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Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases
Journal Article
Glia, ISSN 0894-1491, 04/2014, Volume 62, Issue 4, pp. 592 - 607
ATP is an important regulator of microglia and its effects on microglial cytokine release are currently discussed as important contributors in a variety of... 
antagonists | EXTRACELLULAR ATP | purine receptors | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | FOCAL CEREBRAL-ISCHEMIA | P2X7 RECEPTOR | TUMOR-NECROSIS-FACTOR | neuroinflammation | neuroprotection | P2X RECEPTOR | PURINERGIC RECEPTORS | INTERLEUKIN-1-BETA RELEASE | ACTIVATED MICROGLIA | CYTOKINE RELEASE | Neuroprotection | Neuroinflammation | Antagonists | Purine receptors | NEUROSCIENCES | Tumor Necrosis Factor-alpha - metabolism | Calcium - metabolism | Tumor Necrosis Factor-alpha - genetics | Purinergic P2X Receptor Antagonists - pharmacology | Receptors, Purinergic P2X4 - deficiency | Receptors, Purinergic P2X7 - genetics | Adenosine Triphosphate - pharmacology | Dose-Response Relationship, Drug | Microglia - physiology | Chemokine CCL2 - metabolism | Cell Differentiation - physiology | Interleukin-6 - metabolism | Animals, Newborn | Brain - cytology | Interleukin-6 - genetics | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Connexins - genetics | Chemokine CCL2 - genetics | Nerve Tissue Proteins - genetics | Purinergic P2X Receptor Agonists - pharmacology | Adenosine Triphosphate - analogs & derivatives | Receptors, Purinergic P2X7 - physiology | Connexins - metabolism | Nerve Tissue Proteins - metabolism | Receptors, Purinergic P2X7 - deficiency | Animals | Cell Differentiation - drug effects | Mice
Journal Article
Blood, ISSN 0006-4971, 07/2004, Volume 104, Issue 1, pp. 100 - 106
Journal Article
The Oncologist, ISSN 1083-7159, 08/2018, Volume 23, Issue 8, pp. 943 - 947
On August 30, 2017, the U.S. Food and Drug Administration approved Actemra (tocilizumab, Genentech, Inc., South San Francisco, CA) for the treatment of severe... 
Cytokine release syndrome | Chimeric antigen receptor | Interleukin‐6 | Tocilizumab | T cell | Immunotherapy | Interleukin-6 | MANAGEMENT | ONCOLOGY | REMISSIONS | LEUKEMIA | FDA | Regulatory Issues
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 2016, Volume 22, Issue 10, pp. 1851 - 1860
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 12/2014, Volume 10, Issue 12, pp. 2171 - 2192
SNCA/α-synuclein aggregation plays a crucial role in synucleinopathies such as Parkinson disease and dementia with Lewy bodies. Aggregating and nonaggregating... 
GFAP, glial fibrillary acidic protein | HSPA8/Hsc70, heat shock 70kDa protein 8 | lysosomal degradation | BafA1, bafilomycinA | CASP3/aCasp3, caspase-3 | ESCRT, endosomal sorting complex required for transport | PF, particle fraction | ANXA5, annexin A5 | SNCA-T, tagged α-synuclein | PDGFB/PDGFb, platelet-derived growth factor subunit b | PD, Parkinson disease | S100B/S100b, S100 calcium-binding protein B | HRP, horseradish peroxidase | TUBB3/b-III-Tub, tubulin, β 3 class III | AIF1/Iba1, allograft inflammatory factor 1 | α-synuclein | CA1, cornu ammonis field1 | RT, room temperature | ILVs, intraluminal vesicles | LAMP2A/Lamp2a, lysosomal-associated membrane protein 2, isoform A | MAP2, microtubule-associated protein 2 | SYP, synaptophysin | CD63, CD63 molecule | LN, Lewy neuritis | ALP, autophagy-lysosomal pathway | RAB11A/rab11, member RAS oncogene family | 1 | secretion | EV, empty vector | protein aggregation | TNF/TNFa, tumor necrosis factor α | WT-SNCA, wild-type α-synuclein | CSF, cerebrospinal fluid | RBFOX3/NeuN, RNA binding protein, fox-1 homolog (C. elegans) 3 | DLB, dementia with Lewy bodies | CM, conditioned medium | tg, transgenic | Parkinson disease | ML, molecular layer | ACTB/bAct, actin, β | ER, endoplasmatic reticulum | synucleinopathies | SL, stratum lacunosum; SNCA/aSyn | SNCAIP/Sph1, synphilin-1 | CMA, chaperone-mediated autophagy | inflammation | Neoctx, neocortex | UPS, ubiquitin proteasome system | IL6/IL-6, interleukin-6 | N, neuron | LB, Lewy bodies | MVBs, multivesicular bodies | PS, phosphatidylserine | Hippo, hippocampus | AK, adenylate kinase | Protein aggregation | Lysosomal degradation | Secretion | Synucleinopathies | Inflammation | CALCIUM-DEPENDENT MANNER | CHAPERONE-MEDIATED AUTOPHAGY | LEWY BODY DISEASE | alpha-synuclein | CELL-DEATH | CELL BIOLOGY | TRANSMISSION | MULTIVESICULAR BODIES | PROTEIN-DEGRADATION | NEURONS | PARKINSONS-DISEASE | Animals | Rats, Wistar | Humans | Cells, Cultured | Mice, Transgenic | Signal Transduction - physiology | Autophagy - physiology | Mice | Neurons - metabolism | Parkinson Disease - metabolism | Lewy Bodies - metabolism | alpha-Synuclein - metabolism
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2014, Volume 124, Issue 7, pp. 2935 - 2946
Journal Article