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1. Full Text Crack Cocaine and Cocaine Hydrochloride: Are the Differences Myth or Reality?
by Hatsukami, Dorothy K and Fischman, Marian W
JAMA, ISSN 0098-7484, 11/1996, Volume 276, Issue 19, pp. 1580 - 1588
Objective.—To review and discuss the differences and similarities between the use of crack cocaine and cocaine hydrochloride; and to determine how these... 
INTRAVENOUS COCAINE | MEDICINE, GENERAL & INTERNAL | DRUG-USE | HUMANS | USE PATTERNS | SMOKING | FREE-BASE COCAINE | PYROLYSIS | INTRANASAL | ABUSERS | DEPENDENCE | United States - epidemiology | Prevalence | Humans | Substance Abuse, Intravenous | Cocaine - pharmacokinetics | Administration, Intranasal | Substance-Related Disorders - physiopathology | Crack Cocaine - pharmacokinetics | Cocaine - administration & dosage | Cocaine - pharmacology | Substance-Related Disorders - epidemiology | Crack Cocaine - pharmacology | Opioid-Related Disorders | Crack Cocaine - administration & dosage | Crime - legislation & jurisprudence | Physiological aspects | Cocaine abuse | Cocaine | Dosage and administration | Prisons | Drug abuse | Substance abuse treatment
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2. Full Text Cardiovascular effects of cocaine
by Schwartz, Bryan G and Rezkalla, Shereif and Kloner, Robert A
Circulation, ISSN 0009-7322, 12/2010, Volume 122, Issue 24, pp. 2558 - 2569
chest | pain | cocaine | angina | myocardial infarction | INDUCED CORONARY VASOCONSTRICTION | CARDIAC & CARDIOVASCULAR SYSTEMS | STENT THROMBOSIS | CHEST-PAIN | AORTIC DISSECTION | INTRAVENOUS COCAINE | LEFT-VENTRICULAR DYSFUNCTION | ACUTE MYOCARDIAL-INFARCTION | SUDDEN CARDIAC DEATH | PERIPHERAL VASCULAR DISEASE | INTRANASAL COCAINE | HEMATOLOGY | ARTERY-DISEASE | Cardiovascular Diseases - physiopathology | Coronary Circulation - physiology | Humans | Cardiovascular System - drug effects | Substance-Related Disorders - therapy | Substance-Related Disorders - physiopathology | Cardiovascular System - physiopathology | Animals | Cocaine - toxicity | Cardiovascular Diseases - chemically induced | Coronary Circulation - drug effects | Cocaine - adverse effects | Substance-Related Disorders - diagnosis | Cardiovascular Diseases - diagnosis
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3. Full Text The α-1 adrenoceptor (ADRA1A) genotype moderates the magnitude of acute cocaine-induced subjective effects in cocaine-dependent individuals
by Shorter, Daryl and Nielsen, David A and Hamon, Sara C and Nielsen, Ellen M and Kosten, Thomas R and Newton, Thomas F and De La Garza, Richard
Pharmacogenetics and Genomics, ISSN 1744-6872, 09/2016, Volume 26, Issue 9, pp. 428 - 435
OBJECTIVESWe examined whether a functional variant of the ADRA1A gene moderated cocaine-induced subjective effects in a group of cocaine-dependent individuals.... 
polymorphism | subjective effects | cocaine | ADRA1A | genotype | PHARMACOGENETIC RANDOMIZED-TRIAL | INDUCED REINSTATEMENT | ABUSE DISULFIRAM | CONSTITUTIVE ACTIVITY | LOCUS-CERULEUS | PREFRONTAL CORTEX | BED NUCLEUS | STRIA TERMINALIS | INHIBITOR NEPICASTAT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | POPULATION-STRUCTURE | PHARMACOLOGY & PHARMACY | Double-Blind Method | Humans | Middle Aged | Genotype | Male | Cocaine-Related Disorders - genetics | Young Adult | Cocaine - administration & dosage | Administration, Intravenous | Receptors, Adrenergic, alpha-1 - genetics | Pharmacogenomic Variants | Adult | Female | Polymorphism, Single Nucleotide | Cocaine - adverse effects | Amino Acid Substitution
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4. Full Text Repeated social-defeat stress, cocaine or morphine: Effects on behavioral sensitization and intravenous cocaine self-administration "binges"
by Covington III, H.E and Covington, Herbert E and Miczek, Klaus A and Miczek, K.A
Psychopharmacology, ISSN 0033-3158, 2001, Volume 158, Issue 4, pp. 388 - 398
Rationale: Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants,... 
Opiate | Self-administration | Schedules of reinforcement | Binge | Motor activity | Cocaine | Sensitization | Defeat | Social stress | Stress | stress | EXTRACELLULAR DOPAMINE LEVELS | cocaine | PSYCHIATRY | CROSS-SENSITIZATION | BRAIN REWARD REGIONS | CORTICOSTERONE SECRETION | LOCOMOTOR RESPONSE | NEUROSCIENCES | opiate | motor activity | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | defeat | REFLEXIVE PAIN RESPONSES | binge | self-administration | schedules of reinforcement | INVIVO MICRODIALYSIS | PHARMACOLOGY & PHARMACY | sensitization | social stress | D-AMPHETAMINE | Central Nervous System Stimulants - pharmacology | Dextroamphetamine - pharmacology | Injections, Intravenous | Morphine - pharmacology | Cocaine-Related Disorders - psychology | Rats, Long-Evans | Reinforcement (Psychology) | Rats | Male | Stress, Psychological - psychology | Cocaine - administration & dosage | Cocaine - pharmacology | Reinforcement Schedule | Dominance-Subordination | Self Administration | Animals | Behavior, Animal - drug effects | Female | Corticosterone - blood | Narcotics - pharmacology
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5. Full Text Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products
by Baumann, Michael H and Partilla, John S and Lehner, Kurt R and Thorndike, Eric B and Hoffman, Alexander F and Holy, Marion and Rothman, Richard B and Goldberg, Steven R and Lupica, Carl R and Sitte, Harald H and Brandt, Simon D and Tella, Srihari R and Cozzi, Nicholas V and Schindler, Charles W
Neuropsychopharmacology, ISSN 0893-133X, 03/2013, Volume 38, Issue 4, pp. 552 - 562
The abuse of psychoactive 'bath salts' containing cathinones such as 3,4-methylenedioxypyrovalerone (MDPV) is a growing public health concern, yet little is... 
cathinone | monoamine transporter | uptake blocker | dopamine | designer drug | NOREPINEPHRINE | PSYCHIATRY | DOPAMINE OVERFLOW | LOCOMOTOR-ACTIVITY | MEPHEDRONE | MONOAMINE TRANSPORTERS | NEUROSCIENCES | NUCLEUS-ACCUMBENS | LEGAL HIGHS | DRUGS | PHARMACOLOGY & PHARMACY | D-AMPHETAMINE | UPTAKE INHIBITORS | Motor Activity - physiology | Humans | Motor Activity - drug effects | Male | Corpus Striatum - metabolism | Pyrrolidines - pharmacology | Salts - chemistry | Salts - pharmacology | Psychotropic Drugs - pharmacology | HEK293 Cells | Benzodioxoles - chemistry | Dopamine - metabolism | Organ Culture Techniques | Cocaine - chemistry | Designer Drugs - pharmacology | Mice, Inbred C57BL | Rats | Psychotropic Drugs - chemistry | Random Allocation | Pyrrolidines - chemistry | Rats, Sprague-Dawley | Cocaine - pharmacology | Designer Drugs - chemistry | Animals | Corpus Striatum - drug effects | Mice | Benzodioxoles - pharmacology | Neurochemistry | Brain | Drug abuse | Salts | Dopamine | Intravenous administration | Brain slice preparation | Catecholamines | Data processing | Pharmacology | Nucleus accumbens | Side effects | Tachycardia | Monoamine transporter | Neostriatum | Cocaine | Locomotor activity | Neurotransmission | Public health | addiction & Substance Abuse | blocker | catecholamines | releaser | designer drugs | neuropharmacology | transporter | Original | Psychostimulants
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6. Full Text Intense sweetness surpasses cocaine reward
by Lenoir, Magalie and Serre, Fuschia and Cantin, Lauriane and Ahmed, Serge H
PLoS ONE, ISSN 1932-6203, 08/2007, Volume 2, Issue 8, p. e698
Background. Refined sugars (e.g., sucrose, fructose) were absent in the diet of most people until very recently in human history. Today overconsumption of... 
BIOLOGY | Food Preferences | Meta-Analysis as Topic | Dopamine Uptake Inhibitors - pharmacology | Pleasure - physiology | Rats, Wistar | Humans | Rats | Male | Taste - physiology | Corpus Striatum - metabolism | Substance-Related Disorders - physiopathology | Dopamine Uptake Inhibitors - administration & dosage | Cocaine - administration & dosage | Cocaine - pharmacology | Taste Perception - physiology | Animals | Diet | Conditioning, Operant | Saccharin - administration & dosage | Reward | Sweetening Agents - administration & dosage | Dopamine - metabolism | Locomotion - drug effects | Obesity | Illegal drugs | Taste | Cocaine | Comparative analysis | Beverages | Fructose | Drugs | Drug abuse | Brain | Epidemics | Intravenous administration | Sucrose | Sweetness | Taste receptors | Receptors | Saccharin | Rodents | Reinforcement | Sweet taste | Sugar | Sugars | Food | Drug addiction | Narcotics | Hypersensitivity | Calories | Animal behavior | Tastants | Amphetamines | Intoxication | Life Sciences | Neurons and Cognition
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7. Full Text Management of cocaine-associated chest pain and myocardial infarction: A scientific statement from the American Heart Association acute cardiac care committee of the council on clinical cardiology
by McCord, James and Jneid, Hani and Hollander, Judd E and De Lemos, James A and Cercek, Bojan and Hsue, Priscilla and Gibler, W Brian and Ohman, E Magnus and Drew, Barbara and Philippides, George and Newby, L Kristin and American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology
Circulation, ISSN 0009-7322, 04/2008, Volume 117, Issue 14, pp. 1897 - 1907
Myocardial infarction | Cocaine | AHA Scientific Statement | Substance-related disorders | CONTROLLED-TRIAL | INDUCED CORONARY VASOCONSTRICTION | SODIUM-BICARBONATE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2005 GUIDELINE UPDATE | cocaine | substance-related disorders | myocardial infarction | HUMAN PLATELETS | AORTIC DISSECTION | INTRAVENOUS COCAINE | TASK-FORCE | LIDOCAINE | PERIPHERAL VASCULAR DISEASE | INTRANASAL COCAINE | Smoking - adverse effects | Myocardial Infarction - chemically induced | Humans | Sympathomimetics - pharmacology | Male | Vasoconstrictor Agents - toxicity | Cocaine-Related Disorders - epidemiology | Angioplasty, Balloon, Coronary | Cocaine-Related Disorders - complications | Adult | Female | Myocardial Infarction - physiopathology | Platelet Aggregation Inhibitors - therapeutic use | Cocaine-Related Disorders - diagnosis | Myocardial Infarction - diagnosis | Myocardial Infarction - surgery | Vasoconstrictor Agents - pharmacology | Combined Modality Therapy | Evidence-Based Medicine | Chest Pain - chemically induced | Cardiovascular Agents - therapeutic use | Cocaine - pharmacology | Diagnostic Imaging | Algorithms | Myocardial Infarction - drug therapy | Cocaine - toxicity | Adolescent | Sympathomimetics - toxicity | Thrombophilia - chemically induced | Disease Management | Coronary Circulation - drug effects | Benzodiazepines - therapeutic use | Practice guidelines (Medicine) | Care and treatment | Usage | Heart attack | Chest pain | Index Medicus | Abridged Index Medicus
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8. Full Text Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction
by Volkow, Nora D and Wang, Gene-Jack and Telang, Frank and Fowler, Joanna S and Logan, Jean and Childress, Anna-Rose and Jayne, Millard and Ma, Yeming and Wong, Christopher
Journal of Neuroscience, ISSN 0270-6474, 06/2006, Volume 26, Issue 24, pp. 6583 - 6588
The ability of drugs of abuse to increase dopamine in nucleus accumbens underlies their reinforcing effects. However, preclinical studies have shown that with... 
Caudate | Raclopride | Addiction | receptors | Imaging | Conditioned responses | Putamen | EXTRACELLULAR DOPAMINE | HUMAN BRAIN | RHESUS-MONKEYS | addiction | RATS | conditioned responses | caudate | RELEASE | imaging | NEUROSCIENCES | raclopride | INTRAVENOUS COCAINE | DRUG-ABUSE | D-2 receptors | putamen | NUCLEUS-ACCUMBENS CORE | SEEKING BEHAVIOR | C-11 RACLOPRIDE | Cues | Raclopride - pharmacokinetics | Cocaine-Related Disorders - psychology | Dopamine Antagonists - pharmacokinetics | Humans | Middle Aged | Male | Positron-Emission Tomography | Corpus Striatum - metabolism | Dopamine Uptake Inhibitors - administration & dosage | Cocaine - administration & dosage | Reinforcement Schedule | Cocaine-Related Disorders - metabolism | Brain Mapping | Corpus Striatum - drug effects | Adult | Female | Corpus Striatum - diagnostic imaging | Dopamine - metabolism | Brief Communications | D2 receptors
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9. Full Text Cocaine abuse versus cocaine dependence: Cocaine self-administration and pharmacodynamic response in the human laboratory
by Walsh, Sharon L and Donny, Eric C and Nuzzo, Paul A and Umbricht, Annie and Bigelow, George E
Drug and Alcohol Dependence, ISSN 0376-8716, 2009, Volume 106, Issue 1, pp. 28 - 37
Abstract Cocaine has high abuse liability but only a subset of individuals who experiment with it develop dependence. The DSM-IV (APA. Diagnostic and... 
Psychiatry | Self-administration | Cocaine | Abuse | Humans | DSM-IV diagnosis | Dependence | VENTURESOMENESS | DRUG-USE | RISK-FACTORS | PSYCHIATRY | GAMBLING TASK | HUMAN PREFRONTAL CORTEX | SUBSTANCE ABUSE | ADDICTION | IMPULSIVENESS | SUBSTANCE-USE | DECISION-MAKING | REINFORCEMENT | Recurrence | Substance Abuse, Intravenous - psychology | Middle Aged | Male | Cocaine-Related Disorders - physiopathology | Patient Selection | Dose-Response Relationship, Drug | Exploratory Behavior - physiology | Heart Rate - drug effects | Psychiatric Status Rating Scales | Self Administration | Skin Temperature - drug effects | Exploratory Behavior - drug effects | Adult | Cocaine-Related Disorders - economics | Female | Blood Pressure - drug effects | Safety | Impulsive Behavior | Double-Blind Method | Cocaine-Related Disorders - psychology | Electrocardiography - drug effects | Cocaine - pharmacology | Reinforcement Schedule | Liability (Law) | Mental illness | Cocaine abuse | dependence | abuse | cocaine | self-administration | humans
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10. Full Text Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis
by Jiang, Zhan and Fan, Peidong and Olive, M Foster and Sun, Hai-Ling and Shryock, John and Kim, Hee-Yong and Chu, Nancy and Zablocki, Jeff and Yao, Lina and Lee, Jeongrim and Arolfo, Maria and Diamond, Ivan and Blackburn, Brent and Leung, Kwan
Nature Medicine, ISSN 1078-8956, 09/2010, Volume 16, Issue 9, pp. 1024 - 1028
There is no effective treatment for cocaine addiction despite extensive knowledge of the neurobiology of drug addiction. Here we show that a selective aldehyde... 
PROTEIN-KINASE-A | MEDICINE, RESEARCH & EXPERIMENTAL | ASSAY | TYROSINE-HYDROXYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | CELL BIOLOGY | CIRCUITRY | METABOLISM | DRUG-ADDICTION | NEUROBIOLOGY | BRAIN | Cues | Tyrosine 3-Monooxygenase - metabolism | Mitochondrial Proteins - therapeutic use | Aldehyde Dehydrogenase - antagonists & inhibitors | Aldehyde Dehydrogenase, Mitochondrial | Mitochondrial Proteins - antagonists & inhibitors | Dopamine - biosynthesis | Rats | Tyrosine 3-Monooxygenase - antagonists & inhibitors | Berberine Alkaloids - metabolism | Cocaine - administration & dosage | Animals | Dopamine Antagonists - metabolism | Enzyme Activation | Infusions, Intravenous | Aldehyde Dehydrogenase - therapeutic use | Cocaine-Related Disorders - prevention & control | Disease Models, Animal | Oxidases | Usage | Neurons | Analysis | Cocaine | Aldehydes | Health aspects | Protein kinases | Inhibitor drugs | Addictions | Molecular biology
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11. Full Text Acquisition of cocaine self-administration in male Sprague–Dawley rats: effects of cocaine dose but not initial locomotor response to cocaine
by Mandt, Bruce H and Mandt, Bruce H and Johnston, Nickie L and Johnston, Nickie L and Zahniser, Nancy R and Zahniser, Nancy R and Allen, Richard M and Allen, Richard M
Psychopharmacology, ISSN 0033-3158, 2/2012, Volume 219, Issue 4, pp. 1089 - 1097
We have previously described a model in which adult outbred male Sprague–Dawley rats are classified as either low or high cocaine responders (LCRs or HCRs,... 
Self-administration | Neurosciences | Biomedicine | Rat | Addiction | Reinforcement | Cocaine | Pharmacology/Toxicology | Psychiatry | Locomotor activity | PREDICTS | PSYCHIATRY | CONTINGENT | BEHAVIORAL SENSITIZATION | MOTIVATION | NEUROSCIENCES | NUCLEUS-ACCUMBENS | DOPAMINE CLEARANCE | INDIVIDUAL-DIFFERENCES | PHARMACOLOGY & PHARMACY | AMPHETAMINE | DIFFER | Dose-Response Relationship, Drug | Cocaine - administration & dosage | Cocaine - pharmacology | Reinforcement Schedule | Self Administration | Animals | Conditioning, Operant - drug effects | Motor Activity - drug effects | Rats | Male | Infusions, Intravenous | Rats, Sprague-Dawley | Toy industry | Mergers, acquisitions and divestments | Drug therapy | Rodents | Motor ability | Drug self-administration | Models | Operant conditioning
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12. Full Text Characterizing the cognitive effects of cocaine: A comprehensive review
by Spronk, Desirée B and van Wel, Janelle H.P and Ramaekers, Johannes G and Verkes, Robbert J
Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, 09/2013, Volume 37, Issue 8, pp. 1838 - 1859
Understanding the cognitive sequela of repeated cocaine use is a growing area of research and is crucial to the development of cognitive models of addiction.... 
Neuroimaging | Acute drug effects | Long-term drug effects | Stimulants | Substance dependency | Humans | Cognitive | Substance abuse | Cocaine | Neuropsychology | STOP SIGNAL INHIBITION | DRUG-USE | IMPAIRED INHIBITORY CONTROL | DEPENDENT SUBJECTS | MONETARY REWARD | GAMBLING TASK | NEUROSCIENCES | INTRAVENOUS COCAINE | DECISION-MAKING | EVENT-RELATED POTENTIALS | BEHAVIORAL SCIENCES | CEREBRAL-BLOOD-FLOW | Brain - drug effects | Neuropsychological Tests | Cocaine - pharmacology | Cognition Disorders - physiopathology | Cocaine-Related Disorders - psychology | Brain - physiopathology | Reaction Time - drug effects | Attention - drug effects | Cocaine-Related Disorders - physiopathology | Cognition - drug effects | Cognition Disorders - psychology | Neurosciences | Analysis | Atherosclerosis
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