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Journal of Neuroscience, ISSN 0270-6474, 09/2014, Volume 34, Issue 38, pp. 12893 - 12903
Journal Article
Life Sciences, ISSN 0024-3205, 12/2012, Volume 91, Issue 23-24, pp. 1177 - 1186
Journal Article
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 05/2017, Volume 37, Issue 19, pp. 4928 - 4941
Phosphoinositides and their metabolizing enzymes are involved in A beta(42) metabolism and Alzheimer's disease pathogenesis. In yeast and mammals, Eighty-five... 
PI4KIII alpha | Drosophila | ALZHEIMERS-DISEASE | A beta secretion | BINDING-PROTEIN | AMYLOID-BETA-PROTEIN | neural deficits | PLASMA-MEMBRANE | NEUROSCIENCES | phosphoinositides | PEPTIDE | INTRANEURONAL ACCUMULATION | PHOSPHATIDYLINOSITOL 4-PHOSPHATE | A-BETA | intraneuronal A beta | SOLUBLE OLIGOMERS | ROLLING BLACKOUT
Journal Article
The Journal of neuroscience : the official journal of the Society for Neuroscience, ISSN 0270-6474, 10/2018, Volume 38, Issue 42, pp. 9001 - 9018
Emerging evidences suggest that intraneuronal A beta correlates with the onset of Alzheimer's disease (AD) and highly contributes to neurodegeneration.... 
Intraneuronal Aβ | miR-126 | Alzheimer’s disease | Amyloid beta (Aβ) | TOM1 | Alzheimer's disease | Fcγ-receptor IIb | CLEARANCE | APP | INTRANEURONAL A-BETA | CELL-SURFACE | TAU | NEURODEGENERATION | PATHOLOGY | ENDOCYTOSIS | receptor IIb | NEUROSCIENCES | FC-GAMMA-RIIB | MOUSE MODEL | Amyloid beta (A beta); Intraneuronal A beta; Fc gamma
Journal Article
JOURNAL OF ALZHEIMERS DISEASE, ISSN 1387-2877, 2018, Volume 65, Issue 3, pp. 1001 - 1010
Neuronal amyloid-beta (A beta) accumulation plays an important role in the pathogenesis of Alzheimer's disease (AD). The conformation and toxicity of A beta... 
PI4KIII alpha | Hyccin | PROTEIN | BETA-AMYLOID PEPTIDES | Drosophila | ALZHEIMERS-DISEASE | RECEPTOR | MECHANISMS | PLASMA-MEMBRANE | NEUROSCIENCES | amyloid-beta | INTRANEURONAL ACCUMULATION | TRANSMISSION | TTC7 | HYPOTHESIS | Alzheimer's disease | CONTRIBUTES
Journal Article
Molecules, ISSN 1420-3049, 08/2018, Volume 23, Issue 8, p. 2010
There is growing recognition regarding the role of intracellular amyloid beta (A beta) in the Alzheimer's disease process, which has been linked with aberrant... 
Nitroxide antioxidant | Intraneuronal Aβ | Oxidative stress | Amyloid beta | Spin label | Bifunctional drug | Intracellular Aβ | Oligomer | Alzheimer's disease | intracellular A beta | ACTIVATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | spin label | TOXICITY | CHEMISTRY, MULTIDISCIPLINARY | amyloid beta | OLIGOMERS | nitroxide antioxidant | A beta oligomer | INTRACELLULAR ACCUMULATION | A-BETA | intraneuronal A beta | PRECURSOR PROTEIN | INHIBITORS | bifunctional drug | DERIVATIVES | oxidative stress | AGGREGATION | Reactive Oxygen Species - metabolism | Amyloid beta-Peptides - pharmacology | Amyloid beta-Protein Precursor - chemistry | Humans | Protein Multimerization | Fluorenes - pharmacology | Spin Labels | Alzheimer Disease - pathology | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Neurons - metabolism | Neurons - drug effects | Protein Aggregates - drug effects | Cell Line | Gene Expression | Signal Transduction | Models, Molecular | Amyloid beta-Protein Precursor - genetics | Fluorenes - chemistry | Alzheimer Disease - metabolism | Protein Conformation | Amyloid beta-Peptides - chemistry | Oxidative Stress - drug effects | Alzheimer Disease - genetics | Protein Aggregation, Pathological - metabolism | Fluorene | Image resolution | Toxicity | Fluorescence | Confocal microscopy | Nitroxide | Metabolism | Amyloid precursor protein | Accumulation | Proteins | Mitochondria | Microscopy | Disruption | Synergistic effect | Intracellular | intracellular Aβ | Alzheimer’s disease | intraneuronal Aβ | Aβ oligomer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2007, Volume 282, Issue 26, pp. 18895 - 18906
Immunotherapy against beta-amyloid peptide (A beta) is a leading therapeutic direction for Alzheimer disease (AD). Experimental studies in transgenic mouse... 
MICROGLIAL ACTIVATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRACELLULAR ACCUMULATION | DOWN-SYNDROME | MOUSE MODEL | AMYLOID-PRECURSOR-PROTEIN | PLAQUE-FORMATION | INTRANEURONAL A-BETA-42 ACCUMULATION | MEMORY LOSS | TRANSGENIC MICE
Journal Article
FRONTIERS IN AGING NEUROSCIENCE, ISSN 1663-4365, 03/2018, Volume 10
The N-terminally truncated pyroglutamate A beta(3-42) (A beta(pE3-42)) and A beta(4-42) peptides are known to be highly abundant in the brain of Alzheimer's... 
pyroglutamate A beta | PEPTIDES IN-VITRO | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | N-truncated A beta | BEHAVIORAL DEFICITS | A-BETA | neuron loss | PLAQUE-FORMATION | intraneuronal A beta | MOTOR COORDINATION | ACCUMULATION | behavior | Alzheimer's disease | AGGREGATION | transgenic mouse models | TRANSGENIC MICE
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2015, Volume 44, Issue 4, pp. 1291 - 1302
Journal Article
Journal Article
Journal Article
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 05/2015, Volume 19, Issue 9, pp. 1700 - 1705
OBJECTIVE: We investigated the effects of genetic down-and up-regulation of sac1 expression on A beta(42) accumulation and the associated neural deficits in... 
PROTEIN | Drosophila | ALZHEIMERS-DISEASE | PHOSPHATASE | sac1 | NEURODEGENERATION | Giant fiber pathway | MODEL | Intraneuronal beta amyloid | YEAST | AMYLOID-BETA PEPTIDE | Phosphoinositides phosphatase | METABOLISM | REDUCTION | A-BETA | PHARMACOLOGY & PHARMACY | Alzheimer's disease
Journal Article
MOLECULAR NEURODEGENERATION, ISSN 1750-1326, 01/2013, Volume 8
Background: Although the mechanism of neuron loss in Alzheimer's disease (AD) is enigmatic, it is associated with cerebral accumulation of A beta(42). The... 
Neuron loss | NEURODEGENERATION | PATHOLOGY | Caspase-3 | NEUROSCIENCES | BACE1 | APP GENE | 5XFAD | PROTEASOME | A-BETA | PLAQUE-FORMATION | INTRACELLULAR AMYLOID-BETA | MICE | PATHOGENIC MUTATION | Intraneuronal A beta | Alzheimer's disease | Amyloid-beta | Apoptosis
Journal Article