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PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
LIGAND-BINDING | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | COMPLEXES | REGULATORY T-CELLS | MODULATION THERAPIES | IL-2 | CYTOKINE | HIGH-DOSE INTERLEUKIN-2 | RENAL-CELL CARCINOMA | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Radioactive half-life | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 2046 - 2058
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NI( cells. Here, we determined that TIGIT is upregulated... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION MOLECULE | LIGANDS | DNAM-1 | INHIBITORY RECEPTORS | CHRONIC VIRAL-INFECTION | NECTIN-2 CD112 | UP-REGULATION | PVR CD155 | EXPRESSION | POLIOVIRUS RECEPTOR CD155 | Up-Regulation | Receptors, Immunologic - physiology | Receptors, Virus - biosynthesis | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - physiology | Receptors, Virus - genetics | Receptors, Immunologic - antagonists & inhibitors | Receptors, Immunologic - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Interleukin-2 Receptor beta Subunit - genetics | Neoplasm Proteins - genetics | Antibodies, Monoclonal - immunology | Antigen-Presenting Cells - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Neoplasm Proteins - biosynthesis | Antibodies, Monoclonal - pharmacology | Immunophenotyping | Interleukin-2 Receptor beta Subunit - biosynthesis | Melanoma - pathology | Antigen-Presenting Cells - immunology | Melanoma - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Immunologic Memory | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Programmed Cell Death 1 Receptor - genetics | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Oncology | Immunology | Dermatology | Therapeutics
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 06/2017, Volume 198, Issue 12, pp. 4563 - 4568
Interleukin 2 and IL-15 are two closely related cytokines, displaying important functions in the immune system. They share the heterodimeric CD122/CD132... 
BETA-CHAIN | INTERLEUKIN-2 | LYMPHOID HOMEOSTASIS | ALPHA-CHAIN | IL-15 | TRANS-PRESENTATION | IL-15R-ALPHA | IMMUNOLOGY | EXPRESSION | T-CELLS | Cell Proliferation | Humans | Interleukin Receptor Common gamma Subunit - metabolism | Interleukin-15 Receptor alpha Subunit - metabolism | Interleukin-2 - antagonists & inhibitors | Interleukin-15 - immunology | Interleukin Receptor Common gamma Subunit - immunology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Interleukin-2 - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Killer Cells, Natural - immunology | Interleukin-15 Receptor alpha Subunit - immunology | Interleukin-2 Receptor beta Subunit - genetics | Interleukin-2 Receptor alpha Subunit - immunology | Interleukin-2 - metabolism | Cell Line | Interleukin-15 - antagonists & inhibitors | Interleukin-15 Receptor alpha Subunit - genetics | Interleukin Receptor Common gamma Subunit - genetics | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Interleukin-15 - metabolism | Protein Binding | Mice | CD8-Positive T-Lymphocytes - immunology | Interleukin-2 Receptor beta Subunit - immunology | Cell proliferation | Interleukin 2 receptors | Cytokines | Interleukin 2 | CD8 antigen | Interleukin | Lymphocytes T | Interleukin 15 | Immune system | Recruitment | CD122 antigen | Life Sciences | Cancer
Journal Article
Vascular Pharmacology, ISSN 1537-1891, 2012, Volume 57, Issue 1, pp. 56 - 64
Abstract Objectives Sphingosine 1-phosphate (S1P) – a lysosphingolipid present in HDL – exerts atheroprotective effects in vitro , while FTY720, a... 
Cardiovascular | Sphingosine 1-phosphate (S1P) | Inflammation | High density lipoproteins (HDL) | Atherosclerosis | CHOLESTEROL | ENDOTHELIAL CELL-ADHESION | SPHINGOSINE-1-PHOSPHATE ANALOG | HYPERCHOLESTEROLEMIA | HIGH-DENSITY-LIPOPROTEIN | MACROPHAGE ACCUMULATION | INTERFERON-GAMMA | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | ADIPOSE-TISSUE | Spleen - immunology | Spleen - drug effects | Body Weight - immunology | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Oxadiazoles - pharmacology | Serine Endopeptidases - immunology | CD8-Positive T-Lymphocytes - metabolism | Lymph Nodes - drug effects | Receptors, Lysosphingolipid - metabolism | Interleukin-6 - metabolism | Lymphocytes - metabolism | Propylene Glycols - pharmacology | Atherosclerosis - immunology | CD4-Positive T-Lymphocytes - metabolism | Lymph Nodes - metabolism | Receptors, LDL - metabolism | Lymph Nodes - immunology | Receptors, LDL - immunology | Atherosclerosis - metabolism | Sphingosine - pharmacology | Macrophages - metabolism | Sphingosine - analogs & derivatives | Interleukin-6 - immunology | Receptors, Lysosphingolipid - agonists | Mice | CD8-Positive T-Lymphocytes - immunology | Antigens, CD - immunology | Genes, MHC Class II - immunology | Interleukin-2 - immunology | Lymphocytes - immunology | Female | Propylene Glycols - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Interleukin-2 - metabolism | Atherosclerosis - drug therapy | CD11b Antigen - immunology | Mice, Inbred C57BL | Proprotein Convertases - metabolism | Fingolimod Hydrochloride | Sphingosine - immunology | Proprotein Convertases - immunology | Receptors, Lysosphingolipid - immunology | Animals | Spleen - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | CD8-Positive T-Lymphocytes - drug effects | Lymphocytes - drug effects | Macrophages - drug effects | Serine Endopeptidases - metabolism | CD11b Antigen - metabolism | CD4-Positive T-Lymphocytes - drug effects | Indans - pharmacology | Hypercholesterolemia | Blood lipids | Mitogens | Low density lipoproteins | Sphingosine
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2009, Volume 119, Issue 10, pp. 3011 - 3023
Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | INTERLEUKIN-17 FAMILY | IN-VIVO | GROWTH | IL-17-PRODUCING T-CELLS | FACTOR RECEPTOR P55 | PHASE-II | NECROSIS-FACTOR-ALPHA | NF-KAPPA-B | Humans | Tumor Necrosis Factor-alpha - genetics | Interleukin-17 - immunology | Antibodies, Monoclonal - therapeutic use | Gene Expression Profiling | Chimera - genetics | CD4-Positive T-Lymphocytes - immunology | Interleukin-23 - genetics | Ovarian Neoplasms - genetics | Chimera - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Infliximab | Microarray Analysis | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - therapeutic use | Female | Ovarian Neoplasms - drug therapy | Disease Models, Animal | Interleukin-2 Receptor alpha Subunit - immunology | Receptors, Interleukin - immunology | Mice, Inbred C57BL | Receptors, Tumor Necrosis Factor, Type I | Interleukin-17 - genetics | Clinical Trials as Topic | Receptors, Interleukin - genetics | Interleukin-23 - immunology | Mice, Knockout | Animals | Signal Transduction - physiology | Mice | Ovarian Neoplasms - immunology | Interleukin-2 Receptor alpha Subunit | Signal Transduction | Anti-Inflammatory Agents | Interleukin-23 | Receptors, Interleukin | Antibodies, Monoclonal | Tumor Necrosis Factor-alpha | Life Sciences | Immunology | CD4-Positive T-Lymphocytes | Interleukin-17 | Ovarian Neoplasms | Chimera
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2011, Volume 37, Issue 3, pp. 190 - 197
Abstract One way for intravenous Ig (IVIg) to affect responses of the B cells might be to operate through their TLR7 and TLR9. We confirm the ability of TLR... 
Allergy and Immunology | Intravenous immunoglobulin | B lymphocyte | TLR9 | Autoimmune diseases | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | KAPPA-B | IMMUNOLOGY | PROINFLAMMATORY CYTOKINE PRODUCTION | FC-GAMMA-RIIB | IN-VITRO | NEGATIVE REGULATION | TOLL-LIKE RECEPTORS | UP-REGULATION | BACTERIAL-DNA | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Humans | Toll-Like Receptor 9 - genetics | Molecular Sequence Data | Sialic Acid Binding Ig-like Lectin 2 - immunology | Toll-Like Receptor 9 - agonists | Toll-Like Receptor 9 - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Sialic Acid Binding Ig-like Lectin 2 - metabolism | Toll-Like Receptor 7 - immunology | Myeloid Differentiation Factor 88 - immunology | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | Autoimmune Diseases - drug therapy | B-Lymphocytes - metabolism | Interleukin-2 Receptor alpha Subunit - immunology | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Amino Acid Sequence | B-Lymphocytes - cytology | Toll-Like Receptor 7 - metabolism | Autoimmune Diseases - immunology | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Immunoglobulins, Intravenous - pharmacology | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Interleukin-2 Receptor alpha Subunit - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Lymphocyte Activation - drug effects | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Employee recruitment | Enzymes | Phosphatases | Immunoglobulin G | Oligodeoxyribonucleotides | Interleukin-2 Receptor alpha Subunit | Signal Transduction | Interleukin-10 | Lymphocyte Activation | Toll-Like Receptor 9 | B-Lymphocytes | Myeloid Differentiation Factor 88 | Toll-Like Receptor 7 | Interleukin-6 | Life Sciences | Immunology | Autoimmune Diseases | Sialic Acid Binding Ig-like Lectin 2 | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | Immunoglobulins, Intravenous
Journal Article
Immunity, ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 13 - 25
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth... 
BETA-CHAIN | SEVERE COMBINED IMMUNODEFICIENCY | CYTOKINE RECEPTOR | IN-VIVO | REGULATORY T-CELLS | GENE-EXPRESSION | RECEPTOR-ALPHA-CHAIN | MONOCLONAL-ANTIBODY | IMMUNOLOGY | IL-2 RECEPTOR | GAMMA-CHAIN | T-Lymphocyte Subsets - immunology | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | Interleukin Receptor Common gamma Subunit - metabolism | X-Linked Combined Immunodeficiency Diseases - immunology | Interleukin Receptor Common gamma Subunit - immunology | Leukemia-Lymphoma, Adult T-Cell - immunology | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | T-Lymphocytes, Helper-Inducer - immunology | Immunotherapy | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Leukemia-Lymphoma, Adult T-Cell - therapy | Interleukin-2 - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Immune Tolerance | Receptors, Interleukin-2 - metabolism | X-Linked Combined Immunodeficiency Diseases - therapy | Interleukin Receptor Common gamma Subunit - genetics | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interleukin-15 - metabolism | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Interleukins | T cells | Cell growth | T cell receptors | Cytokines | Kinases | Immune system
Journal Article