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Acta Pharmaceutica Sinica B, ISSN 2211-3835, 09/2016, Volume 6, Issue 5, pp. 363 - 373
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal... 
Organic cations | Organic anions | Drug-drug interactions | Nephrotoxicity | Renal drug transporters | ORGANIC ANION TRANSPORTER | MULTIDRUG-RESISTANCE PROTEINS | KIDNEY PROXIMAL TUBULES | CISPLATIN-INDUCED NEPHROTOXICITY | FUNCTIONAL-CHARACTERIZATION | CLINICAL PHARMACOKINETICS | INTESTINAL P-GLYCOPROTEIN | CATION TRANSPORTER-2 | MOLECULAR-IDENTIFICATION | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY | NSAID, non-steroidal anti-inflammatory drugs | CHO, Chinese hamster ovary | URAT, urate transporter | P-gp, P-glycoprotein | GSH, glutathione | DDIs, drug–drug interactions | HEK, human embryonic kidney | IC50, half maximal inhibitory concentration | SNP, single-nucleotide polymorphism | Review | Cmax, maximum plasma concentration | MPP+, 1-methyl-4-phenylpyridimium | OCTN, Organic zwitterions | SLC, solute carrier | TEA, tetraethylammonium | ABC, ATP-binding cassette | AUC, area under the plasma concentration curve | MRP, multidrug resistance-associated protein | NBD, nucleotide-binding domain | Drug–drug interactions | ITC, International Transporter Consortium | OA, organic anion | OAT or Oat, organic anion transporters | OC, organic cation | ATP, adenosine triphosphate | TMD, transmembrane domain | CL, plasma clearance | FDA, U.S. Food and Drug Administration | MSD, membrane-spanning domain | MW, molecular weight | NME, new molecular entity | BBB, blood–brain barrier | cation transporters | PAH, p-aminohippurate | Ki, inhibitory constant | OATP or Oatp, organic anion-transporting peptide | fe, fraction of the absorbed dose excreted unchanged in urine | MATE, multidrug and toxin extrusion protein | CLR, renal clearance | OCT or Oct, organic cation transporter
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2014, Volume 42, Issue 12, pp. 1991 - 2001
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 8/2015, Volume 32, Issue 8, pp. 2538 - 2547
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 07/2017, Volume 34, Issue 7, pp. 1444 - 1458
Purpose Over expression of ATP-binding cassette transporters is considered one of the major reasons for non-responsiveness to antiepileptic drugs.... 
ABCC2 | pregnane xenobiotic receptor | molecular dynamics simulation | carbamazepine | NUCLEAR RECEPTORS | RESISTANCE PROTEIN MRP2 | DRUG-METABOLIZING-ENZYMES | XENOBIOTIC RECEPTOR | CHEMISTRY, MULTIDISCIPLINARY | ATP-BINDING CASSETTE | EFFLUX TRANSPORTERS | INTERNATIONAL TRANSPORTER CONSORTIUM | CONSTITUTIVE ANDROSTANE RECEPTOR | PHARMACOLOGY & PHARMACY | ST-JOHNS-WORT | MULTIDRUG-RESISTANCE | Humans | Phloroglucinol - chemistry | Receptors, Steroid - antagonists & inhibitors | Receptors, Steroid - agonists | Anticonvulsants - pharmacology | Ketoconazole - pharmacology | Terpenes - pharmacology | Carbamazepine - chemistry | Terpenes - chemistry | Cell Nucleus - metabolism | RNA Interference | Computer Simulation | Phloroglucinol - pharmacology | Active Transport, Cell Nucleus | Binding, Competitive | Carbamazepine - pharmacology | Multidrug Resistance-Associated Proteins - chemistry | Anticonvulsants - metabolism | Ketoconazole - chemistry | Molecular Dynamics Simulation | Hep G2 Cells | Receptors, Steroid - chemistry | Receptors, Steroid - genetics | Anticonvulsants - chemistry | Protein Binding | Ligands | Molecular Docking Simulation | Mutation | Multidrug Resistance-Associated Proteins - metabolism | Phloroglucinol - analogs & derivatives | Molecular dynamics | Analysis | Carbamazepine | Polymerase chain reaction | Drugs | Translocation | Ketoconazole | Simulation | RNA-mediated interference | ATP-binding protein | Antiepileptic agents | Nuclear transport | Molecular docking
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2015, Volume 59, Issue 10, pp. 6551 - 6560
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 06/2019, Volume 105, Issue 6, pp. 1272 - 1278
The past 2 decades have witnessed transformative changes in our approach to drug–drug interactions (DDIs) from scientific research to clinical practice.... 
PBPK | PHARMACOLOGY & PHARMACY | CLOPIDOGREL | INTERNATIONAL TRANSPORTER CONSORTIUM | Drug Development - methods | Drug Industry - trends | Drug Industry - methods | Humans | Drug Development - trends | Drug Interactions - physiology | Index Medicus | Abridged Index Medicus
Journal Article
Epilepsia, ISSN 0013-9580, 08/2018, Volume 59, Issue 8, pp. 1557 - 1566
Journal Article
Journal Article