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1. Full Text Integrative network analysis reveals molecular mechanisms of blood pressure regulation
by Huan, Tianxiao and Meng, Qingying and Saleh, Mohamed A and Norlander, Allison E and Joehanes, Roby and Zhu, Jun and Chen, Brian H and Zhang, Bin and Johnson, Andrew D and Ying, Saixia and Courchesne, Paul and Raghavachari, Nalini and Wang, Richard and Liu, Poching and O'Donnell, Christopher J and Vasan, Ramachandran and Munson, Peter J and Madhur, Meena S and Harrison, David G and Yang, Xia and Levy, Daniel and Int Consortium Blood Pressure GWAS and The International Consortium for Blood Pressure GWAS (ICBP)
Molecular Systems Biology, ISSN 1744-4292, 04/2015, Volume 11, Issue 4, pp. 1 - n/a
Genome‐wide association studies (GWAS) have identified numerous loci associated with blood pressure (BP). The molecular mechanisms underlying BP regulation,... 
systems biology | blood pressure | coexpression network | hypertension | gene expression | GLOBAL BURDEN | SPONTANEOUSLY HYPERTENSIVE-RATS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANGIOTENSIN-II | II-INDUCED HYPERTENSION | CARDIOVASCULAR-DISEASE | CORONARY-HEART-DISEASE | GLYCOGEN-SYNTHASE GENE | ADAPTER PROTEIN LNK | UP-REGULATION | Hypertension | Heart | Substance abuse treatment | Target recognition | Genes | Modules | Genomics | Molecular interactions | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Gene expression | Proteins | Studies | Infusion | Molecular modelling | Network analysis | Angiotensin | Biomarkers | Mice | Blood pressure | Angiotensin II
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2. Full Text Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma
by Kresse, Stine H and Rydbeck, Halfdan and Skårn, Magne and Namløs, Heidi M and Barragan-Polania, Ana H and Cleton-Jansen, Anne-Marie and Serra, Massimo and Liestøl, Knut and Hogendoorn, Pancras C. W and Hovig, Eivind and Myklebost, Ola and Meza-Zepeda, Leonardo A
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e48262
Background: Osteosarcomas are the most common non-haematological primary malignant tumours of bone, and all conventional osteosarcomas are high-grade tumours... 
BREAST-CANCER | OVEREXPRESSION | BIOINFORMATICS | COPY-NUMBER | MULTIDISCIPLINARY SCIENCES | DISEASE | BONE | COMPARATIVE GENOMIC HYBRIDIZATION | CELL-LINES | IDENTIFICATION | EXPRESSION | Genome-Wide Association Study | Oligonucleotide Array Sequence Analysis | Epigenesis, Genetic | Genes, Neoplasm | Humans | RNA, Messenger - genetics | Gene Expression Regulation, Neoplastic | Gene Dosage | RNA, Messenger - metabolism | DNA Copy Number Variations | DNA Methylation | Cell Line, Tumor | Bone Neoplasms - genetics | Polymorphism, Single Nucleotide | Osteosarcoma - genetics | Cluster Analysis | Epigenetic inheritance | Embryonic development | RNA | Osteosarcoma | Analysis | Genes | Genomics | Genetic research | Genetic aspects | Genomes | Methylation | Biotechnology | Copy number | Colorectal cancer | Biology | Bone tumors | Metastasis | Osteoblasts | Consortia | Morphogenesis | Demethylation | Embryogenesis | Alterations | Interleukin 1 | DNA methylation | Biocompatibility | Extracellular matrix | Chromosomes | Bioinformatics | Informatics | Deoxyribonucleic acid--DNA | Cbfa-1 protein | Hematology | Tumor cell lines | Gene expression | Bone cancer | DNA microarrays | Overexpression | Medical prognosis | Cell lines | Epigenetics | Skeletal system | Mutation | Aberration | Tumors | Deoxyribonucleic acid | DNA
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3. Full Text An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training
by Lindholm, Maléne E and Marabita, Francesco and Gomez-Cabrero, David and Rundqvist, Helene and Ekström, Tomas J and Tegnér, Jesper and Sundberg, Carl Johan
Epigenetics, ISSN 1559-2294, 12/2014, Volume 9, Issue 12, pp. 1557 - 1569
Regular endurance exercise training induces beneficial functional and health effects in human skeletal muscle. The putative contribution to the training... 
environment | DNA methylation | transcriptional network | epigenomics | exercise | integrative analysis | 450k arrays | lifestyle | Integrative analysis | Epigenomics | Exercise | Environment | Lifestyle | Transcriptional network | MRF | 3-hydroxyacyl-CoA dehydrogenase | cytosine-guanine dinucleotide | differentially methylated position | citrate synthase | DENSITY | EPIGENETICS | FDR | PACKAGE | GENETICS & HEREDITY | GENE-EXPRESSION | luminometric methylation assay | myogenic regulatory factor | CpG | false discovery rate | MDS | WIDE DNA METHYLATION | DMP | myocyte enhancer factor | BIAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEG | differentially expressed gene | HAD | MEF | PCA | IMPACT | multidimensional scaling | ASSOCIATION | LUMA | principal component analysis | Epigenesis, Genetic | Humans | Gene Expression Regulation | Transcriptome | Male | Muscle, Skeletal - physiology | Physical Endurance | Case-Control Studies | DNA Methylation | Enhancer Elements, Genetic | Adult | Female | Exercise - physiology
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4. Full Text Integrative analysis reveals driver long non-coding RNAs in osteosarcoma
by Luo, Zhenguo and Xiao, Li and Li, Jing and Dong, Buhuai and Wang, Chunsheng
Medicine, ISSN 0025-7974, 02/2019, Volume 98, Issue 6, p. e14302
Transcriptome profiling of osteosarcoma (OS) by next generation sequencing technology (NGS) has been broadly performed by previous researches, which uncovers a... 
SURVIVAL | APOPTOSIS | biomarkers | expression profiling | CANCER GENOME | TUMOR | PROLIFERATION | CHEMOTHERAPY | MEDICINE, GENERAL & INTERNAL | integrative analysis | long non-coding RNA | TUMORIGENESIS | CONTRIBUTES | EXPRESSION | osteosarcoma | PROGRESSION | Care and treatment | Usage | RNA | Osteosarcoma | Development and progression | Genetic aspects | High-throughput screening (Biochemical assaying) | Research
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5. Full Text Proteome and secretome analysis reveals differential post-transcriptional regulation of Toll-like receptor responses
by Koppenol-Raab, Marijke and Sjoelund, Virginie and Manes, Nathan P and Gottschalk, Rachel A and Dutta, Bhaskar and Benet, Zachary L and Fraser, Iain D. C and Nita-Lazar, Aleksandra
Molecular and Cellular Proteomics, ISSN 1535-9476, 04/2017, Volume 16, Issue 4, pp. S172 - S186
The innate immune system is the organism's first line of defense against pathogens. Pattern recognition receptors (PRRs) are responsible for sensing the... 
PATTERN-RECOGNITION | GENE | INTEGRATIVE ANALYSIS | BIOCHEMICAL RESEARCH METHODS | FUNCTIONAL-ANALYSIS | DYNAMICS | COMPONENTS | EXPRESSION | PSEUDOMONAS-CEPACIA | DISCOVERY | ABUNDANCE | Pseudomonas aeruginosa - immunology | RNA Processing, Post-Transcriptional | Signal Transduction | Humans | Gene Expression Profiling | Immunity, Innate | Pseudomonas Infections - immunology | Animals | Proteome - secretion | RAW 264.7 Cells | Mice | Toll-Like Receptors - metabolism | Proteome - metabolism | Macrophages - immunology | Pathogens | Post-transcription | Immune response | Gene regulation | Innate immunity | Secretome | Pattern recognition | Macrophages | Immunity | Proteins | Signal transduction | Signaling | Receptors | Proteomics | Toll-like receptors | MyD88 protein | Immune system | Special Issue | Proteomics and Infectious Disease
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6. Full Text Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancer
by Mishra, Nitish Kumar and Guda, Chittibabu
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 17, pp. 28990 - 29012
Pancreatic cancer (PC) is the fourth leading cause of cancer deaths in the United States with a five-year patient survival rate of only 6%. Early detection and... 
Integrative analysis | Molecular subtypes | Differential methylation | Pancreatic cancer | TCGA | EPIGENOMIC ANALYSIS | CPG ISLAND METHYLATION | DUCTAL ADENOCARCINOMA | TRANSCRIPTION | PATTERNS | BREAST | CELL BIOLOGY | molecular subtypes | pancreatic cancer | SMAD4 PROTEIN | BIOLOGY | GENE-EXPRESSION | R PACKAGE | integrative analysis | differential methylation | Oligonucleotide Array Sequence Analysis | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Humans | Pancreatic Neoplasms - pathology | Gene Expression Regulation, Neoplastic | STAT4 Transcription Factor - metabolism | 3' Untranslated Regions - genetics | Pancreatic Neoplasms - genetics | 5' Untranslated Regions - genetics | Genes, Homeobox - genetics | Promoter Regions, Genetic - genetics | Smad4 Protein - metabolism | Homeodomain Proteins - genetics | DNA Copy Number Variations | DNA-Binding Proteins - metabolism | STAT5 Transcription Factor - metabolism | DNA Methylation | Histones - genetics | CpG Islands - genetics | Histones - metabolism | Genome, Human | Cluster Analysis
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7. Full Text Integrative testis transcriptome analysis reveals differentially expressed miRNAs and their mRNA targets during early puberty in Atlantic salmon
by Skaftnesmo, Kai Ove and Edvardsen, Rolf B and Furmanek, Tomasz and Crespo, D and Andersson, E and Kleppe, Lene and Taranger, G.L and Bogerd, J and Schulz, R.W and Wargelius, Anna
BMC Genomics, ISSN 1471-2164, 10/2017, Volume 18, Issue 1, pp. 801 - 12
Background: Our understanding of the molecular mechanisms implementing pubertal maturation of the testis in vertebrates is incomplete. This topic is relevant... 
microRNA new194 | microRNA new271 | prepuberty | testis | gene cluster | developmental stage | spermatogonium | microRNA 217 | transcriptomics | microRNA 137 | puberty | testis tissue | precocious puberty | signal transduction | MiRNA | animal cell | microRNA 30c | microRNA 222a | microRNA 125b | animal experiment | article | genetic association study | microRNA 181a | microRNA 724 | animal tissue | microRNA 202 | nonhuman | gene expression | male | Aquaculture | unclassified drug | Wnt protein | progesterone | gene control | microRNA 26b | messenger RNA | microRNA 18a | spermatogenesis | microRNA 190a | Sertoli cell | apelin | microRNA 25 | cell proliferation | testis development | microRNA 92b | cell cycle | Salmo salar | microRNA 20a | microRNA 216a | sonic hedgehog protein | microRNA 135a | Integrative analysis | microRNA new289 | sexual maturation | microRNA | microRNA 101 | microRNA 145 | microRNA 222 | unindexed drug | microRNA 2184 | SPERMATOGENESIS | ZEBRAFISH | PROLIFERATION | ANTI-MULLERIAN HORMONE | IDENTIFICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENES | GENETICS & HEREDITY | miRNA | SPERMATOGONIAL DIFFERENTIATION | PROGESTIN | GERM-CELL | MICRORNA | Puberty | Atlantic salmon | Genetic aspects | MicroRNA | Messenger RNA | Research | Cell proliferation | Enrichment | Spermatogenesis | Genomes | Signal transduction | Pathways | Developmental stages | Cell cycle | Fish | Bioinformatics | Integrated approach | Maturation | Salmon | Zebrafish | Gene expression | Studies | Vertebrates | Signaling | Molecular modelling | Hedgehog protein | MicroRNAs | Software | Animal welfare | Progesterone
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8. Full Text Bioinformatics-based analysis reveals elevated MFSD12 as a key promoter of cell proliferation and a potential therapeutic target in melanoma
by Wei, Chuan-Yuan and Zhu, Meng-Xuan and Lu, Nan-Hang and Peng, Rui and Yang, Xuan and Zhang, Peng-Fei and Wang, Lu and Gu, Jian-Ying
Oncogene, ISSN 0950-9232, 03/2019, Volume 38, Issue 11, pp. 1876 - 1891
Although recent therapeutic advances based on our understanding of molecular phenomena have prolonged the survival of melanoma patients, the prognosis of... 
PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | CANCER | CELL BIOLOGY | FACILITATORS | ONCOLOGY | INTEGRATIVE ANALYSIS | GENETICS & HEREDITY | SUPERFAMILY | PROTEINS | PROGRESSION | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Gene Expression Profiling | Molecular Targeted Therapy - trends | Cell Transformation, Neoplastic - genetics | Melanoma - genetics | Skin Neoplasms - mortality | Aged, 80 and over | Adult | Female | Membrane Proteins - metabolism | Molecular Targeted Therapy - methods | Skin Neoplasms - pathology | Cell Proliferation - genetics | Computational Biology - methods | Skin Neoplasms - therapy | Membrane Proteins - genetics | Cells, Cultured | Up-Regulation - genetics | Melanoma - pathology | Disease Progression | Skin Neoplasms - genetics | Survival Analysis | Aged | Biomarkers, Tumor - genetics | Cell Transformation, Neoplastic - pathology | Melanoma - therapy | Melanoma - mortality | Cell proliferation | AKT1 protein | Therapeutic applications | Melanoma | MAP kinase | Gene expression | 1-Phosphatidylinositol 3-kinase | Metastases | Cyclin-dependent kinase 2 | Cell growth | Medical prognosis | Cell cycle | Bioinformatics
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9. Full Text Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers
by Ding, Yongfeng and Zhong, Tingting and Wang, Min and Xiang, Xueping and Ren, Guoping and Jia, Zhongjuan and Lin, Qinghui and Liu, Qian and Dong, Jingwen and Li, Linrong and Li, Xiawei and Jiang, Haiping and Zhu, Lijun and Li, Haoran and Shen, Dejun and Teng, Lisong and Li, Chen and Shao, Jimin
Frontiers in Oncology, ISSN 2234-943X, 10/2019, Volume 9
Mining cancer-omics databases deepens our understanding of cancer biology and can lead to potential breakthroughs in cancer treatment. Here, we propose an... 
Care and treatment | Genetic aspects | Cancer | Messenger RNA | Oncology, Experimental | Ribonucleoside reductase | Physiological aspects | Research | Gene expression | Health aspects | cancer-omics | ribonucleotide reductase | expression characteristics | integrative analysis | gene networks | clinical relevance
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10. Full Text Integrative Omics Analysis Reveals Post-Transcriptionally Enhanced Protective Host Response in Colorectal Cancers with Microsatellite Instability
by Liu, Qi and Zhang, Bing
Journal of Proteome Research, ISSN 1535-3893, 03/2016, Volume 15, Issue 3, pp. 766 - 776
Microsatellite instability (MSI) is a frequent and clinically relevant molecular phenotype in colorectal cancer. MSI cancers have favorable survival compared... 
microsatellite instability | colorectal cancer | integrative omics analysis | post-transcription regulation | protective host response | HUMAN COLON | TRANSCRIPTOME | BIOCHEMICAL RESEARCH METHODS | integrative omits analysis | PROTEIN ABUNDANCE | EXPRESSION SIGNATURES | NEUTROPHIL RECRUITMENT | TUMOR-INFILTRATING LYMPHOCYTES | MESSENGER-RNA | RNA-SEQ | CARCINOMAS | PROTEOMIC ANALYSIS | Microsatellite Instability | Colorectal Neoplasms - immunology | Colorectal Neoplasms - genetics | Humans | Proteomics | Gene Expression Profiling | Transcriptome - genetics | Immunity - genetics | Gene Expression Regulation, Neoplastic - genetics | Cohort Studies
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11. Full Text iTRAQ-based quantitative proteomic analysis reveals Bai-Hu-Tang enhances phagocytosis and cross-presentation against LPS fever in rabbit
by Zhang, Shidong and Wang, Dongsheng and Dong, Shuwei and Yang, Zhiqiang and Yan, Zuoting
Journal of Ethnopharmacology, ISSN 0378-8741, 07/2017, Volume 207, pp. 1 - 7
Bai-Hu-Tang (BHT), a classical anti-febrile Chinese formula comprising of liquorice, anemarrhena rhizome, gypsum and rice, has been traditionally used to... 
Bai-Hu-Tang | Cross presentation | Differentially expressed proteins | Phagocytosis | LPS fever | CELLS | CHEMISTRY, MEDICINAL | HERB FORMULA | MACROPHAGES | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | LIPOPOLYSACCHARIDE | TRADITIONAL CHINESE MEDICINE | PHARMACOLOGY & PHARMACY | Rabbits | Phagocytosis - drug effects | Lipopolysaccharides - toxicity | Liver - metabolism | Drugs, Chinese Herbal - pharmacology | Animals | Proteins - metabolism | Liver - drug effects | Cross-Priming | Drugs, Chinese Herbal - administration & dosage | Proteomics - methods | Chromatography, Liquid - methods | Fever - drug therapy | Tandem Mass Spectrometry - methods | Cluster Analysis | Disease Models, Animal | Liquid chromatography | Mass spectrometry | Mitogens | Analysis | Liver
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12. Full Text Serum metabolomics analysis reveals that obvious cardioprotective effects of low dose Sini decoction against isoproterenol-induced myocardial injury in rats
by Zhou, Jun and Ma, Xiaoqiong and Shi, Min and Chen, Cuiwei and Chen, Junjie and Sun, Yue and Li, Fanzhu and Li, Jingjing and Xiong, Youxiang
Phytomedicine, ISSN 0944-7113, 07/2017, Volume 31, pp. 18 - 31
decoction (SND) is used for cardiovascular disease over thousands of years in China. However, it is still lacking of dose-response relationship of SND in... 
Serum metabolomics | Phospholipid | Bile acids | Cardioprotective effect | Dose-response relationship | Sini decoction | METABONOMICS | CHEMISTRY, MEDICINAL | CARDIOMYOPATHY | XIN-KE-SHU | MODEL | PLANT SCIENCES | INFARCTION | FLIGHT MASS-SPECTROMETRY | LYSOPHOSPHATIDYLCHOLINE | INTEGRATIVE & COMPLEMENTARY MEDICINE | TRADITIONAL CHINESE MEDICINE | PHARMACOLOGY & PHARMACY | EXPRESSION | SYSTEMS BIOLOGY | Biomarkers - metabolism | NF-kappa B - blood | Drugs, Chinese Herbal - pharmacology | Male | Myocardium - pathology | NF-kappa B - metabolism | Biomarkers - blood | Cardiotonic Agents - pharmacology | Metabolomics - methods | Rats, Sprague-Dawley | Dose-Response Relationship, Drug | Animals | Cardiotonic Agents - administration & dosage | Mass Spectrometry | Lipid Metabolism - drug effects | Heart - drug effects | Heart Injuries - prevention & control | Drugs, Chinese Herbal - administration & dosage | Enzymes - blood | Isoproterenol - adverse effects
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13. Full Text Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas
by Beltrami, Caroline Moraes and dos Reis, Mariana Bisarro and Barros-Filho, Mateus Camargo and Marchi, Fabio Albuquerque and Kuasne, Hellen and Pinto, Clóvis Antônio Lopes and Ambatipudi, Srikant and Herceg, Zdenko and Kowalski, Luiz Paulo and Rogatto, Silvia Regina
Clinical Epigenetics, ISSN 1868-7075, 05/2017, Volume 9, Issue 1, pp. 45 - 11
Background: Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with a recent increase in incidence in many countries. Although PTC has been... 
Integrative analysis | DNA methylation | Papillary thyroid cancer | BRAFV600E mutation | Retinoic acid pathway | FGF signaling pathway | SODIUM/IODIDE SYMPORTER | CELLS | BRAF V600E MUTATION | CANCER | GENOME | RETINOIC ACID | BRAF(V600E) MUTATION | ONCOLOGY | GENE-EXPRESSION | PROMOTER | ASSOCIATION | Promoter Regions, Genetic | Carcinoma, Papillary - genetics | Signal Transduction | Oligonucleotide Array Sequence Analysis - methods | Epigenesis, Genetic | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Gene Expression Profiling - methods | Male | Gene Regulatory Networks | Thyroid Cancer, Papillary | Young Adult | Thyroid Neoplasms - genetics | DNA Methylation | Enhancer Elements, Genetic | Computer Simulation | CpG Islands | Adult | Female | Aged | Mutation | 3' Untranslated Regions | Signal transduction | Thyroid cancer | 3' Untranslated regions | Gene regulation | Genomes | Kinases
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