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CANCER AND METASTASIS REVIEWS, ISSN 0167-7659, 12/2008, Volume 27, Issue 4, pp. 631 - 644
The integrin alpha v beta 3 plays an important role in angiogenesis and tumor metastasis. It is expressed on activated endothelial cells as well as some tumor... 
angiogenesis | alpha v beta 3 | molecular imaging | RGD | CANCER ALPHA(V)-INTEGRIN EXPRESSION | CARBON NANOTUBES | ALPHA(V)BETA EXPRESSION | QUANTUM DOTS | BREAST-CANCER | integrins | RGD PEPTIDE | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | ANGIOGENESIS INHIBITORS | IN-VIVO | VX-2 RABBIT TUMORS
Journal Article
THERANOSTICS, ISSN 1838-7640, 2011, Volume 1, pp. 48 - 57
PET imaging of integrin alpha v beta 3 expression has been studied intensely by the academia and recently also by the industry. Imaging of integrin alpha v... 
MEDICINE, RESEARCH & EXPERIMENTAL | RGD PEPTIDES | angiogenesis | CELL-ADHESION | BIODISTRIBUTION | molecular imaging | CANCER ALPHA(V)-INTEGRIN EXPRESSION | ALPHA(V)BETA EXPRESSION | CARBON NANOTUBES | integrin alpha v beta 3 | BREAST-CANCER | F-18-GALACTO-RGD | POSITRON-EMISSION-TOMOGRAPHY | GLY-ASP PEPTIDE | metastasis | PET
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 10/2005, Volume 46, Issue 10, pp. 1707 - 1718
Integrin alpha(v)beta(3) plays a critical role in tumor-induced angiogenesis and metastasis and has become a promising diagnostic indicator and therapeutic... 
microPET | RGD peptide | TRACERS | CANCER ALPHA(V)-INTEGRIN EXPRESSION | BRAIN-TUMORS | PHARMACOKINETICS | ALPHA-V-BETA-3 | tumor angiogenesis | IN-VIVO | multimeric peptide | INTEGRIN ALPHA(V)BETA | integrin | DOSIMETRY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | VITRONECTIN RECEPTOR | Cu-64
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 01/2006, Volume 47, Issue 1, pp. 113 - 121
The development of noninvasive methods to visualize and quantify integrin alpha(v)beta(3) expression in vivo appears to be crucial for the success of... 
dynamic microPET | ANGIOGENESIS | MICROPET | TRACERS | Logan plot | molecular imaging | CANCER ALPHA(V)-INTEGRIN EXPRESSION | RGD-PEPTIDE | POSITRON-EMISSION-TOMOGRAPHY | integrin alpha(v)beta | ULTRASOUND | ALPHA-V-BETA-3 | IN-VIVO | GROWTH | dimeric RGD peptide | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
by Li, ZB and Chen, K and Chen, X
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, ISSN 1619-7070, 06/2008, Volume 35, Issue 6, pp. 1100 - 1108
Purpose We and others have reported that F-18- and Cu-64-labeled arginine-glycine-aspartate (RGD) peptides allow positron emission tomography (PET)... 
Ga-68 | DESIGN | microPET | ANGIOGENESIS | TUMOR | NOTA | RADIOTRACERS | MELANOMA | integrin alpha(v)beta | TRACER | ALPHA-V-BETA-3 | STABILITIES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | multimeric RGD peptides | VITRONECTIN RECEPTOR | PET
Journal Article
ACCOUNTS OF CHEMICAL RESEARCH, ISSN 0001-4842, 07/2009, Volume 42, Issue 7, pp. 969 - 980
The alpha(v)beta(3)- and alpha(5)beta(1)-integrins play a key role in angiogenesis, the formation of new vessels in tissues that lack them. By serving as... 
BREAST-CANCER | F-18-LABELED RGD | POSITRON-EMISSION-TOMOGRAPHY | BIODISTRIBUTION CHARACTERISTICS | BIOLOGICAL EVALUATION | DRUG DEVELOPMENT | CYCLIC RGDFK DIMER | INTEGRIN ALPHA(V)BETA | TUMOR ANGIOGENESIS | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-V-BETA-3 EXPRESSION
Journal Article
by Wu, ZH and Li, ZB and Chen, K and Cai, WB and He, L and Chin, FT and Li, F and Chen, XY
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 09/2007, Volume 48, Issue 9, pp. 1536 - 1544
In vivo imaging of alpha(v)beta(3) expression has important diagnostic and therapeutic applications. Multimeric cyclic RGD peptides are capable of improving... 
tetrameric RGD peptide | microPET | ANGIOGENESIS | INTEGRIN ALPHA(V)BETA EXPRESSION | RECEPTOR | F-18 | CANCER ALPHA(V)-INTEGRIN EXPRESSION | F-18-GALACTO-RGD | PEGylation | POSITRON-EMISSION-TOMOGRAPHY | integrin alpha(v)beta | LIGANDS | PHARMACOKINETICS | ALPHA-V-BETA-3 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 02/2008, Volume 49, Issue 2, pp. 255 - 259
The integrin alpha(v)beta(3) is a key player in angiogenesis and metastasis. Our aim was to study the uptake patterns of the alpha(v)beta(3)-selective PET... 
MIGRATION | integrins | POSITRON-EMISSION-TOMOGRAPHY | angiogenesis | VASCULAR INTEGRIN ALPHA(V)BETA | breast cancer | alpha(v) beta | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | RGD
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 11/2007, Volume 13, Issue 22, pp. 6610 - 6616
Purpose: [F-18]Galacto-RGD has been developed for positron emission tomography (PET)imaging of alpha v beta 3 expression, a receptor involved in angiogenesis... 
F-18-GALACTO-RGD | CANCER-PATIENTS | ANGIOGENESIS | ONCOLOGY | QUANTIFICATION | INPUT FUNCTION | INTEGRIN ALPHA(V)BETA | RADIOTHERAPY | EXPRESSION | TUMORS | PET
Journal Article
BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 11/2005, Volume 16, Issue 6, pp. 1433 - 1441
Near-infrared fluorescence optical imaging is a powerful technique for studying diseases at the molecular level in preclinical models. We recently reported... 
VISUALIZATION | BRAIN-TUMOR ANGIOGENESIS | CONTRAST AGENTS | MICROPET | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGHT | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | RECEPTOR | CHEMISTRY, MULTIDISCIPLINARY | CANCER ALPHA(V)-INTEGRIN EXPRESSION | PROBES | IN-VIVO | CONJUGATE
Journal Article
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, ISSN 0362-4803, 05/2013, Volume 56, Issue 5, pp. 264 - 279
Journal Article
BREAST CANCER RESEARCH, ISSN 1465-542X, 2006, Volume 8, Issue 2
Introduction Studies in xenograft models and experimental models of metastasis have implicated several beta 3 integrin-expressing cell populations, including... 
MIGRATION | ADHESION | CARCINOMA CELLS | ALPHA(V)BETA | ANGIOGENESIS | ONCOLOGY | MATRIX-METALLOPROTEINASE | GROWTH | EXTRACELLULAR-MATRIX | CLINICAL-COURSE | BETA INTEGRIN
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 05/2006, Volume 47, Issue 5, pp. 763 - 769
F-18-Galacto-RGD is a new tracer for PET imaging of alpha v beta 3, a receptor involved in a variety of pathologic processes including angiogenesis and... 
RADIATION-DOSIMETRY | METASTASIS | dosimetry | ANGIOGENESIS | CELL-ADHESION | BIODISTRIBUTION | whole-body biodistribution | POSITRON-EMISSION-TOMOGRAPHY | CANCER-PATIENTS | F-18-Galacto-RGD | alpha v beta 3 expression | INTEGRIN ALPHA(V)BETA | HEALTHY-VOLUNTEERS | ANTAGONISTS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
MINI-REVIEWS IN MEDICINAL CHEMISTRY, ISSN 1389-5575, 02/2006, Volume 6, Issue 2, pp. 227 - 234
Most solid tumors are angiogenesis dependent. Anti-angiogenic pharmaceuticals that inhibit the growth of new blood vessels offer considerable promise as... 
CHEMISTRY, MEDICINAL | ANGIOGENESIS | positron emission tomography (PET) | MICROPET | RGD peptide | TRACERS | molecular imaging | CANCER ALPHA(V)-INTEGRIN EXPRESSION | POSITRON-EMISSION-TOMOGRAPHY | integrin alpha(v)beta | ALPHA-V-BETA-3 | tumor angiogenesis | IN-VIVO | XENOGRAFTS
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 08/2011, Volume 52, Issue 8, pp. 1276 - 1284
PET with F-18-labeled arginine-glycine-aspartic acid (RGD) peptides can visualize and quantify alpha(v)beta(3) integrin expression in patients, but... 
ANALOGS | angiogenesis | ALPHA-V-BETA-3 INTEGRIN | Ga-68 PET/CT | TUMOR ANGIOGENESIS | PEPTIDE | integrins | POSITRON-EMISSION-TOMOGRAPHY | CANCER-PATIENTS | CHEMISTRY | RGD conjugates | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Cu-64 PET/CT
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 11/2014, Volume 74, Issue 21, pp. 5942 - 5947
The tumor microenvironment dynamically regulates the progression of cancer. In the breast, a unique component of the microenvironment is the myoepithelial... 
EPITHELIAL-CELLS | MICROENVIRONMENT | ONCOLOGY | INTEGRIN | DISEASE | GENE-EXPRESSION | RISK | RECURRENCE | INVASIVE BREAST-CANCER | CARCINOMA IN-SITU | DUCTAL CARCINOMA
Journal Article
by Xu, WC and Luo, T and Li, P and Zhou, CQ and Cui, DX and Pang, B and Ren, QS and Fu, S
INTERNATIONAL JOURNAL OF NANOMEDICINE, ISSN 1178-2013, 2012, Volume 7, pp. 915 - 924
Background: Melanoma is known to be radioresistant and traditional treatments have been intractable. Therefore, novel approaches are required to improve the... 
NANOPARTICLES | integrin alpha(v)beta | G2/M arrest | INTEGRIN | ALPHA-V-BETA-3 | radiosensitivity | melanoma | NANOSCIENCE & NANOTECHNOLOGY | PHARMACOLOGY & PHARMACY | gold nanorods | Arg-Gly-Asp peptides | RADIATION
Journal Article
by Li, ZB and Cai, WB and Cao, QZ and Chen, K and Wu, ZH and He, LN and Chen, XY
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 07/2007, Volume 48, Issue 7, pp. 1162 - 1171
Integrin alpha(v)beta(3) plays a critical role in tumor angiogenesis and metastasis. Suitably radiolabeled cyclic arginine-glycine-aspartic (RGD) peptides can... 
TARGET | DESIGN | ANGIOGENESIS | positron emission tomography (PET) | CANCER | RGD multimer | integrin alpha(v)beta | TRACER | ALPHA-V-BETA-3 | tumor angiogenesis | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | VITRONECTIN RECEPTOR | Cu-64
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 04/2019, Volume 60, Issue 5, pp. 1776 - 1788
PURPOSE. To determine the effects of alpha v beta 3 integrin expression and activation on intraocular pressure (IOP). METHODS. Cre(+/-)beta 3(flox/flox) mice... 
DEXAMETHASONE | FLUID-DYNAMICS | TRABECULAR MESHWORK CELLS | glaucoma | ANTERIOR SEGMENT | ORGAN-CULTURE | IOP | TUMOR ANGIOGENESIS | trabecular meshwork | integrins | INDUCED OCULAR HYPERTENSION | INDUCED GLAUCOMA | OPHTHALMOLOGY | MICE | CORTICOSTEROIDS
Journal Article
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