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Vaccine, ISSN 0264-410X, 2015, Volume 33, Issue 32, pp. 3953 - 3962
Journal Article
Scandinavian Journal of Immunology, ISSN 0300-9475, 01/2012, Volume 75, Issue 1, pp. 27 - 37
To control cervical cancer, efficient vaccination against human papillomavirus (HPV) is highly required. Despite the advantages and safety of the protein... 
SHOCK-PROTEIN GP96 | THERAPEUTIC VACCINE | FUSION-PROTEIN | ISCOMATRIX(TM) ADJUVANT | PHYLOGENETIC CONSERVATION | N-TERMINAL FRAGMENT | ANTITUMOR IMMUNITY | IMMUNOLOGY | CERVICAL INTRAEPITHELIAL NEOPLASIA | ANTIGEN-SPECIFIC IMMUNOTHERAPY | CROSS-PRESENTATION | Adjuvants, Immunologic - pharmacology | Viral Vaccines - pharmacology | Immunity, Humoral - immunology | Vaccines, Synthetic - pharmacology | Viral Vaccines - genetics | Papillomavirus E7 Proteins - immunology | Human papillomavirus 16 - immunology | Vaccines, Synthetic - immunology | Antibodies, Viral - blood | Papillomavirus E7 Proteins - genetics | Statistics, Nonparametric | Papillomavirus Infections - immunology | Female | Papillomavirus Infections - virology | Disease Models, Animal | Glycoproteins - genetics | Immunization - methods | Mice, Inbred C57BL | Vaccines, Synthetic - genetics | Uterine Cervical Neoplasms - prevention & control | Uterine Cervical Neoplasms - immunology | Immunity, Cellular - immunology | Glycoproteins - immunology | Animals | Papillomavirus Infections - prevention & control | Uterine Cervical Neoplasms - virology | Mice | Viral Vaccines - immunology | Antigens | Safety regulations | Peptides | Analysis | Vaccination | Heat shock proteins | Papillomavirus infections | Recombinant proteins | Cervical cancer | Protein binding | Index Medicus | Animal models | Immune response | Helper cells | Adjuvants | Data processing | Glycoproteins | Lymphocytes T | Vaccines | E7 protein | Immunity | Immunogenicity | Splenocytes | Immunotherapy | gamma -Interferon | Fusion protein | Life Sciences | Vaccinology | Immunology
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 10/2017, Volume 69, Issue 10, pp. 1293 - 1303
Journal Article
Vaccine, ISSN 0264-410X, 2004, Volume 22, Issue 29, pp. 3968 - 3975
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1123 - 1136
Many immunostimulants act as vaccine adjuvants via activation of the innate immune system, although in many cases it is unclear which specific molecules... 
ADAPTIVE IMMUNITY | MONOPHOSPHORYL-LIPID-A | HEALTHY ADULT VOLUNTEERS | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NLRP3 INFLAMMASOME | T-CELL | ISCOMATRIX ADJUVANT | PARTICULATE VACCINE ADJUVANTS | QUILLAJA-SAPONARIA MOLINA | NALP3 INFLAMMASOME | HIV Envelope Protein gp120 - agonists | Lipid A - agonists | Adjuvants, Immunologic - analysis | Adjuvants, Immunologic - pharmacology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Lipid A - analogs & derivatives | AIDS Vaccines - immunology | AIDS Vaccines - agonists | Th2 Cells - immunology | Th1 Cells - immunology | GTP-Binding Proteins - genetics | Th2 Cells - drug effects | Saponins - chemistry | HIV Envelope Protein gp120 - immunology | Th1 Cells - metabolism | Immunoglobulin G - biosynthesis | Inflammasomes - drug effects | Adjuvants, Immunologic - chemistry | Bone Marrow Cells - immunology | Bone Marrow Cells - drug effects | Dendritic Cells - drug effects | Immunoglobulin G - analysis | Macrophages - immunology | Cell Survival - drug effects | Th1 Cells - drug effects | Immunity, Innate - drug effects | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Cells, Cultured | Solubility | Saponins - analysis | Macrophages - cytology | Th2 Cells - metabolism | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | Lipid A - pharmacology | Macrophages - drug effects | Dendritic Cells - cytology | GTP-Binding Proteins - metabolism | Saponins - pharmacology | Index Medicus | vaccine | Immunology | human immunodeficiency virus (HIV) | caspase 1 (CASP1) | inflammasome | saponin | NLRP3 | Toll-like receptor 4 (TLR4) | monophosphoryl lipid A | adjuvants
Journal Article
Veterinary Parasitology, ISSN 0304-4017, 07/2018, Volume 258, pp. 14 - 23
infection continues to be a major problem in the agriculture sector, particularly in sheep and cattle. Cathepsin L and B proteases are major components of the... 
Fasciola hepatica | Intranasal vaccination | Cysteine protease | Ruminant | Vaccination | PROTECTION | CYSTEINE PROTEINASE | LIVER FLUKE | IN-VITRO | IMMUNE-SYSTEM | ISCOMATRIX(TM) ADJUVANT | VETERINARY SCIENCES | INFECTION | LEUCINE AMINOPEPTIDASE | T-CELLS | PARASITOLOGY | Adjuvants, Immunologic - administration & dosage | Sheep Diseases - parasitology | Vaccination - veterinary | Administration, Intranasal - methods | Cattle | Fasciola hepatica - chemistry | Fertility | Sheep Diseases - prevention & control | Sheep - immunology | Cathepsins - immunology | Antibodies, Helminth - blood | Parasite Egg Count | Cysteine Endopeptidases - administration & dosage | Parasite Load | Vaccines - immunology | Recombinant Proteins - genetics | Injections, Intramuscular | Fasciola hepatica - genetics | Recombinant Proteins - administration & dosage | Sheep Diseases - immunology | Cathepsins - administration & dosage | Fasciola hepatica - immunology | Yeasts - genetics | Antigens, Helminth - immunology | Vaccines - genetics | Animals | Cathepsins - genetics | Recombinant Proteins - immunology | Cysteine Endopeptidases - genetics | Vaccines - administration & dosage | Cysteine Endopeptidases - immunology | Viral antibodies | Antigens | Medical research | Cysteine | Proteases | Medicine, Experimental | Antibodies | Recombinant proteins | Cystine | Index Medicus
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 01/2017, Volume 7, pp. 663 - 663
The adjuvant properties of the saponin QS-21 have been known for decades. It is a component of the Adjuvant System AS01 that is used in several vaccine... 
Saponins | Dendritic cells | Cytokine | Lysosome | Cathepsins | Adjuvant | Vaccine | cytokine | IMMUNITY | CHOLESTEROL | cathepsins | ISCOMATRIX ADJUVANT | INVARIANT CHAIN | IMMUNOLOGY | vaccine | dendritic cells | adjuvant | MACROPINOCYTOSIS | INFLAMMASOME | NLRP3 | SAPONIN | lysosome | saponins | CATHEPSIN-B | ANTIGEN DELIVERY | Physiological aspects | Lysosomes | Research
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, pp. 13324 - 13324
Saponin-based adjuvants (SBAs) are being used in animal and human (cancer) vaccines, as they induce protective cellular immunity. Their adjuvant potency is a... 
MHC CLASS-I | QUILLAJA-SAPONARIA | MULTIDISCIPLINARY SCIENCES | MATRIX M(TM) ADJUVANT | BONE-MARROW CULTURES | ISCOMATRIX ADJUVANT | T-CELL | DIFFERENTIATION-RELATED PROTEIN | THERAPEUTIC VACCINES | NY-ESO-1 PROTEIN | ANTIGEN DELIVERY | Index Medicus
Journal Article
Immunotherapy, ISSN 1750-743X, 03/2017, Volume 9, Issue 3, pp. 249 - 259
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 13582 - 15
Commercially available saponins are extracted from Quillaja saponaria barks, being Quil A (R) the most widely used. Nanoparticulate immunostimulating complexes... 
QS-21 | ACTIVATION | T-CELL RESPONSES | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | MF59 | MICE | ISCOMATRIX ADJUVANT | THERAPEUTIC VACCINES | FORMULATION | ISCOMS | Spleen | Saponins | Dendritic cells | Mucosa | Caspase | Adjuvants | T cell receptors | Lymphocytes T | IL-1β | Immune response (humoral) | Lymph nodes | Caspase-1 | Nanoparticles | Leaves | MyD88 protein | Chemokines
Journal Article