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1. Full Text Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY)
by Stene, Lars C and Oikarinen, Sami and Hyöty, Heikki and Barriga, Katherine J and Norris, Jill M and Klingensmith, Georgeanna and Hutton, John C and Erlich, Henry A and Eisenbarth, George S and Rewers, Marian
Diabetes, ISSN 0012-1797, 12/2010, Volume 59, Issue 12, pp. 3174 - 3180
OBJECTIVE To investigate whether enterovirus infections predict progression to type 1 diabetes in genetically predisposed children repeatedly positive for... 
AUTOANTIBODIES | PATHOGENESIS | PANCREATIC-ISLETS | VIRUS-INFECTION | RISK-FACTOR | ENDOCRINOLOGY & METABOLISM | SERUM | BETA-CELL AUTOIMMUNITY | INDUCTION | BIRTH COHORT | CHILDREN | Autoimmunity | Diabetes Mellitus, Type 1 - epidemiology | Follow-Up Studies | Autoantibodies - blood | Humans | Proportional Hazards Models | Child, Preschool | HLA Antigens - immunology | Islets of Langerhans - immunology | Infant | RNA, Viral - blood | Disease Progression | Time Factors | Enterovirus Infections - complications | Enterovirus Infections - immunology | Diabetes Mellitus, Type 1 - blood | Adolescent | Diabetes Mellitus, Type 1 - immunology | Child | Complications and side effects | Type 1 diabetes | Development and progression | Research | Diagnosis | Risk factors | Enterovirus diseases | Index Medicus | Abridged Index Medicus | Pathophysiology
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2. Full Text Late-onset islet autoimmunity in childhood: the Diabetes Autoimmunity Study in the Young (DAISY)
by Frohnert, Brigitte I and Ide, Lisa and Dong, Fran and Barón, Anna E and Steck, Andrea K and Norris, Jill M and Rewers, Marian J
Diabetologia, ISSN 0012-186X, 6/2017, Volume 60, Issue 6, pp. 998 - 1006
We sought to assess the frequency, determinants and prognosis for future diabetes in individuals with islet autoimmunity and whether these factors differ... 
Islet autoantibody | Autoantibodies | Racial differences | Medicine & Public Health | Human Physiology | Type 1 diabetes | Metabolic Diseases | Internal Medicine | Ethnic differences | Age of diabetes onset | Child | APPEARANCE | SUSCEPTIBILITY | RISK | CHILDREN | PREDICTION | INSULIN | ENDOCRINOLOGY & METABOLISM | BETA-CELL AUTOIMMUNITY | TYPE-1 | AUTOANTIBODY POSITIVITY | AGE | Prospective Studies | Humans | Kaplan-Meier Estimate | Autoimmunity - genetics | Child, Preschool | Diabetes Mellitus, Type 1 - genetics | Islets of Langerhans - immunology | Genotype | Male | Disease Progression | Autoimmunity - physiology | Autoantibodies - immunology | HLA-DR4 Antigen - genetics | HLA-DR3 Antigen - genetics | Autoantibodies - physiology | Adolescent | Age of Onset | Female | Diabetes Mellitus, Type 1 - immunology | Autoimmunity | Development and progression | Analysis | Adolescence | Risk groups | Diabetes mellitus | Histocompatibility antigen HLA | Diabetes | Islets of Langerhans | Children | Pancreas | Hispanics | Age | Siblings | Index Medicus
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3. Full Text The effect of childhood cow's milk intake and HLA‐DR genotype on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young
by Lamb, Molly M and Miller, Melissa and Seifert, Jennifer A and Frederiksen, Brittni and Kroehl, Miranda and Rewers, Marian and Norris, Jill M
Pediatric Diabetes, ISSN 1399-543X, 02/2015, Volume 16, Issue 1, pp. 31 - 38
BackgroundCow's milk intake has been inconsistently associated with islet autoimmunity (IA) and type 1 diabetes (T1D) development. Genetic and environmental... 
HLA‐DR | childhood diet | cow's milk protein | genotype | Childhood diet | HLA-DR genotype | Cow's milk protein | AUTOANTIBODIES | VITAMIN-D | POPULATION | COLORADO YOUTH | MELLITUS | FOOD-FREQUENCY QUESTIONNAIRE | PRESCHOOL-CHILDREN | HLA-DQB1 GENOTYPE | GENETIC RISK | ENDOCRINOLOGY & METABOLISM | IA | PEDIATRICS | COLONIC EPITHELIAL-CELLS | Autoimmunity | Diabetes Mellitus, Type 1 - epidemiology | Disease Susceptibility | Child Nutritional Physiological Phenomena | Humans | Risk Factors | Child, Preschool | Diabetes Mellitus, Type 1 - genetics | Islets of Langerhans - immunology | Genotype | Infant | Male | Eating - physiology | HLA-DR Antigens - genetics | Animals | Diabetes Mellitus, Type 1 - etiology | Cattle | Female | Surveys and Questionnaires | Child | Infant, Newborn | Cohort Studies | Milk | Lactose | Genetic aspects | Type 1 diabetes | Index Medicus | Islet Autoimmunity
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4. Full Text No association of vitamin D intake or 25-hydroxyvitamin D levels in childhood with risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY)
by Simpson, M and Brady, H and Yin, X and Seifert, J and Barriga, K and Hoffman, M and Bugawan, T and Barón, A E and Sokol, R J and Eisenbarth, G and Erlich, H and Rewers, M and Norris, J M
Diabetologia, ISSN 0012-186X, 11/2011, Volume 54, Issue 11, pp. 2779 - 2788
The aim of the study was to investigate the association between vitamin D intake and status and the risk of islet autoimmunity (IA) and subsequent type 1... 
Medicine & Public Health | Human Physiology | Diet | Vitamin D | Type 1 diabetes | Metabolic Diseases | Islet autoimmunity | 25(OH)D | Internal Medicine | AUTOANTIBODIES | POPULATION | VALIDATION | LONGITUDINAL DATA | MELLITUS | 25(OH) D | FOOD-FREQUENCY QUESTIONNAIRE | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | CHILDREN | ENDOCRINOLOGY & METABOLISM | 1,25-DIHYDROXYVITAMIN D-3 | COHORT | Autoimmunity | Prospective Studies | Calcifediol - blood | Diet - adverse effects | Humans | Child, Preschool | Islets of Langerhans - immunology | Infant | Male | Risk | Vitamin D Deficiency - physiopathology | Vitamin D - adverse effects | Diabetes Mellitus, Type 1 - etiology | Female | Surveys and Questionnaires | Vitamin D - administration & dosage | 25-Hydroxyvitamin D 2 - blood | Diabetes Mellitus, Type 1 - immunology | Dietary Supplements - adverse effects | Child | Colorado - epidemiology | Longitudinal Studies | Infant, Newborn | Cohort Studies | Development and progression | Calcifediol | Research | Biometry | Diet therapy | Diabetes | Alfacalcidol | Universities and colleges | Public health | Emergency medical services | Index Medicus
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5. Full Text Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes The BABYDIET study
by Hummel, S and Pfluger, M and Hummel, M and Bonifacio, E and Ziegler, AG
DIABETES CARE, ISSN 0149-5992, 06/2011, Volume 34, Issue 6, pp. 1301 - 1305
OBJECTIVE-To determine whether delaying the introduction of gluten in infants with a genetic risk of islet autoimmunity is feasible, safe, and may reduce the... 
AUTOANTIBODIES | GLUTEN-FREE DIET | ENDOCRINOLOGY & METABOLISM | MICE | EXPOSURE | INFANCY | CELIAC-DISEASE | Celiac Disease - genetics | GTP-Binding Proteins - immunology | Humans | Risk Factors | Infant Food | Autoimmunity - genetics | Child, Preschool | Diabetes Mellitus, Type 1 - genetics | Islets of Langerhans - immunology | Infant | Glutens | Autoantibodies - biosynthesis | Transglutaminases - immunology | Celiac Disease - etiology | Pilot Projects | Diabetes Mellitus, Type 1 - etiology | Diabetes Mellitus, Type 1 - diet therapy | Autoimmunity | Diet therapy | Autoantibodies | Development and progression | Genetic aspects | Infants | Diabetes | Research | Children | Health aspects | Gluten | Risk factors | Celiac disease | Nutrition | Diet | Age | Index Medicus | Original Research
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6. Full Text Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity
by Nakayama, Maki and Beilke, Joshua N and Jasinski, Jean M and Kobayashi, Masakazu and Miao, Dongmei and Li, Marcella and Coulombe, Marilyne G and Liu, Edwin and Elliott, John F and Gill, Ronald G and Eisenbarth, George S
Journal of Clinical Investigation, ISSN 0021-9738, 07/2007, Volume 117, Issue 7, pp. 1835 - 1843
NOD mice with knockout of both native insulin genes and a mutated proinsulin transgene, alanine at position B16 in preproinsulin (B16:A-dKO mice), do not... 
MEDICINE, RESEARCH & EXPERIMENTAL | EPITOPE | DENDRITIC CELLS | NONOBESE DIABETIC MICE | NATIVE INSULIN | TOLERANCE | MOUSE | AUTOANTIGEN | PROINSULIN | TYPE-1 | CD8 T-CELLS | Diabetes Mellitus - pathology | Spleen - immunology | Diabetes Mellitus - genetics | Insulin - immunology | CD4-Positive T-Lymphocytes - immunology | Autoimmunity - immunology | Islets of Langerhans - metabolism | Peptide Fragments - immunology | Bone Marrow Transplantation | Insulin - genetics | Peptide Fragments - genetics | Spleen - transplantation | Immunization | Peptide Fragments - metabolism | CD4-Positive T-Lymphocytes - metabolism | Diabetes Mellitus - metabolism | Islets of Langerhans - immunology | Cell Transplantation | Survival Rate | Autoantibodies - immunology | Insulin - metabolism | Animals | Cross-Priming - immunology | Spleen - metabolism | Diabetes Mellitus - immunology | Mice, Inbred NOD | Mice | Autoimmunity | Antigen receptors, T cell | Receptors | Rats as laboratory animals | DNA damage | Research | T cells | Insulin | Index Medicus | Abridged Index Medicus
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7. Full Text Lack of Association Between Early Exposure to Cow's Milk Protein and β-Cell Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)
by Norris, Jill M and Beaty, Brenda and Klingensmith, Georgeanna and Yu, Liping and Hoffman, Michelle and Chase, H. Peter and Erlich, Henry A and Hamman, Richard F and Eisenbarth, George S and Rewers, Marian
JAMA, ISSN 0098-7484, 08/1996, Volume 276, Issue 8, pp. 609 - 614
Objective.—To examine whether infant dietary exposure to cow's milk is associated with β-cell autoimmunity (BCA), an early predictor of insulin-dependent... 
ANTIBODIES | POPULATION | MEDICINE, GENERAL & INTERNAL | RECALL BIAS | IDDM | RISK | IDENTICAL-TWINS | MELLITUS | PREDICTION | PREGNANCY | ACCURACY | Diabetes Mellitus, Type 1 - epidemiology | Multivariate Analysis | Humans | Breast Feeding | Infant Food | Child, Preschool | Infant | Male | Insulin Antibodies - analysis | Protein Tyrosine Phosphatases - immunology | Diabetes Mellitus, Type 1 - etiology | Milk Proteins - immunology | Autoimmunity - immunology | Dietary Proteins | Autoantibodies - analysis | Female | Milk - immunology | Retrospective Studies | Diabetes Mellitus, Type 1 - immunology | Glutamate Decarboxylase - immunology | Child | Cross-Sectional Studies | Risk Factors | Islets of Langerhans - immunology | Logistic Models | Insulin Antibodies - immunology | Autoantibodies - immunology | HLA Antigens - analysis | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Survival Analysis | Autoimmunity | Physiological aspects | Type 1 diabetes | Health aspects | Risk factors | Milk | Babies | Medical research | Diabetes | Medical immunity | Index Medicus | Abridged Index Medicus
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8. Full Text Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY)
by Waugh, Kathleen and Snell-Bergeon, Janet and Michels, Aaron and Dong, Fran and Steck, Andrea K and Frohnert, Brigitte I and Norris, Jill M and Rewers, Marian
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0174840 - e0174840
Background Type 1 diabetes (TID) is characterized by a loss of pancreatic islet beta cell function resulting in loss of insulin production. Genetic and... 
AUTOANTIBODIES | INSULIN | CYTOKINES | T-CELL RESPONSES | ASSAY | HIGH-RISK | IDDM | MULTIDISCIPLINARY SCIENCES | MELLITUS | PROGRESSION | CHILDREN | Humans | Child, Preschool | Islets of Langerhans - immunology | Infant | Male | Inflammation - immunology | Case-Control Studies | Inflammation - blood | Autoimmunity - immunology | Diabetes Mellitus, Type 1 - blood | Female | Diabetes Mellitus, Type 1 - immunology | Child | Cytokines - blood | Autoimmunity | Complications and side effects | Cytokines | Type 1 diabetes | Analysis | Inflammation | Health aspects | Risk factors | Health care | Immune response | Control methods | Identification methods | Pathogenesis | Diabetes mellitus | Antibodies | Families & family life | Environmental factors | Family medical history | IL-1β | Medical screening | Insulin | Immune systems | Beta cells | Immunology | Damage detection | Diabetes | Children | Chemokines | Age | Immune system | Index Medicus
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9. Full Text Respiratory Infections in Early Life and the Development of Islet Autoimmunity in Children at Increased Type 1 Diabetes Risk: Evidence From the BABYDIET Study
by Beyerlein, Andreas and Wehweck, Fabienne and Ziegler, Anette-Gabriele and Pflueger, Maren
JAMA Pediatrics, ISSN 2168-6203, 09/2013, Volume 167, Issue 9, pp. 800 - 807
IMPORTANCE: There is evidence for a role of infections within the pathogenesis of islet autoimmunity and type 1 diabetes mellitus (T1D), but previous studies... 
AUTOANTIBODIES | ANTIBODIES | PEDIATRICS | DIETARY INTERVENTION | BETA-CELL AUTOIMMUNITY | ENTEROVIRUS INFECTIONS | INDUCTION | MELLITUS | PROSPECTIVE BIRTH COHORT | CHILDHOOD | ASSOCIATION | Autoimmunity | Prospective Studies | Age Factors | Follow-Up Studies | Autoantibodies - blood | Fever - complications | Humans | Risk Factors | Proportional Hazards Models | Child, Preschool | Islets of Langerhans - immunology | Infant | Male | Biomarkers - blood | Diabetes Mellitus, Type 1 - etiology | Respiratory Tract Infections - immunology | Female | Surveys and Questionnaires | Respiratory Tract Infections - complications | Diabetes Mellitus, Type 1 - immunology | Fever - immunology | Infant, Newborn | Infection - complications | Islet cell stimulating antibodies | Research | Pediatric respiratory diseases | Autoimmune diseases | Type 1 diabetes | Risk factors | Index Medicus | Abridged Index Medicus
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10. Full Text Reversion of β-cell autoimmunity changes risk of type 1 diabetes: TEDDY study
by Vehik, Kendra and Lynch, Kristian F and Schatz, Desmond A and Akolkar, Beena and Hagopian, William and Rewers, Marian and She, Jin-Xiong and Simell, Olli and Toppari, Jorma and Ziegle, Anette G and Lernmark, Ake and Bonifacio, Ezio and Krischer, Jeffrey P and TEDDY Study Grp and TEDDY Study Group and the TEDDY Study Group and Lund University and Diabetes och celiaki and Diabetes and Celiac Unit and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
Diabetes Care, ISSN 0149-5992, 09/2016, Volume 39, Issue 9, pp. 1535 - 1542
OBJECTIVE beta-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes. Here, we asked how frequently they revert in a cohort of children... 
ANTIBODIES | SEROCONVERSION | RELATIVES | APPEARANCE | ISLET AUTOANTIBODIES | ENDOCRINOLOGY & METABOLISM | NATURAL-HISTORY | PROGRESSION | PREDICTION | STRATEGIES | CHILDREN | Risk Assessment - methods | Receptor-Like Protein Tyrosine Phosphatases, Class 8 - immunology | Prospective Studies | Autoantibodies - blood | Humans | Insulin - immunology | Risk Factors | Child, Preschool | Genotype | Male | Seroconversion | Insulin Antibodies - immunology | Insulin-Secreting Cells - immunology | Autoantibodies - immunology | Autoimmunity - immunology | Female | Insulin Antibodies - blood | Diabetes Mellitus, Type 1 - immunology | Glutamate Decarboxylase - immunology | Child | Autoantibodies | Research | Children | Type 1 diabetes | Health aspects | Risk factors | Index Medicus | Epidemiology | Health Services Research | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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11. Full Text A Subset of Interleukin-21 + Chemokine Receptor CCR9 + T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity
by McGuire, Helen M and Vogelzang, Alexis and Ma, Cindy S and Hughes, William E and Silveira, Pablo A and Tangye, Stuart G and Christ, Daniel and Fulcher, David and Falcone, Marika and King, Cecile
Immunity, ISSN 1074-7613, 2011, Volume 34, Issue 4, pp. 602 - 615
This study describes a CD4 T helper (Th) cell subset marked by coexpression of the cytokine interleukin 21 (IL-21) and the gut-homing chemokine receptor CCR9.... 
B-LYMPHOCYTES | TERTIARY LYMPHOID STRUCTURES | NOD MICE | IMMUNE-SYSTEM | DENDRITIC CELLS | NONOBESE DIABETIC MICE | MOUSE | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | IL-21 | Autoimmunity | CD8-Positive T-Lymphocytes - cytology | Receptors, Interleukin-21 - immunology | Cell Survival | Humans | Islets of Langerhans - immunology | Sjogren's Syndrome - immunology | Mice, Knockout | Receptors, Interleukin-21 - deficiency | Animals | B-Lymphocytes - immunology | Receptors, CCR - immunology | Diabetes Mellitus - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | T-Lymphocytes, Helper-Inducer - cytology | Female | Mice | Interleukins - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Cell Movement | Medical research | Disease | Research & development--R&D | Insulin | Proteins | Lymphocytes | Rodents | Population | Ligands | Software | Diabetes | Pancreas | Autoimmune diseases | Chemokines | Index Medicus
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12. Full Text Infant Exposures and Development of Type 1 Diabetes Mellitus: The Diabetes Autoimmunity Study in the Young (DAISY)
by Frederiksen, Brittni and Kroehl, Miranda and Lamb, Molly M and Seifert, Jennifer and Barriga, Katherine and Eisenbarth, George S and Rewers, Marian and Norris, Jill M
JAMA Pediatrics, ISSN 2168-6203, 09/2013, Volume 167, Issue 9, pp. 808 - 815
IMPORTANCE The incidence of type 1 diabetes mellitus (T1DM) is increasing worldwide, with the most rapid increase among children younger than 5 years of age.... 
FINNISH CHILDREN | HUMAN-MILK | INCREASED RISK | IDDM | INCREASE | ISLET AUTOIMMUNITY | PEDIATRICS | WEIGHT-GAIN | GENETIC PREDISPOSITION | CHILDHOOD | INCIDENCE TRENDS | Prospective Studies | Diet Surveys | Humans | Risk Factors | Breast Feeding | Proportional Hazards Models | Child, Preschool | Diabetes Mellitus, Type 1 - genetics | Feeding Behavior | Infant | Male | Genetic Markers | HLA-DQ beta-Chains - genetics | HLA-DR4 Antigen - genetics | HLA-DR3 Antigen - genetics | Diabetes Mellitus, Type 1 - etiology | Diet | Female | Child | Longitudinal Studies | Infant, Newborn | Development | Infants | Research | Type 1 diabetes | Risk factors | Index Medicus | Abridged Index Medicus
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13. Full Text Concordance for Islet Autoimmunity among Monozygotic Twins
by Orban, Tihamer and Redondo, Maria J and Jeffrey, Joy and Fain, Pamela R and Eisenbarth, George S
The New England Journal of Medicine, ISSN 0028-4793, 12/2008, Volume 359, Issue 26, pp. 2849 - 2850
To the Editor: The risk of type 1 diabetes among the monozygotic twins of patients with type 1 diabetes is reported to be as low as 30%; this percentage is... 
INSULIN | MEDICINE, GENERAL & INTERNAL | Autoimmunity | Humans | Middle Aged | Child, Preschool | Islets of Langerhans - immunology | Infant | Twins, Monozygotic - immunology | Young Adult | Autoantibodies - immunology | Adolescent | Adult | Diabetes Mellitus, Type 1 - immunology | Child | Diseases in Twins - immunology | Longitudinal Studies | Index Medicus | Abridged Index Medicus
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