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by Morrissy, A. Sorana and Cavalli, Florence M. G and Remke, Marc and Ramaswamy, Vijay and Shih, David J. H and Holgado, Borja L and Farooq, Hamza and Donovan, Laura K and Garzia, Livia and Agnihotri, Sameer and Kiehna, Erin N and Mercier, Eloi and Mayoh, Chelsea and Papillon-Cavanagh, Simon and Nikbakht, Hamid and Gayden, Tenzin and Torchia, Jonathon and Picard, Daniel and Merino, Diana M and Vladoiu, Maria and Luu, Betty and Wu, Xiaochong and Daniels, Craig and Horswell, Stuart and Thompson, Yuan Yao and Hovestadt, Volker and Northcott, Paul A and Jones, David T. W and Peacock, John and Wang, Xin and Mack, Stephen C and Reimand, Jüri and Albrecht, Steffen and Fontebasso, Adam M and Thiessen, Nina and Li, Yisu and Schein, Jacqueline E and Lee, Darlene and Carlsen, Rebecca and Mayo, Michael and Tse, Kane and Tam, Angela and Dhalla, Noreen and Ally, Adrian and Chuah, Eric and Cheng, Young and Plettner, Patrick and Li, Haiyan I and Corbett, Richard D and Wong, Tina and Long, William and Loukides, James and Buczkowicz, Pawel and Hawkins, Cynthia E and Tabori, Uri and Rood, Brian R and Myseros, John S and Packer, Roger J and Korshunov, Andrey and Lichter, Peter and Kool, Marcel and Pfister, Stefan M and Schüller, Ulrich and Dirks, Peter and Huang, Annie and Bouffet, Eric and Rutka, James T and Bader, Gary D and Swanton, Charles and Ma, Yusanne and Moore, Richard A and Mungall, Andrew J and Majewski, Jacek and Jones, Steven J. M and Das, Sunit and Malkin, David and Jabado, Nada and Marra, Marco A and Taylor, Michael D
Nature Genetics, ISSN 1061-4036, 05/2017, Volume 49, Issue 5, pp. 780 - 788
Spatial heterogeneity of transcriptional and genetic markers between physically isolated biopsies of a single tumor poses major barriers to the identification... 
IN-VITRO | EVOLUTION | SOLID TUMORS | SUBTYPES | INTRATUMOR HETEROGENEITY | GROWTH | GENETICS & HEREDITY | EXPRESSION | RENAL-CELL CARCINOMA | T-CELLS | LYMPHOCYTES | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Transcriptome | Child, Preschool | Male | INDEL Mutation | DNA Copy Number Variations | Medulloblastoma - pathology | Aged, 80 and over | Adult | Female | Cerebellar Neoplasms - pathology | Medulloblastoma - genetics | Child | Principal Component Analysis | Genome-Wide Association Study | Gene Expression Profiling - methods | Cerebellar Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Genetic Heterogeneity | Aged | Polymorphism, Single Nucleotide | Mutation | Cluster Analysis | Brain | Gene mutations | Biopsy | Medulloblastoma | Genetic aspects | Diagnosis | Health aspects | Methods | Pediatrics | Laboratories | Neuropathology | Brain cancer | Colleges & universities | Oncology | Genomes | Biology | Neurosurgery | Consortia | Heterogeneity | Immunology | Renal cell carcinoma | Genetics | Bioindicators | Research centers | Medical research | Hematology | Gene expression | Children & youth | Genetic markers | Hospitals | Glioma | Biomarkers | Tumors | Index Medicus | Spatial heterogeneity | glioblastoma multiforme | renal cell carcinoma | gene expression profiling | medulloblastoma | whole exome sequencing
Journal Article
Cancer Research, ISSN 0008-5472, 01/2016, Volume 76, Issue 1, pp. 4 - 6
Heterogeneity is commonplace in all cancer types and at several levels-intrinsic (genetic), epigenetic, positional, and at the population level. The different... 
CELLS | METASTASIS | ONCOLOGY | INTRATUMOR HETEROGENEITY | CLINICAL-IMPLICATIONS | SELECTION | HYPOXIA | CANCER | PROGRESSION | Tumor Microenvironment | Neoplasms - genetics | Neoplasms - pathology | Humans | Genetic Heterogeneity | Index Medicus
Journal Article
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2018, Volume 24, Issue 17, pp. 4137 - 4144
Purpose: Tumor heterogeneity may represent a barrier to preoperative genomic characterization by needle biopsy in clear cell renal cell carcinoma (ccRCC). The... 
MOLECULAR SUBTYPES | IMPACT | EVOLUTION | ONCOLOGY | INTRATUMOR HETEROGENEITY | NATURAL-HISTORY | CELL CARCINOMA | KIDNEY CANCER | Index Medicus | Genomic Profile | Renal Biopsy | Heterogeneity | Small Renal Mass | Renal Cell Carcinoma
Journal Article