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1. Full Text Modular organization of Interleukin-6 and Interleukin-11 α-receptors
by Nitz, Rebecca and Lokau, Juliane and Aparicio-Siegmund, Samadhi and Scheller, Jürgen and Garbers, Christoph
Biochimie, ISSN 0300-9084, 12/2015, Volume 119, pp. 175 - 182
Signal transduction | Proliferation | Interleukin-11 | Proteolysis | Plasticity | Interleukin-6 | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Subunits | Receptors, Interleukin-6 - chemistry | Cell Proliferation | Cytokine Receptor gp130 - genetics | Humans | Interleukin-11 Receptor alpha Subunit - agonists | Cytokine Receptor gp130 - agonists | Interleukin-6 Receptor alpha Subunit - metabolism | Interleukin-6 Receptor alpha Subunit - agonists | Protein Interaction Domains and Motifs | Interleukin-11 Receptor alpha Subunit - genetics | Binding Sites | Interleukin-6 - metabolism | Peptide Fragments - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Cell Line | Peptide Fragments - metabolism | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Signal Transduction | Receptors, Interleukin-6 - genetics | Cytokine Receptor gp130 - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Interleukin-11 - genetics | Interleukin-11 - metabolism | Interleukin-11 Receptor alpha Subunit - metabolism | Interleukin-6 Receptor alpha Subunit - chemistry | Interleukin-6 Receptor alpha Subunit - genetics | Peptide Fragments - chemistry | Animals | Interleukin-11 Receptor alpha Subunit - chemistry | Peptide Fragments - agonists | Ligands | Mice | Receptors, Interleukin-6 - agonists | Receptors, Interleukin-6 - metabolism | Index Medicus
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2. Full Text Interleukin-6 and its receptor in cancer: Implications for translational therapeutics
by Hong, David S and Angelo, Laura S and Kurzrock, Razelle
Cancer, ISSN 0008-543X, 11/2007, Volume 110, Issue 9, pp. 1911 - 1928
Interleukin-6 receptor | Translational therapeutics | Monoclonal antibody | Interleukin-6 | Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Tumors | Neoplasms - metabolism | Animals | Humans | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Interleukin-6 - metabolism | Drug Delivery Systems | Neoplasms - drug therapy | Receptors, Interleukin-6 - metabolism | Physiological aspects | Genetic aspects | Research | Genetic translation | Cancer | Index Medicus | Abridged Index Medicus
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3. Full Text T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation
by Tu, Eric and Chia, Cheryl P.Z and Chen, Weiwei and Zhang, Dunfang and Park, Sang A and Jin, Wenwen and Wang, Dandan and Alegre, Maria-Luisa and Zhang, Ying E and Sun, Lingyun and Chen, WanJun
Immunity (Cambridge, Mass.), ISSN 1074-7613, 04/2018, Volume 48, Issue 4, pp. 745 - 759.e6
signaling | T cell activation | receptor I downregulation | autoimmunity | NF-kB | TCR signaling | T cell quiescence | TGF-β | CARD11 | IL-6 | Life Sciences & Biomedicine | Immunology | Science & Technology | Cell Proliferation | Humans | Transforming Growth Factor beta1 - metabolism | Colitis - pathology | NF-kappa B - metabolism | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Receptor, Transforming Growth Factor-beta Type I - metabolism | Signal Transduction - immunology | CARD Signaling Adaptor Proteins - metabolism | Lymphocyte Activation - immunology | Autoimmunity - immunology | HEK293 Cells | Lupus Erythematosus, Systemic - immunology | Receptors, Antigen, T-Cell - immunology | Colitis - immunology | Transforming Growth Factor beta1 - biosynthesis | Disease Models, Animal | Cell Line | Receptor, Transforming Growth Factor-beta Type I - biosynthesis | Mice, Inbred C57BL | Guanylate Cyclase - metabolism | Mice, Knockout | Animals | Down-Regulation - immunology | Interleukin-6 - immunology | Guanylate Cyclase - genetics | Mice | Mice, Inbred BALB C | Cell proliferation | NF-κB protein | Antigens | Transcription factors | Statistical analysis | Research & development--R&D | Transforming growth factor | Interleukin | Caspase | Autoantigens | Lymphocytes T | T cell receptors | Experiments | Interleukin 6 | Proteins | T-cell receptor | Mitigation | Studies | Signaling | Cell activation | Lymphocytes | Index Medicus
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4. Full Text TLR9 responses of B cells are repressed by intravenous immunoglobulin through the recruitment of phosphatase
by Séité, Jean-François and Guerrier, Thomas and Cornec, Divi and Jamin, Christophe and Youinou, Pierre and Hillion, Sophie
Journal of autoimmunity, ISSN 0896-8411, 2011, Volume 37, Issue 3, pp. 190 - 197
Allergy and Immunology | Intravenous immunoglobulin | B lymphocyte | TLR9 | Autoimmune diseases | Life Sciences & Biomedicine | Immunology | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Biological and medical sciences | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Humans | Toll-Like Receptor 9 - genetics | Molecular Sequence Data | Sialic Acid Binding Ig-like Lectin 2 - immunology | Toll-Like Receptor 9 - agonists | Toll-Like Receptor 9 - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Sialic Acid Binding Ig-like Lectin 2 - metabolism | Toll-Like Receptor 7 - immunology | Myeloid Differentiation Factor 88 - immunology | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | Autoimmune Diseases - drug therapy | B-Lymphocytes - metabolism | Interleukin-2 Receptor alpha Subunit - immunology | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Amino Acid Sequence | B-Lymphocytes - cytology | Toll-Like Receptor 7 - metabolism | Autoimmune Diseases - immunology | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Immunoglobulins, Intravenous - pharmacology | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Interleukin-2 Receptor alpha Subunit - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Lymphocyte Activation - drug effects | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Employee recruitment | Enzymes | Phosphatases | Immunoglobulin G | Index Medicus | Oligodeoxyribonucleotides | Interleukin-2 Receptor alpha Subunit | Signal Transduction | Interleukin-10 | Lymphocyte Activation | Toll-Like Receptor 9 | B-Lymphocytes | Myeloid Differentiation Factor 88 | Toll-Like Receptor 7 | Interleukin-6 | Life Sciences | Autoimmune Diseases | Sialic Acid Binding Ig-like Lectin 2 | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | Immunoglobulins, Intravenous
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5. Full Text The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
by Swerdlow, Daniel I and Holmes, Michael V and Kuchenbaecker, Karoline B and Engmann, Jorgen E. L and Shah, Tina and Sofat, Reecha and Guo, Yiran and Chung, Christina and Peasey, Anne and Ster, Roman Pfi and Mooijaart, Simon P and Ireland, Helen A and Leusink, Maarten and Langenberg, Claudia and Li, KaWah and Palmen, Jutta and Howard, Philip and Cooper, Jackie A and nos, Fotios and Hardy, John and Nalls, Michael A and Li, Yun Rose and Lowe, Gordon and Stewart, Marlene and Bielinski, Suzette J and Peto, Julian and Timpson, Nicholas J and Gallacher, John and Dunlop, Malcolm and Houlston, Richard and Tomlinson, Ian and Tzoulaki, Ioanna and Luan, Jian'an and Boer, Jolanda M. A and Forouhi, Nita G and Onland-Moret, N. Charlotte and van der Schouw, Yvonne T and Schnabel, Renate B and Hubacek, Jaroslav A and Kubinova, Ruzena and Baceviciene, Migle and Tamosiunas, Abdonas and Pajak, Anzej and Navis, Gerjan and Mateo Leach, Irene and Bakker, Stephan J. L and Gansevoort, Ron T and Kumari, Meena and van der Harst, Pim and Asselbergs, Folkert W and The Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium and Interleukin-6 Receptor Mendelian R and Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium
The Lancet (British edition), ISSN 0140-6736, 03/2012, Volume 379, Issue 9822, pp. 1214 - 1224
Internal Medicine | C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | SOLUBLE IL-6 | INDIVIDUAL PARTICIPANTS DATA | JOINT ANALYSIS | IL-6 RECEPTOR | GENOME-WIDE ASSOCIATION | TOCILIZUMAB | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cardiology. Vascular system | Heart | Biological and medical sciences | General aspects | Medical sciences | Coronary heart disease | Antibodies, Monoclonal, Humanized - adverse effects | Gene Frequency - genetics | Antibodies, Monoclonal, Humanized - therapeutic use | Genetic Association Studies | Receptors, Interleukin-6 - genetics | Humans | Inflammation Mediators - blood | Genotype | Treatment Outcome | Receptors, Interleukin-6 - antagonists & inhibitors | Signal Transduction - genetics | Randomized Controlled Trials as Topic | Coronary Disease - prevention & control | Phenotype | Coronary Disease - genetics | Signal Transduction - drug effects | Mendelian Randomization Analysis | Polymorphism, Single Nucleotide - genetics | Genetic Variation - genetics | Prevention | Drug therapy | Health aspects | Risk factors | Interleukin-6 | Cytokine receptors | Physiological aspects | Genetic aspects | Research | Studies | Medical research | Cardiovascular disease | Cholesterol | Cancer | Index Medicus | Abridged Index Medicus | Medicin och hälsovetenskap
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6. Full Text SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke): A Randomized Controlled Phase 2 Trial
by Smith, Craig J and Hulme, Sharon and Vail, Andy and Heal, Calvin and Parry-Jones, Adrian R and Scarth, Sylvia and Hopkins, Karen and Hoadley, Margaret and Allan, Stuart M and Rothwell, Nancy J and Hopkins, Stephen J and Tyrrell, Pippa J
Stroke (1970), ISSN 0039-2499, 05/2018, Volume 49, Issue 5, pp. 1210 - 1216
Brain ischemia | Clinical trial | Stroke | C-reactive protein | Interleukin-1 receptor antagonist | Interleukin-6 | Clinical Neurology | Peripheral Vascular Disease | Neurosciences & Neurology | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Double-Blind Method | Area Under Curve | Humans | Middle Aged | Male | Treatment Outcome | Inflammation | Stroke - drug therapy | Tissue Plasminogen Activator - therapeutic use | Brain Ischemia - immunology | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Brain Ischemia - drug therapy | Fibrinolytic Agents - therapeutic use | Injections, Subcutaneous | Thrombolytic Therapy | Interleukin-6 - immunology | Aged, 80 and over | Female | Aged | Odds Ratio | C-Reactive Protein - immunology | Stroke - immunology | Stroke (Disease) | Cerebral ischemia | Care and treatment | Interleukin-1 | Prognosis | Analysis | Clinical trials | Research | Index Medicus
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7. Full Text Efficacy of the anti–IL-6 receptor antibody tocilizumab in neuromyelitis optica: A pilot study
by Araki, Manabu and Matsuoka, Takako and Miyamoto, Katsuichi and Kusunoki, Susumu and Okamoto, Tomoko and Murata, Miho and Miyake, Sachiko and Aranami, Toshimasa and Yamamura, Takashi
Neurology, ISSN 0028-3878, 04/2014, Volume 82, Issue 15, pp. 1302 - 1306
Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Diseases of visual field, optic nerve, optic chiasma and optic tracts | Cerebrospinal fluid. Meninges. Spinal cord | Biological and medical sciences | Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis | Medical sciences | Ophthalmology | Nervous system (semeiology, syndromes) | Antibodies, Monoclonal, Humanized - adverse effects | Neuromyelitis Optica - drug therapy | Antibodies, Monoclonal, Humanized - therapeutic use | Fatigue - drug therapy | Humans | Middle Aged | Male | Treatment Outcome | Receptors, Interleukin-6 - antagonists & inhibitors | Secondary Prevention | Neuralgia - drug therapy | Pilot Projects | Adult | Female | Index Medicus | Abridged Index Medicus | 132 | 224
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8. Full Text Therapeutic targeting of the interleukin-6 receptor
by Tanaka, Toshio and Narazaki, Masashi and Kishimoto, Tadamitsu
Annual review of pharmacology and toxicology, ISSN 0362-1642, 2012, Volume 52, Issue 1, pp. 199 - 219
Autoimmune | Inflammation | Tocilizumab | Humanized anti-interleukin-6 receptor antibody | Interleukin-6 | Biological and medical sciences | Medical sciences | Blood. Blood coagulation. Reticuloendothelial system | Pharmacology. Drug treatments | Bones, joints and connective tissue. Antiinflammatory agents | Th1 Cells - drug effects | Antibodies, Monoclonal, Humanized - therapeutic use | Humans | Autoimmune Diseases - immunology | Inflammation - immunology | Receptors, Interleukin-6 - antagonists & inhibitors | Randomized Controlled Trials as Topic | T-Lymphocytes, Regulatory - drug effects | Th17 Cells - drug effects | Animals | Cell Differentiation - drug effects | Inflammation - drug therapy | Interleukin-6 - immunology | Receptors, Interleukin-6 - immunology | Drug Delivery Systems - methods | Autoimmune Diseases - drug therapy | Disease Models, Animal | Physiological aspects | Research | Interleukins | Pharmacokinetics | Health aspects | Index Medicus
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