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1. Full Text Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro
by Russ, Holger A and Parent, Audrey V and Ringler, Jennifer J and Hennings, Thomas G and Nair, Gopika G and Shveygert, Mayya and Guo, Tingxia and Puri, Sapna and Haataja, Leena and Cirulli, Vincenzo and Blelloch, Robert and Szot, Greg L and Arvan, Peter and Hebrok, Matthias
The EMBO Journal, ISSN 0261-4189, 07/2015, Volume 34, Issue 13, pp. 1759 - 1772
Directed differentiation of human pluripotent stem cells into functional insulin‐producing beta‐like cells holds great promise for cell replacement therapy for... 
insulin‐producing cells, pancreas | diabetes | human embryonic stem cells | beta‐like cells | beta-like cells | insulin-producing cells pancreas | TRANSCRIPTION FACTORS | insulin-producing cells | MOLECULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDODERM | CELL BIOLOGY | ISLET TRANSPLANTATION | pancreas | EMBRYONIC STEM-CELLS | GENERATION | DIFFERENTIATION | LINEAGE | ENDOCRINE-CELLS | Insulin-Secreting Cells - physiology | Embryonic Stem Cells - cytology | Streptozocin | Humans | Pancreas - cytology | Cells, Cultured | Mice, Transgenic | Glucose - pharmacology | Mice, SCID | Cell Culture Techniques - methods | Diabetes Mellitus, Experimental - therapy | Embryonic Stem Cells - physiology | Diabetes Mellitus, Experimental - blood | Animals | Insulin-Secreting Cells - drug effects | Cell Differentiation | Insulin-Secreting Cells - cytology | Mice | Blood Glucose - metabolism | Insulin-Secreting Cells - transplantation | Glucose | Diabetes | Pancreas | Insulin | Stem cells | Index Medicus | insulin-producing cells, pancreas
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2. Full Text Conversion of adult pancreatic α-cells to Β-cells after extreme Β-cell loss
by Thorel, Fabrizio and Népote, Virginie and Avril, Isabelle and Kohno, Kenji and Desgraz, Renaud and Chera, Simona and Herrera, Pedro L
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7292, pp. 1149 - 1154
Pancreatic insulin-producing beta-cells have a long lifespan, such that in healthy conditions they replicate little during a lifetime. Nevertheless, they show... 
GLUCAGON-SECRETION | DIABETES-MELLITUS | PROGENITOR CELLS | ENDOCRINE PANCREAS | IN-VITRO | MOUSE PANCREAS | REGENERATION | MULTIDISCIPLINARY SCIENCES | DIPHTHERIA-TOXIN RECEPTOR | ECTOPIC EXPRESSION | TRANSCRIPTION FACTOR | Diphtheria Toxin - pharmacology | Glucagon - biosynthesis | Cell Proliferation | Cell Count | Humans | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - biosynthesis | Cellular Reprogramming | Insulin-Secreting Cells - metabolism | Cell Transdifferentiation - physiology | Glucagon-Secreting Cells - metabolism | Female | Insulin-Secreting Cells - cytology | Cell Death - drug effects | Cell Differentiation - physiology | Insulin Secretion | Biomarkers - metabolism | Glucagon-Secreting Cells - cytology | Insulin - pharmacology | Rats | Mice, Transgenic | Regeneration - physiology | Cell Lineage | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Glucagon - metabolism | Mice | Index Medicus | Demand | Regeneration | Adults | Diabetes | Differentiation | Ablation | Conversion | insulin | regeneration | cell lineage tracing | islet | precursor cell | reprogramming | mouse | pancreas | transdifferentiation | diphtheria toxin | glucagon | transgenic | cell plasticity | cell ablation | diabetes
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3. Full Text In vivo generation of β-cell–like cells from CD34+ cells differentiated from human embryonic stem cells
by Goodrich, A. Daisy and Ersek, Adel and Varain, Nicole M and Groza, Daria and Cenariu, Mihai and Thain, David S and Almeida-Porada, Graca and Porada, Christopher D and Zanjani, Esmail D
Experimental Hematology, ISSN 0301-472X, 2010, Volume 38, Issue 6, pp. 516 - 525.e4
Objective CD34+ cells, present within the bone marrow, have previously been shown to possess pancreatic endocrine potential. Based on this observation, we... 
Hematology, Oncology and Palliative Medicine | Advanced Basic Science | INSULIN | MEDICINE, RESEARCH & EXPERIMENTAL | GENE | GLUCOSE | BONE-MARROW | PANCREAS | SHEEP | C-PEPTIDE | HEMATOLOGY | EXPRESSION | TRANSDIFFERENTIATION | TRANSPLANTATION | Immunohistochemistry | Embryonic Stem Cells - cytology | Blood Glucose - analysis | Enzyme-Linked Immunosorbent Assay | Humans | Islets of Langerhans - immunology | RNA, Messenger - analysis | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | Animals | Antigens, CD34 - immunology | DNA - analysis | Base Sequence | Islets of Langerhans - cytology | Sheep | Cell Differentiation | Embryonic Stem Cells - immunology | Insulin - genetics | Index Medicus | Human embryonic stem cells | Transplantation | Beta-cells | Pancreas | C-peptide
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4. Full Text Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice
by Vegas, Arturo J and Veiseh, Omid and Gürtler, Mads and Millman, Jeffrey R and Pagliuca, Felicia W and Bader, Andrew R and Doloff, Joshua C and Li, Jie and Chen, Michael and Olejnik, Karsten and Tam, Hok Hei and Jhunjhunwala, Siddharth and Langan, Erin and Aresta-Dasilva, Stephanie and Gandham, Srujan and McGarrigle, James J and Bochenek, Matthew A and Hollister-Lock, Jennifer and Oberholzer, Jose and Greiner, Dale L and Weir, Gordon C and Melton, Douglas A and Langer, Robert and Anderson, Daniel G
Nature Medicine, ISSN 1078-8956, 03/2016, Volume 22, Issue 3, pp. 306 - 311
The transplantation of glucose-responsive, insulin-producing cells offers the potential for restoring glycemic control in individuals with diabetes'. Pancreas... 
IMMUNOISOLATION | MEDICINE, RESEARCH & EXPERIMENTAL | NONIMMUNOSUPPRESSED PATIENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOLLOW-UP | IMMUNOCOMPETENT DIABETIC MICE | MATURATION | PRIMATES | CELL BIOLOGY | ISLET TRANSPLANTATION | IN-VITRO | INSULIN-PRODUCING CELLS | ALLOGRAFTS | Care and treatment | Pancreatic beta cells | Usage | Stem cells | Physiological aspects | Diabetes | Research | Polymers | Index Medicus
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5. Full Text A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
by Christian Schulz and Elisa Gomez Perdiguero and Laurent Chorro and Heather Szabo-Rogers and Nicolas Cagnard and Katrin Kierdorf and Marco Prinz and Bishan Wu and Sten Eirik W. Jacobsen and Jeffrey W. Pollard and Jon Frampton and Karen J. Liu and Frederic Geissmann
Science, ISSN 0036-8075, 4/2012, Volume 336, Issue 6077, pp. 86 - 90
Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs).... 
Bacteriophages | Kidneys | Lungs | Blood cells | Liver | REPORTS | Islets of Langerhans | Macrophages | Embryos | Blood | Hematopoietic stem cells | MICROGLIA DERIVE | IMMUNOHISTOCHEMICAL LOCALIZATION | YOLK-SAC | MULTIDISCIPLINARY SCIENCES | FLT3 EXPRESSION | SELF-RENEWAL | C-MYB | MONONUCLEAR PHAGOCYTE SYSTEM | TRANSCRIPTION FACTOR | AORTIC ENDOTHELIUM | LANGERHANS CELLS | Myeloid Cells - cytology | Cell Proliferation | Myeloid Cells - physiology | Dendritic Cells - physiology | Genes, myb | Liver - embryology | Yolk Sac - cytology | Microglia - physiology | Gene Expression Regulation, Developmental | Gene Deletion | Trans-Activators - genetics | Hematopoietic Stem Cells - physiology | Myelopoiesis | Macrophages - physiology | Microglia - cytology | Proto-Oncogene Proteins - metabolism | Kupffer Cells - cytology | Kupffer Cells - physiology | Proto-Oncogene Proteins - genetics | Macrophages - cytology | Chick Embryo | Proto-Oncogene Proteins c-myb - metabolism | Cell Lineage | Animals | Embryo, Mammalian - cytology | Hematopoietic Stem Cells - cytology | Langerhans Cells - physiology | Trans-Activators - metabolism | Dendritic Cells - cytology | Mice | Langerhans Cells - cytology | Physiological aspects | Transcription factors | Dendritic cells | Health aspects | Infections | Rodents | Inflammatory diseases | Stem cells | Index Medicus
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6. Full Text Signals From the Embryonic Mouse Pancreas Induce Differentiation of Human Embryonic Stem Cells Into Insulin-Producing β-Cell–Like Cells
by Gabriella K.C. Brolén and Nico Heins and Josefina Edsbagge and Henrik Semb
Diabetes, ISSN 0012-1797, 10/2005, Volume 54, Issue 10, pp. 2867 - 2874
Signals From the Embryonic Mouse Pancreas Induce Differentiation of Human Embryonic Stem Cells Into Insulin-Producing β-Cell–Like Cells Gabriella K.C. Brolén 1... 
RAT | GROWTH | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | NEURONS | MICE | IN-VITRO DIFFERENTIATION | ISLET CELLS | LINEAGES | AGGREGATION | Immunohistochemistry | Insulin - analysis | C-Peptide - blood | Humans | Islets of Langerhans - chemistry | Trans-Activators - analysis | Green Fluorescent Proteins - genetics | Stem Cells - cytology | Insulin - biosynthesis | Stem Cell Transplantation | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Cell Differentiation | Mice, Inbred C57BL | C-Peptide - analysis | Mice, Transgenic | Pancreas - metabolism | Mice, SCID | Pancreas - embryology | Stem Cells - chemistry | Animals | Embryo, Mammalian - cytology | Homeodomain Proteins - analysis | Fluorescent Antibody Technique | Signal Transduction - physiology | Mice | Index Medicus | Abridged Index Medicus
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7. Full Text δ‐cells and β‐cells are electrically coupled and regulate α‐cell activity via somatostatin
by Briant, L. J. B and Reinbothe, T. M and Spiliotis, I and Miranda, C and Rodriguez, B and Rorsman, P and Institute of Neuroscience and Physiology and Göteborgs universitet and Gothenburg University and Institute of Neuroscience and Physiology, Department of Physiology and Sahlgrenska Academy and Sahlgrenska akademin and Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi and Institutionen för neurovetenskap och fysiologi
The Journal of Physiology, ISSN 0022-3751, 01/2018, Volume 596, Issue 2, pp. 197 - 215
We used a mouse expressing a light‐sensitive ion channel in β‐cells to understand how α‐cell activity is regulated by β‐cells. Light activation of β‐cells... 
alpha cell | beta cell | delta cell | electrophysiology | Islet cell | somatostatin | optogenetics | computer modelling | PHYSIOLOGY | GLUCOSE CONTROL | MOUSE | INHIBIT GLUCAGON-SECRETION | FUNCTIONAL-CHARACTERIZATION | RELEASE | NEUROSCIENCES | INSULIN | PANCREATIC-ISLET | GAP-JUNCTIONS | CHANNELS | PARACRINE | Index Medicus | Research Paper | Endocrine, Nutrition and Metabolism | Neurologi | functional-characterization | glucose | paracrine | Fysiologi | k-atp channels | control | Neurosciences & Neurology | Neurology | mouse | inhibit glucagon-secretion | receptor | insulin-release | Physiology | gap-junction channels | pancreatic-islets
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8. Full Text Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes
by Lawlor, Nathan and George, Joshy and Bolisetty, Mohan and Kursawe, Romy and Sun, Lili and Sivakamasundari, V and Kycia, Ina and Robson, Paul and Stitzel, Michael L
Genome Research, ISSN 1088-9051, 02/2017, Volume 27, Issue 2, pp. 208 - 222
Blood glucose levels are tightly controlled by the coordinated action of at least four cell types constituting pancreatic islets. Changes in the proportion... 
CONGENITAL HYPERINSULINISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN-SECRETION | SURFACE-MARKERS | ENDOCRINE PANCREAS | PYRUVATE-CARBOXYLASE | GLUCOSE-METABOLISM | ENERGY HOMEOSTASIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | EPIGENETIC REGULATION | PANCREATIC BETA-CELL | RNA-SEQ DATA | Carrier Proteins - genetics | Islets of Langerhans - pathology | Gene Expression Regulation - genetics | Islets of Langerhans - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Gene Expression Profiling - methods | Signal Transduction - genetics | Transcriptome - genetics | Diabetes Mellitus, Type 2 - pathology | Single-Cell Analysis | Index Medicus | Research
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9. Full Text A scalable system for production of functional pancreatic progenitors from human embryonic stem cells
by Schulz, Thomas C and Young, Holly Y and Agulnick, Alan D and Babin, M. Josephine and Baetge, Emmanuel E and Bang, Anne G and Bhoumik, Anindita and Cepa, Igor and Cesario, Rosemary M and Haakmeester, Carl and Kadoya, Kuniko and Kelly, Jonathan R and Kerr, Justin and Martinson, Laura A and McLean, Amanda B and Moorman, Mark A and Payne, Janice K and Richardson, Mike and Ross, Kelly G and Sherrer, Eric S and Song, Xuehong and Wilson, Alistair Z and Brandon, Eugene P and Green, Chad E and Kroon, Evert J and Kelly, Olivia G and D'Amour, Kevin A and Robins, Allan J
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, pp. e37004 - e37004
Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will require the translation of proof-of-principle concepts into a... 
SUSPENSION-CULTURE | ISLET TRANSPLANTATION | EXPANSION | GROWTH | BIOLOGY | GENE-EXPRESSION | ENDODERM | DIFFERENTIATION | COLONY | LINES | Embryonic Stem Cells - cytology | Streptozocin | Humans | Male | Gene Expression Profiling | Mice, SCID | Diabetes Mellitus, Type 1 - therapy | Cryopreservation - methods | Embryonic Stem Cells - physiology | Animals | Flow Cytometry | Analysis of Variance | Embryonic Stem Cells - transplantation | Fluorescent Antibody Technique | Insulin-Secreting Cells - cytology | Mice | Batch Cell Culture Techniques - methods | Cell Differentiation - physiology | Type 1 diabetes | Stem cells | Transplantation | Embryonic stem cells | Banks (Finance) | Production processes | Diabetes therapy | Cell culture | Flow cytometry | Surgical implants | Embryo cells | Stem cell transplantation | Biology | Glucose | Kinases | Hyperglycemia | Embryogenesis | Suspension culture | Allografts | Cyclic GMP | Manufacturing | Pancreas | Diabetes mellitus | Implantation | Gene expression | Insulin | Embryos | Cytometry | In vivo methods and tests | Islets of Langerhans | Differentiation | Index Medicus
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10. Full Text Formation of composite endothelial cell-mesenchymal stem cell islets: A novel approach to promote islet revascularization
by Johansson, Ulrika and Rasmusson, Ida and Niclou, Simone P and Forslund, Naomi and Gustavsson, Linda and Nilsson, Bo and Korsgren, Olle and Magnusson, Peetra U and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Klinisk immunologi and Institutionen för onkologi, radiologi och klinisk immunologi and Uppsala universitet
Diabetes, ISSN 0012-1797, 09/2008, Volume 57, Issue 9, pp. 2393 - 2401
OBJECTIVE-Mesenchymal stern cells (MSCs) contribute to endothelial cell (EC) migration by producing proteases, thereby paving the way into the tissues for ECs.... 
HUMAN PANCREATIC-ISLETS | ANGIOGENESIS | TO-RAT | GRAFTS | IN-VIVO | GROWTH | ENDOCRINOLOGY & METABOLISM | MECHANISMS | EXPRESSION | TRANSPLANTATION | XENOGRAFTS | Islets of Langerhans - blood supply | Tissue Engineering - methods | Gels | Coculture Techniques | Humans | Cells, Cultured | Cell Communication - physiology | Cell Movement - physiology | Fibrin | Microscopy, Confocal | Neovascularization, Physiologic - physiology | Mesenchymal Stromal Cells - cytology | Endothelial Cells - cytology | Extracellular Matrix - physiology | Islets of Langerhans - cytology | Cell Survival - physiology | Physiological aspects | Diabetes | Research | Cell differentiation | Methods | Stem cells | Index Medicus | Abridged Index Medicus | Islet Studies | Tissue Engineering/methods | Medical and Health Sciences | Medicin och hälsovetenskap | MEDICIN | angiogenesis | Islets of Langerhans/blood supply/cytology | MEDICINE | Endothelial Cells/cytology | Mesenchymal Stem Cells/cytology
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