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Diabetes, Obesity and Metabolism, ISSN 1462-8902, 02/2018, Volume 20, Issue 2, pp. 283 - 291
AimsGlucagon receptor (GCGR) blockers are being investigated as potential therapeutics for type 1 and type 2 diabetes. Here we report the safety, tolerability,... 
phase 1 | glucagon stimulation | REGN | 1193 | GCGR | REGN1193 | ALPHA-CELLS | BLOOD-GLUCOSE | PANCREAS | HYPERPLASIA | ANTAGONIST LY2409021 | ISLET-CELL TUMOR | INSULIN | ENDOCRINOLOGY & METABOLISM | MICE | SECRETION | TYPE-2 DIABETES-MELLITUS | Receptors, Glucagon - antagonists & inhibitors | Follow-Up Studies | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Half-Life | Male | Metabolic Clearance Rate | Antibodies, Blocking - pharmacology | Patient Dropouts | Antibodies, Blocking - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Hypoglycemic Agents - administration & dosage | Adult | Female | Antibodies, Blocking - blood | Hypoglycemic Agents - pharmacokinetics | Lost to Follow-Up | Blood Glucose - analysis | Double-Blind Method | Antibodies, Monoclonal - pharmacology | Antibodies, Monoclonal - pharmacokinetics | Receptors, Glucagon - metabolism | Biomarkers - blood | Hypoglycemic Agents - pharmacology | Antibodies, Blocking - adverse effects | Antibodies, Monoclonal - administration & dosage | Infusions, Intravenous | Hypoglycemic Agents - adverse effects | Cohort Studies | Type 2 diabetes | Hyperglycemia | Safety and security measures | Glucagon | Analysis | Therapeutics | Monoclonal antibodies | Glucose | Dextrose | Homeopathy | Materia medica and therapeutics | Food | Lipoproteins (low density) | Pharmacodynamics | Diabetes mellitus | Liver | Diabetes mellitus (insulin dependent) | Hypoglycemia | Plasma levels | Safety | Pharmacokinetics | Diabetes mellitus (non-insulin dependent) | Nonlinear systems | Index Medicus | Original
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