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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2016, Volume 59, Issue 22, pp. 9981 - 10005
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 5, p. e10431
... their relevance for pre-clinical drug discovery, disease modeling and basic research. Primary and non-transformed prostate epithelial cells, but also several PrCa lines, formed well... 
EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | GENE-EXPRESSION SIGNATURE | STEM-CELLS | MAMMARY EPITHELIA | METASTASIS | BIOLOGY | TUMOR-CELL INVASION | DIFFERENTIATION | CULTURE MODEL | LINES | Laminin - pharmacology | Epithelial Cells - drug effects | Humans | Mesoderm - drug effects | Spheroids, Cellular - pathology | Male | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Spheroids, Cellular - enzymology | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | Prostate - pathology | Prostatic Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Prostate - drug effects | Antineoplastic Agents - pharmacology | Collagen - pharmacology | Spheroids, Cellular - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Principal Component Analysis | Prostatic Neoplasms - drug therapy | Epithelium - drug effects | Prostatic Neoplasms - pathology | Epithelium - pathology | Neoplasm Invasiveness | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Epithelial Cells - pathology | Cell Shape - drug effects | Phenotype | Proteoglycans - pharmacology | Signal Transduction - drug effects | Models, Biological | Prostatic Neoplasms - enzymology | Cell Proliferation - drug effects | TOR Serine-Threonine Kinases | Cell Transformation, Neoplastic - pathology | Mesoderm - pathology | Drug Combinations | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Epigenetic inheritance | Growth | Oncology, Experimental | Genes | Research | Gene expression | Ionizing radiation | Stem cells | Physiological aspects | Models | Drug discovery | Drug therapy | Prostate cancer | Integrins | Cancer | Cell culture | Biotechnology | Transformation | Motility | Leukocyte migration | Mesenchyme | Epithelial cells | Homeostasis | AKT protein | Metastasis | Drug resistance | Tissues | Ovarian cancer | Cell adhesion & migration | Metastases | Rodents | Fibroblasts | Extracellular matrix | Basal lamina | Lipid metabolism | Medical research | Invasiveness | Phenotypic plasticity | Tumor cell lines | Metabolism | Spheroids | 1-Phosphatidylinositol 3-kinase | Signaling | Interferon | Three dimensional models | Prostate | Cell migration
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e88193 - e88193
Intrinsic resistance to cytotoxic drugs has been a main issue in cancer therapy for decades... 
APOPTOSIS | PLASMA | VESICLES | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR PH | TRAFFICKING | PROTON PUMP INHIBITORS | MECHANISMS | EXPRESSION | H+-ATPASES | CHEMOTHERAPY | Exosomes - drug effects | Exosomes - metabolism | Proton Pump Inhibitors - pharmacology | Intracellular Space - drug effects | Humans | Extracellular Space - drug effects | Chromatography, High Pressure Liquid | Cisplatin - pharmacology | Melanoma - pathology | Mice, SCID | Spectrophotometry, Atomic | Xenograft Model Antitumor Assays | Extracellular Space - metabolism | Reference Standards | Animals | Solutions | Hydrogen-Ion Concentration - drug effects | Intracellular Space - metabolism | Cell Line, Tumor | Female | Cell Death - drug effects | Buffers | Cellular Microenvironment - drug effects | Drug Resistance, Neoplasm - drug effects | Drugs | Drug delivery systems | Care and treatment | Melanoma | Health aspects | Cisplatin | Vehicles | Cancer | Cell culture | Toxicity | Chemoresistance | Cytotoxicity | Drug delivery | Metastasis | Drug resistance | Exosomes | pH effects | Cancer therapies | Skin cancer | Prevention | Hydrogen ions | Xenografts | Biocompatibility | Inhibition | Pretreatment | Deoxyribonucleic acid--DNA | Antigens | Acidity | Breast cancer | Liquid chromatography | High-performance liquid chromatography | Medicine | Studies | Inductively coupled plasma | Protonation | Scientific imaging | Acidosis | Mass spectrometry | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Biomaterials, ISSN 0142-9612, 2015, Volume 72, pp. 74 - 89
Abstract Dual responsive nanoparticles are developed for co-delivery of multiple anticancer drugs to target the drug resistance mechanisms of cancer stem-like cells (CSCs... 
Advanced Basic Science | Dentistry | Topoisomerase | Co-delivery | Drug resistance | Cancer stem-like cell | CD44 | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | TRANSCRIPTION | TOPOISOMERASE-I | DRUG-RESISTANCE | COMBINATION | PACLITAXEL | THERAPY | ANTICANCER | DNA TOPOISOMERASES | ANTITUMOR EFFICACY | XENOGRAFTS | Nanoparticles - chemistry | Neoplastic Stem Cells - drug effects | Humans | Male | Spheroids, Cellular - cytology | Drug Delivery Systems | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Camptothecin - analogs & derivatives | Poloxamer - chemistry | Tissue Distribution - drug effects | Intracellular Space - drug effects | Lactic Acid - chemistry | Endocytosis - drug effects | Hyaluronic Acid - chemistry | Nanoparticles - ultrastructure | Animals | Chitosan - chemistry | Mice, Nude | Intracellular Space - metabolism | Polyglycolic Acid - chemistry | Cell Line, Tumor | Drug Liberation | Camptothecin - pharmacology | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Hydrogen-Ion Concentration | Nanoparticles | Anthracyclines | Hyaluronic acid | Doxorubicin | Drug approval | Cancer | Biomedical engineering | Drugs | Surgical implants | Biomedical materials | Pluronic F127 | Hydroxyapatite | Chitosan | co-delivery | cancer stem-like cell | topoisomerase | drug resistance
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 21, pp. 5344 - 5358
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2016, Volume 114, Issue 2, pp. 177 - 187
Background: Oestrogen receptor-negative (ER-) breast cancer is intrinsically sensitive to chemotherapy. However, tumour response is often incomplete, and... 
CELLS | REDUCES TUMOR-GROWTH | STAT1 | DNA-DAMAGE | chemotherapy | IFN | THERAPY | NEOADJUVANT CHEMOTHERAPY | ONCOLOGY | ER-negative breast cancer | GENE-EXPRESSION | RESISTANCE | PATHWAY ANALYSIS | predictive signature | XENOGRAFTS | Caspase 7 - metabolism | Immunohistochemistry | Receptors, Estrogen - metabolism | Cytoskeletal Proteins - genetics | Humans | Intracellular Signaling Peptides and Proteins - drug effects | Caspase 3 - metabolism | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Interferon-gamma - metabolism | Carrier Proteins - drug effects | Mitochondrial Proteins - drug effects | STAT1 Transcription Factor - metabolism | Mitochondrial Proteins - metabolism | Caspase 3 - genetics | Interferon-beta - genetics | Cytokines - genetics | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Ubiquitins - metabolism | Caspase 7 - drug effects | Antigens - drug effects | Caspase 7 - genetics | Membrane Proteins - genetics | Myxovirus Resistance Proteins - drug effects | Capecitabine - pharmacology | STAT1 Transcription Factor - genetics | Breast Neoplasms - drug therapy | Blotting, Western | Breast Neoplasms - genetics | Interferon-beta - metabolism | Signal Transduction - drug effects | Mice, Nude | Membrane Proteins - drug effects | Mice | Myxovirus Resistance Proteins - genetics | Ubiquitins - drug effects | Antigens - genetics | Neoplasm Transplantation | Phosphorylation | Ubiquitins - genetics | Gene Expression Regulation, Neoplastic | Interferon-gamma - drug effects | STAT1 Transcription Factor - drug effects | Mitochondrial Proteins - genetics | Interferon-beta - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | In Situ Hybridization | Caspase 3 - drug effects | Cytoskeletal Proteins - metabolism | Female | Cytoskeletal Proteins - drug effects | Membrane Proteins - metabolism | Interferon-gamma - genetics | Cytokines - metabolism | Antigens - metabolism | Cisplatin - pharmacology | Xenograft Model Antitumor Assays | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cytokines - drug effects | Myxovirus Resistance Proteins - metabolism | Life Sciences | Computer Science | Translational Therapeutics
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 33, Issue 9, pp. 2780 - 2790
...-CD, resulting in bypass of P-glycoprotein (P-gp)-mediated drug efflux. After complex formation of the mdr1 siRNA with Dox-loaded QDs via electrostatic interaction... 
Advanced Basic Science | Dentistry | QDs | β-CD | Co-delivery | siRNA | Doxorubicin | Multidrug resistance | SiRNA | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | MODULATORS | MECHANISMS | DRUG-RESISTANCE | CANCER | P-GLYCOPROTEIN | NANOPARTICLES | MDR1 | THERAPY | beta-CD | INHIBITORS | EXPRESSION | RNA, Small Interfering - genetics | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Adsorption - drug effects | Cell Tracking - methods | Flow Cytometry | Time Factors | Gene Expression Regulation, Neoplastic - drug effects | Gene Transfer Techniques | Microscopy, Electron, Transmission | Drug Resistance, Multiple - genetics | Intracellular Space - drug effects | Spectrometry, Fluorescence | Static Electricity | Cell Shape - drug effects | Particle Size | Microscopy, Confocal | Drug Resistance, Neoplasm - genetics | Quantum Dots | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Intracellular Space - metabolism | ATP Binding Cassette Transporter, Sub-Family B | HeLa Cells | Drug Delivery Systems - methods | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Drug resistance in microorganisms | Chemotherapy | Anthracyclines | Biological products | Messenger RNA | Genes | Fluorescence | Cyclodextrins | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63404
Although multidrug-resistance-associated protein-1 (MRP1) is a major contributor to multi-drug resistance (MDR... 
OXIDATIVE STRESS | GAMMA-GLUTAMYLCYSTEINE SYNTHETASE | TRANSCRIPTION FACTOR NRF2 | MRP/GS-X PUMP | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR P-GLYCOPROTEIN | ANTICANCER DRUGS | DRUG-RESISTANCE | ADAPTIVE RESPONSE | RESPONSIVE ELEMENT | INDUCIBLE EXPRESSION | Immunohistochemistry | Antioxidants - metabolism | Drug Resistance, Multiple - drug effects | Humans | Lung Neoplasms - metabolism | Molecular Sequence Data | 5' Flanking Region - genetics | Gene Knockdown Techniques | Small Cell Lung Carcinoma - metabolism | Base Sequence | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents - pharmacology | Response Elements - genetics | Gene Expression Regulation, Neoplastic - drug effects | Lung Neoplasms - genetics | Drug Resistance, Multiple - genetics | Signal Transduction - genetics | Small Cell Lung Carcinoma - genetics | Mutation - genetics | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Software | Multidrug Resistance-Associated Proteins - metabolism | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Comparative analysis | Drug resistance | Lung cancer | Cancer | Drugs | Oxidative stress | Genes | Regulatory sequences | Drug development | Tissues | Cancer therapies | Proteins | Antioxidants | Toxicology | Reporter gene | Rodents | Localization | MRP1 protein | Enzymes | Small cell lung carcinoma | Multidrug resistance | Gene expression | Pathology | Correlation analysis | Regulatory mechanisms (biology)
Journal Article