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Journal of experimental medicine, ISSN 0022-1007, 2009, Volume 206, Issue 1, pp. 25 - 34
The in vivo requirements for human natural killer (NK) cell development and differentiation into cytotoxic effectors expressing inhibitory receptors for... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER-CELLS | SEVERE COMBINED IMMUNODEFICIENCY | HUMAN-DISEASE | INTERLEUKIN-15 | COMPLEXES | SOLUBLE IL-15R-ALPHA | INHIBITORY RECEPTORS | MICE | IMMUNOLOGY | HELIX FACTOR ID3 | Interleukin-15 - administration & dosage | Recombinant Fusion Proteins - pharmacology | Humans | bcl-X Protein - genetics | Receptors, Interleukin-15 - metabolism | Transplantation, Heterologous | Recombinant Fusion Proteins - metabolism | Receptors, Interleukin-15 - genetics | Retroviridae - genetics | Antigens, Differentiation - metabolism | Animals, Newborn | Cell Survival - drug effects | Transduction, Genetic | Mice, Inbred C57BL | Lymphoid Tissue - metabolism | Hematopoietic Stem Cells - metabolism | DNA-Binding Proteins - genetics | Interleukin Receptor Common gamma Subunit - genetics | Mice, Knockout | Interleukin-15 - pharmacology | Killer Cells, Natural - cytology | Lymphoid Tissue - cytology | Animals | Receptors, Interleukin-15 - agonists | Cell Differentiation - drug effects | Mice, Nude | Hematopoietic Stem Cells - cytology | Recombinant Fusion Proteins - genetics | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Mice | Mice, Inbred BALB C | Hematopoietic Stem Cell Transplantation - methods | Killer Cells, Natural - metabolism | bcl-X Protein - metabolism | Index Medicus | Brief Definitive Reports
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2013, Volume 288, Issue 25, pp. 18093 - 18103
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8565 - 8570
Interleukin (IL)-15 and its specific receptro chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism... 
T lymphocytes | Histograms | Receptors | Cell growth | Cytokines | Cell lines | Coculture techniques | Cultured cells | Recycling | Cells | Synapse | Cell-cell interaction | Autocrine | IL-2Rβ | Lymphocyte | NATURAL-KILLER | DENDRITIC CELLS | cell-cell interaction | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | SOLUBLE IL-15R-ALPHA | IL-2R beta | synapse | lymphocyte | CHAIN | INTERLEUKIN-15 | IN-VIVO | LEUKEMIA | EXPRESSION | autocrine | PARACRINE | Cell Communication - immunology | Cell Proliferation | Coculture Techniques | Dendritic Cells - immunology | Humans | STAT5 Transcription Factor - immunology | Interleukin-15 Receptor alpha Subunit - metabolism | Interleukin-15 - immunology | Protein Transport - immunology | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Flow Cytometry | T-Lymphocytes - metabolism | HEK293 Cells | Killer Cells, Natural - immunology | Interleukin-15 Receptor alpha Subunit - immunology | Dendritic Cells - metabolism | Cell Line | Interleukin-15 Receptor alpha Subunit - genetics | Antigen Presentation - immunology | Cell Survival - immunology | Protein Binding - immunology | Interleukin-15 - genetics | Interleukin-15 - metabolism | Cell Line, Tumor | T-Lymphocytes - immunology | HeLa Cells | Killer Cells, Natural - metabolism | Microscopy, Fluorescence | Index Medicus | Biological Sciences | cell–cell interaction
Journal Article
Molecular Immunology, ISSN 0161-5890, 11/2018, Volume 103, pp. 293 - 305
Journal Article
Endocrinology, ISSN 0013-7227, 03/2016, Volume 157, Issue 3, pp. 1315 - 1320
IL-15 is a cytokine that is part of the innate immune system, as well as a proposed myokine released from skeletal muscle during physical exercise that... 
Interleukin-15 - secretion | Animals | Half-Life | Protein Binding | Interleukin-15 - blood | Cell Membrane - metabolism | Mice | Receptors, Interleukin-15 - immunology | Interleukin-15 - immunology | Receptors, Interleukin-15 - blood | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 2010, Volume 223, Issue 1, pp. 65 - 72
Abstract Interleukin (IL)-15 can cross the blood–brain barrier to act on its specific brain receptor (IL15Rα) and co-receptors. The important roles of neuronal... 
Neurology | Allergy and Immunology | Brain | Autoimmune disease | IL15 | Immunity | Cytokine | Blood–brain barrier | Blood-brain barrier | MONONUCLEAR-CELLS | HIPPOCAMPAL-DEPENDENT MEMORY | IL-15 MESSENGER-RNA | IMMUNOLOGY | CEREBROSPINAL-FLUID | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | REMITTING MULTIPLE-SCLEROSIS | IMMUNE-RESPONSES | CENTRAL-NERVOUS-SYSTEM | GENE DELETION | T-CELLS | Interleukin-15 - physiology | Neurons - pathology | Receptors, Interleukin-15 - biosynthesis | Spinal Cord - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Interleukin-15 - biosynthesis | Brain - metabolism | Receptors, Interleukin-15 - genetics | Genetic Predisposition to Disease - etiology | Spinal Cord - pathology | Encephalomyelitis, Autoimmune, Experimental - diagnosis | Female | Interleukin-15 - therapeutic use | Neurons - metabolism | Adjuvants, Immunologic - therapeutic use | Adjuvants, Immunologic - deficiency | Receptors, Interleukin-15 - physiology | Severity of Illness Index | Adjuvants, Immunologic - physiology | Mice, Inbred C57BL | Neurons - immunology | Up-Regulation - genetics | Adjuvants, Immunologic - biosynthesis | Interleukin-15 - deficiency | Mice, Knockout | Spinal Cord - immunology | Encephalomyelitis, Autoimmune, Experimental - therapy | Animals | Receptors, Interleukin-15 - deficiency | Up-Regulation - immunology | Brain - pathology | Mice | Brain - immunology | Index Medicus | Autoimmune diseases | cytokine | blood-brain barrier | immunity | brain | autoimmune disease
Journal Article
American Journal of Clinical Nutrition, ISSN 0002-9165, 10/2013, Volume 98, Issue 4, pp. 1123 - 1135
Background: On ingestion of gliadin, the major protein component of wheat and other cereals, the celiac intestine is characterized by the proliferation of... 
GROWTH-FACTOR RECEPTOR | CELLS | RESPONSES | ONCOGENE | NUTRITION & DIETETICS | HORMONE | PROTEIN | INTERLEUKIN-15 | GENES | DIFFERENTIATION | CANCER | Interleukin-15 - physiology | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Interleukin-15 Receptor alpha Subunit - antagonists & inhibitors | Epidermal Growth Factor - physiology | Humans | Peptide Fragments - pharmacology | Transfection | Celiac Disease - immunology | Peptide Fragments - immunology | Enterocytes - pathology | Receptor, Epidermal Growth Factor - physiology | Caco-2 Cells | Gliadin - immunology | Epidermal Growth Factor - genetics | Interleukin-15 Receptor alpha Subunit - physiology | Cells, Cultured | RNA, Small Interfering - physiology | Interleukin-15 Receptor alpha Subunit - genetics | Immunity, Innate | Enterocytes - immunology | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Celiac Disease - pathology | Interleukin-15 - pharmacology | Interleukin-15 - genetics | Signal Transduction - drug effects | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Signal Transduction - physiology | Cell Proliferation - drug effects | Epidermal Growth Factor - pharmacology | Gliadin - pharmacology | Celiac disease | Care and treatment | Epidermal growth factor | Diagnosis | Analysis | Risk factors | Proteins | Cell growth | Peptides | Wheat | Immune system | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2659 - 2666
In the thymus, interactions with both cortical and medullary microenvironments regulate the development of self-tolerant conventional CD4(+) and CD8(+) alpha... 
PATHWAY | KILLER T-CELLS | CENTRAL TOLERANCE | MICE | RANK | COSTIMULATION | DIFFERENTIATION | IMMUNOLOGY | THYMOCYTES | SELF-TOLERANCE | FAMILY | Interleukin-15 - administration & dosage | Receptors, Interleukin-15 - administration & dosage | Epithelial Cells - metabolism | RANK Ligand - metabolism | Antigens, CD1d - immunology | Thymocytes - metabolism | Transcription Factor RelB - immunology | Receptors, Interleukin-15 - immunology | Interleukin-15 - immunology | RANK Ligand - immunology | Receptors, Interleukin-15 - genetics | Cell Differentiation - genetics | Flow Cytometry | Natural Killer T-Cells - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Antigens, CD1d - genetics | Receptor Activator of Nuclear Factor-kappa B - metabolism | Thymus Gland - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Epithelial Cells - transplantation | Transcription Factor RelB - genetics | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Mice, Inbred C57BL | Thymus Gland - cytology | Reverse Transcriptase Polymerase Chain Reaction | Cellular Microenvironment - immunology | Antigens, CD1d - metabolism | Mice, Knockout | Thymocytes - immunology | Cell Differentiation - immunology | Animals | Interleukin-15 - genetics | Transcription Factor RelB - metabolism | Cell Differentiation - drug effects | Epithelial Cells - immunology | Thymocytes - cytology | Thymus Gland - immunology | Cellular Microenvironment - genetics | Receptor Activator of Nuclear Factor-kappa B - immunology | Cellular Microenvironment - drug effects | Natural Killer T-Cells - immunology | Index Medicus | Abridged Index Medicus | Immune System Development
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2012, Volume 188, Issue 9, pp. 4149 - 4157
IL-15 plays many important roles within the immune system. IL-15 signals in lymphocytes via trans presentation, where accessory cells such as macrophages and... 
ACTIVATION | INHIBITION | DENDRITIC CELLS | NK CELLS | INTERLEUKIN-15 | IN-VIVO | RECEPTOR | TRANS-PRESENTATION | IMMUNOLOGY | EXPRESSION | T-CELLS | CD8-Positive T-Lymphocytes - cytology | Dendritic Cells - immunology | Humans | Interleukin-2 Receptor beta Subunit - metabolism | MAP Kinase Kinase 4 - immunology | NF-kappa B - metabolism | STAT Transcription Factors - immunology | Interleukin-15 Receptor alpha Subunit - metabolism | Bone Marrow Cells - immunology | CD8-Positive T-Lymphocytes - metabolism | DNA-Binding Proteins - immunology | Infection - immunology | Interleukin-15 Receptor alpha Subunit - genetics | Signal Transduction - genetics | Mice, Knockout | Immunologic Memory - physiology | Killer Cells, Natural - cytology | Infection - genetics | Infection - metabolism | Macrophages - metabolism | Infection - pathology | Neoplasms - immunology | Interleukin-15 - metabolism | Chemokine CCL5 - genetics | MAP Kinase Kinase 4 - genetics | Mice | Killer Cells, Natural - metabolism | CD8-Positive T-Lymphocytes - immunology | Neoplasms - metabolism | NF-kappa B - immunology | STAT Transcription Factors - metabolism | Interleukin-15 - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | MAP Kinase Kinase 4 - metabolism | Neoplasms - genetics | Killer Cells, Natural - immunology | Interleukin-15 Receptor alpha Subunit - immunology | Interleukin-2 Receptor beta Subunit - genetics | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Bone Marrow Cells - cytology | Nuclear Proteins - metabolism | Macrophages - cytology | DNA-Binding Proteins - genetics | Nuclear Proteins - immunology | Organ Specificity | STAT Transcription Factors - genetics | Animals | Chemokine CCL5 - biosynthesis | Interleukin-15 - genetics | NF-kappa B - genetics | Dendritic Cells - cytology | Neoplasms - pathology | Interleukin-2 Receptor beta Subunit - immunology | Bone Marrow Cells - metabolism | Chemokine CCL5 - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Cytokine, ISSN 1043-4666, 12/2011, Volume 56, Issue 3, pp. 804 - 810
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 06/2017, Volume 198, Issue 12, pp. 4563 - 4568
Interleukin 2 and IL-15 are two closely related cytokines, displaying important functions in the immune system. They share the heterodimeric CD122/CD132... 
BETA-CHAIN | INTERLEUKIN-2 | LYMPHOID HOMEOSTASIS | ALPHA-CHAIN | IL-15 | TRANS-PRESENTATION | IL-15R-ALPHA | IMMUNOLOGY | EXPRESSION | T-CELLS | Cell Proliferation | Humans | Interleukin Receptor Common gamma Subunit - metabolism | Interleukin-15 Receptor alpha Subunit - metabolism | Interleukin-2 - antagonists & inhibitors | Interleukin-15 - immunology | Interleukin Receptor Common gamma Subunit - immunology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Interleukin-2 - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Killer Cells, Natural - immunology | Interleukin-15 Receptor alpha Subunit - immunology | Interleukin-2 Receptor beta Subunit - genetics | Interleukin-2 Receptor alpha Subunit - immunology | Interleukin-2 - metabolism | Cell Line | Interleukin-15 - antagonists & inhibitors | Interleukin-15 Receptor alpha Subunit - genetics | Interleukin Receptor Common gamma Subunit - genetics | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Interleukin-15 - metabolism | Protein Binding | Mice | CD8-Positive T-Lymphocytes - immunology | Interleukin-2 Receptor beta Subunit - immunology | Cell proliferation | Interleukin 2 receptors | Cytokines | Interleukin 2 | CD8 antigen | Interleukin | Lymphocytes T | Interleukin 15 | Immune system | Recruitment | CD122 antigen | Index Medicus | Abridged Index Medicus | Life Sciences | Cancer
Journal Article