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21. Full Text Intracellular Ca2+ sensing: role in calcium homeostasis and signaling
by Bagur, Rafaela and Hajnóczky, György
Molecular cell, ISSN 1097-2765, 6/2017, Volume 66, Issue 6, pp. 780 - 788
Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can become toxic and cause cell death. Selective control of specific... 
Endoplasmic Reticulum | STIM1 | MICU1 | mitochondria | Miro1 | IP3 receptor
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22. Full Text Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate-evoked calcium signaling
by Wilson, Calum and Wilson, Calum and Lee, Matthew D and Lee, Matthew D and Heathcote, Helen R and Heathcote, Helen R and Zhang, Xun and Zhang, Xun and Buckley, Charlotte and Buckley, Charlotte and Girkin, John M and Girkin, John M and Saunter, Christopher D and Saunter, Christopher D and McCarron, John G and McCarron, John G
Journal of Biological Chemistry, ISSN 0021-9258, 01/2019, Volume 294, Issue 3, pp. 737 - 758
Endothelial cells are reported to be glycolytic and to minimally rely on mitochondria for ATP generation. Rather than providing energy, mitochondria in... 
inositol 1,4,5-trisphosphate (IP3) | endothelium | Ca2+ signaling | endothelial cell | fluorescence imaging | mitochondria | reactive oxygen species (ROS) | myoendothelial junction | mesenteric artery | cell signaling | inositol trisphosphate | endoplasmic reticulum (ER) | ATP | calcium imaging | K-CA | 1,4,5-TRISPHOSPHATE RECEPTOR | CA2+ RELEASE | SARCOPLASMIC-RETICULUM | SMOOTH-MUSCLE | PROTEIN S-GLUTATHIONYLATION | MESENTERIC-ARTERIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IP3 RECEPTORS | Ca2+signaling | MYOENDOTHELIAL GAP-JUNCTIONS | ENDOPLASMIC-RETICULUM | Signal Transduction
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23. Full Text IP(3)R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2
by Akl, H and Monaco, G and La Rovere, R and Welkenhuyzen, K and Kiviluoto, S and Vervliet, T and Molgo, J and Distelhorst, CW and Missiaen, L and Mikoshiba, K and Parys, JB and De Smedt, H and Bultynck, G
CELL DEATH & DISEASE, ISSN 2041-4889, 05/2013, Volume 4
Disrupting inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)/B-cell lymphoma 2 (Bcl-2) complexes using a cell-permeable peptide (stabilized TAT-fused... 
Bcl-2 | Ca2+ signaling | cell death | FAMILY-MEMBERS | MITOCHONDRIA | apoptosis | OUTER-MEMBRANE PERMEABILIZATION | CELL BIOLOGY | IP3 receptors | IP3 RECEPTOR | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS | ENDOPLASMIC-RETICULUM | LEUKEMIA | PROTEINS | TYPE-2 | CA2+ HOMEOSTASIS | B-cell lymphoma
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24. Full Text IP3 Receptor-Dependent Cytoplasmic Ca2+ Signals Are Tightly Controlled by Cavβ3
by Belkacemi, Anouar and Hui, Xin and Wardas, Barbara and Laschke, Matthias W and Wissenbach, Ulrich and Menger, Michael D and Lipp, Peter and Beck, Andreas and Flockerzi, Veit
Cell Reports, ISSN 2211-1247, 01/2018, Volume 22, Issue 5, pp. 1339 - 1349
Voltage-gated calcium channels (Cavs) are major Ca entry pathways in excitable cells. Their β subunits facilitate membrane trafficking of the channel’s... 
wound healing | Ca2+ signaling | Cavβ2 | Cavβ3 | cell migration | Cavβ3 KO | voltage-gated Ca2+ channel | Ca2+ release | IP3 receptor | IP3 binding
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25. Full Text The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca2+-release channel
by Vervloessem, Tamara and Yule, David I and Bultynck, Geert and Parys, Jan B
BBA - Molecular Cell Research, ISSN 0167-4889, 09/2015, Volume 1853, Issue 9, pp. 1992 - 2005
The inositol 1,4,5-trisphosphate (IP ) receptor (IP R) type 2 (IP R2) is an intracellular Ca -release channel located on the endoplasmic reticulum (ER). IP R2... 
Heart | Senescence | Secretion | IP3 | Apoptosis | Cancer | IP | TRISPHOSPHATE RECEPTOR | PANCREATIC ACINAR-CELLS | INDUCED CALCIUM-RELEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | RECONSTITUTED LIPID VESICLES | CELL BIOLOGY | DIFFERENTIAL CELLULAR EXPRESSION | INSP-INDUCED CA2+ RELEASE | VENTRICULAR CARDIAC MYOCYTES | IP3 RECEPTOR | SMOOTH-MUSCLE-CELLS | Arrhythmias, Cardiac - metabolism | Calcium - metabolism | Humans | Endoplasmic Reticulum - metabolism | Cardiomegaly - pathology | Organ Specificity | Arrhythmias, Cardiac - pathology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Mice | Calcium Signaling | Cardiomegaly - metabolism
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26. Full Text The inositol trisphosphate/calcium signaling pathway in health and disease
by Berridge, Michael J
Physiological Reviews, ISSN 0031-9333, 10/2016, Volume 96, Issue 4, pp. 1261 - 1296
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by different signaling pathways. One of these is the inositol... 
GROWTH-FACTOR-BETA | PHYSIOLOGY | IP3-DEPENDENT CA2+ RELEASE | IP3 RECEPTOR | ALZHEIMERS-DISEASE | INTRACELLULAR CALCIUM-RELEASE | 1,4,5-TRIPHOSPHATE RECEPTOR | 1,4,5-TRISPHOSPHATE RECEPTOR EXPRESSION | ENDOPLASMIC-RETICULUM | BIPOLAR DISORDER | VASCULAR SMOOTH-MUSCLE | Animals | Calcium Channels - metabolism | Calcium - metabolism | Calcium Signaling - physiology | Humans | Ryanodine Receptor Calcium Release Channel - metabolism | Signal Transduction - physiology | Inositol 1,4,5-Trisphosphate - metabolism | Cell proliferation | Inositol phosphates | Cellular signal transduction | Research | Metabolism | Analysis
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27. Full Text A dual role for Ca2+ in autophagy regulation
by Decuypere, Jean-Paul and Bultynck, Geert and Parys, Jan B
Cell Calcium, ISSN 0143-4160, 2011, Volume 50, Issue 3, pp. 242 - 250
Abstract Autophagy is a cellular process responsible for delivery of proteins or organelles to lysosomes. It participates not only in maintaining cellular... 
Advanced Basic Science | Bcl-2 | Autophagy | Beclin 1 | APOPTOSIS | TRISPHOSPHATE RECEPTOR | PROAPOPTOTIC BAX | PHOSPHORYLATION | IP3 receptor | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | CELL BIOLOGY | CA2+-RELEASE CHANNELS | Ca2 | CALCIUM | ENDOPLASMIC-RETICULUM
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28. Full Text Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles
by Garland, Christopher J and Bagher, Pooneh and Powell, Chloe and Ye, Xi and Lemmey, Hamish A.L and Borysova, Lyudmyla and Dora, Kim A
Science Signaling, ISSN 1945-0877, 07/2017, Volume 10, Issue 486, p. eaal3806
Vascular smooth muscle contraction is suppressed by feedback dilation mediated by the endothelium. In skeletal muscle arterioles, this feedback can be... 
CELLS | VASOMOTION | RYANODINE RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | PHENYLEPHRINE | CHANNELS | IP3 | EXPRESSION | VASOCONSTRICTION | MODULATION | CELL BIOLOGY
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29. Full Text DAG/PKCδ and IP3/Ca2+/CaMK IIβ operate in parallel to each other in PLCγ1-driven cell proliferation and migration of human gastric adenocarcinoma cells, through Akt/mTOR/S6 pathway
by Dai, Lianzhi and Zhuang, Luhua and Zhang, Bingchang and Wang, Fen and Chen, Xiaolei and Xia, Chun and Zhang, Bing
International Journal of Molecular Sciences, ISSN 1661-6596, 12/2015, Volume 16, Issue 12, pp. 28510 - 28522
Phosphoinositide specific phospholipase Cγ (PLCγ) activates diacylglycerol (DAG)/protein kinase C (PKC) and inositol 1,4,5-trisphosphate... 
Cell proliferation | IP3/Ca | Migration | Akt/mTOR/S6 | DAG/PKCδ | Human gastric adenocarcinoma cells | CaMK IIβ | PLCγ1 | Adenocarcinoma - pathology | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Calcium - metabolism | Humans | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Adenocarcinoma - metabolism | Heterografts | Diglycerides - metabolism | Protein Kinase C - metabolism | Phospholipase C gamma - genetics | Proto-Oncogene Proteins c-akt - metabolism | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Disease Models, Animal | Stomach Neoplasms - genetics | Phospholipase C gamma - metabolism | Signal Transduction | Protein Kinase C - antagonists & inhibitors | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - antagonists & inhibitors | Cell Movement - drug effects | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Phospholipase C gamma - antagonists & inhibitors | human gastric adenocarcinoma cells | IP3/Ca2+/CaMK IIβ | cell proliferation | migration
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30. Full Text Oxytocin induces intracellular Ca2+ release in cardiac fibroblasts from neonatal rats
by Ali, Ifrah I and Al-Salam, Suhail and Howarth, Frank C and Shmygol, Anatoliy
Cell Calcium, ISSN 0143-4160, 12/2019, Volume 84, p. 102099
Pituitary neuropeptide oxytocin is increasingly recognised as a cardiovascular hormone, in addition to its many regulatory roles in other organ systems.... 
Calcium signalling | Cardiac fibroblasts | IP3 receptors | Oxytocin | Endoplasmic reticulum
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31. Full Text Mechanism of interleukin-1 receptor antagonist protection against myocardial ischaemia/reperfusion-induced injury
by Qian, Wenhao and Zhao, Changyun and Li, Dongye and Dai, Rui
Archives of Cardiovascular Diseases, ISSN 1875-2136, 10/2018, Volume 111, Issue 10, pp. 545 - 554
New therapeutic targets are required for ischaemic heart disease; our study was designed to assess the theoretical foundation and experimental basis underlying... 
Myocarde | Ischaemia/reperfusion-induced injury | Interleukin-1 receptor antagonist | Myocardium | Calcium overload | Antagoniste des récepteurs à l’interleukine I | Récepteur IP3 | Lésions ischémie/reperfusion myocardique | Surcharge calcique | IP3 receptor
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32. Full Text L-asparaginase-induced apoptosis in ALL cells involves IP3 receptor signaling
by Vervliet, Tim and Parys, Jan B
Cell Calcium, ISSN 0143-4160, 11/2019, Volume 83, p. 102076
L-asparaginase treatment is used in the clinic to treat acute lymphoblastic leukemia (ALL) patients. Lee et al. (2019, Blood 133:2222-2232) demonstrated that... 
Huntingtin-associated protein 1 | Acute lymphoblastic leukemia | Huntingtin | L-asparaginase | IP3 receptor | CELL BIOLOGY
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33. Full Text Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor
by Devogelaere, Benoit and Beullens, Monique and Sammels, Eva and Derua, Rita and Waelkens, Etienne and Van Lint, Johan and Parys, Jan B and Missiaen, Ludwig and Bollen, Mathieu and De Smedt, Humbert
Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 2, pp. 303 - 311
IRBIT is an IP3R [IP3 (inositol 1,4,5-trisphosphate) receptor]-binding protein that competes with IP3 for binding to the IP3R. Phosphorylation of IRBIT is... 
Casein kinase 1 | R | Phosphorylation | Calcium | Inositol 1,4,5-trisphosphate receptor (IP | Protein phosphatase-1 (PP1) | Signalling | SITE | calcium | KINASE-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | MASS-SPECTROMETRY | protein phosphatase-1 (PP1) | inositol 1,4,5-trisphosphate receptor (IP3R) | casein kinase 1 | IP3 RECEPTOR | SUBSTRATE RECOGNITION MOTIFS | SUPPRESSES | phosphorylation | BINDING | signalling | MODULATION | Protein Phosphatase 1 - physiology | Animals | Calcium Channels - metabolism | Membrane Glycoproteins - metabolism | Inositol 1,4,5-Trisphosphate Receptors | Protein Binding | Adenosylhomocysteinase - metabolism | Mice | Binding Sites | Receptors, Cytoplasmic and Nuclear - metabolism | mIRBIT, mouse IRBIT | MK-2, MAPK-activated protein kinase 2 | PP2, protein phosphatase-2 | PKD, protein kinase D | IRBIT, IP3R-binding protein released by IP3 | TBS, Tris-buffered saline | DTT, dithiothreitol | HRP, horseradish peroxidase | AKAP9, A-kinase anchoring protein 9 | CaMK, Ca2 | IP3, inositol 1,4,5-trisphosphate | GST, glutathione transferase | GFP, green fluorescent protein | calmodulin-dependent protein kinase | PKC, protein kinase C | PP1, protein phosphatase-1 | NIPP1, nuclear inhibitor of PP1 | AHCY, S-adenosylhomocysteine hydrolase | IP3R, IP3 receptor | AMPK, AMP-activated kinase | CK1, casein kinase 1 | EGFP, enhanced GFP | IPTG, isopropyl β-D-thiogalactoside | MAPK, mitogen-activated protein kinase
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34. Full Text Defining the stoichiometry of inositol 1,415-trisphosphate binding required to initiate Ca2+ release
by Alzayady, KJ and Wang, LW and Chandrasekhar, R and Wagner, LE and Van Petegem, F and Yule, DI
SCIENCE SIGNALING, ISSN 1945-0877, 04/2016, Volume 9, Issue 422
Inositol 1,4,5-trisphosphate (IP3) receptors (IP(3)Rs) are tetrameric intracellular Ca2+-release channels with each subunit containing a binding site for IP3... 
TRISPHOSPHATE RECEPTORS | SYSTEM | CELLS | ACTIVATION | LIGAND-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | IP3 RECEPTORS | CHANNELS | TYPE-2 | DOMAINS | 1,4,5-TRISPHOSPHATE RECEPTORS | CELL BIOLOGY
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35. Full Text miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2
by Nelson, Charles and Ambros, Victor and Baehrecke, Eric H
Molecular Cell, ISSN 1097-2765, 11/2014, Volume 56, Issue 3, pp. 376 - 388
Macroautophagy (autophagy) is a lysosome-dependent degradation process that has been implicated in age-associated diseases. Autophagy is involved in both cell... 
BCL-2 | METABOLISM | GROWTH ARREST | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | REQUIRES | DROSOPHILA | MICRORNA | CELL BIOLOGY | Cell Line | Calcium - metabolism | Drosophila melanogaster - cytology | Phosphotransferases (Alcohol Group Acceptor) - genetics | Drosophila Proteins - metabolism | Autophagy | Salivary Glands - cytology | Larva - cytology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Animals | RNA Interference | Larva - growth & development | Drosophila melanogaster - enzymology | Drosophila melanogaster - growth & development | Larva - enzymology | Drosophila Proteins - genetics | MicroRNAs - physiology | Inositol 1,4,5-Trisphosphate - metabolism | Second Messenger Systems | Inositol | Starvation | Biochemistry | MicroRNA | Cell death | autophagy | calcium | miR-14 | microRNA | programmed cell death | IP3 signaling | Calmodulin | IP3 kinase
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