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irf-1 (551) 551
humans (407) 407
animals (373) 373
interferon regulatory factor-1 (274) 274
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immunology (215) 215
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expression (204) 204
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activation (127) 127
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gene-expression (121) 121
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interferon regulatory factor 1 (67) 67
phosphoproteins - physiology (66) 66
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binding (38) 38
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blotting, western (37) 37
hela cells (37) 37
interferon-gamma - physiology (37) 37
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1. Full Text Rs56288038 (C/G) in 3′UTR of IRF-1 Regulated by MiR-502-5p Promotes Gastric Cancer Development
by Wang, Bo and Yang, Huan and Shen, Liqin and Wang, Ji and Pu, Wangyang and Chen, Zhigang and Shen, Xudong and Fu, Jinxiang and Zhuang, Zhixiang
Cellular Physiology and Biochemistry, ISSN 1015-8987, 11/2016, Volume 40, Issue 1-2, pp. 391 - 399
IRF-1 | 3′UTR | Metastasis and survival | MiR-502-5p
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2. Full Text Interferon Regulatory Factor 1 (IRF-1) induces p21 WAF1/CIP1 dependent cell cycle arrest and p21 WAF1/CIP1 independent modulation of survivin in cancer cells
by Armstrong, Michaele J and Stang, Michael T and Liu, Ye and Gao, Jinbo and Ren, Baoguo and Zuckerbraun, Brian S and Mahidhara, Raja S and Xing, Quanhua and Pizzoferrato, Eva and Yim, John H
Cancer Letters, ISSN 0304-3835, 06/2012, Volume 319, Issue 1, pp. 56 - 65
We have shown that the ectopic expression of Interferon Regulatory Factor 1 (IRF-1) results in human cancer cell death accompanied by the down-regulation of... 
IRF-1 | Survivin | P21 | Cell cycle | Cancer
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3. Full Text Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients
by Annibali, Viviana and Umeton, Renato and Palermo, Antonia and Severa, Martina and Etna, Marilena Paola and Giglio, Simona and Romano, Silvia and Ferraldeschi, Michela and Buscarinu, Maria Chiara and Vecchione, Andrea and Annese, Anita and Policano, Claudia and Mechelli, Rosella and Pizzolato Umeton, Raffaella and Fornasiero, Arianna and Angelini, Daniela Francesca and Guerrera, Gisella and Battistini, Luca and Coccia, Eliana Marina and Salvetti, Marco and Ristori, Giovanni
Journal of Neuroimmunology, ISSN 0165-5728, 11/2018, Volume 324, pp. 165 - 171
Several evidences emphasize B-cell pathogenic roles in multiple sclerosis (MS). We performed transcriptome analyses on peripheral B cells from therapy-free... 
Multiple Sclerosis | CXCL10 axis | Transcriptome analysis | IRF-1 | B cells | Hsa-miR-424 | OCRELIZUMAB | PLACEBO | FACTOR-I IRF-1 | INDUCTION | IMMUNOLOGY | INTERLEUKIN-6 | NEUROSCIENCES | IFN-BETA | CXCL10 | GENE-EXPRESSION | MICRORNA | LYMPHOCYTES | Multiple sclerosis | RNA | Analysis | Interferon | Biological response modifiers | Gene expression
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4. Full Text TLR4, but not TLR2, mediates IFN-β-induced STAT1α/β-dependent gene expression in macrophages
by Toshchakov, Vladimir and Hamilton, Thomas A and Jones, Bryan W and Vogel, Stefanie N and Cody, M. Joshua and Zhang, Shuling and Perera, Pin-Yu and Fenton, Matthew J and Thomas, Karen and Major, Jennifer and Williams, Bryan R. G
Nature Immunology, ISSN 1529-2908, 04/2002, Volume 3, Issue 4, pp. 392 - 398
Toll-like receptor 2 (TLR2) agonists induce a subset of TLR4-inducible proinflammatory genes, which suggests the use of differential signaling pathways. Murine... 
ACTIVATION | PROTEIN-KINASE | LIPOPOLYSACCHARIDE | MICE | IRF-1 | INTERFERON-BETA | INDUCTION | IMMUNOLOGY | BINDING | CUTTING EDGE
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5. Full Text Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling
by Clarke, Robert and Liu, Minetta C and Bouker, Kerrie B and Gu, Zhiping and Lee, Richard Y and Zhu, Yuelin and Skaar, Todd C and Gomez, Bianca and O'Brien, Kerry and Wang, Yue and Hilakivi-Clarke, Leena A
Oncogene, ISSN 0950-9232, 10/2003, Volume 22, Issue 47, pp. 7316 - 7339
Antiestrogens include agents such as tamoxifen, toremifene, raloxifene, and fulvestrant. Currently, tamoxifen is the only drug approved for use in breast... 
Estrogen receptor | ICI 182,780 | Tamoxifen | Faslodex | Coregulator | PROTEIN-KINASE-C | estrogen receptor | MESSENGER-RNA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | coregulator | TAMOXIFEN-INDUCED APOPTOSIS | ONCOLOGY | HORMONE-INDEPENDENT GROWTH | EPIDERMAL-GROWTH-FACTOR | GENETICS & HEREDITY | LIGAND-BINDING DOMAIN | NF-KAPPA-B | TRANSCRIPTION FACTOR IRF-1 | tamoxifen | REGULATORY FACTOR-I | Receptors, Estrogen - metabolism | Humans | Drug Resistance, Neoplasm | Breast Neoplasms - drug therapy | Estrogen Receptor Modulators - pharmacology | Breast Neoplasms - metabolism | Estrogen Receptor Modulators - therapeutic use | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Tamoxifen - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Estrogens - metabolism | X box-binding protein 1 | nucleophosmin | IRF-1 protein
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6. Full Text IRF-1 acts as a positive regulator in the transcription of grass carp (Ctenopharyngodon idella) IFN gene
by Lai, Qinan and Lin, Gang and Ma, Meisheng and Huang, Shenghe and Li, Wen and Li, Dongming and Gu, Meihui and Mao, Huiling and Hu, Chengyu
Fish and Shellfish Immunology, ISSN 1050-4648, 06/2013, Volume 34, Issue 6, pp. 1432 - 1438
Interferon regulatory factors (IRFs) are well-known to be crucial for modulating the innate immune responses to viral infections. In the present study, the... 
IRF-1 | Interferon | Grass carp | Transcriptional regulation | Antiviral activity | MOLECULAR CHARACTERIZATION | FACTOR-1 IRF-1 | EXPRESSION ANALYSIS | INTERFERON GENES | FACTOR-I IRF-1 | INDUCTION | IMMUNOLOGY | FISHERIES | CLONING | MARINE & FRESHWATER BIOLOGY | VERTEBRATES | VETERINARY SCIENCES | PROMOTER | ATLANTIC SALMON | Recombinant Proteins - metabolism | Amino Acid Sequence | Carps - metabolism | Fish Proteins - chemistry | DNA, Complementary - genetics | Gene Expression Regulation | Fish Proteins - metabolism | Molecular Sequence Data | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Phylogeny | Organ Specificity | Carps - immunology | Interferon Regulatory Factor-1 - genetics | Fish Proteins - genetics | Animals | Interferon Regulatory Factor-1 - chemistry | Base Sequence | Electrophoretic Mobility Shift Assay | Poly I-C - immunology | Carps - genetics | Real-Time Polymerase Chain Reaction | Interferon Regulatory Factor-1 - metabolism | Virus diseases | Carp | Promoters (Genetics) | Analysis | Genes | Luciferase | Genetic research | Tryptophan | Genetic transcription | Biological response modifiers
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7. Full Text Activities of IRF-1
by Kröger, Andrea and Köster, Mario and Schroeder, Katharina and Hauser, Hansjörg and Mueller, Peter P
Journal of Interferon and Cytokine Research, ISSN 1079-9907, 2002, Volume 22, Issue 1, pp. 5 - 14
Interferon (IFN) regulatory factor-1 (IRF-1) was isolated by virtue of its affinity to specific DNA sequences in the IFN-beta promoter that mediate virus... 
TUMOR-SUPPRESSOR IRF-1 | NATURAL-KILLER-CELLS | FACTOR 1 IRF-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERFERON-INDUCIBLE GENES | CELL-GROWTH INHIBITION | IMMUNOLOGY | CELL BIOLOGY | IFN-BETA-GENE | TRANSCRIPTION FACTOR IRF-1 | NF-KAPPA-B | REGULATORY FACTOR-I | SEQUENCE-BINDING-PROTEIN | Protein Structure, Tertiary | Amino Acid Sequence | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Transcription Factors - chemistry | Signal Transduction | Humans | Transcriptional Activation | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Immunity | Phosphoproteins - chemistry | Animals | Interferon Regulatory Factor-1 | Cell Transformation, Neoplastic | Cell Division | Interferons - physiology | Phosphoproteins - physiology | Apoptosis
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8. Full Text IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
by Taniguchi, Tadatsugu and Honda, Kenya
Nature Reviews Immunology, ISSN 1474-1733, 09/2006, Volume 6, Issue 9, pp. 644 - 658
The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I... 
PLASMACYTOID DENDRITIC CELLS | INDEPENDENT ANTIVIRAL RESPONSE | DOUBLE-STRANDED-RNA | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INNATE IMMUNE-RESPONSES | RESPIRATORY-SYNCYTIAL-VIRUS | IMMUNOLOGY | NF-KAPPA-B | TRANSCRIPTION FACTOR IRF-1 | INTERFERON-ALPHA PRODUCTION | SEQUENCE-BINDING-PROTEIN | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Interferon Regulatory Factors - immunology | Animals | Disease | Receptors, Pattern Recognition - immunology | Cytosol - immunology | Humans | Toll-Like Receptors - immunology | Interferon Regulatory Factors - metabolism | Cytosol - metabolism | Toll-Like Receptors - metabolism
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9. Full Text The antineoplastic drug metformin downregulates YAP by interfering with IRF-1 binding to the YAP promoter in NSCLC
by Jin, Dan and Guo, Jiwei and Wang, Xiaohong and Wang, Deqiang and Wu, Yan and Gao, Yong and Shao, Cuijie and Xu, Xin and Tan, Shuying
EBioMedicine, ISSN 2352-3964, 11/2018, Volume 37, pp. 188 - 204
Activation of the oncogene has been shown to be related to lung cancer progression and associates with poor prognosis and metastasis. Metformin is a drug... 
YAP | Verteporfin | IRF-1 | Metformin | EMT | Lung cancer | FACTOR-1 IRF-1 | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | STATISTICS | HIPPO PATHWAY | CELL LUNG-CANCER | AMPK-MEDIATED REGULATION | SIGNALING PATHWAY | RESISTANCE
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10. Full Text Critical role of interferon regulatory factor‐1 in murine liver transplant ischemia reperfusion injury
by Ueki, Shinya and Dhupar, Rajeev and Cardinal, Jon and Tsung, Allan and Yoshida, Junichi and Ozaki, Kikumi S and Klune, John R and Murase, Noriko and Geller, David A
Hepatology, ISSN 0270-9139, 05/2010, Volume 51, Issue 5, pp. 1692 - 1701
Interferon regulatory factor‐1 (IRF‐1) is a transcription factor that regulates gene expression during immunity. We hypothesized that IRF‐1 plays a pivotal... 
RAT-LIVER | NKT CELLS | APOPTOSIS | ISCHEMIA/REPERFUSION INJURY | HEPATOCYTES | PATHWAY | MICE | GASTROENTEROLOGY & HEPATOLOGY | TRANSCRIPTION FACTOR IRF-1 | CELL-DEATH | REQUIREMENT | Up-Regulation | Liver Transplantation - adverse effects | Mice, Inbred C57BL | Interferon Regulatory Factor-1 - physiology | RNA, Messenger - metabolism | Mice, Knockout | Animals | Interferon Regulatory Factor-1 - deficiency | Reperfusion Injury - physiopathology | Mice | Apoptosis - physiology | Liver Transplantation - immunology | Interferon-gamma - biosynthesis | Ischemia | Gene expression | Liver | Rodents | Fas | IRF-1 | TRAIL | transplantation | ischemia
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11. Full Text Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
by Oda, E and Ohki, R and Murasawa, H and Nemoto, J and Shibue, T and Yamashita, T and Tokino, T and Taniguchi, T and Tanaka, N
SCIENCE, ISSN 0036-8075, 05/2000, Volume 288, Issue 5468, pp. 1053 - 1058
A critical function of tumor suppressor p53 is the induction of apoptosis in cells exposed to noxious stresses. We report a previously unidentified... 
CYTOCHROME-C | PROTEIN | P53-DEPENDENT APOPTOSIS | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | BAX | THYMOCYTE APOPTOSIS | TRANSCRIPTION FACTOR IRF-1 | DEPENDENT ACTIVATION | CELL-DEATH | P53
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12. Full Text The regulation role of interferon regulatory factor-1 gene and clinical relevance
by Dou, Lei and Liang, Hui-Fang and Geller, David A and Chen, Yi-Fa and Chen, Xiao-Ping
Human Immunology, ISSN 0198-8859, 2014, Volume 75, Issue 11, pp. 1110 - 1114
Abstract IRF-1, a kind of transcription factors, is expressed constitutively in all cells types except early embryonal cells. By virtue of its interaction with... 
Allergy and Immunology | Infection | Oncogenesis | IRF-1 | Injury | Interaction | Immune system | GROWTH-INHIBITION | TUMOR SUPPRESSION | IFN-GAMMA | LIVER ISCHEMIA | IMMUNOLOGY | CELL-DEATH | ISCHEMIA-REPERFUSION INJURY | SIGNALING PATHWAY | NITRIC-OXIDE | TRANSCRIPTION FACTOR IRF-1 | INNATE IMMUNITY | Adaptive Immunity | Autoimmunity | Inflammation - pathology | Virus Diseases - immunology | Reperfusion Injury - pathology | Signal Transduction | Gene Expression Regulation - immunology | Interferon Regulatory Factor-1 - immunology | Humans | Virus Diseases - virology | Inflammation - immunology | Immunity, Innate | Immunologic Surveillance - genetics | Interferon Regulatory Factor-1 - genetics | Neoplasms - genetics | Neoplasms - immunology | Reperfusion Injury - immunology | Virus Diseases - pathology | Inflammation - genetics | Transcription, Genetic | Neoplasms - pathology | Virus Diseases - genetics | Reperfusion Injury - genetics | Genetic research | Interferon | Biological response modifiers | Genes
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