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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 37, pp. 14393 - 14406
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2008, Volume 291, Issue 1, pp. 71 - 78
In order to investigate the toxic effect of intermittent high glucose (IHG) and sustained high glucose (SHG) on rat pancreatic beta cell functions and the... 
Oxidative stress | Rat pancreatic islet | INS-1 cell | Glucotoxicity | Intermittent high glucose | Endoplasmic reticulum stress | TRANSCRIPTION FACTOR PDX-1 | N-TERMINAL KINASE | CHRONIC OXIDATIVE STRESS | glucotoxicity | ENDOPLASMIC-RETICULUM STRESS | endoplasmic reticulum stress | TRANSLATIONAL CONTROL | CELL BIOLOGY | INSULIN GENE-EXPRESSION | UNFOLDED PROTEIN RESPONSE | intermittent high glucose | ENDOTHELIAL-CELLS | MONOCYTE ADHESION | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | oxidative stress | rat pancreatic islet | Transcription Factor CHOP - genetics | eIF-2 Kinase - metabolism | Endoplasmic Reticulum - metabolism | Male | Tyrosine - analogs & derivatives | Insulin-Secreting Cells - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Glucose - toxicity | Insulin-Secreting Cells - cytology | Deoxyguanosine - analogs & derivatives | eIF-2 Kinase - genetics | Cell Survival | Cells, Cultured | Activating Transcription Factor 4 - genetics | Rats | Rats, Sprague-Dawley | Tyrosine - metabolism | Animals | Activating Transcription Factor 4 - metabolism | Insulin-Secreting Cells - drug effects | Eukaryotic Initiation Factor-2 - genetics | Glucose - metabolism | Stress, Psychological | Deoxyguanosine - metabolism | Signal Transduction - physiology | Enzyme Activation | Transcription Factor CHOP - metabolism | Glucose metabolism | Pancreatic beta cells | Glucose | Gene expression | Dextrose | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 2005, Volume 183, Issue 2, pp. 259 - 267
In this study the effects of stable and intermittent high glucose concentrations on ICAM-1, VCAM-1 and E-selectin production, PKC activity and PKCβI, βII and δ... 
Adhesion molecules | PKC | Mitochondrial superoxide | Intermittent glucose | Endothelium | endothelium | OXIDATIVE STRESS | ACTIVATION | CIRCULATING ADHESION MOLECULES | BLOOD-GLUCOSE | ATHEROSCLEROSIS | MECHANISMS | intermittent glucose | DIABETES-MELLITUS | mitochondrial superoxide | HYPERGLYCEMIA | adhesion molecules | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | Endothelium, Vascular - cytology | Mitochondria - enzymology | Vascular Cell Adhesion Molecule-1 - drug effects | Gene Expression - drug effects | Humans | Glucose - administration & dosage | Dose-Response Relationship, Drug | RNA, Messenger - biosynthesis | E-Selectin - genetics | Protein Kinase C - metabolism | Intercellular Adhesion Molecule-1 - biosynthesis | E-Selectin - biosynthesis | Superoxides - metabolism | Intercellular Adhesion Molecule-1 - drug effects | Vascular Cell Adhesion Molecule-1 - genetics | E-Selectin - drug effects | Umbilical Veins - cytology | Deoxyguanosine - analogs & derivatives | Infant, Newborn | Enzyme-Linked Immunosorbent Assay | Protein Kinase C - drug effects | RNA, Messenger - genetics | Cells, Cultured | Blotting, Western | Blotting, Northern | Endothelium, Vascular - metabolism | Intercellular Adhesion Molecule-1 - genetics | Deoxyguanosine - metabolism | Vascular Cell Adhesion Molecule-1 - biosynthesis | Oxidative Stress - drug effects | In Vitro Techniques | Sweetening Agents - administration & dosage | Umbilical Veins - metabolism | Messenger RNA | Atherosclerosis | Superoxide | Glucose | Protein kinases | Dextrose | Porphyrins
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 01/2018, Volume 97, pp. 1229 - 1237
Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with glucose intolerance, insulin resistance and type 2 diabetes mellitus (T2DM). Although... 
Intermittent hypoxia | Type 2 diabetes | Honokiol | Pancreatic β cell | Nrf2/ARE signaling pathway | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | OBSTRUCTIVE SLEEP-APNEA | OXIDATIVE STRESS | LIPID-PEROXIDATION | Pancreatic beta cell | SENSITIVITY | RESPONSES | MAGNOLOL | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | MICE | NF-KAPPA-B
Journal Article
Journal Article
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, ISSN 1538-7933, 08/2004, Volume 2, Issue 8, pp. 1453 - 1459
It has been previously reported that endothelial cells exposed to constant high concentrations of glucose upregulate the expression of adhesion molecules.... 
poly (ADP-ribose) polymerase | OXIDATIVE STRESS | GLYCEMIC CONTROL | INTERCELLULAR-ADHESION MOLECULE-1 | ACUTE HYPERGLYCEMIA | ICAM-1 | intermittent glucose | MICROVASCULAR COMPLICATIONS | IL-6 | DIABETES-MELLITUS | E-selectin | VCAM-1 | REACTIVE OXYGEN | NITROTYROSINE FORMATION | ENDOTHELIAL-CELLS | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY
Journal Article
Journal Article
International Journal of Clinical and Experimental Medicine, ISSN 1940-5901, 2015, Volume 8, Issue 4, pp. 5462 - 5469
Objectives: Glucose fluctuation is suggested to be the leading cause of beta-cell damages. To determine how it induces beta-cell dysfunction, we systematically... 
Intermittent high glucose | Pancreatic beta-cells | Treatment | MEDICINE, RESEARCH & EXPERIMENTAL | treatment | APOPTOSIS | ENZYME GENE-EXPRESSION | PTEN | pancreatic beta-cells | MECHANISMS | DELETION | CALCIUM-CHANNELS | ENDOTHELIAL-CELLS | CLINICAL-IMPLICATIONS | RESISTANCE | INSULIN HYPERSENSITIVITY
Journal Article