-FACTOR-I | Body Mass Index | Europe | Humans | Menopause | Middle Aged | Risk Factors | Male | North America | Case-Control Studies | Asia | Diabetes Mellitus - epidemiology | Aged, 80 and over | Adult | Breast Neoplasms - mortality | Female | Aged | Breast Neoplasms - epidemiology | Cohort Studies
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4. Full Text The human placenta in gestational diabetes mellitus
by Desoye, G and Mouzon, SHD
DIABETES CARE, ISSN 0149-5992, 07/2007, Volume 30, pp. S120 - S126
MESSENGER-RNA EXPRESSION | HUMAN-PREGNANCY | GLYCOGEN-CONTENT | ENDOCRINOLOGY & METABOLISM | INFLAMMATORY PATHWAYS | GLUCOSE-TRANSPORT | PROINFLAMMATORY CYTOKINES | MATERNAL GLUCOSE | AMNIOTIC-FLUID | INSULIN-RECEPTORS | ADIPOSE-TISSUE
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5. Full Text Akt signaling pathway in macrophage activation and M1/M2 polarization
by Vergadi, Eleni and Ieronymaki, Eleftheria and Lyroni, Konstantina and Vaporidi, Katerina and Tsatsanis, Christos
Journal of Immunology, ISSN 0022-1767, 02/2017, Volume 198, Issue 3, pp. 1006 - 1014
Macrophages become activated initiating innate immune responses. Depending on the signals, macrophages obtain an array of activation phenotypes, described by... 
RHEUMATOID-ARTHRITIS | MAMMALIAN TARGET | PHOSPHOINOSITIDE 3-KINASE DELTA | PHOSPHATIDYLINOSITOL 3-KINASE | NEGATIVE REGULATION | ENDOTOXIN TOLERANCE | REGULATES AUTOPHAGY | TUMOR-ASSOCIATED MACROPHAGES | IMMUNOLOGY | INFLAMMATORY RESPONSE | SERINE/THREONINE KINASE | Macrophages - physiology | Cell Polarity | Protein-Serine-Threonine Kinases - physiology | Humans | PTEN Phosphohydrolase - physiology | Proto-Oncogene Proteins c-akt - physiology | Autophagy | Macrophage Activation | Animals | Apolipoproteins E - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Endotoxins - toxicity | Phagocytosis | TOR protein | Polarization | Serine | Cytokine receptors | AKT protein | Activation | Hormones | Macrophages | Kinases | Signal transduction | Receptors | Cell activation | Insulin receptors | AKT1 protein | Immune response | Threonine | Cytokines | RNA-mediated interference | AKT2 protein | Metabolism | Ribonucleic acid--RNA | Insulin | Disease control | 1-Phosphatidylinositol 3-kinase | Signaling | Isoforms
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6. Full Text Der Insulinrezeptor in Aktion — wie Insulin seinen Rezeptor aktiviert
by Gutmann, Theresia
BIOspektrum, ISSN 0947-0867, 09/2019, Volume 25, Issue 5, pp. 485 - 487
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7. Full Text Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study
by Fassnacht, Martin, MD and Berruti, Alfredo, MD and Baudin, Eric, MD and Demeure, Michael J, MD and Gilbert, Jill, MD and Haak, Harm, MD and Kroiss, Matthias, MD and Quinn, David I, FRACP and Hesseltine, Elizabeth, MSN and Ronchi, Cristina L, MD and Terzolo, Massimo, MD and Choueiri, Toni K, MD and Poondru, Srinivasu, PhD and Fleege, Tanya, MS and Rorig, Ramona and Chen, Jihong, PhD and Stephens, Andrew W, MD and Worden, Francis, MD and Hammer, Gary D, Prof
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 4, pp. 426 - 435
Summary Background Adrenocortical carcinoma is a rare, aggressive cancer for which few treatment options are available. Linsitinib (OSI-906) is a potent, oral... 
Hematology, Oncology and Palliative Medicine | GROWTH-FACTOR RECEPTOR | ADJUVANT MITOTANE | ADVANCED SOLID TUMORS | ONCOLOGY | PLATINUM-BASED CHEMOTHERAPY | ANTIBODY CIXUTUMUMAB | GENE-EXPRESSION | FACTOR-I | INHIBITOR | CANCER | INSULIN-RECEPTORS | Double-Blind Method | Humans | Imidazoles - adverse effects | Middle Aged | Pyrazines - administration & dosage | Kaplan-Meier Estimate | Imidazoles - administration & dosage | Male | Adrenocortical Carcinoma - pathology | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Adrenocortical Carcinoma - drug therapy | Neoplasm Metastasis - drug therapy | Neoplasm Metastasis - pathology | Drug-Related Side Effects and Adverse Reactions | Pyrazines - adverse effects | Aged, 80 and over | Placebos | Adult | Female | Aged | Care and treatment | Carcinoma | Metastasis | Cancer
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8. Full Text Insulin-like signaling, nutrient homeostasis, and life span
by Taguchi, Akiko and White, Morris F
Annual Review of Physiology, ISSN 0066-4278, 2008, Volume 70, Issue 1, pp. 191 - 212
Insulin-like signaling is critical for nutrient homeostasis, growth and survival. However, work with lower metazoans-Caenorhabditis elegans and... 
Oxidative stress | Insulin receptors | Age-related disease | Autonomous | Calorie restriction | Nonautonomous | FORKHEAD TRANSCRIPTION FACTOR | PHYSIOLOGY | caloric restriction | TISSUE-SPECIFIC ACTIVITIES | IRS2 KNOCKOUT MICE | age-related disease | AGE-RELATED LESIONS | autonomous | RANDOMIZED CONTROLLED-TRIAL | nonautonomous | RESTRICTION-INDUCED LONGEVITY | BETA-CELL FUNCTION | insulin receptors | CAENORHABDITIS-ELEGANS | oxidative stress | TERM CALORIE RESTRICTION | Insulin - metabolism | Animals | Life Expectancy | Homeostasis - physiology | Humans | Receptor, Insulin - metabolism | Signal Transduction - physiology | Food | Life spans (Biology) | Receptors | Analysis | Homeostasis | Research | Insulin
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9. Full Text 289-OR: Aerobic Exercise Counteracts Mitochondrial Dysfunction in the Insulin Resistant Brain
by RUEGSEGGER, GREGORY and VANDERBOOM, PATRICK M and DASARI, SURENDRA and KLAUS, KATHERINE and NAIR, K. SREEKUMARAN
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 289
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10. Full Text 1785-P: Mice with Muscle-Specific Insulin Receptor Overexpression Are Protected from Diet-Induced Obesity and Glucose Intolerance but Develop Post-Receptor Insulin Resistance
by WANG, GUOXIAO and CAI, WEIKANG and BATISTA, THIAGO M and SOFTIC, SAMIR and KAHN, C. RONALD
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1785
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11. Full Text The metabolism hypothesis of Alzheimer’s disease: from the concept of central insulin resistance and associated consequences to insulin therapy
by Morgen, Katrin and Frölich, Lutz
Journal of Neural Transmission, ISSN 0300-9564, 4/2015, Volume 122, Issue 4, pp. 499 - 504
The concept of central insulin resistance and dysfunctional insulin signaling in Alzheimer’s disease (AD) has been developed by Siegfried Hoyer in 1985–2000.... 
Neurology | Glucose metabolism | Neurosciences | Medicine & Public Health | Alzheimer’s disease | Insulin receptors | Synaptic dysfunction | Connectivity | Pharmacology/Toxicology | Psychiatry | Insulin
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12. Full Text Insulin & related proteins
: structure to function and pharmacology
by Dieken, Markus Leyck and Federwisch, Matthias and De Meyts, Pierre and Wollmer, Axel, 1935
2002, ISBN 9781402006555
Receptors | Insulin-Like Growth-Factor-Binding Proteins | Insulin | pharmacology
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13. Full Text Clinically Defined Type 2 Diabetes Mellitus and Prognosis in Early-Stage Breast Cancer
by Kirsten Erickson and Ruth E. Patterson and Shirley W. Flatt and Loki Natarajan and Barbara A. Parker and Dennis D. Heath and Gail A. Laughlin and Nazmus Saquib and Cheryl L. Rock and John P. Pierce
Journal of Clinical Oncology, ISSN 0732-183X, 01/2011, Volume 29, Issue 1, pp. 54 - 60
Purpose Self-reported diabetes has been associated with poor breast cancer outcomes. Research is needed to investigate the relationship between biologically... 
SURVIVAL | MORTALITY | WOMEN | POPULATION | ONCOLOGY | OLDER | RANDOMIZED-TRIAL | LIVING WHEL | INSULIN-RECEPTORS | COMORBIDITY | AGE | Prognosis | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Breast Neoplasms - complications | Disease-Free Survival | Diabetes Mellitus, Type 2 - blood | Breast Neoplasms - blood | Adult | Breast Neoplasms - mortality | Female | Aged | Hemoglobinuria - blood | Diabetes Mellitus, Type 2 - complications | Original Reports | Bc1
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14. Comparative analysis of antibodies to insulin receptors for children with typE B insulin -depen dan T diabetes subject to the illness stage
by Baturin, V.A and Bykov, Yu.V and Mamtseva, G.I and Uglova, T.I
Medical News of North Caucasus, ISSN 2073-8137, 2016, Volume 11, Issue 1, pp. 80 - 82
Autoantibodies | Insulin receptors | Insulin-dependent diabetes
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15. Full Text Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer's Disease: in Search of a Relevant Mechanism
by Grieb, P
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 04/2016, Volume 53, Issue 3, pp. 1741 - 1752
Streptozotocin (STZ), a glucosamine-nitrosourea compound derived from soil bacteria and originally developed as an anticancer agent, in 1963 has been found to... 
Brain | Non-transgenic Alzheimer's disease model | RESISTANT BRAIN STATE | CEREBRAL GLUCOSE-UTILIZATION | COGNITIVE IMPAIRMENT | NEUROSCIENCES | DIABETES-MELLITUS | Insulin receptors | Insulin producing cells | FREE FATTY-ACIDS | INSULIN-RESISTANCE | AMYLOID-BETA | Intracerebroventricular streptozotocin injection | RAT-BRAIN | ENERGY-METABOLISM | TRANSGENIC MICE | Animals | Humans | Injections, Intraventricular | Glucose - metabolism | Receptor, Insulin - metabolism | Streptozocin - administration & dosage | Alzheimer Disease - chemically induced | Alzheimer Disease - pathology | Disease Models, Animal | Glucose metabolism | Pancreatic beta cells | Analysis | Liver | Brain damage | Models | Genetic engineering | Glucose | Alzheimer's disease | Soil microbiology | Dextrose | Alzheimers disease | Insulin | Rodents | Neurobiology | Index Medicus
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16. Full Text Insulin in the ventral tegmental area reduces cocaine‐evoked dopamine in the nucleus accumbens in vivo
by Naef, Lindsay and Seabrook, Lauren and Hsiao, Jeff and Li, Calvin and Borgland, Stephanie L
European Journal of Neuroscience, ISSN 0953-816X, 08/2019, Volume 50, Issue 3, pp. 2146 - 2155
Mesolimbic dopamine circuits, implicated in incentive motivation, are sensitive to changes in metabolic state such as weight loss and diet‐induced obesity.... 
VTA | insulin | cocaine | fast scan cyclic voltammetry | dopamine | NAc | LEPTIN | INTRANASAL INSULIN | FOOD-INTAKE | REWARD | NEUROSCIENCES | TRANSMISSION | NEURONS | MESOLIMBIC DOPAMINE | RECEPTORS | BRAIN | MODULATION | Ventral tegmentum | Dopamine | Glucagon | Neurons | Mesolimbic system | Menopause | Body weight loss | Metabolism | Insulin | Pedunculopontine tegmental nucleus | Nucleus accumbens | Motivation | Insulin receptors | Ghrelin | Leptin | Neostriatum | Synaptic depression | Cocaine | Dopamine receptors
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17. Full Text The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of Alzheimer's disease
by Batista, Andre F and Forny‐Germano, Leticia and Clarke, Julia R and Lyra e Silva, Natalia M and Brito‐Moreira, Jordano and Boehnke, Susan E and Winterborn, Andrew and Coe, Brian C and Lablans, Ann and Vital, Juliana F and Marques, Suelen A and Martinez, Ana MB and Gralle, Matthias and Holscher, Christian and Klein, William L and Houzel, Jean‐Christophe and Ferreira, Sergio T and Munoz, Douglas P and De Felice, Fernanda G
The Journal of Pathology, ISSN 0022-3417, 05/2018, Volume 245, Issue 1, pp. 85 - 100
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of... 
liraglutide | insulin receptors | PKA signaling | non‐human primates | neurodegeneration | tau pathology | GLP‐1 | Alzheimer's disease | diabetes | synapse damage | GLP-1 | non-human primates | MODULATING TAU HYPERPHOSPHORYLATION | INTRANASAL INSULIN | MEMORY IMPAIRMENT | PATHOLOGY | A-BETA OLIGOMERS | GLYCOGEN-SYNTHASE KINASE-3-BETA | GLUCAGON-LIKE PEPTIDE-1 | ONCOLOGY | AMYLOID-BETA | MOUSE MODEL | CENTRAL-NERVOUS-SYSTEM | LONG-TERM POTENTIATION | Type 2 diabetes | Brain | Analysis | Physiological aspects | Primates | Brain damage | Drug therapy | Insulin | Diabetes therapy | Protein kinase A | Neuroprotection | Animal models | Glucagon | Memory | Cognitive ability | Impairment | Ventricles (cerebral) | Activation | Oligomers | Infusion | Signal transduction | Receptors | Insulin receptors | Diabetes mellitus (non-insulin dependent) | Neurodegenerative diseases | Diabetes mellitus | Pathology | Signaling | Tau protein | Mice | Diabetes | Receptor mechanisms | Ventricle | Alzheimers disease | Brain injury | Hippocampus | Synapses | Original Papers | Original Paper
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