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Nature (London), ISSN 1476-4687, 2012, Volume 484, Issue 7395, pp. 529 - 533
The immunostimulatory cytokine interleukin-2 (IL-2) is a growth factor for a wide range of leukocytes, including T cells and natural killer (NK) cells(1-3).... 
CHAIN | ALPHA-RECEPTOR | KINETICS | MULTIDISCIPLINARY SCIENCES | SELECTIVE STIMULATION | COMPLEXES | DYNAMICS | MOLECULAR-CLONING | PROTEINS | EXPRESSION | Surface Plasmon Resonance | Neoplasm Transplantation | Phosphorylation | Cell Proliferation | Humans | Interleukin-2 Receptor beta Subunit - metabolism | Crystallography, X-Ray | Mutant Proteins - pharmacology | STAT5 Transcription Factor - metabolism | Interleukin-2 - immunology | Immunotherapy | Protein Engineering | Killer Cells, Natural - immunology | Interleukin-2 - chemistry | Mutant Proteins - immunology | Binding Sites | Interleukin-2 Receptor alpha Subunit - immunology | Cell Line | Interleukin-2 Receptor alpha Subunit - deficiency | Mice, Inbred C57BL | Mutant Proteins - genetics | Models, Molecular | Directed Molecular Evolution | Molecular Dynamics Simulation | Neoplasms - drug therapy | Interleukin-2 - genetics | Animals | Interleukin-2 Receptor alpha Subunit - chemistry | Interleukin-2 Receptor alpha Subunit - metabolism | Interleukin-2 Receptor beta Subunit - chemistry | T-Lymphocytes - cytology | Neoplasms - immunology | Mutant Proteins - chemistry | Interleukin-2 - pharmacology | Protein Conformation | T-Lymphocytes - immunology | Mice | Mutation | Physiological aspects | Interleukin-2 | Tissue engineering | Methods | Yeast | Engineers | Cytokines | CHEM | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
LIGAND-BINDING | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | COMPLEXES | REGULATORY T-CELLS | MODULATION THERAPIES | IL-2 | CYTOKINE | HIGH-DOSE INTERLEUKIN-2 | RENAL-CELL CARCINOMA | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2002, Volume 169, Issue 9, pp. 4850 - 4860
We show that the lymphoid hyperplasia observed in IL-2Ralpha- and IL-2-deficient mice is due to the lack of a population of regulatory cells essential for CD4... 
GROWTH-FACTOR-BETA | INFLAMMATORY-BOWEL-DISEASE | EFFECTOR FUNCTION | IN-VIVO | IMMUNOREGULATORY CELLS | IMMUNOLOGICAL SELF-TOLERANCE | MICE | IMMUNOLOGY | AUTOIMMUNE-DISEASE | ANTIGEN RECEPTOR | LYMPHOCYTES-T | T-Lymphocyte Subsets - immunology | Interphase - immunology | Lymphopenia - pathology | CD4-Positive T-Lymphocytes - immunology | Lymphopenia - mortality | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | Receptors, Interleukin-2 - deficiency | Bone Marrow Transplantation | Radiation Chimera - immunology | Adjuvants, Immunologic - physiology | Radiation Chimera - genetics | Receptors, Interleukin-2 - biosynthesis | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Homeostasis - immunology | T-Lymphocyte Subsets - transplantation | Mice, Knockout | Interleukin-2 - genetics | Animals | CD4-Positive T-Lymphocytes - transplantation | T-Lymphocyte Subsets - metabolism | Interleukin-2 - deficiency | Survival Analysis | Lymphocyte Count | Lymphopenia - immunology | Mice | Receptors, Interleukin-2 - physiology | Interphase - genetics | Lymphopenia - genetics | Homeostasis - genetics | T-Lymphocyte Subsets | Interleukin-2 | Adjuvants, Immunologic | Interphase | Homeostasis | Radiation Chimera | Life Sciences | Immunology | Lymphopenia | CD4-Positive T-Lymphocytes | Receptors, Interleukin-2
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 26, pp. 11906 - 11911
IL-2 immunotherapy is an attractive treatment option for certain metastatic cancers. However, administration of IL-2 to patients can lead, by ill-defined... 
Receptors | Lungs | Cell lines | Melanoma | Cellular immunity | Mice | Natural killer cells | Pulmonary edema | Endothelial cells | Tumors | Tumor | T cell | Cytokine/mAb complexes | Cytokine | NK cell | cytokine | IMMUNE-COMPLEXES | MULTIDISCIPLINARY SCIENCES | ANTIBODY | ALPHA | TOXICITY | RENAL-CANCER | tumor | cytokine/mAb complexes | IN-VIVO | BIOLOGICAL-ACTIVITY | REGULATORY T-CELLS | HIGH-DOSE INTERLEUKIN-2 | CD8(+) CELLS | Recombinant Proteins - therapeutic use | Immunotherapy - methods | Interleukin-2 - adverse effects | Homeodomain Proteins - metabolism | Humans | Interleukin-2 - therapeutic use | Interleukin-2 - antagonists & inhibitors | Recombinant Proteins - adverse effects | Lung - cytology | Pulmonary Edema - etiology | Interleukin-2 Receptor alpha Subunit - genetics | Lymphocytes - immunology | Melanoma, Experimental - immunology | Lung Neoplasms - secondary | Interleukin-2 - administration & dosage | Melanoma, Experimental - secondary | Antibodies, Monoclonal - immunology | Interleukin-2 Receptor alpha Subunit - deficiency | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Receptors, Interleukin-2 - metabolism | Lung Neoplasms - therapy | Homeodomain Proteins - genetics | Recombinant Proteins - administration & dosage | Immunotherapy - adverse effects | Mice, Knockout | Endothelial Cells - immunology | Lung Neoplasms - immunology | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Antibodies, Monoclonal - administration & dosage | Pulmonary Edema - immunology | Antigen-Antibody Complex - administration & dosage | Antigen-Antibody Complex - immunology | Lung - immunology | Care and treatment | Interleukin-2 | Health aspects | Immunotherapy | Methods | Biological Sciences | mAb complexes
Journal Article
Nature (London), ISSN 0028-0836, 2019, Volume 565, Issue 7738, pp. 186 - 191
We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in... 
HALF-LIFE | INTERLEUKIN-2 | MOLECULAR-DYNAMICS | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | RECEPTOR | ALPHA | CYTOKINE | GENERATION | T-CELL | PROTEINS | Colonic Neoplasms - drug therapy | Humans | Interleukin-2 - therapeutic use | Crystallography, X-Ray | Interleukin-15 - immunology | Signal Transduction - immunology | Molecular Mimicry | Interleukin-2 - immunology | Colonic Neoplasms - immunology | Computer Simulation | Drug Design | Interleukin-15 - therapeutic use | Protein Stability | Binding Sites | Disease Models, Animal | Interleukin-2 Receptor alpha Subunit - immunology | Amino Acid Sequence | Models, Molecular | Receptors, Interleukin-2 - metabolism | Receptors, Interleukin-2 - immunology | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Melanoma - immunology | Melanoma - drug therapy | Mice | Receptors, Interleukin-2 - agonists | Physiological aspects | Protein engineering | Interleukin-15 | Interleukin-2 | Methods | Interleukin 2 receptors | Animal models | Cytokines | Toxicity | Interleukin | Melanoma | Amino acid sequence | Topology | Interleukin 15 | Design optimization | Design | Proteins | Signaling | Colon cancer | Interleukin 2 | Immunogenicity | Computer applications | CD25 antigen | Software | Colon | Binding sites | Cancer | Crystal structure | cytokine | functional | interleukin-2 | Neo-2 | hyper-stable | De novo | interleukin-15 | therapeutic | Neoleukin-2 | protein | design | il-15 | il-2 | mimetic | Neoleukin | mimic | cancer
Journal Article
Clinical cancer research, ISSN 1557-3265, 2016, Volume 22, Issue 3, pp. 680 - 690
Journal Article
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 3874 - 12
While IL-2 can potently activate both NK and T cells, its short in vivo half-life, severe toxicity, and propensity to amplify Treg cells are major barriers... 
INTERLEUKIN-2 | IMMUNE CELLS | MELANOMA | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | FUSION PROTEIN | INNATE | CYTOKINE | CANCER | NK | LYMPHOCYTES | Recombinant Proteins - therapeutic use | Humans | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin-2 - therapeutic use | Cell Line, Tumor - transplantation | Cetuximab - therapeutic use | T-Lymphocytes, Cytotoxic - drug effects | Immunoconjugates - pharmacology | Immunoconjugates - therapeutic use | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Disease Models, Animal | Interleukin-2 Receptor alpha Subunit - immunology | T-Lymphocytes, Cytotoxic - immunology | Cetuximab - pharmacology | Treatment Outcome | Drug Resistance, Neoplasm - immunology | Recombinant Proteins - genetics | Lymphocytes, Tumor-Infiltrating - drug effects | Recombinant Proteins - pharmacology | B7-H1 Antigen - immunology | Antineoplastic Agents, Immunological - pharmacology | Neoplasms - drug therapy | Drug Synergism | Interleukin-2 - genetics | Animals | B7-H1 Antigen - antagonists & inhibitors | Interleukin-2 Receptor alpha Subunit - metabolism | Antineoplastic Agents, Immunological - therapeutic use | Neoplasms - immunology | Immunoconjugates - genetics | Interleukin-2 - pharmacology | Mutation | Neoplasms - pathology | Interleukin-2 Receptor beta Subunit - immunology | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Lymphocytes, Tumor-Infiltrating - immunology | Binding | Therapy | Toxicity | CD8 antigen | Antibodies | Cytotoxicity | Lymphocytes T | Anticancer properties | Immune checkpoint | Interleukin 2 | Lymphocytes | CD25 antigen | Antitumor activity | Biocompatibility | Tumors | Cancer | CD122 antigen
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2010, Volume 28, Issue 33, pp. 4969 - 4975
Journal Article
Journal Article