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Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2245 - 2255
Due to its implications for both dose level and frequency, clearance rate is one of the most important pharmacokinetic parameters to consider in the design of... 
HALF-LIFE | HEPATOCYTES | CHEMISTRY, MEDICINAL | METABOLISM | IN-VIVO | HUMANS | LIVER-MICROSOMES | INTRINSIC CLEARANCE | PLASMA-PROTEIN BINDING | DISPOSITION | PREDICTION
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 07/2019, Volume 108, Issue 7, pp. 2500 - 2504
Accurately predicting the hepatic clearance of compounds using to extrapolation (IVIVE) is crucial within the pharmaceutical industry. However, several groups... 
clearance | in vitro/in vivo correlation(s) (IVIVC) | hepatic clearance | in vitro/in vivo correlation(s) (IVIVC) | CHEMISTRY, MEDICINAL | METABOLIC-CLEARANCE | PROTEIN-BINDING | FATTY-ACIDS | MODEL | INTRINSIC CLEARANCE | CHEMISTRY, MULTIDISCIPLINARY | FRESH | PREDICTION | CRYOPRESERVED HEPATOCYTES | PHARMACOLOGY & PHARMACY | LIVER-MICROSOMES | DRUG-METABOLISM
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2019, Volume 47, Issue 3, pp. 320 - 327
Human and rat hepatocytes have a strong tendency to underpredict hepatic intrinsic clearance (CLint) and the extent of underprediction increases with... 
VITRO | MONKEY | RAT | CRYOPRESERVED HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | METABOLIC-CLEARANCE | LIVER-MICROSOMES | MODEL | IN VIVO EXTRAPOLATION | INTRINSIC CLEARANCE | DRUG-METABOLISM | Hepatocytes | Bias | Liver | Dependence | Scaling | In vivo methods and tests | Metabolism | Scaling factors
Journal Article
Microchemical Journal, ISSN 0026-265X, 01/2018, Volume 136, pp. 193 - 199
Journal Article