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Oncotarget, ISSN 1949-2553, 09/2018, Volume 9, Issue 74, pp. 33871 - 33883
Insulin-like growth factors (IGFs) have been shown to induce proliferation of many types of cells. Insulin receptor substrates (IRSs) are major targets of... 
Ubiquitin | IGF-I | IRS-2 | USP9X | Prostate cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2010, Volume 285, Issue 51, pp. 40050 - 40059
The calcium-regulated phosphatase calcineurin intersects with both calcium and cAMP-mediated signaling pathways in the pancreatic beta-cell. Pharmacologic... 
DIABETES-MELLITUS | GLUCOSE-HOMEOSTASIS | PROTEIN-KINASE-B | GLUCAGON-LIKE PEPTIDE-1 | CYCLIN D1 | KIDNEY-TRANSPLANTATION | COACTIVATOR TORC2 | PRIMARY MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | IRS-2 EXPRESSION | GENE-EXPRESSION | Pancreatic Islet | Molecular Bases of Disease | Diabetes | Insulin | Calcineurin | Apoptosis
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 03/2017, Volume 199, pp. 119 - 127
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 1835
In humans, type 2 diabetes progresses when beta-cells fail to compensate peripheral insulin resistance. Insulin receptor substrate (IRS) proteins mediate a... 
Hyperinsulinemia | Neurons | Insulin-like growth factor I | Secretion | Arcuate nucleus | Diabetes mellitus | Homeostasis | Insulin-like growth factors | Hypothalamus | Glucose | Gene deletion | Insulin | High fat diet | Beta cells | Energy balance | Hyperglycemia | Clonal deletion | Arginine | IRS-2 protein | Insulin resistance | Diabetes | Pancreas | Diabetes mellitus (non-insulin dependent)
Journal Article
Gut, ISSN 0017-5749, 06/2019, Volume 68, Issue Suppl 2, p. A114
IntroductionObesity is increasingly prevalent worldwide and has deleterious consequences on our health, including type 2 diabetes. Risk factors of obesity... 
IRS-1 gene | Obesity | Diabetes mellitus | Liver | Microbiomes | Metabolism | Gene expression | Insulin | Risk factors | Polymerase chain reaction | Glucose metabolism | Signal transduction | Insulin receptor substrate 1 | Specific pathogen free | IRS-2 protein | Diabetes | Genetic factors | MMP28 gene | Lipid metabolism | Pancreas | Diabetes mellitus (non-insulin dependent)
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2006, Volume 103, Issue 32, pp. 12093 - 12097
Journal Article
Cancer research, ISSN 0008-5472, 11/2010, Volume 70, Issue 22, pp. 9197 - 9206
The distal-less homeobox gene ( dlx ) 5 encodes a transcription factor that controls jaw formation and appendage differentiation during embryonic development.... 
Ovarian Cancer | AKT | IRS-2 | DLX5 | MET
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2008, Volume 105, Issue 27, pp. 9250 - 9255
Journal Article
Journal of Functional Foods, ISSN 1756-4646, 01/2019, Volume 52, pp. 284 - 290
In this study, the therapeutic effects of buckwheat hull flavonoids (BHFs) on type 2 diabetes mice were investigated. After administration by BHFs nine weeks,... 
Type 2 diabetes | Lipid synthesis | Insulin resistance | Buckwheat hull flavonoids | db/db mice | Glycogen synthesis | OXIDATIVE STRESS | BRAN | IRS-2 | FOOD SCIENCE & TECHNOLOGY | MUSCLE | OBESITY | NUTRITION & DIETETICS | STEROL REGULATION | LIVER | CONSUMPTION | EXTRACT
Journal Article
Cell Cycle, ISSN 1538-4101, 10/2009, Volume 8, Issue 19, pp. 3218 - 3226
Journal Article
Journal Article