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ISSN 1355-6037, 2016
$\textbf{Objective}$ Maladaptive repair contributes towards the development of heart failure following myocardial infarction (MI). The α$_{v}$β$_{3}$ integrin... 
remodelling | positron emission tomography | integrin | PET/CT | myocardial infarction
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2017, Volume 16, Issue 10, pp. 2191 - 2200
Glioblastoma (GBM) is the most common primary malignant astrocytoma characterized by extensive invasion, angiogenesis, hypoxia, and micrometastasis. Despite... 
BRAIN-BARRIER | IRRADIATION | THERAPY | ALPHA(V)BETA | ANGIOGENESIS | ONCOLOGY | DRUG-DELIVERY | IN-VIVO | CLINICAL-IMPLICATIONS | TUMOR | EXPRESSION | Liposomes - administration & dosage | Humans | Capillary Permeability - drug effects | Alpha Particles - therapeutic use | Glioblastoma - radiotherapy | Capillary Permeability - radiation effects | Drug Delivery Systems | Neovascularization, Pathologic - pathology | Glioblastoma - genetics | Biological Transport - genetics | Neovascularization, Pathologic - radiotherapy | DNA Damage - drug effects | Actinium | Blood-Brain Barrier - drug effects | Liposomes - chemistry | Animals | Neovascularization, Pathologic - drug therapy | Glioblastoma - pathology | Blood-Brain Barrier - radiation effects | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Mice | Integrin alphaVbeta3 - administration & dosage | Glioblastoma - drug therapy | DNA Damage - radiation effects | Brain | Brain tumors | DNA damage | Glioblastoma | Central nervous system | Membrane permeability | Radioisotopes | Blood | Anticancer properties | Angiogenesis | Blood-brain barrier | Astrocytoma | Deoxyribonucleic acid--DNA | Complications | Alpha rays | Blood vessels | Radiation therapy | Permeability | Barriers | Hypoxia | Antitumor activity | Liposomes | Tumors | Cancer | Index Medicus | Integrin αvβ3 | Drug delivery | Blood brain-tumor barrier | Alpha particle radiotherapy
Journal Article
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 06/2013, Volume 15, Issue 6, pp. 625 - 625
How different integrins that bind to the same type of extracellular matrix protein mediate specific functions is unclear. We report the functional analysis of... 
MIGRATION | INTERACTION DATABASE | QUANTITATIVE PROTEOMICS | ALPHA-V-BETA-3 | IN-VIVO | KINASE | CELL-MATRIX ADHESIONS | MATURATION | ALPHA-V INTEGRINS | FOCAL ADHESIONS | CELL BIOLOGY
Journal Article
Science Translational Medicine, ISSN 1946-6234, 10/2014, Volume 6, Issue 260, pp. 260ra149 - 260ra149
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 08/1999, Volume 146, Issue 3, pp. 673 - 682
Integrin-associated protein (CD47) is a multiply membrane spanning member of the immunoglobulin superfamily that regulates some adhesion-dependent cell... 
DOMAIN | LIGAND-BINDING | plasma membrane | GLYCOLIPID MICRODOMAINS | IDENTIFICATION | PLASMA-MEMBRANE | CELL BIOLOGY | LEUKOCYTE RESPONSE INTEGRIN | vitronectin | cell adhesion | cholesterol | T-CELL ACTIVATION | integrin | THROMBOSPONDIN | RECEPTOR-BINDING | GPI-ANCHORED PROTEINS | Cell organelles | Research | G proteins | Formation | Cholesterol | Plasma membranes
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 02/2016, Volume 15, Issue 2, pp. 232 - 240
We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp-containing octapeptide... 
POTENT | PEPTIDOMIMETICS | STREPTAVIDIN | LIGANDS | ONCOLOGY | ALPHA-V-BETA-3 INTEGRIN | LIBRARY | CANCER
Journal Article
TRAFFIC, ISSN 1398-9219, 04/2012, Volume 13, Issue 4, pp. 610 - 625
Integrin trafficking plays an important role in cellular motility and cytokinesis. Integrins undergo constant endo/exocytic shuttling to facilitate the dynamic... 
ACTIVATION | ALPHA-V-BETA-3 INTEGRIN | recycling | conformation | PLASMA-MEMBRANE | CELL BIOLOGY | ADHESION | VESICULAR-TRANSPORT | CELL-MIGRATION | endocytosis | EARLY ENDOSOMES | integrin | trafficking | ALPHA-5-BETA-1 INTEGRIN
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 07/1998, Volume 142, Issue 2, pp. 595 - 607
The beta 2 integrins and intercellular adhesion molecule-1 (ICAM-1) are important for monocyte migration through inflammatory endothelium. Here we demonstrate... 
L-SELECTIN | MAC-1 CD11B/CD18 | TRANSENDOTHELIAL MIGRATION | ICAM-1 | ADHESION MOLECULES | VASCULAR ENDOTHELIUM | CELL BIOLOGY | SIGNAL-TRANSDUCTION | PHYSIOLOGICAL FLOW | alpha L beta 2 integrin | ICAM-1 CD54 | alpha v beta 3 integrin | CELL-MIGRATION | migration | monocyte | BETA-SUBUNIT | Physiological aspects | Monocytes | Cell adhesion molecules | Endothelium
Journal Article
ANALYTICAL CHEMISTRY, ISSN 0003-2700, 06/2017, Volume 89, Issue 11, pp. 5992 - 5998
We describe a highly sensitive competition ELISA to measure integrin-binding of RGD-peptides in high-throughput without using cells, ECM-proteins, or... 
ALPHA-5-BETA-1 INTEGRINS | CHEMISTRY, ANALYTICAL | ANTAGONIST | LIGANDS | ALPHA-V-BETA-3 | CONFORMATIONAL CONTROL | INHIBITORS | LASSO PEPTIDES | SELECTIVITY | PET
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 11/2004, Volume 64, Issue 21, pp. 8009 - 8014
Noninvasive visualization of cell adhesion molecule alpha(v)beta(3) integrin expression in vivo has been well studied by using the radionuclide imaging... 
BREAST-CANCER | RGD-PEPTIDE | METASTASIS | ANGIOGENESIS | ONCOLOGY | MICROPET | ALPHA-V-BETA-3 | RECEPTOR | CONTRAST | INTEGRIN ALPHA(V)BETA | EXPRESSION
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 07/2019, Volume 203, Issue 5, pp. 1383 - 1391
CD40L plays a major role in immune response and is a major therapeutic target for inflammation. Integrin α5β1 and CD40 simultaneously bind to CD40L. It is... 
CELLS | ADHESION | LIGAND EXPRESSION | ANTAGONIST | GENE | ALPHA(V)BETA | DEFECTIVE MUTANT | ALPHA-V-BETA-3 | VITRONECTIN | IMMUNOLOGY | ALPHA-5-BETA-1 INTEGRIN
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 07/2019, Volume 62, Issue 16, pp. 7417 - 7430
Halogenated L- or D-tryptophan obtained by biocatalytic halogenation was incorporated into RGD peptides together with a variety of alkyl or aryl boronic acids.... 
TRYPTOPHAN | ENZYMATIC HALOGENATION | DESIGN | CHEMISTRY, MEDICINAL | MECHANISM | AMINO-ACIDS | INTEGRIN | ALPHA-V-BETA-3 | PARAMETRIZATION | CHLORINATION | CYCLIC PENTAPEPTIDES | Index Medicus
Journal Article
ACCOUNTS OF CHEMICAL RESEARCH, ISSN 0001-4842, 07/2009, Volume 42, Issue 7, pp. 969 - 980
The alpha(v)beta(3)- and alpha(5)beta(1)-integrins play a key role in angiogenesis, the formation of new vessels in tissues that lack them. By serving as... 
BREAST-CANCER | F-18-LABELED RGD | POSITRON-EMISSION-TOMOGRAPHY | BIODISTRIBUTION CHARACTERISTICS | BIOLOGICAL EVALUATION | DRUG DEVELOPMENT | CYCLIC RGDFK DIMER | INTEGRIN ALPHA(V)BETA | TUMOR ANGIOGENESIS | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-V-BETA-3 EXPRESSION
Journal Article
MOLECULAR BIOLOGY OF THE CELL, ISSN 1059-1524, 06/2013, Volume 24, Issue 11, pp. 1661 - 1675
beta 1 integrin has been shown to promote metastasis in a number of tumor models, including breast, ovarian, pancreatic, and skin cancer; however, the... 
INTEGRIN ALPHA-V-BETA-3 | BINDING DOMAINS | ACTIVATION | MAMMARY-TUMORS | TYROSINE PHOSPHORYLATION | CARCINOMA CELLS | ACTIN POLYMERIZATION | IN-VIVO | TUMOR-CELL INVASION | HUMAN BREAST-CANCER | CELL BIOLOGY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 12/2017, Volume 60, Issue 23, pp. 9874 - 9884
Herein, we report the synthesis and biological characterization of the new peptide psi RGDechi as the first step toward novel targeted theranostics in... 
CHEMISTRY, MEDICINAL | THERAPY | ANTAGONIST | METASTASIS | AMINO-ACIDS | ALPHA-V-BETA-3 INTEGRIN | RESISTANCE | TUMOR ANGIOGENESIS | EXPRESSION | CANCER STEM-CELLS | REAL-TIME
Journal Article
JOURNAL OF NUCLEAR MEDICINE, ISSN 0161-5505, 06/2008, Volume 49, Issue 6, pp. 879 - 886
The integrin alpha(v)beta(3) receptor is upregulated on tumor cells and endothelium and plays important roles in angiogenesis and metastasis. Arg-Gly-Asp (RGD)... 
CELLS | ANGIOGENESIS | PROGNOSTIC INDICATOR | RGD | ALPHA-V-BETA-3 EXPRESSION | tumor | EMISSION-TOMOGRAPHY | INTEGRIN ALPHA(V)BETA | integrin | positron emission tomography | alpha(v)beta | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET
Journal Article
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