X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2041) 2041
Book Review (342) 342
Publication (198) 198
Book Chapter (56) 56
Book / eBook (12) 12
Government Document (9) 9
Conference Proceeding (8) 8
Dissertation (6) 6
Paper (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (1384) 1384
humans (779) 779
animals (647) 647
irreversible inhibitors (521) 521
biochemistry & molecular biology (494) 494
irreversible inhibitor (450) 450
chemistry, medicinal (405) 405
pharmacology & pharmacy (295) 295
irreversible inhibition (268) 268
chemistry, organic (265) 265
kinetics (237) 237
oncology (235) 235
male (220) 220
structure-activity relationship (216) 216
female (207) 207
mice (207) 207
rats (194) 194
enzyme inhibitors - pharmacology (173) 173
growth-factor receptor (170) 170
cancer (168) 168
analysis (162) 162
molecular structure (144) 144
models, molecular (141) 141
chemistry, multidisciplinary (140) 140
cell line, tumor (138) 138
drug design (138) 138
antineoplastic agents - pharmacology (132) 132
article (128) 128
enzymes (127) 127
enzyme inhibitors (121) 121
protein kinase inhibitors - pharmacology (119) 119
derivatives (118) 118
binding sites (117) 117
tyrosine kinase inhibitors (117) 117
receptor, epidermal growth factor - antagonists & inhibitors (113) 113
dose-response relationship, drug (111) 111
ornithine decarboxylase (111) 111
inhibitors (110) 110
egfr (106) 106
drug discovery (105) 105
mechanism (104) 104
acquired-resistance (101) 101
enzyme inhibitors - chemistry (101) 101
research (101) 101
proteins (100) 100
alpha-difluoromethylornithine (97) 97
cell lung-cancer (95) 95
design (95) 95
antineoplastic agents - therapeutic use (93) 93
biophysics (93) 93
mutation (93) 93
protein kinase inhibitors - chemistry (93) 93
potent (90) 90
gefitinib (88) 88
tyrosine kinase (86) 86
chemistry (84) 84
protein binding (84) 84
in-vitro (83) 83
binding (82) 82
bortezomib (77) 77
antineoplastic agents - chemistry (75) 75
discovery (75) 75
apoptosis (74) 74
cysteine (72) 72
inhibition (72) 72
neurosciences (72) 72
activation (71) 71
crystal-structure (70) 70
tyrosine (70) 70
cells (69) 69
lung neoplasms - drug therapy (69) 69
toxicology (69) 69
catalysis (68) 68
cell biology (68) 68
tyrosine kinase inhibitor (68) 68
escherichia-coli (67) 67
receptor, epidermal growth factor - metabolism (67) 67
resistance (65) 65
analogs (64) 64
expression (64) 64
irreversible binding (64) 64
antitumor-activity (63) 63
active-site (62) 62
ligands (62) 62
substrate specificity (62) 62
amino acid sequence (61) 61
molecular sequence data (61) 61
polyamines (61) 61
cell proliferation - drug effects (60) 60
time factors (60) 60
middle aged (59) 59
tumors (59) 59
adult (58) 58
crystallography, x-ray (58) 58
biological evaluation (57) 57
cell line (57) 57
in vitro techniques (57) 57
lung cancer (57) 57
carcinoma, non-small-cell lung - drug therapy (56) 56
growth (56) 56
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (10) 10
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Earth Sciences (Noranda) - Stacks (1) 1
Mathematical Sciences - Missing (1) 1
Online Resources - Online (1) 1
Physics - Stacks (1) 1
UofT at Mississauga - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2086) 2086
Chinese (9) 9
Japanese (9) 9
German (6) 6
Russian (3) 3
Czech (2) 2
French (2) 2
Polish (2) 2
Dutch (1) 1
Italian (1) 1
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


The New England Journal of Medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 18, pp. 1689 - 1699
AZD9291, an irreversible inhibitor of epidermal growth factor receptor, was associated with tumor responses in the majority of patients with advanced... 
MEDICINE, GENERAL & INTERNAL | GEFITINIB | PLACEBO | PHASE-III | ACQUIRED-RESISTANCE | OPEN-LABEL | MUTATIONS | AFATINIB | IRREVERSIBLE EGFR | CHEMOTHERAPY | ERLOTINIB | Lung Neoplasms - drug therapy | Humans | Middle Aged | ErbB Receptors - genetics | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Acrylamides - pharmacokinetics | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Aniline Compounds - administration & dosage | Lung Neoplasms - genetics | Protein Kinase Inhibitors - pharmacokinetics | ErbB Receptors - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - genetics | Aniline Compounds - pharmacokinetics | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Drug Resistance, Neoplasm - genetics | Acrylamides - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Aniline Compounds - adverse effects | Acrylamides - adverse effects | Clinical trials | Care and treatment | Usage | Diagnosis | Lung cancer, Non-small cell | Patient outcomes | Tyrosine | Appetite | Inhibitor drugs | Epidermal growth factor receptors | Lung | Lung cancer | Diarrhea | Nausea | Drug resistance | Kinases | Patients | Epidermal growth factor | Pharmacokinetics | Protein-tyrosine kinase | Index Medicus | Abridged Index Medicus
Journal Article
ChemBioChem, ISSN 1439-4227, 04/2019, Volume 20, Issue 7, pp. 900 - 905
Glutathione S ‐transferase π (GSTP 1‐1 ) is overexpressed in many types of cancer and is involved in drug resistance. Therefore, GSTP 1‐1 is an important... 
covalent inhibitors | sulfonyl fluoride | irreversible inhibitors | transferase | glutathione | antitumor agents | glutathione S-transferase | LOCALIZATION | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPRESSION | Thiols | Enzyme inhibitors | Permeability | Drug resistance | Glutathione transferase | Cells | Fluoride | Inhibitors | Chloronitrobenzene | Inhibition | Glutathione | Cancer
Journal Article
Blood, ISSN 0006-4971, 06/2010, Volume 115, Issue 22, pp. 4478 - 4487
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 05/2016, Volume 55, Issue 19, pp. 5745 - 5748
Elevated expression of the immunoproteasome has been associated with autoimmune diseases, inflammatory diseases, and various types of cancer. Selective... 
inhibitors | immunoproteasome | irreversible inhibition | drug design | small-molecule inhibitors | ACTIVE-SITE | CONSTITUTIVE PROTEASOME | RESISTANCE | COVALENT DRUGS | LIGAND | CHEMISTRY, MULTIDISCIPLINARY | Chymotrypsin | Enzyme inhibitors | Rodents | Index Medicus
Journal Article
Cancer Science, ISSN 1347-9032, 08/2016, Volume 107, Issue 8, pp. 1134 - 1140
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2012, Volume 55, Issue 23, pp. 10317 - 10327
Journal Article
1970, 1st ed., International encyclopedia of pharmacology and therapeutics, ISBN 008006633X, Volume section 13., v.
Book
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2018, Volume 57, Issue 6, pp. 1601 - 1605
The structure‐based design of M‐525 as the first‐in‐class, highly potent, irreversible small‐molecule inhibitor of the menin‐MLL interaction is presented.... 
irreversible inhibitors | menin-MLL protein–protein interaction | drug design | MLL leukemia | TRANSFORMATION | CELLS | THERMAL SHIFT ASSAY | MIXED LINEAGE LEUKEMIA | HEMATOPOIESIS | menin-MLL protein-protein interaction | CHEMISTRY, MULTIDISCIPLINARY | FUSION PROTEINS | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Small Molecule Libraries - pharmacology | Myeloid-Lymphoid Leukemia Protein - metabolism | Protein Interaction Domains and Motifs - drug effects | Humans | Crystallography, X-Ray | Small Molecule Libraries - metabolism | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Molecular Dynamics Simulation | Small Molecule Libraries - chemistry | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Histone-Lysine N-Methyltransferase - metabolism | Drug Design | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Binding Sites | Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors | Enzyme inhibitors | Analysis | Leukemia | Crystals | Gene expression | Structure | Mass spectrometry | Protein-protein interactions | Proteins | Spectrometry | MLL protein | Inhibitors | Inhibition | Kinases | Protein interaction | Protein structure | Crystal structure | Mode of action | Index Medicus
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2017, Volume 25, Issue 20, pp. 5433 - 5440
Journal Article