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1. Full Text Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System
by LaPorte, Sherry L and Juo, Z. Sean and Vaclavikova, Jana and Colf, Leremy A and Qi, Xiulan and Heller, Nicola M and Keegan, Achsah D and Garcia, K. Christopher
Cell, ISSN 0092-8674, 2008, Volume 132, Issue 2, pp. 259 - 272
Interleukin-4 and Interleukin-13 are cytokines critical to the development of T cell-mediated humoral immune responses, which are associated with allergy and... 
MOLIMMUNO | SIGNALING | SEVERE COMBINED IMMUNODEFICIENCY | COMPLEX | ALPHA-CHAIN | JUXTAMEMBRANE DOMAIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMMON GAMMA-CHAIN | IL-4 RECEPTOR | THERAPEUTIC TARGETS | FUNCTIONAL COMPONENT | BINDING | CELL BIOLOGY | Phosphorylation | Receptors, Interleukin-4 - chemistry | Humans | Molecular Sequence Data | Crystallography, X-Ray | Histidine - metabolism | Receptors, Interleukin-13 - metabolism | Dose-Response Relationship, Drug | Thermodynamics | Interleukin-13 - genetics | Interleukin-4 - pharmacology | Molecular Mimicry | X-Ray Diffraction | Interleukin-13 - isolation & purification | Receptors, Interleukin-13 - chemistry | Interleukin-4 - genetics | Receptors, Cytokine - metabolism | Binding Sites | Dimerization | STAT3 Transcription Factor - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Protein Structure, Secondary | Signal Transduction | Interleukin-4 - metabolism | Receptors, Interleukin-4 - metabolism | Models, Molecular | STAT6 Transcription Factor - metabolism | Interleukin-13 - metabolism | Interleukin-13 - pharmacology | Sequence Homology, Amino Acid | Tyrosine - metabolism | Interleukin-4 - isolation & purification | Hydrogen Bonding | Receptors, Cytokine - chemistry | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Kinetics | Cytokines | Interleukins | Physiological aspects
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2. Full Text IL-13 and IL-13Rα1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation
by Zhang, Mingzhi and Zhang, Yanjie and Li, Zhaoming and Li, Chaoping
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 4, pp. 2715 - 2720
Extranodal NK/T cell lymphoma (NKTCL) is a rare but aggressive subtype of non-Hodgkin lymphoma. Multi-agent chemotherapy and involved-field radiotherapy are... 
Extranodal NK/T cell lymphoma | P-stat6 | Interleukin-13Rα1 | Autocrine factor | Interleukin-13 | Autocrine Communication | Prognosis | Interleukin-13 - antagonists & inhibitors | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | STAT6 Transcription Factor - genetics | STAT6 Transcription Factor - metabolism | Interleukin-13 - metabolism | Interleukin-13 - pharmacology | Case-Control Studies | Disease Progression | Antibodies - pharmacology | Dose-Response Relationship, Drug | Interleukin-13 Receptor alpha1 Subunit - genetics | Lymphoma, Extranodal NK-T-Cell - genetics | Interleukin-13 - genetics | Lymphoma, Extranodal NK-T-Cell - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Phosphorylation - drug effects | Interleukin-13 Receptor alpha1 Subunit - metabolism | Lymphoma, Extranodal NK-T-Cell - metabolism
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3. Full Text IL-13 Induces Esophageal Remodeling and Gene Expression by an Eosinophil-Independent, IL-13R alpha 2-Inhibited Pathway
by Zuo, L and Fulkerson, PC and Finkelman, FD and Mingler, M and Fischetti, CA and Blanchard, C and Rothenberg, ME
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2010, Volume 185, Issue 1, pp. 660 - 669
Eosinophilic esophagitis (EE) is an emerging disease associated with both food and respiratory allergy characterized by extensive esophageal tissue remodeling... 
FIBROSIS | LUNG | RESPONSES | INFLAMMATION | IMMUNOLOGY | RECEPTOR ALPHA-2 | CHILDREN | Eosinophils - metabolism | Interleukin-13 - physiology | Humans | Gene Expression Profiling | Eosinophils - immunology | Esophagitis - pathology | Eosinophilia - pathology | Interleukin-13 - biosynthesis | Esophagitis - genetics | Interleukin-13 Receptor alpha2 Subunit - physiology | Signal Transduction - immunology | Interleukin-13 - genetics | Pulmonary Alveoli - metabolism | Eosinophilia - genetics | Eosinophils - pathology | Disease Models, Animal | Pulmonary Alveoli - pathology | Mice, Transgenic | Up-Regulation - genetics | Signal Transduction - genetics | Down-Regulation - genetics | Interleukin-13 Receptor alpha2 Subunit - antagonists & inhibitors | Mice, Knockout | Esophagitis - immunology | Animals | Eosinophilia - immunology | Up-Regulation - immunology | Down-Regulation - immunology | Interleukin-13 Receptor alpha2 Subunit - genetics | Mice | Mice, Inbred BALB C | Pulmonary Alveoli - immunology
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4. Full Text Direct control of hepatic glucose production by interleukin-13 in mice
by Stanya, Kristopher J and Jacobi, David and Liu, Sihao and Bhargava, Prerna and Dai, Lingling and Gangl, Matthew R and Inouye, Karen and Barlow, Jillian L and Ji, Yewei and Mizgerd, Joseph P and Qi, Ling and Shi, Hang and McKenzie, Andrew N.J and Lee, Chih-Hao
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 261 - 271
Hyperglycemia is a result of impaired insulin action on glucose production and disposal, and a major target of antidiabetic therapies. The study of... 
MEDICINE, RESEARCH & EXPERIMENTAL | GLUCONEOGENIC GENES | CYTOKINE RESPONSES | METABOLISM IN-VIVO | TYPE-2 IMMUNITY | MACROPHAGE POLARIZATION | CARBOHYDRATE-METABOLISM | ALTERNATIVE ACTIVATION | RECEPTOR-ALPHA | INDUCED INSULIN-RESISTANCE | ADIPOSE-TISSUE | Liver - pathology | Diabetes Mellitus, Type 2 - genetics | Interleukin-13 - immunology | Th2 Cells - immunology | Diabetes Mellitus, Type 2 - metabolism | Th1 Cells - immunology | Hyperglycemia - genetics | Th1 Cells - metabolism | Interleukin-13 - genetics | Interleukin-13 Receptor alpha1 Subunit - immunology | Liver - immunology | Diabetes Mellitus, Type 2 - immunology | Hyperglycemia - pathology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Glucose - immunology | Liver - metabolism | Hyperglycemia - immunology | Gluconeogenesis - immunology | Glucose - genetics | Interleukin-13 - metabolism | Th2 Cells - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Interleukin-13 Receptor alpha1 Subunit - genetics | Animals | Gluconeogenesis - genetics | Insulin Resistance - genetics | Glucose - metabolism | Insulin Resistance - immunology | Mice | Mice, Inbred BALB C | Diabetes Mellitus, Type 2 - pathology | STAT3 Transcription Factor - immunology | Interleukin-13 Receptor alpha1 Subunit - metabolism | Physiological aspects | Glucose metabolism | Hyperglycemia | Research | Blood sugar | Diabetes therapy
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5. Full Text Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13
by Hallett, Miranda A and Venmar, Katherine T and Fingleton, Barbara
Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 24, pp. 6338 - 6343
The Th2 cytokines interleukin (IL)-4 and -13 are acknowledged regulators of lymphocyte proliferation and activation. They have also been well studied in the... 
APOPTOSIS | INTERLEUKIN-4 | ONCOLOGY | PROGNOSIS | COLORECTAL-CANCER | MACROPHAGES | GENE-EXPRESSION | RESISTANCE | RECEPTOR | DEATH | TUMOR-GROWTH | Interleukin-13 - physiology | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Neoplasms, Glandular and Epithelial - metabolism | Receptors, Interleukin-13 - metabolism | Neoplasms, Glandular and Epithelial - immunology | Cytokines - physiology | Neoplasms, Glandular and Epithelial - genetics | Interleukin-4 - pharmacology | Receptors, Interleukin-13 - physiology | Interleukin-4 - physiology | Neoplasms, Glandular and Epithelial - pathology | Interleukin-4 - metabolism | Receptors, Interleukin-4 - metabolism | Epithelial Cells - pathology | Interleukin-13 - metabolism | Interleukin-13 - pharmacology | Receptors, Interleukin-13 - genetics | Stimulation, Chemical | Animals | Receptors, Interleukin-4 - physiology | Models, Biological | Epithelial Cells - immunology | Receptors, Interleukin-4 - genetics | Cytokines - pharmacology
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6. Full Text Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease
by Starkey, M.R and Essilfie, A.T and Horvat, J.C and Kim, R.Y and Nguyen, D.H and Beagley, K.W and Mattes, J and Foster, P.S and Hansbro, P.M
Mucosal Immunology, ISSN 1933-0219, 05/2013, Volume 6, Issue 3, pp. 569 - 579
Deleterious responses to pathogens during infancy may contribute to infection and associated asthma. Chlamydia respiratory infections in early life are common... 
HYPERREACTIVITY | STREPTOCOCCUS-PNEUMONIAE | REGULATORY T-CELLS | SYNCYTIAL-VIRUS | NITRIC-OXIDE | INTERLEUKIN-13 | ASTHMA | RECEPTOR | MICE | IMMUNOLOGY | ALTERNATIVE ACTIVATION | Animals, Newborn | Antibodies, Blocking - metabolism | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Humans | Cells, Cultured | Interleukin-13 - immunology | STAT6 Transcription Factor - genetics | Chlamydia - immunology | Interleukin-13 - metabolism | Respiratory Hypersensitivity - immunology | Mice, Knockout | Interleukin-13 Receptor alpha1 Subunit - genetics | Interleukin-13 - genetics | Interleukin-13 Receptor alpha1 Subunit - immunology | Animals | Chlamydial Pneumonia - immunology | Age of Onset | Mice | Mice, Inbred BALB C | Chlamydial Pneumonia - epidemiology | Respiratory Hypersensitivity - epidemiology | Interleukin-13 Receptor alpha1 Subunit - metabolism
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7. Full Text Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells
by Kong, Seogkyoung and Sengupta, Sadhak and Tyler, Betty and Bais, Anthony J and Ma, Qiangzhong and Doucette, Saryn and Zhou, Jinyuan and Sahin, Ayguen and Carter, Bob S and Brem, Henry and Junghans, Richard P and Sampath, Prakash
Clinical Cancer Research, ISSN 1078-0432, 11/2012, Volume 18, Issue 21, pp. 5949 - 5960
Purpose: Glioblastoma multiforme (GBM) remains highly incurable, with frequent recurrences after standard therapies of maximal surgical resection, radiation,... 
MALIGNANT GLIOMA | CHAIN | THERAPY | RECOGNITION | ONCOLOGY | CLONING | REJECTION | INTERLEUKIN-13 RECEPTOR | COMPONENT | BRAIN-TUMORS | LYMPHOCYTES | Immunotherapy, Adoptive - methods | Interleukin-13 Receptor alpha2 Subunit - metabolism | Receptors, Antigen, T-Cell - metabolism | Signal Transduction | Humans | Protein Multimerization | Interleukin-13 - immunology | CD28 Antigens - immunology | Glioblastoma - therapy | Xenograft Model Antitumor Assays | Interleukin-13 - genetics | Animals | CD28 Antigens - genetics | Glioblastoma - immunology | T-Lymphocytes - metabolism | Interleukin-13 Receptor alpha2 Subunit - immunology | Cell Line, Tumor | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | Mutation | Gene Order | Glioblastoma - mortality | Disease Models, Animal
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8. Full Text IL-13 Is Pivotal in the Fibro-Obliterative Process of Bronchiolitis Obliterans Syndrome
by Keane, Michael P and Gomperts, Brigitte N and Weigt, Samuel and Xue, Ying Ying and Burdick, Marie D and Nakamura, Hiromi and Zisman, David A and Ardehali, Abbas and Saggar, Rajan and Lynch, Joseph P., III and Hogaboam, Cory and Kunkel, Steven L and Lukacs, Nicholas W and Ross, David J and Grusby, Michael J and Strieter, Robert M and Belperio, John A
The Journal of Immunology, ISSN 0022-1767, 01/2007, Volume 178, Issue 1, pp. 511 - 519
Acute allograft rejection is considered to be a predominately type 1 immune mediated response to the donor alloantigen. However, the type 2 immune mediated... 
PATHOGENESIS | ALLOGRAFT-REJECTION | INDUCED PULMONARY FIBROSIS | CYCLOSPORINE-A | INTERLEUKIN-13 RECEPTOR | MICE | INDUCED AIRWAY HYPERREACTIVITY | LUNG-TRANSPLANT RECIPIENTS | INDUCTION | IMMUNOLOGY | CHEMOKINE BIOLOGY | Up-Regulation | Interleukin-13 - antagonists & inhibitors | Cyclosporine - pharmacology | Humans | Bronchoalveolar Lavage Fluid - immunology | Male | Receptors, Interleukin-13 - metabolism | Interleukin-13 - analysis | Mice, Mutant Strains | Female | Bronchiolitis Obliterans - pathology | Receptors, Interleukin-13 - antagonists & inhibitors | Interleukin-4 - metabolism | Bronchiolitis Obliterans - immunology | Interleukin-13 - metabolism | Receptors, Interleukin-13 - genetics | Syndrome | Antibodies - pharmacology | Animals | Fibrosis | Lung Transplantation - immunology | Mice | Bronchoalveolar Lavage Fluid - chemistry | Graft Rejection - immunology | Transforming Growth Factor beta - metabolism
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9. Full Text Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency
by Moraga, Ignacio and Richter, David and Wilmes, Stephan and Winkelmann, Hauke and Jude, Kevin and Thomas, Christoph and Suhoski, Megan M and Engleman, Edgar G and Piehler, Jacob and Garcia, K. Christopher
Science Signaling, ISSN 1945-0877, 11/2015, Volume 8, Issue 402, pp. ra114 - ra114
Cytokines dimerize cell surface receptors to activate signaling and regulate many facets of the immune response. Many cytokines have pleiotropic effects,... 
INTERLEUKIN-2 | GROWTH-HORMONE | I INTERFERON RECEPTOR | STRUCTURAL BASIS | AFFINITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATORY T-CELLS | SURFACE | TRAFFICKING | EXPRESSION | LOW-DOSE IL-2 | CELL BIOLOGY | Phosphorylation | Humans | Protein Multimerization | Crystallography, X-Ray | Interleukin-4 Receptor alpha Subunit - genetics | Genetic Variation | Endocytosis | Interleukin-13 - genetics | Protein Engineering | Protein Structure, Quaternary | Receptors, Cytokine - metabolism | Receptors, Cytokine - genetics | Recombinant Proteins - metabolism | Cell Line | Interleukin-4 Receptor alpha Subunit - metabolism | Biophysical Phenomena | Signal Transduction | Models, Molecular | Recombinant Proteins - chemistry | Interleukin-13 - chemistry | Recombinant Proteins - genetics | STAT6 Transcription Factor - metabolism | Interleukin-13 - metabolism | Interleukin-13 Receptor alpha1 Subunit - genetics | Interleukin-13 Receptor alpha1 Subunit - chemistry | Models, Biological | Receptors, Cytokine - chemistry | Protein Binding | Ligands | HeLa Cells | Interleukin-13 Receptor alpha1 Subunit - metabolism | Interleukin-4 Receptor alpha Subunit - chemistry
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10. Full Text IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2
by Kasaian, Marion T and Raible, Donald and Marquette, Kimberly and Cook, Timothy A and Zhou, Simon and Tan, Xiang-Yang and Tchistiakova, Lioudmila
Journal of Immunology, ISSN 0022-1767, 07/2011, Volume 187, Issue 1, pp. 561 - 569
Human studies using Abs to two different, nonoverlapping epitopes of IL-13 suggested that epitope specificity can have a clinically significant impact on... 
Interleukin-13 Receptor alpha2 Subunit - metabolism | Isoantibodies - physiology | Dose-Response Relationship, Immunologic | Interleukin-13 - antagonists & inhibitors | Humans | Antibody-Dependent Cell Cytotoxicity - immunology | Interleukin-13 - immunology | Macaca fascicularis | Interleukin-13 - metabolism | Receptors, Scavenger - antagonists & inhibitors | Extracellular Space - immunology | Interleukin-13 Receptor alpha2 Subunit - antagonists & inhibitors | Drug Delivery Systems | HT29 Cells | Interleukin-13 Receptor alpha2 Subunit - biosynthesis | Extracellular Space - metabolism | Animals | Receptors, Scavenger - physiology | Mice | Mice, Inbred BALB C | Receptors, Scavenger - metabolism
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11. Full Text On the role IL-4/IL-13 heteroreceptor plays in regulation of type 1 diabetes
by Ukah, Tobechukwu K and Cattin-Roy, Alexis N and Chen, Weirong and Miller, Mindy M and Barik, Subhasis and Zaghouani, Habib
Journal of Immunology, ISSN 0022-1767, 08/2017, Volume 199, Issue 3, pp. 894 - 902
Type 1 diabetes (T1D) manifests when the insulin-producing pancreatic beta cells are destroyed as a consequence of an inflammatory process initiated by... 
HELPER TYPE-1 | EFFECTOR T-CELLS | NOD MICE | TGF-BETA | RESISTANCE | INTERLEUKIN-13 RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | NEONATAL IMMUNITY | SUPPRESSION | LINEAGE | Interleukin-13 Receptor alpha1 Subunit - deficiency | Pancreas - cytology | Lectins, C-Type - immunology | Interleukin-13 - immunology | Adoptive Transfer | Th1 Cells - immunology | T-Lymphocytes, Regulatory - immunology | Interleukin-13 Receptor alpha1 Subunit - immunology | Diabetes Mellitus, Type 1 - immunology | Macrophages - immunology | Disease Models, Animal | Receptors, Cell Surface - metabolism | Blood Glucose | Pancreas - immunology | Receptors, Cell Surface - immunology | Insulin-Secreting Cells - immunology | Interleukin-13 Receptor alpha1 Subunit - genetics | Interleukin-4 - immunology | Animals | Mannose-Binding Lectins - immunology | Th17 Cells - immunology | Mice, Inbred NOD | Mice | Interleukin-13 Receptor alpha1 Subunit - metabolism | Receptors, Cell Surface - genetics | Spleen | Cytokines | Immunoregulation | Diabetes mellitus | Helper cells | Lymphocytes T | Inflammation | Interleukin 13 | Regulatory sequences | Glucose | Macrophages | Insulin | Immunological tolerance | Interleukin 4 | Gene disruption | Lymphocytes | Diabetes | Islets of Langerhans | Pancreas | Immune system
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12. Full Text IL-13 Induces Disease-Promoting Type 2 Cytokines, Alternatively Activated Macrophages and Allergic Inflammation during Pulmonary Infection of Mice with Cryptococcus neoformans
by Muller, Uwe and Stenzel, Werner and Kohler, Gabriele and Werner, Christoph and Polte, Tobias and Hansen, Gesine and Schutze, Nicole and Straubinger, Reinhard K and Blessing, Manfred and McKenzie, Andrew N. J and Brombacher, Frank and Alber, Gottfried
The Journal of Immunology, ISSN 0022-1767, 10/2007, Volume 179, Issue 8, pp. 5367 - 5377
In the murine model of Cryptococcus neoformans infection Th1 (IL-12/IFN-gamma) and Th17 (IL-23/IL-17) responses are associated with protection, whereas an... 
CUTANEOUS LEISHMANIASIS | FUNGICIDAL ACTIVITY | AIRWAY RESPONSIVENESS | IFN-GAMMA | RECEPTOR-ALPHA CHAIN | INTERLEUKIN-13 | IMMUNOLOGY | PROTECTIVE TH1 RESPONSE | EXPRESSION | T-CELLS | HOST-RESISTANCE | Inflammation - pathology | Interleukin-13 - physiology | Antibodies, Fungal - biosynthesis | Macrophages, Alveolar - parasitology | Antibodies, Fungal - classification | Cryptococcus neoformans - immunology | Inflammation - parasitology | Respiratory Hypersensitivity - pathology | Interleukin-13 - biosynthesis | Interleukin-13 - genetics | Lung Diseases, Fungal - pathology | Lung Diseases, Fungal - parasitology | Female | Macrophages, Alveolar - immunology | Respiratory Hypersensitivity - parasitology | Lung Diseases, Fungal - immunology | Interleukin-13 - deficiency | Mice, Transgenic | Inflammation - immunology | Cryptococcosis - immunology | Respiratory Hypersensitivity - immunology | Lung Diseases, Fungal - mortality | Macrophage Activation | Mice, Knockout | Immunoglobulin Isotypes - biosynthesis | Animals | Mice | Mice, Inbred BALB C | Macrophages, Alveolar - metabolism | Cytokines - biosynthesis
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13. Full Text Requirement for IL-13 Independently of IL-4 in Experimental Asthma
by Gabriele Grunig and Martha Warnock and Adil E. Wakil and Rajeev Venkayya and Frank Brombacher and Donna M. Rennick and Dean Sheppard and Markus Mohrs and Debra D. Donaldson and Richard M. Locksley and David B. Corry
Science, ISSN 0036-8075, 12/1998, Volume 282, Issue 5397, pp. 2261 - 2263
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4... 
T lymphocytes | Phenotypes | Receptors | Intestines | Cytokines | Lungs | Goblets | Reports | Ova | Asthma | Eosinophils | LUNG | INTERLEUKIN-4 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | AIRWAY HYPERREACTIVITY | EOSINOPHILIA | MICE | MODEL | INDUCTION | EXPRESSION | T-LYMPHOCYTES | Interleukin-13 - physiology | Interleukin-13 - antagonists & inhibitors | Ovalbumin - immunology | Recombinant Fusion Proteins - pharmacology | Humans | Th2 Cells - immunology | Adoptive Transfer | Interleukin-13 Receptor alpha1 Subunit | Receptors, Interleukin-13 | Bronchial Hyperreactivity | Interleukin-13 - genetics | Interleukin-4 - pharmacology | Allergens - immunology | Asthma - immunology | Bronchoalveolar Lavage Fluid - cytology | Interleukin-4 - genetics | Interleukin-4 - physiology | Receptors, Interleukin - physiology | Asthma - physiopathology | Receptors, Interleukin - immunology | Immunoglobulin Fc Fragments | Interleukin-13 - pharmacology | Receptors, Interleukin - genetics | Asthma - genetics | Chromosomes, Human, Pair 5 | Phenotype | Animals | Receptors, Interleukin-4 - physiology | Receptors, Interleukin-4 - genetics | Mice | Mice, Inbred BALB C | Goblet Cells - pathology | Asthma - pathology | Interleukins | Research | Medical research
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14. Full Text Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
by Gauvreau, Gail M and Boulet, Louis-Philippe and Cockcroft, Donald W and Fitzgerald, J. Mark and Carlsten, Chris and Davis, Beth E and Deschesnes, Francine and Duong, Mylinh and Durn, Billie L and Howie, Karen J and Hui, Linda and Kasaian, Marion T and Killian, Kieran J and Strinich, Tara X and Watson, Richard M and Nathalie, Y and Zhou, Simon and Raible, Donald and O'Byrne, Paul M
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 04/2011, Volume 183, Issue 8, pp. 1007 - 1014
Rationale: Extensive evidence in animal models supports a role for IL-13 in the pathobiology of asthma. IMA-638 and IMA-026 are fully humanized IgG(1)... 
Allergen inhalation challenge | Late asthmatic response | Anti-interleukin-13 therapy | Mild asthma | Airway inflammation | airway inflammation | CELLS | HUMAN LUNG FIBROBLASTS | mild asthma | allergen inhalation challenge | late asthmatic response | RECEPTOR ALPHA-2 | IL-13 NEUTRALIZATION | CHALLENGE | SMOOTH-MUSCLE | RESPIRATORY SYSTEM | INFLAMMATION | anti-interleukin-13 therapy | CYNOMOLGUS MONKEYS | UP-REGULATION | EXPRESSION | CRITICAL CARE MEDICINE | Sputum - cytology | Double-Blind Method | Immunoglobulin G - blood | Interleukin-13 - antagonists & inhibitors | Humans | Middle Aged | Immunoglobulin G - therapeutic use | Interleukin-13 - immunology | Male | Treatment Outcome | Asthma - drug therapy | Forced Expiratory Volume | Young Adult | Antibodies, Neutralizing - immunology | Sputum - immunology | Allergens - immunology | Immunoglobulin G - immunology | Antibodies, Neutralizing - therapeutic use | Adolescent | Adult | Female | Antibodies, Neutralizing - blood | Interleukin-13 - blood
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15. Full Text Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells
by Kahlon, Kanwarpal S and Brown, Christine and Cooper, Laurence J. N and Raubitschek, Andrew and Forman, Stephen J and Jensen, Michael C
Cancer Research, ISSN 0008-5472, 12/2004, Volume 64, Issue 24, pp. 9160 - 9166
The interleukin (IL) 13 receptor alpha2 (IL13Ralpha2) is a glioma-restricted cell-surface epitope not otherwise detected within the central nervous system.... 
CANCER-CELLS | THERAPY | ONCOLOGY | MALIGNANT GLIOMAS | RECEPTOR | CYTOTOXINS | EXPRESSION | BRAIN | LYMPHOCYTES | Receptors, Interleukin - biosynthesis | Humans | DNA, Complementary - genetics | Interleukin-13 - immunology | Male | Interleukin-13 Receptor alpha1 Subunit | Receptors, Interleukin-13 | Interleukin-13 - genetics | Brain Neoplasms - immunology | Transfection | Epitopes, T-Lymphocyte - immunology | T-Lymphocytes, Cytotoxic - immunology | Immunotherapy, Adoptive - methods | Receptors, Interleukin - immunology | Lymphocyte Activation | Interleukin-13 - metabolism | Mice, SCID | T-Lymphocytes, Cytotoxic - physiology | Glioblastoma - therapy | Xenograft Model Antitumor Assays | Animals | Glioblastoma - immunology | Brain Neoplasms - therapy | Cell Line, Tumor | Mice, Inbred NOD | Mice
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