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Pharmacology and Therapeutics, ISSN 0163-7258, 2010, Volume 127, Issue 3, pp. 261 - 270
Thioredoxin 1 (Trx 1) is a 12-kDa protein with redox-active dithiol in the active site –Cys–Gly–Pro–Cys– that is ubiquitously present in the human body. Trx 1... 
Metabolic disorder | Inflammation | Thioredoxin-binding protein-2 (TBP-2) | Thioredoxin 1 (Trx 1) | Cancer | INHIBITORY FACTOR MIF | OXIDATIVE STRESS | CARBOHYDRATE RESPONSE ELEMENT | T-CELL LEUKEMIA | ISCHEMIA-REPERFUSION INJURY | INTERACTING PROTEIN | FAMILIAL COMBINED HYPERLIPIDEMIA | PANCREATIC BETA-CELLS | PHARMACOLOGY & PHARMACY | UP-REGULATED PROTEIN-1 | TRANSGENIC MICE | Neoplasms - metabolism | Recombinant Proteins - therapeutic use | Up-Regulation | Metabolic Diseases - pathology | Apoptosis - drug effects | Humans | Oxidative Stress - physiology | Metabolic Diseases - drug therapy | Antineoplastic Agents - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Thioredoxins - genetics | Thioredoxins - pharmacology | Thioredoxins - metabolism | Antineoplastic Agents - pharmacology | Thioredoxins - physiology | Thioredoxins - therapeutic use | Carrier Proteins - physiology | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Neoplasms - drug therapy | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Metabolic Diseases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Cell Proliferation - drug effects | Apoptosis - physiology | Neoplasms - pathology | Care and treatment | Anti-inflammatory drugs | Streptozocin | Leukemia | Glucose | Thioredoxin | T cells | Dextrose | Glucose metabolism | Physiological aspects | Diabetes | Health aspects
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92731
Journal Article
Journal Article
Oxidative Medicine and Cellular Longevity, ISSN 1942-0900, 2016, Volume 2016, pp. 4856431 - 17
Oxidative stress plays an essential role in the development of age-related cataract. Thioredoxin binding protein-2 (TBP-2) is a negative regulator of... 
CLEARANCE | ACTIVATION | INTERACTING PROTEIN | PATHWAY | DEGRADATION | MECHANISMS | SENESCENCE | HUNTINGTIN | EXPRESSION | CATARACT | CELL BIOLOGY | Infection | Oxidative stress | Ionizing radiation | Thioredoxin | Protein binding | Cataracts | Phosphorylation | Research | Kinases | Mammals | Experiments | Autophagy | Proteins | Studies | Chinese medicine | Hospitals | Cell cycle | Alzheimers disease | Apoptosis
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2005, Volume 25, Issue 50, pp. 11645 - 11654
Caspase-1 plays a role in the pathogenesis of a variety of neurological diseases. Caspase-1 activation is an early event in models of Huntington's disease... 
RNA interference | Huntington's disease | Cell death | Cop | Caspase-1 | Rip2 | PATHWAYS | APOPTOSIS | cell death | FUNCTIONAL-ROLE | DOMINANT-NEGATIVE MUTANT | NEUROSCIENCES | INTERLEUKIN-1-BETA CONVERTING-ENZYME | INHIBITION | ISCHEMIC BRAIN-INJURY | MICE | TRANSGENIC MOUSE MODEL | caspase-1 | EXPRESSION | Neurons - pathology | Receptor-Interacting Protein Serine-Threonine Kinases | Humans | Huntington Disease - pathology | Caspase 1 - metabolism | Stem Cells - metabolism | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Neurons - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Huntington Disease - enzymology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - physiology | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Caspase Inhibitors | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - antagonists & inhibitors | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Death - physiology | Caspase 1 - genetics | Huntington Disease - genetics | Stem Cells - pathology | Mice | HeLa Cells | Enzyme Activation - physiology | Neurobiology of Disease
Journal Article
Pediatric Research, ISSN 0031-3998, 02/2010, Volume 67, Issue 2, pp. 138 - 143
Journal Article
Journal Article