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1. Full Text Simulation of cardiac work transitions, in vitro: effects of simultaneous Ca2+and ATPase additions on isolated porcine heart mitochondria
by Territo, P.R and French, S.A and Balaban, R.S
Cell Calcium, ISSN 0143-4160, 07/2001, Volume 30, Issue 1, pp. 19 - 27
During increases in cardiac work there are net increases in cytosolic [Ca2+] and ATP hydrolysis by myofiliments and ion transport ATPases. However, it is still... 
RAT HEARTS | OXIDATIVE-PHOSPHORYLATION | RUTHENIUM RED | P-31 NMR | OXYGEN-CONSUMPTION | RESPIRATORY CONTROL | MYOCYTES | INTACT HEART | INTRACELLULAR CALCIUM | MUSCLE-CELLS | CELL BIOLOGY | Membrane Potentials - drug effects | Mitochondria, Heart - enzymology | Mitochondria, Heart - drug effects | Membrane Potentials - physiology | NAD - drug effects | Oxygen Consumption - physiology | Oxidative Phosphorylation - drug effects | Animals | Calcium - physiology | Mitochondria, Heart - physiology | Oxygen Consumption - drug effects | Swine | Adenosine Triphosphate - metabolism | Cell Respiration - drug effects | Cell Respiration - physiology | Adenosine Diphosphate - metabolism | Adenosine Triphosphatases - physiology | NAD - metabolism
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2. Full Text Role of ranolazine in angina, heart failure, arrhythmias, and diabetes
by Sossalla, Samuel and Maier, Lars S
Pharmacology and Therapeutics, ISSN 0163-7258, 03/2012, Volume 133, Issue 3, pp. 311 - 323
Ranolazine which is currently approved as an antianginal agent reduces the Na-dependent Ca overload via inhibition of the late sodium current (late I ) and... 
Heart failure | Ischemia | Atrial fibrillation | Angina | Diabetes | Ca overload | Late Na current | Arrhythmias | Ranolazine | LATE SODIUM CURRENT | INTACT PORCINE HEART | ACUTE CORONARY SYNDROMES | LONG-QT SYNDROME | RANDOMIZED CONTROLLED-TRIAL | PALMITOYL-L-CARNITINE | FATTY-ACID OXIDATION | ISCHEMIC RAT HEARTS | PHARMACOLOGY & PHARMACY | LATE I-NA | LEFT-VENTRICULAR FUNCTION | Cardiovascular Agents - therapeutic use | Animals | Diabetes Mellitus - physiopathology | Heart Diseases - physiopathology | Humans | Diabetes Mellitus - drug therapy | Acetanilides - therapeutic use | Heart Diseases - drug therapy | Piperazines - therapeutic use | Diabetics | Arrhythmia | Hypoglycemic agents | Angina pectoris | Index Medicus
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3. Full Text Antiarrhythmic properties of ranolazine: A review of the current evidence
by Gupta, Tanush and Khera, Sahil and Kolte, Dhaval and Aronow, Wilbert S and Iwai, Sei
International Journal of Cardiology, ISSN 0167-5273, 2015, Volume 187, Issue 1, pp. 66 - 74
Abstract Ranolazine was developed as an antianginal agent and was approved by the Food and Drug Administration in 2006 for use in chronic stable angina... 
Cardiovascular | Ventricular tachycardia | Late sodium current | Peak sodium current | Atrial fibrillation | Ranolazine | CHRONIC HEART-FAILURE | CURRENT BLOCKER RANOLAZINE | TORSADES-DE-POINTES | CARDIAC & CARDIOVASCULAR SYSTEMS | CHRONIC STABLE ANGINA | INTACT PORCINE HEART | LATE NA+ CURRENT | ACUTE CORONARY SYNDROMES | LONG-QT SYNDROME | RANDOMIZED CONTROLLED-TRIAL | Heart Conduction System - physiopathology | Atrial Fibrillation - drug therapy | Humans | Sodium Channel Blockers - pharmacology | Heart Conduction System - drug effects | Atrial Fibrillation - physiopathology | Ranolazine - pharmacology | Coronary heart disease | Analysis | Cardiac patients | Anti-arrhythmia drugs
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4. Full Text Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity
by Bonatti, Rodolfo, BS and Silva, Ana Flavia Garcia, BS and Batatinha, Julio Americo Pereira, BS and Sobrado, Lucas F., BS and Machado, Ananda Dianni, BS and Varone, Bruno B., BS and Nearing, Bruce D., PhD and Belardinelli, Luiz, MD and Verrier, Richard L., PhD
Heart Rhythm, ISSN 1547-5271, 2014, Volume 11, Issue 10, pp. 1827 - 1835
Background Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias. Objective We examined whether selectively targeting late... 
Cardiovascular | Depolarization | Heterogeneity | Repolarization | Antiarrhythmic drugs | Late INa | Ventricular ischemia | Atrial fibrillation | Atrial ischemia | Ventricular fibrillation | Late Ina | Antiarrhythmicdrugs | Ventricularischemia | Atrialischemia | FIBRILLATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISM | Late I-Na | INTACT PORCINE HEART | CARDIAC-ARRHYTHMIA | VULNERABILITY | SUPPRESSION | TRIAL | POTENT | RANOLAZINE | T-WAVE ALTERNANS | Triazoles - administration & dosage | Coronary Stenosis - complications | Injections, Intravenous | Pyridines - administration & dosage | Ventricular Fibrillation - drug therapy | Atrial Fibrillation - drug therapy | Male | Treatment Outcome | Heart Conduction System - drug effects | Atrial Fibrillation - physiopathology | Ventricular Fibrillation - etiology | Dose-Response Relationship, Drug | Animals | Heart Conduction System - physiopathology | Time Factors | Swine | Coronary Stenosis - physiopathology | Sodium Channel Blockers - administration & dosage | Atrial Fibrillation - etiology | Electrocardiography | Ventricular Fibrillation - physiopathology | Heart | Ischemia | Heart diseases | Electrocardiogram
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5. Full Text Synergistic antiarrhythmic effect of combining inhibition of Ca2+ -activated K+ (SK) channels and voltage-gated Na+ channels in an isolated heart model of atrial fibrillation
by Kirchhoff, Jeppe Egedal, MS and Goldin Diness, Jonas, PhD and Sheykhzade, Majid, PhD and Grunnet, Morten, PhD and Jespersen, Thomas, PhD
Heart Rhythm, ISSN 1547-5271, 2015, Volume 12, Issue 2, pp. 409 - 418
Background Application of antiarrhythmic compounds is limited by both proarrhythmic and extracardiac toxicities, as well as incomplete antiarrhythmic efficacy.... 
Cardiovascular | Calcium-activated potassium channel | Combination therapy | Flecainide | Lidocaine | Ranolazine | Calcium-activatedpotassiumchannel | INDUCED ARRHYTHMIAS | AMIODARONE | SODIUM | CARDIAC & CARDIOVASCULAR SYSTEMS | INTACT PORCINE HEART | BLOCK | PROLONGATION | COMBINATION | FLecainide | VENTRICULAR REPOLARIZATION | Acetanilides - pharmacology | Voltage-Gated Sodium Channels - drug effects | Guinea Pigs | Atrial Fibrillation - drug therapy | Anti-Arrhythmia Agents - pharmacology | Electrocardiography - drug effects | Flecainide - pharmacology | Atrial Fibrillation - physiopathology | Piperazines - pharmacology | Small-Conductance Calcium-Activated Potassium Channels - metabolism | Small-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors | Drug Synergism | Atrial Fibrillation - metabolism | Animals | Voltage-Gated Sodium Channel Blockers - pharmacology | Female | Drug Therapy, Combination | Voltage-Gated Sodium Channels - metabolism | Disease Models, Animal | Index Medicus
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6. Full Text The late Na current as a therapeutic target: Where are we?
by Maier, Lars S and Sossalla, Samuel
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2013, Volume 61, pp. 44 - 50
Abstract In this article we review the late Na current which functionally can be measured using patch-clamp electrophysiology (INa,late ). This current is... 
Cardiovascular | Heart failure | Angina | Ischemia | INa,late | Arrhythmias | Ranolazine | LATE SODIUM CURRENT | CHRONIC HEART-FAILURE | CARDIAC & CARDIOVASCULAR SYSTEMS | I-Na,I-late | INTACT PORCINE HEART | ACUTE CORONARY SYNDROMES | LONG-QT SYNDROME | ATRIAL-FIBRILLATION | CELL BIOLOGY | PALMITOYL-L-CARNITINE | FATTY-ACID OXIDATION | RAT VENTRICULAR MYOCYTES | PROTEIN-KINASE-II | Arrhythmias, Cardiac - metabolism | Myocardial Contraction | Myocardial Ischemia - metabolism | Atrial Fibrillation - drug therapy | Humans | Heart Failure - physiopathology | Sodium Channel Blockers - pharmacology | Heart Failure - metabolism | Atrial Fibrillation - physiopathology | Myocardial Ischemia - drug therapy | Arrhythmias, Cardiac - physiopathology | Heart Failure - drug therapy | Atrial Fibrillation - metabolism | Arrhythmias, Cardiac - drug therapy | Animals | Calcium - physiology | Myocardium - metabolism | Myocardial Ischemia - physiopathology | Sodium Channel Blockers - therapeutic use
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7. Full Text Delivery of drugs, growth factors, genes and stem cells via intrapericardial, epicardial and intramyocardial routes for sustained local targeted therapy of myocardial disease
by Maslov, Mikhail and Foianini, Stephan and Lovich, Mark
Expert Opinion on Drug Delivery, ISSN 1742-5247, 10/2017, Volume 14, Issue 10, pp. 1227 - 1239
Introduction: Local myocardial delivery (LMD) of therapeutic agents is a promising strategy that aims to treat various myocardial pathologies. It is designed... 
intrapericardial drug delivery | Epicardial drug delivery | heart disease | therapy | intramyocardial drug delivery | INTACT PORCINE HEART | CONTROLLED-RELEASE | BONE-MARROW-CELLS | POSTOPERATIVE ATRIAL-FIBRILLATION | ISCHEMIC-HEART-DISEASE | IMPROVES CARDIAC-FUNCTION | PLATELET-RICH PLASMA | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | CORONARY-ARTERY-DISEASE | LEFT-VENTRICULAR FUNCTION | Stem Cell Transplantation | Drug Administration Routes | Gene Transfer Techniques | Animals | Humans | Myocardium - metabolism | Intercellular Signaling Peptides and Proteins - administration & dosage | Pharmaceutical Preparations - administration & dosage | Cardiomyopathies - therapy | Drug Delivery Systems
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8. Normal values for heart electrophysiology parameters of healthy swine determined on electrophysiology study
by Noszczyk-Nowak, Agnieszka and Cepiel, Alicja and Janiszewski, Adrian and Pasławski, Robert and Gajek, Jacek and Pasławska, Urszula and Nicpoń, Jozef
Advances in Clinical and Experimental Medicine, ISSN 1899-5276, 11/2016, Volume 25, Issue 6, pp. 1249 - 1254
Background. Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental... 
Heart | Swine | Reference values | Electrophysiology study | swine | FIBRILLATION | MEDICINE, RESEARCH & EXPERIMENTAL | reference values | electrophysiology study | CARDIOMYOPATHY | INTACT PORCINE HEART | ABLATION | MODEL | heart | ECHOCARDIOGRAPHIC-ASSESSMENT | Heart Rate - physiology | Reference Values | Animals | Electrophysiology - methods | Sus scrofa | Heart - physiology
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9. Late sodium current inhibition: The most promising antiarrhythmic principle in the near future?
by Frommeyer, G and Milberg, P and Maier, L.S and Eckardt, L
Current Medicinal Chemistry, ISSN 0929-8673, 2014, Volume 21, Issue 11, pp. 1271 - 1278
Ranolazine has primarily been developed and so far approved as an antianginal drug. However, it also has potentially interesting and relevant antiarrhythmic... 
Late sodium current | Proarrhythmia | Post-repolarization refractoriness | Atrial fibrillation | Ranolazine | Ventricular fibrillation | ventricular fibrillation | CHRONIC HEART-FAILURE | CURRENT BLOCKER RANOLAZINE | TORSADES-DE-POINTES | POSTREPOLARIZATION REFRACTORINESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | REDUCES VENTRICULAR-ARRHYTHMIAS | INTACT PORCINE HEART | RANDOMIZED CONTROLLED-TRIAL | proarrhythmia | late sodium current | PERSISTENT ATRIAL-FIBRILLATION | ACUTE-CORONARY-SYNDROME | EXPERIMENTAL-MODEL | ranolazine | PHARMACOLOGY & PHARMACY | post-repolarization refractoriness | Arrhythmias, Cardiac - drug therapy | Sodium - chemistry | Atrial Fibrillation - drug therapy | Humans | Anti-Arrhythmia Agents - chemistry | Anti-Arrhythmia Agents - therapeutic use | Electrophysiological Phenomena | Sodium - metabolism | Drug Combinations
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10. Full Text Perspective: does ranolazine have potential for the treatment of atrial fibrillation?
by Hancox, Jules C and Doggrell, Sheila A
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 12/2010, Volume 19, Issue 12, pp. 1465 - 1474
Atrial fibrillation is the most common arrhythmia seen in clinical practice, and novel pharmacological approaches for treatment are sought. Ranolazine (Ranexa;... 
antiarrhythmic | ranolazine | atrial fibrillation | TORSADES-DE-POINTES | ANTIARRHYTHMIC COMPOUND AZD7009 | SODIUM-CHANNEL BLOCK | NA+ CURRENTS | CHRONIC STABLE ANGINA | INTACT PORCINE HEART | ANTIANGINAL AGENT | RANDOMIZED CONTROLLED-TRIAL | VENTRICULAR MYOCYTES | INTRAVENOUS AZD7009 | PHARMACOLOGY & PHARMACY | Drug Evaluation, Preclinical - methods | Evidence-Based Medicine - methods | Acetanilides - pharmacology | Atrial Fibrillation - drug therapy | Humans | Treatment Outcome | Piperazines - chemistry | Piperazines - therapeutic use | Atrial Fibrillation - physiopathology | Piperazines - pharmacology | Ranolazine | Evidence-Based Medicine - trends | Ion Channel Gating - physiology | Animals | Acetanilides - chemistry | Acetanilides - therapeutic use | Clinical Trials as Topic - methods | Ion Channel Gating - drug effects
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11. Full Text Endothelium-mediated control of the coronary circulation. Exercise training-induced vascular adaptations
by Laughlin, M.H and McAllister, R.M and Jasperse, J.L and Crader, S.E and Williams, D.A and Huxley, V.H
Sports Medicine, ISSN 0112-1642, 1996, Volume 22, Issue 4, pp. 228 - 250
This review discusses the role of the endothelium in the regulation of coronary vascular function. The role of endothelium-mediated mechanisms at rest, during... 
INTACT PORCINE HEARTS | CONSCIOUS DOGS | SPORT SCIENCES | ATRIAL-NATRIURETIC-PEPTIDE | CAPILLARY HYDRAULIC CONDUCTIVITY | NITRIC-OXIDE SYNTHESIS | RELAXING FACTOR | MYOCARDIAL OXYGEN-CONSUMPTION | PERFUSED RABBIT HEART | GUINEA-PIG HEART | BLOOD-FLOW
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12. Right heart function during prosthetic left ventricular assistance in a porcine model of congestive heart failure
by Chow, E and Farrar, D.J
Journal of Thoracic and Cardiovascular Surgery, ISSN 0022-5223, 1992, Volume 104, Issue 3, pp. 569 - 578
A left ventricular assist device was used to produce a 90 % reduction in peak systolic left ventricular pressure in pigs with congestive heart failure, and the... 
SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | OPERATING-ROOM MODEL | INTACT HEART | PERFORMANCE | CONSEQUENCES | TACHYCARDIA | CANINE HEART | DIMENSION RELATIONSHIP | PRESSURE-VOLUME RELATIONSHIP | DOG | TRANSPLANTATION | Blood Pressure | Heart - physiopathology | Stroke Volume | Heart Failure - therapy | Animals | Models, Cardiovascular | Swine | Cardiac Output | Heart Failure - physiopathology | Hemodynamics | Heart-Assist Devices | Pulmonary Artery - physiology
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13. Full Text Native Bovine and Porcine Pericardia Respond to Load With Additive Recruitment of Collagen Fibers
by Bagno, Andrea and Aguiari, Paola and Fiorese, Michele and Iop, Laura and Spina, Michele and Gerosa, Gino
Artificial Organs, ISSN 0160-564X, 05/2018, Volume 42, Issue 5, pp. 540 - 548
Bovine and porcine pericardia are currently used for manufacturing prosthetic heart valves: their design has become an increasingly important area of... 
Percutaneous valves | Porcine pericardium | Preconditioning | Bovine pericardium | Heart valves | MECHANICS | ENGINEERING, BIOMEDICAL | INTACT | TIME | TEAR RESISTANCE | TRANSPLANTATION | Tensile Strength | Heart Valve Prosthesis | Bioprosthesis | Materials Testing | Collagen - metabolism | Biomechanical Phenomena | Animals | Pericardium - physiology | Cattle | Swine | Pericardium - ultrastructure | Weight-Bearing | Collagen - analysis | Pericardium - chemistry | Collagen | Biological products | Prostheses | Deformation | Deformation mechanisms | Collagens | Mechanical properties | Valves | Pericardium | Fibers | Recruitment | Mechanical analysis | Biomaterials | Biomedical materials
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14. Full Text Left ventricular unloading decreases rate of isovolumic right ventricular pressure decline
by Brown, C.D and Chow, E and Farrar, D.J
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0002-9513, 1993, Volume 265, Issue 5, pp. H1663 - H1669
To determine whether direct ventricular interaction affects right ventricular (RV) relaxation, we compared the minimum rate of change of RV pressure... 
ventricular interaction | porcine intact heart | right ventricular function | ventricular relaxation | INTACT CANINE HEART | PHYSIOLOGY | VENTRICULAR INTERACTION | ISCHEMIA | CARDIAC-MUSCLE | TIME-COURSE | HYPOXIA | INTERDEPENDENCE | VENTRICULAR RELAXATION | RIGHT VENTRICULAR FUNCTION | PORCINE INTACT HEART | LOAD-DEPENDENT RELAXATION | FALL | HEMODYNAMIC DETERMINANTS | Myocardial Contraction | Heart - anatomy & histology | Heart Rate | Ventricular Function, Left | Heart - physiology | Male | Systole | Pulmonary Artery - physiology | Animals | Pericardium - physiology | Swine | Electrocardiography | Female | Muscle, Smooth, Vascular - physiology
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15. Full Text Phosphorylation by protein kinase C and the responsiveness of Mg2+-ATPase to Ca2+ of myofibrils isolated from stunned and non-stunned porcine myocardium
by Bezstarosti, Karel and Soei, Loe Kie and Verdouw, Pieter D and Lamers, Jos M.J
Molecular and Cellular Biochemistry, ISSN 0300-8177, 11/1997, Volume 176, Issue 1, pp. 211 - 218
Previously we showed in an in situ porcine model that the thiadiazinone derivative [+]EMD 60263, a Ca2+ sensitizer without phosphodiesterase III inhibitory... 
Life Sciences | Biochemistry, general | cardiac myofibrils | human, pig | thiadiazinone derivatives | Medical Biochemistry | Oncology | Ca 2+ stimulated Mg 2+ -ATPase | Cardiology | stunning | cardiac sarcoplasmic reticulum | ATPASE ACTIVITY | CARDIAC MYOCYTES | INTACT | SARCOPLASMIC-RETICULUM | CALCIUM SENSITIVITY | pig | PHOSPHATIDYLINOSITOL CYCLE | TROPONIN-I | CELL BIOLOGY | CANINE MYOCARDIUM | Ca2+ stimulated Mg2+-ATPase | MGATPASE ACTIVITY | CA-2 | human | Proteins | Kinases | Phosphorylation
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16. Full Text Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia
by Bossu, Alexane and Houtman, Marien J. C and Meijborg, Veronique M. F and Varkevisser, Rosanne and Beekman, Henriette D. M and Dunnink, Albert and de Bakker, Jacques M. T and Mollova, Nevena and Rajamani, Sridharan and Belardinelli, Luiz and van der Heyden, Marcel A. G and Vos, Marc A
British journal of pharmacology, ISSN 0007-1188, 2018, Volume 175, Issue 12, pp. 2470 - 2482
Background and Purpose: Enhanced late sodium current (late INa) in heart failure and long QT syndrome type 3 is proarrhythmic. This study investigated the... 
ATRIOVENTRICULAR-BLOCK DOG | INTACT PORCINE MODEL | CHRONIC AV-BLOCK | SHORT-TERM VARIABILITY | EARLY AFTERDEPOLARIZATIONS | VENTRICULAR-TACHYCARDIA | LATE NA+ CURRENT | HEART MODEL | PHARMACOLOGY & PHARMACY | LONG-QT-SYNDROME | LATE I-NA | Triazoles - administration & dosage | Arrhythmias, Cardiac - chemically induced | Pyridines - administration & dosage | Anti-Arrhythmia Agents - pharmacology | Torsades de Pointes - chemically induced | Anti-Arrhythmia Agents - administration & dosage | Phenethylamines | Dose-Response Relationship, Drug | Triazoles - pharmacology | Arrhythmias, Cardiac - drug therapy | Animals | Myocytes, Cardiac - drug effects | Sulfonamides | Dogs | Pyridines - pharmacology | Torsades de Pointes - drug therapy | Heart | Arrhythmia | Cardiomyocytes | Mapping | Dispersion | Mode of action | Inhibitors | Sodium | Torsades de pointes | Electrocardiography | Long QT syndrome | In vivo methods and tests | Ventricle | Heart diseases | Research Papers | Research Paper
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17. Full Text Systematic review of the mechanisms driving effective blood flow during adult CPR
by Georgiou, Marios and Papathanassoglou, Elizabeth and Xanthos, Theodoros
Resuscitation, ISSN 0300-9572, 2014, Volume 85, Issue 11, pp. 1586 - 1593
Abstract Background High quality chest