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Science, ISSN 0036-8075, 5/2003, Volume 300, Issue 5622, pp. 1145 - 1148
Journal Article
03/2012
Cardiovascular disease, and myocardial infarction (MI) in particular, remains a major burden in the developed world today. In fact, the remodeling process,... 
Interferon Regulatory Factor-3 | Myocardial Infarction | Innate Immunity | 0719 | Cardiac Remodeling
Dissertation
Journal of Immunology, ISSN 0022-1767, 10/2003, Volume 171, Issue 8, pp. 4304 - 4310
We previously reported a new Toll/IL-1R (TIR)-containing molecule, named TIR domain-containing adaptor inducing IFN-beta (TRIF). Although initial study... 
TBK1 | IKK-EPSILON | RECOGNITION | PATHWAY | MOLECULE | ENDOTOXIN | INNATE | COMPONENTS | INDUCTION | IMMUNOLOGY | TIRAP | Membrane Glycoproteins - metabolism | Humans | NF-kappa B - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | DNA-Binding Proteins - metabolism | Interferon Regulatory Factor-3 | Signal Transduction - immunology | Toll-Like Receptors | Membrane Glycoproteins - physiology | Interferon-beta - genetics | Receptors, Cell Surface - physiology | Binding, Competitive - immunology | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Proteins - physiology | NF-kappa B - antagonists & inhibitors | Peptide Fragments - metabolism | Adaptor Proteins, Vesicular Transport - physiology | Gene Expression Regulation - immunology | Adaptor Proteins, Vesicular Transport - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Interferon-beta - biosynthesis | Receptors, Cell Surface - metabolism | I-kappa B Kinase | Protein Binding - immunology | Interferon-beta - antagonists & inhibitors | Receptors, Interleukin-1 - metabolism | Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | TNF Receptor-Associated Factor 6 | Animals | Proteins - metabolism | Amino Acid Motifs - immunology | Receptors, Interleukin-1 - physiology | Mice | Promoter Regions, Genetic - immunology | Protein Structure, Tertiary - physiology
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2016, Volume 111, pp. 804 - 814
Macrolide antibiotics exert immunomodulatory activity by reducing pro-inflammatory cytokine production by airway epithelial cells, fibroblasts, vascular... 
IRF-3 | Innate immunity | Interferon | Airway epithelial cells | Macrolide | PHOSPHORYLATION | TOLL-LIKE RECEPTOR | NECROSIS-FACTOR-ALPHA | RSV BRONCHIOLITIS | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | INFECTION | MACROLIDE ANTIBIOTICS | NF-KAPPA-B | EXPRESSION | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Protein Multimerization | Respiratory Syncytial Virus Infections - metabolism | Interferon Regulatory Factor-3 - genetics | Respiratory Syncytial Virus Infections - immunology | Respiratory Syncytial Virus, Human - genetics | Lung - virology | Transfection | Respiratory Syncytial Virus Infections - drug therapy | Inflammation Mediators - metabolism | Lung - metabolism | Active Transport, Cell Nucleus | Interferons - genetics | Respiratory Syncytial Virus Infections - virology | Respiratory Syncytial Virus, Human - pathogenicity | A549 Cells | Respiratory Syncytial Virus, Human - drug effects | Immunity, Innate - drug effects | Toll-Like Receptor 3 - metabolism | Host-Pathogen Interactions | Signal Transduction - drug effects | Respiratory Syncytial Virus, Human - immunology | Epithelial Cells - immunology | Epithelial Cells - virology | Lung - drug effects | Interferon Regulatory Factor-3 - metabolism | Interferons - metabolism | Clarithromycin - pharmacology | Immunologic Factors - pharmacology | Lung - immunology | Medical colleges | Biological response modifiers | Antibacterial agents | Phosphates | Lung diseases, Obstructive | Clarithromycin | Microbiology | Melanoma | Cystic fibrosis | B cells | Oligomers | Interleukins | Monoclonal antibodies | Mitogens | Health aspects | Telomerase | Protein kinases | Tretinoin
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62729
Heterogeneous nuclear ribonucleoparticule A1/A2 (hnRNP A1/A2) and splicing factor 2/alternative splicing factor (SF2/ASF) are pivotal for precursor messenger... 
LINKING INFLAMMATION | SURVIVAL | IMMUNITY | HEPATOCELLULAR-CARCINOMA | ACTIVATION | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENE-EXPRESSION | IRF-3 | NUCLEAR TRANSLOCATION | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Interferon-beta - immunology | Alternative Splicing | Exons | Coculture Techniques | Humans | Molecular Sequence Data | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - antagonists & inhibitors | Lung Neoplasms - pathology | RNA Precursors - immunology | Interferon Regulatory Factor-3 - genetics | Base Sequence | Leukocytes, Mononuclear - immunology | Chemokine CXCL10 - immunology | Interferon-beta - genetics | Nuclear Proteins - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics | Interferon Regulatory Factor-3 - immunology | RNA-Binding Proteins - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Immunomodulation | Introns | RNA-Binding Proteins - immunology | Gene Expression Regulation | RNA Precursors - genetics | Nuclear Proteins - immunology | Heterogeneous Nuclear Ribonucleoprotein A1 | Carcinoma, Non-Small-Cell Lung - immunology | Leukocytes, Mononuclear - pathology | Lung Neoplasms - immunology | Chemokine CXCL10 - genetics | Nuclear Proteins - antagonists & inhibitors | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - immunology | Serine-Arginine Splicing Factors | Cell Line, Tumor | Infection | Messenger RNA | Genes | Lung cancer, Small cell | Interferon | Biological response modifiers | Lung cancer, Non-small cell | Health aspects | Alternative splicing | β-Interferon | Lung cancer | Interleukin | Amino acids | Leukocytes (mononuclear) | Infections | Antagonists | mRNA | Metastasis | Proteins | Microorganisms | Peripheral blood mononuclear cells | IP-10 protein | Tumor necrosis factor-TNF | Binding | Medical research | Splicing | RNA-mediated interference | Non-small cell lung carcinoma | Cultures | Inflammation | Tumor necrosis factor-α | Gene expression | Ribonucleic acids | Interferon regulatory factor 3 | Electrophoretic mobility | CXCL10 protein | Interleukin 10 | Laboratory animals | Splicing factors | Chemokines | Interferon regulatory factor | Cervical cancer | Viral infections | Cancer | Tumors | Geriatrics
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 07/1998, Volume 12, Issue 13, pp. 2061 - 2072
Journal Article
Apoptosis, ISSN 1360-8185, 07/2017, Volume 22, Issue 7, pp. 920 - 932
Breast cancer is one of the most lethal malignancies for women. Retinoic acid (RA) and double-stranded RNA (dsRNA) are considered signaling molecules with... 
dsRNA | Breast cancer | TRAIL | Type-I IFNs | IRF3 | Retinoic acid | ACTIVATION | IRF-3 TRANSCRIPTION FACTOR | POSITIVE FEEDBACK | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOLLOW-UP | RANDOMIZED TRIAL | CELL BIOLOGY | PHASE-III TRIAL | LUNG-CANCER | DEATH LIGAND TRAIL | TOLL-LIKE RECEPTORS | INNATE IMMUNITY | Tretinoin - administration & dosage | RNA, Double-Stranded - administration & dosage | Apoptosis - drug effects | Humans | Apoptosis - genetics | Breast Neoplasms - drug therapy | Interferon Regulatory Factor-3 - genetics | Receptors, Tumor Necrosis Factor, Member 10c - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Interferon Type I - genetics | Female | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Toll-Like Receptor 3 - genetics | Gene Expression Regulation, Neoplastic - drug effects | TNF-Related Apoptosis-Inducing Ligand - genetics | GPI-Linked Proteins - genetics | RNA | Cancer cells | Interferon | Biological response modifiers | Tretinoin | Apoptosis | Surgical implants | Correlation | Paracrine signalling | Activation | Caspase-3 | Anticancer properties | Receptors | Biomedical materials | Toll-like receptors | Biocompatibility | Inhibition | Autocrine signalling | Pathogens | Double-stranded RNA | Caspase | Poly (I:C) | TLR3 protein | Caspase-8 | Depletion | Ribonucleic acids | Interferon regulatory factor 3 | Breast | Antitumor activity | TRAIL protein | Interferon regulatory factor | Recognition | Cancer
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, p. e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article