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Journal of Biotechnology, ISSN 0168-1656, 02/2019, Volume 291, pp. 17 - 25
Antibody-cytokine fusion proteins are a class of biopharmaceuticals, with the potential to modulate the activity of the immune system at the site of disease.... 
Linker optimization | Tumor targeting | Interleukin-12 | Fibronectin | Immunocytokines | ANTIBODY | CYTOKINE | CANCER | ANTITUMOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | FIBRONECTIN ISOFORM | CHRONIC INFLAMMATION | EXPRESSION | TARGETED DELIVERY | Fibronectins | Care and treatment | Biological products | Interleukins | Immunoglobulin G | Amino acids | Cancer | Index Medicus
Journal Article
World Journal of Microbiology and Biotechnology, ISSN 0959-3993, 9/2017, Volume 33, Issue 9, pp. 1 - 11
We report a new recombinant fusion protein composed of full-length Legionella pneumophila flagellin A and peptidoglycan-associated lipoprotein (PAL), rFLA-PAL,... 
Biochemistry, general | Flagellin A | Biotechnology | Chemistry | Microbiology | Environmental Engineering/Biotechnology | Applied Microbiology | Legionella pneumophila | PAL | Vaccine | Fusion protein | MACROPHAGES | LEGIONNAIRES-DISEASE | INDUCTION | PNEUMONIA | A/J MOUSE MODEL | RESPONSES | INTRACELLULAR GROWTH | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFECTION | LIPOPROTEIN PAL | EXPRESSION | Recombinant Fusion Proteins - immunology | Genes, Bacterial - genetics | Bacterial Vaccines - genetics | Antigens, Bacterial - immunology | Legionella pneumophila - genetics | Interferon-gamma - metabolism | Peptidoglycan - immunology | Antigens, Bacterial - genetics | Antibodies, Bacterial | Legionnaires' Disease - immunology | Legionnaires' Disease - prevention & control | Bacteremia - prevention & control | Escherichia coli - metabolism | Flagellin - genetics | Female | Legionella pneumophila - pathogenicity | Disease Models, Animal | Legionella pneumophila - immunology | Flagellin - immunology | Immunization | Cytokines - metabolism | Interleukin-12 | Survival Rate | Peptidoglycan - genetics | Recombinant Proteins - genetics | Recombinant Fusion Proteins - chemistry | Tumor Necrosis Factor-alpha | Animals | Analysis of Variance | Bacterial Vaccines - immunology | Recombinant Proteins - immunology | Escherichia coli - genetics | Recombinant Fusion Proteins - genetics | Mice | Mice, Inbred BALB C | Gene Expression Regulation, Bacterial | Immunity, Cellular | Viral antibodies | Antigens | Immune response | Analysis | Escherichia coli | Genetically modified organisms | Antibodies | Genetic engineering | Recombinant proteins | Chromatography | Intravenous administration | Peptidoglycans | Flagellin | Cultures | Interleukin 12 | Immunity | Immunity (cell-mediated) | Bacteremia | Lethal dose | Proteins | Immunology | FlaA protein | Tumor necrosis factor | Interferon | Recombinant | Index Medicus
Journal Article
Journal Article
International Journal of Oncology, ISSN 1019-6439, 6/2016, Volume 48, Issue 6, pp. 2381 - 2386
Whereas cancer immunotherapy with cytokines in recent research was demonstrated effective in activating immune response against tumor cells, one major obstacle... 
Fas | apoptosis | natural killer cell | interleukin-12 | Natural killer cell | Interleukin-12 | Apoptosis | Care and treatment | Gene therapy | Immunotherapy | Methods | Innovations | Cancer | Proteins | Enzymes | Cytokines | Cloning | Ligands | Tumor necrosis factor-TNF | Cytotoxicity | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e44482 - e44482
Successful immunotherapy of Hodgkin's disease is so far hampered by the striking unresponsiveness of lymphoma infiltrating immune cells. To mobilize both... 
REED-STERNBERG CELLS | CYTOKINES | FRAGMENTS | IMMUNE-SYSTEM | MULTIDISCIPLINARY SCIENCES | ANTI-CD16/CD30 BISPECIFIC ANTIBODY | DISEASE | LYSIS | SUBSETS | TUMOR-CELLS | EXPRESSION | Recombinant Fusion Proteins - immunology | Interleukin-12 - genetics | Dendritic Cells - immunology | Humans | Ki-1 Antigen - immunology | Recombinant Fusion Proteins - metabolism | Single-Chain Antibodies - metabolism | Flow Cytometry | Interleukin-2 - immunology | Single-Chain Antibodies - genetics | Killer Cells, Natural - immunology | Dendritic Cells - metabolism | Interleukin-2 - metabolism | Interleukin-12 - metabolism | Mice, SCID | Interleukin-2 - genetics | Animals | Hodgkin Disease - therapy | Interleukin-12 - immunology | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Hodgkin Disease - immunology | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Single-Chain Antibodies - immunology | Killer cells | Care and treatment | Interleukins | Immunotherapy | Physiological aspects | Genetic aspects | Research | Non-Hodgkin's lymphomas | T cells | Spatial discrimination | Cytotoxicity | Lymphocytes T | Vaccines | Anticancer properties | Proteins | Cell activation | CD30 antigen | Interleukin 2 | Lymphocytes | Animal tissues | Interleukin 1 | Fusion protein | Reed-Sternberg cells | Antigens | Immunoglobulins | Cytokines | Interleukin 12 | Inflammation | Lymphoma | Immune systems | γ-Interferon | Lymphomas | Interferon | Hodgkin's disease | Cancer | Tumors | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 7, pp. 1998 - 2005
Purpose: AS1409 is a fusion protein comprising a humanized antibody BC1 linked to interleukin-12 (IL-12). It is designed to deliver IL-12 to tumor-associated... 
TRIAL | IMMUNOCYTOKINE | INTERFERON-GAMMA | ONCOLOGY | B-CONTAINING FIBRONECTIN | INTERLEUKIN-12 | ISOFORM | ANTITUMOR-ACTIVITY | TUMORS | Interleukin-12 - genetics | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Kidney Neoplasms - immunology | Male | Antineoplastic Agents - therapeutic use | Carcinoma, Renal Cell - immunology | Young Adult | Adult | Female | Antineoplastic Agents - pharmacokinetics | Interleukin-12 - therapeutic use | Carcinoma, Renal Cell - drug therapy | Antibodies - therapeutic use | Interleukin-12 - pharmacokinetics | Antigens, Neoplasm - immunology | Treatment Outcome | Melanoma - pathology | Tumor Burden - drug effects | Melanoma - immunology | Melanoma - drug therapy | Recombinant Fusion Proteins - pharmacokinetics | Recombinant Fusion Proteins - genetics | Antibodies - genetics | Kidney Neoplasms - pathology | Aged | Kidney Neoplasms - drug therapy | Interferon-gamma - blood | Index Medicus | Headache | Immune response | Toxicity | Immune response (cell-mediated) | Liver | biomarkers | Melanoma | Antibodies | Clinical trials | Fatigue | Interleukin 12 | transaminase | imaging | Fever | Fibronectin | Metabolic response | Atrophy | renal cell carcinoma | Vomiting | gamma -Interferon | IP-10 protein | Fusion protein | Pharmacokinetics | EDB-fibronectin | malignant melanoma | monoclonal antibody | interleukin-12 | phase 1 trial
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 10, pp. 6561 - 6568
Because Mycobacterium bovis bacillus Calmette-Guerin (BCG) unconvincingly activates human naive CD8(+) T cells, a rBCG (BCG-70M) that secretes a fusion protein... 
MYCOBACTERIUM-TUBERCULOSIS | HEAT-SHOCK-PROTEIN-70 | DENDRITIC CELLS | IMMUNOSTIMULATORY ACTIVITY | BOVIS BCG | VACCINE | PEPTIDE BINDING | IMMUNOLOGY | LEPRAE | LEPROSY | ANTIGEN | Recombinant Fusion Proteins - immunology | Dendritic Cells - immunology | Humans | Brefeldin A - pharmacology | Interferon-gamma - metabolism | Recombinant Fusion Proteins - metabolism | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Acetylcysteine - analogs & derivatives | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Dendritic Cells - metabolism | Matrix Metalloproteinase 2 - immunology | HSP70 Heat-Shock Proteins - immunology | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Membrane Proteins - immunology | Interleukin-12 - metabolism | Toll-Like Receptor 2 - metabolism | HSP70 Heat-Shock Proteins - metabolism | Animals | Cross-Priming - immunology | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Acetylcysteine - pharmacology | BCG Vaccine - immunology | Interleukin-12 - immunology | Toll-Like Receptor 2 - immunology | Anti-Bacterial Agents - pharmacology | Mice | CD8-Positive T-Lymphocytes - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, pp. e31908 - e31908
Tuberculosis (TB) remains a major worldwide health problem. The only vaccine against TB, Mycobacterium bovis Bacille Calmette-Guerin (BCG), has demonstrated... 
PHAGOSOME MATURATION | LATENT INFECTION | HEPARIN-BINDING HEMAGGLUTININ | DNA VACCINES | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | ACTIVE DISEASE | CALMETTE-GUERIN VACCINATION | BCG VACCINATION | CHEMOTHERAPY | Lung - microbiology | Spleen - immunology | Mycobacterium smegmatis - metabolism | Recombinant Fusion Proteins - pharmacology | Humans | Recombinant Fusion Proteins - therapeutic use | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Tuberculosis - microbiology | Membrane Proteins - pharmacology | Spleen - drug effects | Membrane Proteins - therapeutic use | Protective Agents - therapeutic use | Th1 Cells - immunology | Mycobacterium tuberculosis - drug effects | Bacterial Proteins - therapeutic use | Spleen - microbiology | Protective Agents - pharmacology | Tuberculosis - drug therapy | Cloning, Molecular | Interleukin-12 - therapeutic use | Tuberculosis - blood | Tuberculosis Vaccines - immunology | Interleukin-12 - pharmacology | Mycobacterium smegmatis - growth & development | Th1 Cells - drug effects | Immunization | Lung - pathology | Tuberculosis Vaccines - administration & dosage | Treatment Outcome | Enzyme-Linked Immunospot Assay | Blotting, Western | Tuberculosis - immunology | Bacterial Proteins - pharmacology | Phenotype | Animals | Interferon-gamma - immunology | Lung - drug effects | Fluorescent Antibody Technique | Mycobacterium smegmatis - drug effects | Mice | Lung - immunology | Recombination, Genetic - drug effects | Tuberculosis vaccines | Tuberculosis | Interleukins | Vaccination | Lectins | Antitubercular agents | Anticoagulants (Medicine) | Protein binding | Interleukin | Infections | Lymphocytes T | Vaccines | Proteins | Immunology | Interleukin 2 | DNA methylation | Hemagglutinins | Bacteria | Fusion protein | Deoxyribonucleic acid--DNA | Recombinant | Antigens | Immune response | Cytokines | Cloning | BCG | Interleukin 12 | Strain | Chemotherapy | Lungs | γ-Interferon | Heparin | Laboratory animals | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article