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humans (98) 98
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nutrition & dietetics (27) 27
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physiology (26) 26
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triglycerides (20) 20
weight-loss (20) 20
intramyocellular lipid-accumulation (19) 19
magnetic-resonance-spectroscopy (19) 19
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induced insulin-resistance (18) 18
rats (18) 18
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oxidation-reduction (13) 13
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cell biology (12) 12
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nuclear magnetic resonance spectroscopy (12) 12
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1. Full Text Lkb1 Deletion Promotes Ectopic Lipid Accumulation in Muscle Progenitor Cells and Mature Muscles
by Shan, Tizhong and Zhang, Pengpeng and Bi, Pengpeng and Kuang, Shihuan
Journal of Cellular Physiology, ISSN 0021-9541, 05/2015, Volume 230, Issue 5, pp. 1033 - 1041
Excessive intramyocellular triglycerides (muscle lipids) are associated with reduced contractile function, insulin resistance, and Type 2 diabetes, but what... 
INTRAMYOCELLULAR LIPIDS | SKELETAL-MUSCLE | PHYSIOLOGY | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | IN-VIVO | SELF-RENEWAL | SATELLITE CELLS | ENERGY-METABOLISM | LIPOPROTEIN-LIPASE | ADIPOSE-TISSUE | CELL BIOLOGY | Muscle, Skeletal - growth & development | Cells, Cultured | Gene Expression Regulation | Feeding Behavior | Signal Transduction - genetics | Muscle Fibers, Skeletal - metabolism | Muscle, Skeletal - cytology | Stem Cells - metabolism | Myoblasts - metabolism | Animals | Adenylate Kinase - metabolism | Diet, High-Fat | Gene Deletion | Lipid Metabolism - genetics | Mice | Adipogenesis - genetics | Protein-Serine-Threonine Kinases - metabolism | Type 2 diabetes | Physiological aspects | Insulin resistance | Triglycerides | Gene expression | Stem cells
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2. Full Text Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle
by De Stefanis, Daniela and De Stefanis, Daniela and Mastrocola, Raffaella and Mastrocola, Raffaella and Nigro, Debora and Nigro, Debora and Costelli, Paola and Costelli, Paola and Aragno, Manuela and Aragno, Manuela
European Journal of Nutrition, ISSN 1436-6207, 2/2017, Volume 56, Issue 1, pp. 363 - 373
In recent years, the increasing consumption of soft drinks containing high-fructose corn syrup or sucrose has caused a rise in fructose intake, which has been... 
Chemistry | Glucose | Nutrition | Autophagy | Fructose | Intramyocellular lipids | OXIDATIVE STRESS | FATTY LIVER-DISEASE | OBESITY | NUTRITION & DIETETICS | INSULIN-RESISTANCE | SUCROSE | MITOCHONDRIAL DYSFUNCTION | MICE | FRUCTOSE CONSUMPTION | CARBOHYDRATE-METABOLISM | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Cholesterol - blood | Male | Muscle, Skeletal - metabolism | Insulin - blood | Glucose - administration & dosage | Interleukin-6 - blood | Muscle, Skeletal - drug effects | Suppressor of Cytokine Signaling 3 Protein - blood | Disease Models, Animal | Glucose - adverse effects | Fructose - adverse effects | Mice, Inbred C57BL | Insulin Resistance | Metabolic Diseases - blood | Metabolic Diseases - chemically induced | Suppressor of Cytokine Signaling 3 Protein - genetics | Fibrinogen - genetics | Animals | Fibrinogen - metabolism | Lipid Metabolism - drug effects | Triglycerides - blood | Beclin-1 - genetics | Mice | Beclin-1 - metabolism | Blood Glucose - metabolism | Fructose - administration & dosage | Interleukins | Analysis | Body weight | Muscles | Lipids | Insulin resistance | Beverages | Sugar | Dextrose
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3. Intracellular Lipid Accumulation in Liver and Muscle and the Insulin Resistance Syndrome
by Lara-Castro, Cristina and Garvey, W. Timothy
Endocrinology and Metabolism Clinics of North America, ISSN 0889-8529, 12/2008, Volume 37, Issue 4, pp. 841 - 856
This article emphasizes intrahepatocellular and intramyocellular lipid accumulation as components of the insulin resistance syndrome. It examines the... 
Intramyocellular fat | Insulin resistance | Muscle fat | Inflammation | Hepatic steatosis | DEPENDENT DIABETES-MELLITUS | METABOLIC SYNDROME | WEIGHT-LOSS | CLINICAL-COURSE | SKELETAL-MUSCLE | FREE FATTY-ACIDS | ADIPOSE-TISSUE INFLAMMATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MITOCHONDRIAL DYSFUNCTION | Metabolic Syndrome - etiology | Humans | Liver - metabolism | Metabolic Syndrome - metabolism | Obesity - physiopathology | Diabetes Mellitus, Type 2 - metabolism | Obesity - metabolism | Diabetes Mellitus, Type 2 - ethnology | Animals | Metabolic Syndrome - ethnology | Intracellular Space - metabolism | Diabetes Mellitus, Type 2 - etiology | Body Fat Distribution | Continental Population Groups | Muscles - metabolism | Lipid Metabolism - physiology
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4. Full Text Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet
by Baik, Myunggi and Baik, Myunggi and Lee, Mi Sun and Lee, Mi Sun and Kang, Hyeok Joong and Kang, Hyeok Joong and Park, Seung Ju and Park, Seung Ju and Piao, Min Yu and Piao, Min Yu and Nguyen, Trang Hoa and Nguyen, Trang Hoa and Hennighausen, Lothar and Hennighausen, Lothar
European Journal of Nutrition, ISSN 1436-6207, 3/2017, Volume 56, Issue 2, pp. 569 - 579
Growth hormone (GH) controls liver metabolism through the transcription factor signal transducer and activator of transcription 5 (STAT5). However, it remains... 
Chemistry | Intramyocellular lipid accumulation | Nutrition | Lipid and glucose metabolism | STAT5 muscle deletion | Hepatic lipid accumulation | NONALCOHOLIC STEATOHEPATITIS | BODY-COMPOSITION | FACTOR-I | NUTRITION & DIETETICS | METABOLISM | IMPROVES GLUCOSE-HOMEOSTASIS | GENE-EXPRESSION | OLDER MEN | GROWTH-HORMONE DEFICIENCY | INDUCED OBESITY | ADIPOSE-TISSUE | Receptors, LDL - genetics | CD36 Antigens - genetics | Lipoprotein Lipase - genetics | Liver - metabolism | Mice, Inbred C57BL | STAT5 Transcription Factor - physiology | RNA, Messenger - analysis | Muscle, Skeletal - metabolism | Mice, Knockout | Animals | Diet, High-Fat | Up-Regulation - physiology | Glucose - metabolism | Signal Transduction - physiology | Mice | STAT5 Transcription Factor - deficiency | Lipid Metabolism - physiology | Circuit components | Deregulation | RNA | Liver | Low density lipoproteins | Muscles | Lipoprotein lipase | Triglycerides | Genetic transcription | Glucose | Fatty acids | Dextrose | Physiological aspects
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5. Full Text Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle
by Peck, Bailey and Huot, Josh and Renzi, Tim and Arthur, Susan and Turner, Michael J and Marino, Joseph S
American journal of physiology. Regulatory, integrative and comparative physiology, ISSN 0363-6119, 03/2018, Volume 314, Issue 3, pp. R468 - R477
Protein kinase C-theta (PKC-theta) is a lipid-sensitive molecule associated with lipid-induced insulin resistance in skeletal muscle. Rodent models have not... 
intramyocellular lipid | skeletal muscle insulin sensitivity | protein kinasse C-θ | ACTIVATION | PHYSIOLOGY | KINASE-C-THETA | SENSITIVITY | FATTY-ACIDS | GLUCOSE-TRANSPORT | OBESITY | GENE | IN-VIVO | RESISTANCE | TNF-ALPHA | protein kinasse C-theta | Tumor Necrosis Factor-alpha - metabolism | Muscle, Skeletal - enzymology | Phosphorylation | Signal Transduction | Mice, Inbred C57BL | Tumor Necrosis Factor-alpha - genetics | Insulin Resistance | Genotype | Lipid Metabolism | Male | Fatty Acid-Binding Proteins - metabolism | Fatty Acid-Binding Proteins - genetics | Protein Kinase C-theta - deficiency | Mice, Knockout | Insulin - metabolism | Phenotype | Animals | Diet, High-Fat | Protein Kinase C-theta - genetics | Blood Glucose - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Weight Gain
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6. Full Text Redundancy in regulation of lipid accumulation in skeletal muscle during prolonged fasting in obese men
by Høgild, Morten L and Gudiksen, Anders and Pilegaard, Henriette and Stødkilde‐Jørgensen, Hans and Pedersen, Steen Bønløkke and Møller, Niels and Jørgensen, Jens O. L and Jessen, Niels
Physiological Reports, 11/2019, Volume 7, Issue 21, p. n/a
Fasting in human subjects shifts skeletal muscle metabolism toward lipid utilization and accumulation, including intramyocellular lipid (IMCL) deposition.... 
pyruvate dehydrogenase activity | fasting | Growth hormone | skeletal muscle | intramyocellular lipid | Metabolomics | Fasting | Secretion | Glycerol | Lipid peroxidation | Pyruvic acid | Lipids | Ketone bodies | Glucose | Fatty acids | Skeletal muscle | Lipolysis | Intermediates | Magnetic resonance spectroscopy | Metabolites | Insulin resistance | Oxidation | Lipid metabolism
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7. Full Text Effects of rosiglitazone on intramyocellular lipid accumulation in Psammomys obesus
by Molero, Juan Carlos and Lee, Scott and Leizerman, Ilit and Chajut, Ayelet and Cooper, Adrian and Walder, Ken
BBA - Molecular Basis of Disease, ISSN 0925-4439, 2010, Volume 1802, Issue 2, pp. 235 - 239
To examine the effects of rosiglitazone in intramyocellular lipid (IMCL) content in diabetic using novel electron microscopy technologies. is an unique... 
Rosiglitazone | Psammomys obesus | Intramyocellular lipid | Thiazolidinedione | GLYCEMIC CONTROL | MUSCLE TRIGLYCERIDE CONTENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZUCKER FATTY RATS | WEIGHT-LOSS | IKK-BETA | INDUCED INSULIN-RESISTANCE | SKELETAL-MUSCLE | BIOPHYSICS | SCANNING-ELECTRON-MICROSCOPY | PPAR-GAMMA | TYPE-2 DIABETES-MELLITUS
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8. Full Text Intracellular lipid accumulation and shift during diabetes progression
by Wolf, Peter and Winhofer, Yvonne and Anderwald, Christian-Heinz and Krššák, Martin and Krebs, Michael
Wiener Medizinische Wochenschrift, ISSN 0043-5341, 8/2014, Volume 164, Issue 15, pp. 320 - 329
In past decades, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease developed into a global public health disease with an endemic scale.... 
NAFLD | Intramyocellular lipid content | Geriatrics/Gerontology | Fettsäuren | General Practice / Family Medicine | Internal Medicine | Type 2 diabetes mellitus | Medicine/Public Health, general | Ectopic lipid deposition | Herzfettgehalt | Glucose tolerance | Medicine & Public Health | Glukosetoleranz | Diabetic cardiomyopathy | Infectious Diseases | Insulin resistance | Intrahepatischer Fettgehalt | Pharmacology/Toxicology | Comorbidity | Humans | Non-alcoholic Fatty Liver Disease - therapy | Ventricular Dysfunction, Left - diagnosis | Non-alcoholic Fatty Liver Disease - physiopathology | Diabetic Cardiomyopathies - diagnosis | Diabetic Cardiomyopathies - physiopathology | Disease Progression | Ventricular Dysfunction, Left - physiopathology | Diabetes Mellitus, Type 2 - diagnosis | Ventricular Dysfunction, Left - therapy | Diabetes Mellitus, Type 2 - physiopathology | Insulin Resistance - physiology | Diabetes Mellitus, Type 2 - therapy | Non-alcoholic Fatty Liver Disease - diagnosis | Fatty Acids, Nonesterified - blood | Diabetic Cardiomyopathies - therapy | Blood Glucose - metabolism
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9. Full Text Ektope Fettspeicherung bei Insulinresistenz und Diabetes Mellitus Typ 2
by Wolf, Peter and Wolf, Peter and Winhofer, Yvonne and Winhofer, Yvonne and Anderwald, Christian-Heinz and Anderwald, Christian-Heinz and Krššák, Martin and Krššák, Martin and Krebs, Michael and Krebs, Michael
Wiener Medizinische Wochenschrift, ISSN 0043-5341, 08/2014, Volume 164, Issue 15-16, pp. 320 - 329
Glucose tolerance | NAFLD | Intramyocellular lipid content | Diabetic cardiomyopathy | Insulin resistance | Type 2 diabetes mellitus | Ectopic lipid deposition
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10. Full Text Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation
by Timmers, S and Bosch, J and Towler, M.C and Schaart, G and Kornips, E and Mensink, R.P and Hesselink, M.K and Hardie, D.G and Schrauwen, P
Journal of Lipid Research, ISSN 0022-2275, 02/2010, Volume 51, Issue 2, pp. 352 - 359
Skeletal muscle triglyceride accumulation is associated with insulin resistance in obesity. Recently, it has been suggested that alpha lipoic acid (ALA)... 
MITOCHONDRIAL BIOGENESIS | PROTEIN-KINASE | THIOCTIC ACID | FOOD-INTAKE | GLUCOSE-TRANSPORT | AMP-activated protein kinase | INSULIN SENSITIVITY | DIABETES-MELLITUS | SKELETAL-MUSCLE | intramyocellular lipid accumulation | METABOLISM | glucose tolerance | EXPRESSION | Glucose tolerance | Intramyocellular lipid accumulation | BIOCHEMISTRY & MOLECULAR BIOLOGY | Thioctic Acid - administration & dosage | AMP-Activated Protein Kinases - metabolism | Rats, Wistar | Humans | Body Weight - drug effects | Male | Muscle, Skeletal - metabolism | Body Composition - drug effects | Dietary Fats - pharmacology | Muscle, Skeletal - drug effects | Adult | Muscles - metabolism | Glucose Tolerance Test | Obesity - chemically induced | Rats | Obesity - physiopathology | Thioctic Acid - pharmacology | Enzyme Activation - drug effects | Obesity - metabolism | Eating - drug effects | Insulin - metabolism | Animals | Signal Transduction - drug effects | Muscles - drug effects | Obesity - prevention & control | Lipid Metabolism - drug effects | Glucose - metabolism | Absorption - drug effects | Dietary Supplements
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11. Full Text Determinants of intramyocellular lipid accumulation after dietary fat loading in non‐obese men
by Sakurai, Yuko and Tamura, Yoshifumi and Takeno, Kageumi and Kumashiro, Naoki and Sato, Fumihiko and Kakehi, Saori and Ikeda, Shinichi and Ogura, Yuji and Saga, Norio and Naito, Hisashi and Katamoto, Shizuo and Fujitani, Yoshio and Hirose, Takahisa and Kawamori, Ryuzo and Watada, Hirotaka
Journal of Diabetes Investigation, ISSN 2040-1116, 08/2011, Volume 2, Issue 4, pp. 310 - 317
Aims/Introduction:  Accumulation of intramyocellular lipid (IMCL) is associated with insulin resistance. However, the factors affecting the change in IMCL... 
Intramyocellular lipid | Physical activity | Adiponectin | METABOLIC SYNDROME | LIPOPROTEIN-LIPASE ACTIVITY | SENSITIVITY | HUMANS | HUMAN SKELETAL-MUSCLE | EXERCISE | INSULIN-RESISTANCE | GLUCOSE | ENDOCRINOLOGY & METABOLISM | PHYSICAL-ACTIVITY | Original
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12. Full Text Dexamethasone facilitates lipid accumulation and mild feed restriction improves fatty acids oxidation in skeletal muscle of broiler chicks ( Gallus gallus domesticus)
by Wang, Xiaojuan and Lin, Hai and Song, Zhigang and Jiao, Hongchao
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 2010, Volume 151, Issue 4, pp. 447 - 454
Effects of dexamethasone (DEX) and mild feed restriction on the uptake and utilization of fatty acids in skeletal muscle of broiler chicks ( ) were... 
Energy deficit | Utilization | Glucocorticoids | Intramyocellular lipid | Uptake | METABOLIC SYNDROME | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN | COENZYME-A | LIPOPROTEIN-LIPASE | DIETARY-PROTEIN | ZOOLOGY | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | FIBER-TYPE | TOXICOLOGY | CARNITINE PALMITOYLTRANSFERASE | AMP-Activated Protein Kinases - metabolism | Carnitine O-Palmitoyltransferase - genetics | Male | Muscle, Skeletal - metabolism | RNA, Messenger - metabolism | Adipose Tissue - metabolism | Dexamethasone - pharmacology | Liver - drug effects | Carnitine O-Palmitoyltransferase - metabolism | Muscle, Skeletal - drug effects | Energy Metabolism - physiology | Fatty Acids - metabolism | Body Size - drug effects | Oxidation-Reduction | Liver - metabolism | Lipoproteins, VLDL - drug effects | Down-Regulation - drug effects | Food Deprivation - physiology | Animals | Lipoproteins, VLDL - blood | Chickens | Lipid Metabolism - drug effects | Glucocorticoids - pharmacology | Adipose Tissue - drug effects | AMP-Activated Protein Kinases - genetics
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13. Full Text The Role of Lipid Accumulation in Liver and Muscle for Insulin Resistance and Type 2 Diabetes Mellitus in Humans
by Krssak, Martin and Roden, Michael
Reviews in Endocrine and Metabolic Disorders, ISSN 1389-9155, 5/2004, Volume 5, Issue 2, pp. 127 - 134
insulin sensitivity | nonesterified fatty acids | non-alcoholic fatty liver disease | Medicine & Public Health | Internal Medicine | Diabetes | intramyocellular lipids | hepatic steatosis | Hepatic steatosis | Non-alcoholic fatty liver disease | Insulin sensitivity | Intramyocellular lipids | Nonesterified fatty acids | PROTEIN-KINASE-C | ACYL-COA ESTERS | INTRAMUSCULAR TRIGLYCERIDE | TRIGLYCERIDE CONTENT | COMPUTED-TOMOGRAPHY | SKELETAL-MUSCLE | MAGNETIC-RESONANCE-SPECTROSCOPY | FREE FATTY-ACIDS | ENDOCRINOLOGY & METABOLISM | GLUCOSE-PRODUCTION | Animals | Diabetes Mellitus, Type 2 - physiopathology | Insulin Resistance - physiology | Humans | Lipids - blood | Liver - metabolism | Lipid Metabolism | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Type 2 diabetes | Insulin resistance | Liver diseases | Knowledge-based systems | Liver
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14. Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma
by Zhang, Qunhao and Cao, Haihui and Astrakas, Loukas G and Mintzopoulos, Dionyssios and Mindrinos, Michael N and Schulz III, John and Tompkins, Ronald G and Rahme, Laurence G and Tzika, A. Aria
International Journal of Molecular Medicine, ISSN 1107-3756, 12/2006, Volume 18, Issue 6, pp. 1223 - 1229
Burn trauma is a clinical condition accompanied by muscle wasting that severely impedes rehabilitation in burn survivors. Mitochondrial uncoupling protein 3... 
Burn trauma | Uncoupling protein 3 | Nuclear magnetic resonance | Intramyocellular lipids | Skeletal muscle | trauma | MEDICINE, RESEARCH & EXPERIMENTAL | burn | MESSENGER-RNA EXPRESSION | THERMAL-INJURY | TIME-COURSE | nuclear magnetic resonance | intramyocellular lipids | SKELETAL-MUSCLE | MAGNETIC-RESONANCE-SPECTROSCOPY | MITOCHONDRIAL ENERGY-METABOLISM | uncoupling protein 3 | FREE FATTY-ACIDS | INSULIN-RESISTANCE | UCP3 | IN-VIVO | skeletal muscle | Cold Temperature | Fatty Acids - analysis | Lipid Metabolism | Male | Muscle, Skeletal - metabolism | Mice, Inbred Strains | RNA, Messenger - metabolism | Animals | Ion Channels - metabolism | Time Factors | Mitochondrial Proteins - metabolism | Burns - pathology | Muscle, Skeletal - chemistry | Hindlimb - pathology | Nuclear Magnetic Resonance, Biomolecular | Burns - metabolism | Mice | Fatty Acids - metabolism | Hindlimb - metabolism | Uncoupling Protein 3
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15. Full Text Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid β-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women
by Adams, Sean H and Hoppel, Charles L and Lok, Kerry H and Zhao, Ling and Wong, Scott W and Minkler, Paul E and Hwang, Daniel H and Newman, John W and Garvey, W. Timothy
Journal of Nutrition, ISSN 0022-3166, 06/2009, Volume 139, Issue 6, pp. 1073 - 1081
Inefficient muscle long-chain fatty acid (LCFA) combustion is associated with insulin resistance, but molecular links between mitochondrial fat catabolism and... 
SIGNALING PATHWAYS | NUTRITION & DIETETICS | TOLL-LIKE RECEPTOR-4 | INTRAMYOCELLULAR LIPID-ACCUMULATION | WEIGHT-LOSS | DIFFERENTIAL MODULATION | UNCOUPLING PROTEIN-3 | HUMAN SKELETAL-MUSCLE | CARNITINE METABOLISM | MASS-SPECTROMETRY | INDUCED INSULIN-RESISTANCE | Fatty Acids - chemistry | Oxidation-Reduction | Obesity - complications | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Carnitine - blood | African Americans | Ion Channels - genetics | NF-kappa B - metabolism | Mitochondrial Proteins - genetics | Mutation, Missense | Polymorphism, Genetic | Young Adult | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - ethnology | Aged, 80 and over | Adult | Female | Aged | Citric Acid Cycle - physiology | Carnitine - analogs & derivatives | Fatty Acids - metabolism | Uncoupling Protein 3
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