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1. Full Text IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3
by Zhu, Pingping and Zhu, Xiaoxiao and Wu, Jiayi and He, Luyun and Lu, Tiankun and Wang, Yanying and Liu, Benyu and Ye, Buqing and Sun, Lei and Fan, Dongdong and Wang, Jing and Yang, Liuliu and Qin, Xiwen and Du, Ying and Li, Chong and He, Lei and Ren, Weizheng and Wu, Xin and Tian, Yong and Fan, Zusen
Nature immunology, ISSN 1529-2908, 02/2019, Volume 20, Issue 2, pp. 183 - 194
Life Sciences & Biomedicine | Immunology | Science & Technology | Cell Self Renewal - immunology | Intestinal Mucosa - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Interleukin-13 - immunology | RNA, Messenger - metabolism | Colitis, Ulcerative - immunology | RNA - genetics | Cell Self Renewal - genetics | Intestinal Mucosa - cytology | beta Catenin - immunology | Signal Transduction - immunology | Interleukin-13 Receptor alpha1 Subunit - immunology | Lymphocytes - immunology | Intestinal Mucosa - immunology | Regeneration - genetics | Female | RNA, Circular | Disease Models, Animal | RNA - metabolism | Lymphocytes - metabolism | RNA - immunology | Mice, Inbred C57BL | Signal Transduction - genetics | Interleukin-13 - metabolism | beta Catenin - metabolism | Mice, Inbred ICR | Dextran Sulfate - toxicity | Mice, Knockout | Interleukin-13 Receptor alpha1 Subunit - genetics | Carrier Proteins - genetics | Cell Differentiation - immunology | Animals | Colitis, Ulcerative - chemically induced | Stem Cells - physiology | Mice | Regeneration - immunology | Interleukin-13 Receptor alpha1 Subunit - metabolism | Research | RNA | Gene expression | Interleukin-13 | Stem cells | Translocation | Lymphoid cells | Stem cell transplantation | Homeostasis | Interleukin 13 | Gene deletion | Epithelium | Ribonucleic acid--RNA | Nuclear transport | Foxp1 protein | Regeneration | β-catenin | Signaling | Clonal deletion | Intestine | Interleukin 1 | Circular RNA | Immune system | Cytokines | β-Catenin | Index Medicus
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2. Full Text Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13
by Hallett, Miranda A and Venmar, Katherine T and Fingleton, Barbara
Cancer research (Chicago, Ill.), ISSN 0008-5472, 12/2012, Volume 72, Issue 24, pp. 6338 - 6343
Life Sciences & Biomedicine | Oncology | Science & Technology | Interleukin-13 - physiology | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Neoplasms, Glandular and Epithelial - metabolism | Receptors, Interleukin-13 - metabolism | Neoplasms, Glandular and Epithelial - immunology | Cytokines - physiology | Neoplasms, Glandular and Epithelial - genetics | Interleukin-4 - pharmacology | Receptors, Interleukin-13 - physiology | Interleukin-4 - physiology | Neoplasms, Glandular and Epithelial - pathology | Interleukin-4 - metabolism | Receptors, Interleukin-4 - metabolism | Epithelial Cells - pathology | Interleukin-13 - metabolism | Interleukin-13 - pharmacology | Receptors, Interleukin-13 - genetics | Stimulation, Chemical | Animals | Receptors, Interleukin-4 - physiology | Models, Biological | Epithelial Cells - immunology | Receptors, Interleukin-4 - genetics | Cytokines - pharmacology | Index Medicus
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3. Full Text Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System
by LaPorte, Sherry L and Juo, Z. Sean and Vaclavikova, Jana and Colf, Leremy A and Qi, Xiulan and Heller, Nicola M and Keegan, Achsah D and Garcia, K. Christopher
Cell (Cambridge), ISSN 0092-8674, 2008, Volume 132, Issue 2, pp. 259 - 272
MOLIMMUNO | SIGNALING | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | Receptors, Interleukin-4 - chemistry | Humans | Molecular Sequence Data | Crystallography, X-Ray | Histidine - metabolism | Receptors, Interleukin-13 - metabolism | Dose-Response Relationship, Drug | Thermodynamics | Interleukin-13 - genetics | Interleukin-4 - pharmacology | Molecular Mimicry | X-Ray Diffraction | Interleukin-13 - isolation & purification | Receptors, Interleukin-13 - chemistry | Interleukin-4 - genetics | Receptors, Cytokine - metabolism | Binding Sites | Dimerization | STAT3 Transcription Factor - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Protein Structure, Secondary | Signal Transduction | Interleukin-4 - metabolism | Receptors, Interleukin-4 - metabolism | Models, Molecular | STAT6 Transcription Factor - metabolism | Interleukin-13 - metabolism | Interleukin-13 - pharmacology | Sequence Homology, Amino Acid | Tyrosine - metabolism | Interleukin-4 - isolation & purification | Hydrogen Bonding | Receptors, Cytokine - chemistry | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Kinetics | Cytokines | Interleukins | Physiological aspects | Index Medicus
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4. Full Text IL-13 Induces Esophageal Remodeling and Gene Expression by an Eosinophil-Independent, IL-13R alpha 2-Inhibited Pathway
by Zuo, Li and Fulkerson, Patricia C and Finkelman, Fred D and Mingler, Melissa and Fischetti, Christine A and Blanchard, Carine and Rothenberg, Marc E
The Journal of immunology (1950), ISSN 0022-1767, 07/2010, Volume 185, Issue 1, pp. 660 - 669
Life Sciences & Biomedicine | Immunology | Science & Technology | Eosinophils - metabolism | Interleukin-13 - physiology | Humans | Gene Expression Profiling | Eosinophils - immunology | Esophagitis - pathology | Eosinophilia - pathology | Interleukin-13 - biosynthesis | Esophagitis - genetics | Interleukin-13 Receptor alpha2 Subunit - physiology | Signal Transduction - immunology | Interleukin-13 - genetics | Pulmonary Alveoli - metabolism | Eosinophilia - genetics | Eosinophils - pathology | Disease Models, Animal | Pulmonary Alveoli - pathology | Mice, Transgenic | Up-Regulation - genetics | Signal Transduction - genetics | Down-Regulation - genetics | Interleukin-13 Receptor alpha2 Subunit - antagonists & inhibitors | Mice, Knockout | Esophagitis - immunology | Animals | Eosinophilia - immunology | Up-Regulation - immunology | Down-Regulation - immunology | Interleukin-13 Receptor alpha2 Subunit - genetics | Mice | Mice, Inbred BALB C | Pulmonary Alveoli - immunology | Index Medicus | Abridged Index Medicus
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5. Full Text Direct control of hepatic glucose production by interleukin-13 in mice
by Stanya, Kristopher J and Jacobi, David and Liu, Sihao and Bhargava, Prerna and Dai, Lingling and Gangl, Matthew R and Inouye, Karen and Barlow, Jillian L and Ji, Yewei and Mizgerd, Joseph P and Qi, Ling and Shi, Hang and McKenzie, Andrew N.J and Lee, Chih-Hao
The Journal of clinical investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 261 - 271
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Liver - pathology | Diabetes Mellitus, Type 2 - genetics | Interleukin-13 - immunology | Th2 Cells - immunology | Diabetes Mellitus, Type 2 - metabolism | Th1 Cells - immunology | Hyperglycemia - genetics | Th1 Cells - metabolism | Interleukin-13 - genetics | Interleukin-13 Receptor alpha1 Subunit - immunology | Liver - immunology | Diabetes Mellitus, Type 2 - immunology | Hyperglycemia - pathology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Glucose - immunology | Liver - metabolism | Hyperglycemia - immunology | Gluconeogenesis - immunology | Glucose - genetics | Interleukin-13 - metabolism | Th2 Cells - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Interleukin-13 Receptor alpha1 Subunit - genetics | Animals | Gluconeogenesis - genetics | Insulin Resistance - genetics | Glucose - metabolism | Insulin Resistance - immunology | Mice | Mice, Inbred BALB C | Diabetes Mellitus, Type 2 - pathology | STAT3 Transcription Factor - immunology | Interleukin-13 Receptor alpha1 Subunit - metabolism | Physiological aspects | Glucose metabolism | Hyperglycemia | Research | Blood sugar | Diabetes therapy | Index Medicus | Abridged Index Medicus
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6. Full Text Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion
by Varin, Audrey and Mukhopadhyay, Subhankar and Herbein, Georges and Gordon, Siamon
Blood, ISSN 0006-4971, 01/2010, Volume 115, Issue 2, pp. 353 - 362
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Interleukin-13 - immunology | Th2 Cells - immunology | Proto-Oncogene Proteins c-akt - genetics | Interleukin-13 - genetics | Interleukin-4 - pharmacology | Time Factors | Myeloid Differentiation Factor 88 - immunology | Neisseria meningitidis, Serogroup B | Phosphorylation - immunology | Phosphorylation - drug effects | Receptors, Immunologic - immunology | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Myeloid Differentiation Factor 88 - genetics | Macrophages, Peritoneal - immunology | Receptors, Cell Surface - metabolism | Interleukin-13 - metabolism | Receptors, Cell Surface - immunology | Th2 Cells - metabolism | Macrophage Activation | Mice, Knockout | Interleukin-4 - immunology | Interleukin-4 - secretion | Animals | Proto-Oncogene Proteins c-akt - immunology | Mice | Macrophages, Peritoneal - metabolism | Receptors, Immunologic - genetics | Myeloid Differentiation Factor 88 - metabolism | Phagocytosis | Receptors, Immunologic - metabolism | Receptors, Cell Surface - genetics | Index Medicus | Abridged Index Medicus | Interleukin-4 | Phosphorylation | Macrophages, Peritoneal | Interleukin-13 | Receptors, Cell Surface | Myeloid Differentiation Factor 88 | Th2 Cells | Proto-Oncogene Proteins c-akt | Life Sciences | Immunology | Receptors, Immunologic | Phagocytes, Granulocytes, and Myelopoiesis
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7. Full Text Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency
by Moraga, Ignacio and Richter, David and Wilmes, Stephan and Winkelmann, Hauke and Jude, Kevin and Thomas, Christoph and Suhoski, Megan M and Engleman, Edgar G and Piehler, Jacob and Garcia, K. Christopher
Science signaling, ISSN 1945-0877, 11/2015, Volume 8, Issue 402, pp. ra114 - ra114
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | Humans | Protein Multimerization | Crystallography, X-Ray | Interleukin-4 Receptor alpha Subunit - genetics | Genetic Variation | Endocytosis | Interleukin-13 - genetics | Protein Engineering | Protein Structure, Quaternary | Receptors, Cytokine - metabolism | Receptors, Cytokine - genetics | Recombinant Proteins - metabolism | Cell Line | Interleukin-4 Receptor alpha Subunit - metabolism | Biophysical Phenomena | Signal Transduction | Models, Molecular | Recombinant Proteins - chemistry | Interleukin-13 - chemistry | Recombinant Proteins - genetics | STAT6 Transcription Factor - metabolism | Interleukin-13 - metabolism | Interleukin-13 Receptor alpha1 Subunit - genetics | Interleukin-13 Receptor alpha1 Subunit - chemistry | Models, Biological | Receptors, Cytokine - chemistry | Protein Binding | Ligands | HeLa Cells | Interleukin-13 Receptor alpha1 Subunit - metabolism | Interleukin-4 Receptor alpha Subunit - chemistry | Index Medicus
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8. Full Text IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2
by Kasaian, Marion T and Raible, Donald and Marquette, Kimberly and Cook, Timothy A and Zhou, Simon and Tan, Xiang-Yang and Tchistiakova, Lioudmila
The Journal of immunology (1950), ISSN 0022-1767, 07/2011, Volume 187, Issue 1, pp. 561 - 569
Interleukin-13 Receptor alpha2 Subunit - metabolism | Isoantibodies - physiology | Dose-Response Relationship, Immunologic | Interleukin-13 - antagonists & inhibitors | Humans | Antibody-Dependent Cell Cytotoxicity - immunology | Interleukin-13 - immunology | Macaca fascicularis | Interleukin-13 - metabolism | Receptors, Scavenger - antagonists & inhibitors | Extracellular Space - immunology | Interleukin-13 Receptor alpha2 Subunit - antagonists & inhibitors | Drug Delivery Systems | HT29 Cells | Interleukin-13 Receptor alpha2 Subunit - biosynthesis | Extracellular Space - metabolism | Animals | Receptors, Scavenger - physiology | Mice | Mice, Inbred BALB C | Receptors, Scavenger - metabolism | Index Medicus | Abridged Index Medicus
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9. Full Text Regulation of IFN‐γ by IL‐13 dictates susceptibility to secondary postinfluenza MRSA pneumonia
by Rynda‐Apple, Agnieszka and Harmsen, Ann and Erickson, Anfin S and Larson, Kyle and Morton, Rachelle V and Richert, Laura E and Harmsen, Allen G
European journal of immunology, ISSN 0014-2980, 11/2014, Volume 44, Issue 11, pp. 3263 - 3272
IFN‐γ ⋅ IL‐13 ⋅ Influenza ⋅ Methicillin‐resistant Staphylococcus aureus (MRSA) ⋅ Secondary‐bacterial infections | IFN-γ | IL-13 | Methicillin-resistant Staphylococcus aureus (MRSA) | Secondary-bacterial infections | Influenza | Life Sciences & Biomedicine | Immunology | Science & Technology | Lung - microbiology | Coinfection | Interleukin-13 - immunology | Viral Load | Interleukin-13 Receptor alpha2 Subunit - biosynthesis | Interleukin-13 - genetics | Lung - virology | Superinfection - microbiology | Interferon-gamma - genetics | Disease Susceptibility | Staphylococcal Infections - immunology | Mice, Inbred C57BL | Methicillin-Resistant Staphylococcus aureus - immunology | Bacterial Load | Recombinant Proteins - pharmacology | Interleukin-13 - pharmacology | Interleukin-13 Receptor alpha2 Subunit - antagonists & inhibitors | Mice, Knockout | Superinfection - immunology | Animals | Interleukin-13 Receptor alpha2 Subunit - immunology | Pneumonia, Bacterial - immunology | Mice | Mice, Inbred BALB C | Orthomyxoviridae Infections - immunology | Index Medicus
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10. Full Text Interleukin-13 drives metabolic conditioning of muscle to endurance exercise
by Knudsen, Nelson H and Stanya, Kristopher J and Hyde, Alexander L and Chalom, Mayer M and Alexander, Ryan K and Liou, Yae-Huei and Starost, Kyle A and Gangl, Matthew R and Jacobi, David and Liu, Sihao and Sopariwala, Danesh H and Fonseca-Pereira, Diogo and Li, Jun and Hu, Frank B and Garrett, Wendy S and Narkar, Vihang A and Ortlund, Eric A and Kim, Jonathan H and Paton, Chad M and Cooper, Jamie A and Lee, Chih-Hao
Science (American Association for the Advancement of Science), ISSN 0036-8075, 05/2020, Volume 368, Issue 6490, p. 488
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Mitochondria, Muscle - metabolism | Male | Muscle, Skeletal - metabolism | Interleukin-13 - genetics | Myoblasts - metabolism | Glycogen - metabolism | Female | Fatty Acids - metabolism | Interleukin-13 - blood | Physical Conditioning, Animal | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell Line | Oxidation-Reduction | Mice, Inbred C57BL | Interleukin-13 - metabolism | Mice, Knockout | Interleukin-13 Receptor alpha1 Subunit - genetics | Adaptation, Physiological - immunology | Animals | Running | Mice | Blood Glucose - metabolism | Physical Endurance - immunology | Interleukin-13 Receptor alpha1 Subunit - metabolism | Adaptations | Physical training | Physical activity | Downstream effects | Cell interactions | Electron transport chain | Signal transduction | Mitochondria | Exercise | Fitness training programs | Cytokines | Durability | Interleukin 13 | Metabolism | Gene expression | Ablation | Fatty acids | Substrates | Physical fitness | Molecular modelling | Leukocytes (granulocytic) | Gene regulation | Homeostasis | Biosynthesis | Lymphocytes T | Activation | Parasites | Tissues | Adaptive control | Physiological responses | Glucose metabolism | Energy resources | Immunology | Interleukin 1 | Substrate preferences | Fuel economy | Oxidation | Endurance | Oxygen demand | Glycogen | Hypersensitivity | Muscles | Ribonucleic acid--RNA | Skeletal muscle | Glucose tolerance | Musculoskeletal system | Exercise physiology | Nuclear fuels | Utilization | Glycolysis | Energy demand | Respiration | Electron transport | Fitness | Index Medicus
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11. Full Text Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
by Gauvreau, Gail M and Boulet, Louis-Philippe and Cockcroft, Donald W and Fitzgerald, J. Mark and Carlsten, Chris and Davis, Beth E and Deschesnes, Francine and Duong, Mylinh and Durn, Billie L and Howie, Karen J and Hui, Linda and Kasaian, Marion T and Killian, Kieran J and Strinich, Tara X and Watson, Richard M and Nathalie, Y and Zhou, Simon and Raible, Donald and O'Byrne, Paul M
American journal of respiratory and critical care medicine, ISSN 1073-449X, 04/2011, Volume 183, Issue 8, pp. 1007 - 1014
Allergen inhalation challenge | Late asthmatic response | Anti-interleukin-13 therapy | Mild asthma | Airway inflammation | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Sputum - cytology | Double-Blind Method | Immunoglobulin G - blood | Interleukin-13 - antagonists & inhibitors | Humans | Middle Aged | Immunoglobulin G - therapeutic use | Interleukin-13 - immunology | Male | Treatment Outcome | Asthma - drug therapy | Forced Expiratory Volume | Young Adult | Antibodies, Neutralizing - immunology | Sputum - immunology | Allergens - immunology | Immunoglobulin G - immunology | Antibodies, Neutralizing - therapeutic use | Adolescent | Adult | Female | Antibodies, Neutralizing - blood | Interleukin-13 - blood | Index Medicus | Abridged Index Medicus
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